investigation of chlorouine-induced keratopathy on in vivo confocal microscopy
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Investigation of chlorouine-induced keratopathy on in vivo confocal microscopy. Jianjiang Xu, Wenqing Zhu, Jiaxu Hong Eye & ENT Hospital Fudan University Shanghai, China. Title: Investigation of chlorouine-induced keratopathy on in vivo confocal microscopy. Paper ID : 365 Disclosure Block : - PowerPoint PPT PresentationTRANSCRIPT
Investigation of chlorouine-induced keratopathy on in vivo confocal microscopy
Jianjiang Xu, Wenqing Zhu, Jiaxu Hong
Eye & ENT HospitalFudan UniversityShanghai, China
Title: Investigation of chlorouine-induced keratopathy on in vivo confocal microscopy
Paper ID: 365
Disclosure Block: None of commercial relationships with authors.
Outlines
Background Objective Methods Results Conclusion
Eye & ENT Hospital
Background Chloroquine (CHQ) was used successfully for the
treatment of several chronic autoimmune diseases However, a variety of side effects have been
reported, of which ophthalmic toxicity is of the utmost importance.
Chloroquine Corneal Deposits
Background In vivo confocal microscopy(CM) has dramatically
changed the ophthalmic clinical landscape, allowing a non-invasive approach to in vivo visualize cornea at a magnification of up to ×700
50 µm
Epithelium EndotheliumStromaCornea
To investigate morphological changes of the cornea by CM in patients diagnosed as rheumatoid arthritis and treated with CHQ
Objective
Subjects•30 patients with rheumatoid arthritis were enrolled•20 were treated with CHQ•the rest served as control
Examination:•Bilateral eyes were examined by slitlamp biomicroscope and CM•CHQ deposits and corneal cellular densities were analyzed
Methods
Deposits•No deposit was observed
by SLB examination. •Under CM, CHQ deposits were
observed in 28 (70.0%) of 40
eyes in patients•CM deposits demonstrate different
characteristic features of the CHQ
between two groups.
Results
Cellular density•The cellular density of each layer had no significant difference between two groups except the density of anterior stromal keratocytes.
Results
Conclusion CM is a useful tool for the investigation of keratopathy
induced by CHQ treatment CHQ deposits were mainly identified in corneal epithelium
and stroma
① They might correspond to intracellular lysosome-like corpuscles which could not be metabolised
② Abnormal microenvironment on basal epithelial cells leads to a vicious cycle on the maturation of epithelial cells.
AcknowledgementTeam
Prof. Jianjiang Xu
Wenqing Zhu M.D.
Jiaxu Hong M.D.
Anji Wei M.D.
Gang Li Ph.D
Grants: This work was supported partly by grants from the Key Clinic Medicine Research Program, the Ministry of Health, China (2007-2009).
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