iodine status has no impact on thyroid function

8/18/2019 Iodine Status Has No Impact on Thyroid Function

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IODINE STATUS HAS NOIMPACT ON THYROID

FUNCTION INEARLY HEALTHYPREGNANCY

YULIANA RAMADANI

14120130074


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INTRODUCTIONpentung


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METHOD

Design :

Su!e"# : In order to select pregnant women with normalthyroid tests, we proposed a thyroid screen to all women

who age > 18 years, without personal history of thyroid disease consulting at the obstetric clinic of our hospital

before 12 weeks of amenorrhea (WA) with a singleton

pregnancy between uly 2!!" and uly 2!!#

S$%&'ing : We included 11! $%&'negatie women withstrict criteria of normal thyroid tests who agreed to

participate and signed a consent form


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NE(T))

An$'*sis : tatistical analyses were

performed using the software A ersion *+1+alues were considered significant when P <

0.05. All tests were two-sided.


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RESULTS Clinical Characteristics of the 110 Included

o!en

1+ $heir median age was 2"+- y (1#./!),

2+ their body mass inde0 (I) was 22+/ (13./-+4)4+ a weight at inclusion of 31+- kg (/4.12# kg)

/+ they were nuliparous in //+-5+

-+ -45 had neer smoked, 1#5 were former

smokers, and 2#5 were current smokers+3+ 1-5 had a family history of thyroid disease

"+ #25 were born in 6rance (including -35 in the

authors area)+


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RESULTample characteristic


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TA+LE 1, IODURIA AND THYROID TESTSPERFORMED AT - .EE/S OF AMENORRHEA

12 IN THE 110 INCLUDED .OMENmedian mean ± SD Min Max

Ioduria µg/L 116 139 ± 98 < 15 399

FT4 pmol/L 14,35 14,57 ± 1,65 12.0 19,16

TS !"I/L 1.18 1.24 ± 0.58 0.13 2.47

FT3 pmol/L 5.0 5.1 ± 0,5 3.8 6.7

TT4 #mol/L 110.7 111,1 ± 23 50,7 167,4

T$% m g/mL 26,7 28,1 ± 7,2 12,8 50

Tg #g/mL 17.4 22,3 ± 17,2 1.3 100

β&'% "I/L 62.724 65.289 ± 47.845 1025 220.731

rT3 #mol/L 0,27 0,27 ± 0,07 0.13 0.51


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DISCUSSION


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DISCUSSIONA+ $he median 7I8 in our population with no iodine

supplementation was 113 "#$%, which is &elow the

currently recommended threshold in pregnancy (1-!

"#$%', in the range of mild iodine deficiency 913+

While spot ioduria is useless to establish thediagnosis of I; at an indiidual leel, gien its

ariation from day to day 91, so far it remains the

gold standard at the population leel 91"+

+ ased on 7I8, in our study of selected women with

normal thyroid function in early pregnancy, I; waspresent in 335 of cases, using a threshold of 1-!

"#$%. (his pre)alence was si!ilar to those many

studies worldwide performed at the same gestational

age, e0cept for rander in wit


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NE(T))=+ 7I8 did not correlate with any parameters of

maternal thyroid function at this stage of pregnancy

in our selected healthy population+ We had already

reported this lack of correlation in our preious

study performed during the third trimester 92+;+ &f note, we report a strong correlation of *hC+

with 7I8+ &ne physiological e0planation could be

that *hC+ stimulates rela0in secretion by the

corpus luteum, which plays an importantphysiologic role in the maternal renal adaptation to

pregnancy 941+ We speculate that this could

contribute to gestational increased 7I8 during the

first trimester+


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Ioduria

()ga*i+ "ia i-u r 0.2 0.05

olum) *iroid r 0.22 0.03

oi*i+ β'% r 0.27 < 0.01

TS

()ga*i+ +T4 r 0.27 < 0.005

rT3 r 0.24 0.01

β&'% r 0.36 < 0.0001

oi*i+ $)ra* -ada# i-u r 0.19 0.06

+T4

()ga*i+ $)ra* -ada# i-u r 0.2 0.05

oi*i+ TT4 r 0.44 < 0.0001

rT3 r 0.44 < 0.0001

/ 3 &'% r 0.18 0.058


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+T3

oi*i+ Tg r 0.22 0.02

rT3

()ga*i+ !)roo 0.001

oi*i+ β&'% r 0.4 < 0.0001

+T4 r 0.44 < 0.0001

TT4 r 0.5 < 0.0001

T$% r 0.33 0.0005

Tg

oi*i+ +T3 r 0.22 0.02

!)roo 0.0001

- &'%

()ga*i+ TS r 0.36 < 0.0001

oi*i+ Ioduria r 0.27 < 0.01

TT4 r 0.3 < 0.005

FT4 r 0.18 0.058

rT3 r 0.4 < 0.0001

T$% r 0.40 < 0.0001

olum) *iroid

()ga*i+ Ioduria r 0.22 0.05oi*i+ !)roo 0.02


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CONCLUSION$he absence of correlation between 7I8 and thyroid tests at that stage of pregnanc$he absence of correlation between 7I8 and thyroid tests at that stage of pregnanc


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iodine status has no impact on thyroid function

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