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Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207 4085 www.eastlinden.net Email:[email protected]

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Page 1: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Introduction to World Traditional Medicine Patent

Database(WTMPD)

Beijing East Linden Science & Technology Co., Ltd

Tel:+86 10 5129 6683 Fax:+86 10 8207 4085

www.eastlinden.net Email:[email protected]

Page 2: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Main Components

WTMPDWTMPD

manually processed/indexed/ translated data

5 auxiliary files 2 helping tools multiple search entries

•Data covers22countries2international organizations•Over 110,000basic patents•Over 200,000family patents•Data start from 1985 to date

•Compound Registry File•Traditional MedicineRegistry File

•Formula File •Synonym File•TCM Name Dictionary File

•TCM Dictionary•User Thesaurus

•Quick Search •Form Search •Advanced Search •IPC Search•Formula Search •Formula Similarity Search•Natural Medicine Search•Chemical Structure Search

Page 3: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

prologue World traditional medicine patent database (WTM) produced by East

Linden is the world’s first bilingual (English and Chinese) traditional medicine patent database with integration of multinational patent resources.

Based on high-quality manually processed/indexed/translated data, assisted by five auxiliary files as well as two facilitating helping tools, plus functional search engine which provides multiple search entries, WTMPD is a valuable patent information resource in terms of providing professional search capabilities and analytical tools for global research academies and enterprises in the field of natural medicine research and drug development. Besides, natural products with pharmaceutical, nutraceutical, cosmetic and agrochemical interest are also included.

This file will present a detailed introduction to the database from the

following five aspects. 1. Introduction to Manually Processed & Deeply-indexed Data 2. Introduction to Auxiliary Files 3. Introduction to Helping Tools 4. Introduction to Search & Analyzing Platform 5. Introduction to Search Queries & Results Management Interface

Page 4: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

1. Manually Processed & Deeply-indexed Data

Page 5: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Outline

1.1 A Full Record Sample1.2 Data Description1.3 Rewritten Title 1.4 Enhanced Abstract 1.5 Unifying IPC Format &

Supplementing IPC 1.6 Index Terms 1.7 Indexed Term Codes 1.8 Therapeutic Effects Indexation 1.9 TCM Formulae

Page 6: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

A Full Record Sample1.1

Page 7: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Data Description1.2

•Data Coverage:

China, United States, Japan, Korea, Austria, Canada, Switzerland, East Germany, France, South Africa, Spain, Great Britain, Ireland, Israel, India, Netherlands, New Zealand, Philippines, Russia, Soviet Union, Singapore, Taiwan, EPO, WIPO

•Time Scope: 1985 to date

•IPC Coverage:

A61K35 A61K33 A23L A61K9 A61K31 A61K7 A61K38 A61K49 A61K47 A61K39 C12N1/14 A01G1/04 A61K36 A61K8 A61P

Page 8: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Rewritten Title Rewritten Title 1.3

More descriptive information added to the title:•Name of drug or product, drug ingredients•Method of preparation•Novelty•Physiological activity or biological mechanism •Uses

1.PN:US6004559 Original Title : Nontoxic extract of larrea tridentata and method of making

the sameRewritten Title: Nontoxic, therapeutic agent prepared with extract of

larrea tridentata for the treatment diseases caused by viruses and inflammatory diseases, and method of making the same

2. PN: WO0191770 Original Title : Compositions and methods for treating eye discomfortRewritten Title : Compositions containing herbals, natural nutritional

supplements, minerals and vitamins and methods for treating eye discomfort

Samples

Page 9: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

More descriptive information about technique is added to abstracts:

• The subject or purpose of the invention

• Standardization of compound or medicine name

• Method of preparation

• Advantages

• Physiological activity or biological mechanism

• Uses

• Means of taking medicine

Enhanced Abstract 1.4

Page 10: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

• PN: US5012761 Original Abstract: Chickens are fed a composition including fish oil

over a period of time. Modified eggs laid by such chickens contain substantial quantities of omega-3 polyunsaturated fatty acids. The modified eggs are fed to humans with the result that serum cholesterol, serum triglycerides and blood pressure are reduced a compared to human eating a like number of regular eggs with a subsequent decrease in heart disease.

Enhanced Abstract: A method of increasing the OMEGA-3 polyunsaturated fatty acid content of chicken eggs comprises the steps of: (a) obtaining a grain based chicken feed; (b) forming a mixture of the chicken feed and an oil containing OMEGA-3 polyunsaturated fatty acid such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with the oil being from about 3.0 percent to about 10.0 percent by weight of the mixture; (c) thereafter feeding chicken laying hens the mixture as a primary source of food for the hens; and (d) collecting the eggs of such hens laid subsequent to the hens eating the mixture. The oil is fish oil, and fish oil may be deodorized. Said hen eggs contain low cholesterol content, which can be fed to humans with the result that serum cholesterol, serum triglycerides, very low density lipoprotein and blood pressure are reduced as compared to humans eating a like number of regular eggs with a subsequent decrease in heart disease for example coronary heart disease.

Sample 1

Page 11: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

• PN:  US20020082780 • Original Abstract: Therapeutic compositions made from the herb

Tribulus terrestris and methods of making and using the same are provided, The therapeutic compositions include an enriched extract having an increased spirostanol saponin content that is prepared from the harvested Tribulus terrestris L. The enriched extract is prepared using discrete hydrolysis, separation and enrichment steps. The resulting therapeutic may be combined with a cream base and is useful for treating bacterial, fungal, and viral infections, particularly gynecologic infections. This product was also found to be very successful in suppository form for the treatment of vulvo-vaginal, vulvo-hemorrhoidal and colonic conditions.

• Enhanced Abstract: An anti-bacterial, anti-virus, anti-herpes topical medication comprising extract of Tribulus terrestris L. (Tribulus terrestris, Puncture Vine, Caltrop fruit) is prepared by the steps of: (a) Preparing an aqueous first extract of Tribulus terrestris L; (b) Treating the first extract to convert furostanol saponin compounds of protodioscine contained therein to spirostanol saponin compounds of diosgenin by BETA-Glucosidase or acid hydrolysis; (c) isolating the spirostanol compounds from the first extract; and (d) adding the isolated spirostanol compounds to second Tribulus terrestris L extract. The resulting therapeutic medication may be formulated into cream, ointments, eye and ear drops. It is useful in the treatment of conditions related to viral, bacterial, fungal, viral, yeast, parasitic infections, particularly gynecologic infections, including genital, and eye and ear infections, vaginal infections, candidiasis, skin disorders such as skin infection, acne, skin burning and rashes, herpes simplex I, herpes simplex II, cervical wounds, cervical erosion, diabetic wounds, Burger disease, phlebitis, varicose veins and broken split skin. It may block cancer cells from growing. It also can be used for the treatment of vulvo-vaginal, vulvo-hemorrhoidal and colonic conditions in the form of suppository.

Sample 2

Page 12: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Unified IPC format, making IPC format more standard IF the subject of the patent is about USE (Therapeutic Effects),

IPC A61P will be added to the patent record IF the subject of the patent is about FOR ( Formulation Process),

IPC A61K009 will be added to the patent record IF a patent is about a medicine relevant to plant or epiphyte, IPC

A61K035/78 and A61K035/84 will be added to the patent record

Unifying IPC Format and Supplementing IPC

1.5

• PN: US6004559 Original IPC:A23C 9/00; A23L 1/304; A23L 2/00; A23L 2/40

After:A23C009/00; A23L001/304; A23L002/00; A23L002/40; A23C009/152; A23L002/52; A23L002/42; A23L002/44;

A23L002/54 A23L002/54; A61P003/02

Sample

Supplementing A61P based on

IPC7

Page 13: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Indexing Terms1.6

All Traditional Medicine , Specific Compounds , Generic Structure , Animal Medicine, Plant Medicine existing in the patent document are indexed to support a special search

• PN:US6368641• Abstract: Lactic acid food products comprise a starter for use in producing

lactic acid food products and soy milk or a mixture of soy-milk and dairy milk. The starter comprises Lactobacillus acidophilus strain 317/402, Lactobacillus acidophilus non-mucus producing strain, Streptococcus diacetilactis, Lactobacillus salivarius, Streptococcus cremoris. The lactic acid food products can be made into sour cream, cottage cheese, lactic acid desserts, dry drinks, ice cream, frozen dessert. Lactic acid food products can be used in a normal diet or in medicine both for their nutritive value, and for the physiologically active substances they contain. It can be used for the medical treatment of health problems such as gastrointestinal disorders (such as gastritis, hyperemia, and ulcer of a stomach), pulmonary disease and allergies. It also can be used as part of a medical treatment to promote the growth of the natural microflora of intestine and to lower cholesterol levels in the blood.

• Indexed Terms: SOY MILK; DAIRY MILK; LACTOBACILLUS ACIDOPHILUS STRAIN 317/402; LACTOBACILLUS ACIDOPHILUS NON MUCUS PRODUCING STRAIN; STREPTOCOCCUS DIACETILACTIS; LACTOBACILLUS SALIVARIUS; STREPTOCOCCUS CREMORIS; LACTIC ACID FOOD PRODUCT; SOUR CREAM; COTTAGE CHEESE; LACTIC ACID DESSERTS; DRYDRINKS; ICE CREAM; FROZEN DESSERT

Sample

Page 14: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Indexed Term Codes 1.7

According to subject of the patent, all patents in the database are classified into eight categories with different Indexed Term Codes (ITC) as below

ITC Description of ITCCOM COMBINATION

EXT EXTRACTION

FOR FORMULATION

NTU NEW THERAPEUTIC USE

PHY PHYSICAL PROCESS

ANA ANALYTIC PROCESS

BIO BIOLOGICAL PROCESS

PLA PLANTING TECHNIQUE

Page 15: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: COM (COMBINATION PROCESS)PN:US20040115163Abstract:A cosmetic product with skin-aging retarding effect

comprises vegetable lipidic extracts. The lipidic extracts include sea fennel wax, Cistus monspeliensis wax, Helichrysum italicum wax and Lavandula stoechas wax, which are prepared from Crithmum maritimum (sea fennel, Apiaceae family, Crithmum genus), Cistus monspeliensis (Cistaceae family, Cistus genus), Helichrysum italicum (Asteraceae family, Helichrysum genus) and Lavandula stoechas (Lamiaceae family, Lavandula genus) by means of supercritical CO2 co-extraction in the presence of a solvent composed of vegetal origin triglycerides. And a vegetable oil which is solid at room temperature is added to the lipidic extracts. The cosmetic product can be available in the form of a vegetal wax; and can be used as a food supplement. The vegetal waxes act both on epidermal differentiation and on keratinocyte division. They have effect in retarding skin aging. They also may be used in dermatology as the active principle of a pharmaceutical product to treat the disorders of keratinocyte differentiation, in particular as an anti-psoriatic agent; and moreover may be used as the active principle of a pharmaceutical used in speeding up scar formation. .

Sample 1

Page 16: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC:EXT (EXTRACTION PROCESS )PN:US20060057238Abstact: A method of making extract of buds of cryptomeria

japonica D. Don (Taxodiaceae, Cryptomeria japonica) includes three stages, first solid/liquid extraction stage at a temperature between 3-100℃ with water, alcohol (such as butylene glycol) or a polyol, followed by a second solid/liquid separation step, then a third liquid phase retrieval step. The solid/liquid extraction step is performed by maceration, digestion, fluid bed extraction, microwave-assisted extraction, ultrasound-assisted extraction, countercurrent extraction, percolation, repercolation, leaching, low-pressure extraction, supercritical fluid extraction and so on.Said extract can be used to make face cream, Slimming Body Milk, O/W Emulsion, W/O Emulsion, Microemulsion, Sunscreen, Makeup Foundation and so on.

Sample 2

Page 17: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: FOR (FORMULATION PROCESS )PN: US5012761 Abstrac: A method of increasing the OMEGA-3 polyunsaturated

fatty acid content of chicken eggs comprises the steps of: (a) obtaining a grain based chicken feed; (b) forming a mixture of the chicken feed and an oil containing OMEGA-3 polyunsaturated fatty acid such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with the oil being from about 3.0 percent to about 10.0 percent by weight of the mixture; (c) thereafter feeding chicken laying hens the mixture as a primary source of food for the hens; and (d) collecting the eggs of such hens laid subsequent to the hens eating the mixture. The oil is fish oil, and fish oil may be deodorized. Said hen eggs contain low cholesterol content, which can be fed to humans with the result that serum cholesterol, serum triglycerides, very low density lipoprotein and blood pressure are reduced as compared to humans eating a like number of regular eggs with a subsequent decrease in heart disease for example coronary heart disease.

Sample 3

Page 18: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: NTU (NEW THERAPEUTIC USE)PN: US5776463 Abstract: Oral pharmaceutical composition contains petals

of borage (Boraginacae, Borago officinalis) or extract of borage petals, wherein the extract is freeze-dried soluble extracts of borage petals, and is obtained by extracting with solvent selected from acetone, methyl ethyl ketone and diethyl ketone. The composition is used for reducing heart rate and blood pressure due to stress, prevention and treatment of circulatory heart diseases such as angina, palpitations and hypertension as well as symptoms such as chest pains traveling down to the shoulders and arms, shortness of breath, numbness in fingers, irregular heart beats, arrhythmia, anxiety. The composition can be made into capsule, film-coated tablet, oral drops, tea composition.

Sample 4

Page 19: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: PHY (PHYSICAL PROCESS)PN:US5368874Abstract: A method for manufacturing intermediate products for

preparation of animal feeds. The process comprising the steps of reducing the crude raw material (soya beans, fodder beans, cereals, peas, rape seed and broad beans) in size, heating a crude granular raw material in a vessel containing a heating device at a temperature of 100℃ which is sufficient to toast the raw material, feeding the toasted crude raw material from the vessel to a container, cooling the toasted raw material within the container by contacting the toasted raw material with cold air (10-30℃) in counterflow to the feeding of the toasted raw material in order to heat and moisten the cold air and to cool and dry the raw material so as to obtain the intermediate products, feeding the heated moist air back to the vessel thereby recovering the energy from the heating step. In this method, energy and moisture from the heating process can be recovered and re-used. The method eliminates the anti-nutritional factors in the raw materials of animal feeds and improves the nutritional value of the raw materials.

Sample 5

Page 20: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: ANA (ANALYTIC PROCESS ); FOR PN:US6759517Abstract: An allergenic protein from natural rubber latex is

provided. The allergenic protein is from the latex or tissue of rubber tree, Hevea brasiliensis. It is oligomeric of monomeric polypeptides. The allergenic protein can be used in assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex, and can be use in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex. Said allergens can be used as de-sensitizing agents in the treatment of latex protein allergy.

Sample 6

Page 21: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC:BIO (BIOLOGICAL PROCESS )PN:US20040241784Abstract: A method for selecting non-pathogenic Gram-positive lactic acid bacteria

(Lactobacilli) strains which can combat infections via tissue adherence by a pathogenic Gram-negative or Gram-positive bacteria strains, such as enteropathogenic bacteria strains of Salmonellas, Helicobacter pylori, Yersinia, and Clostridies, especially ECET/0147: K88ac serotype strain of Escherichia coli; and has the properties of the ability to adhere to tissues of an organ that is likely to be infected, the ability to fix to one another via mutual adhesion sites, and the ability to fix to the attachment determinants of the pathogenic bacterial strain responsible for the infection. The method comprises insolating a single strain from duodenum of each piglets or sows, culturing, and identifying to obtain strains of Lactobacillus and Leuconostoc; treating duodenum of a host (an animal, such as a fowl, a pig, a bovine, a dog, a cat, a horse, an ovine, a caprine or a fish, preferably a piglet) with the Krebs buffer and a glycerolized buffer sequentially to obtain enterocytes and mucous membrane, suspending in buffer, adding the lactic acid bacteria strains suspension, and stirring to displaying tissue adherence properties on the mucous membrane and on the enterocytes of the duodenum; mixing lactic acid bacteria strains suspension with the pathogenic bacteria suspension, and stirring mildly to observe autoaggregation (adherence between the lactic acid bacteria of a same strain) and coaggregation (adherence between the lactic acid bacteria and the pathogenic bacteria) properties; and measuring the specificity of the adherence of the lactic acid bacteria to pathogenic bacteria expressing K88 fimbriae. The bacteria strains selected with this method can be mixed with a pharmaceutically acceptable vehicle to prevent or treat infection of a host digestive tract by pathogenic bacterial strains.

Sample 7

Page 22: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

ITC: PLA (PLANTING)PN:US6337071Abstract: A plant of the species Leptospermum liversidgei which is

able to block the carbon dioxide message to mosquitoes and/or fleas within the vicinity of its locus. The clone of Leptospermum liversidgei is planted through clonal selection on the basis of tissue oil content, and propagating asexually. Said plant has a content of citronellal and/or the citronellal analogues isopulegol and pulegol. It can be planted in either outdoor or indoor situations for repelling mosquito and/or flea. Crude or refined essential oil extract from the said plant can be obtained to prepare an essential oil composition comprising said essential oil extract for repelling mosquitoes and/or fleas.

Sample 8

Page 23: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Therapeutic Effects Indexation (USE) 1.8• Therapeutic effects indexation can be divided into: Therapeutic

effect ( THEF ) and diagnosis ( DIAG )

• PN-US20020049251 • Abstract: A composition comprises a mixture of annatto (Bixa orellana linn seed,

Bixa orellana seed, Bixaceae family, reddish-orange colorant) extract with tocotrienol and a natural plant extract; and wherein the mixture has standardized low levels of tocopherols. The tocotrienol includes all the chemically synthesized forms of alpha-tocopherol, delta-tocotrienol and gamma-tocotrienol, such as alpha-T1, delta-T3, gamma-T3, DL-delta-tocotrienol and DL-gamma-tocotrienol; and the natural extract is selected from the group consisting of soybean, corn, rice bran, palm, olive, wheat germ, oat bran, sunflower seed, cottonseed, cranberry seed, and litchi seed. The composition has effects in activating PPARs, regulating SREBP transcription factors, decreasing the blood level of the triglyceride, against inflammation, lowering cholesterol, decreasing cardiovascular risk index, decreasing metabolic risk index, reducing osteoporosis, increasing bone mineralization, enhancing immune system, lowering lipids, reversing insulin resistance, increasing natriuresis, improving autonomic nervous, aidding nerve growth, healing damaged nerves, and reversing chronic aging system, and extending life; and can be used for treating skin malady, eczema, prediabetes, diabetes and diabetes-related cardiovascular disease, lipidemia and diabetic dyslipidemia, hypertension, T2DM, PCOS, fatty liver disease, cancer, acute nerve damage, neural degenerative genetic disease, acute brain damage, brain trauma, chronic nerve damage, neural toxicity, chronic brain damage, Alzheimer's, Parkinson's, and Huntington's.

• USE:ANTIINFLAMMATORY; CHOLESTEROLEMIA; OSTEOPOROSIS; BONE MINERALIZATION; NATRIURESIS; PREDIABETES; DIABETES; CARDIOVASCULAR DISEASE; LIPIDEMIA; DIABETIC DYSLIPIDEMIA; HYPERTENSION; DERMATOLOGICAL; HYPERTRIG AUTONOMIC NERVE LYCERIDEMIA; METABOLIC DISEASE; IMMUNOSTIMULANT; AUTONOMIC NERVE; NERVE TRAUMA; AGING; DERMATOLOGICAL; ECZEMA; LIPIDEMIA; T2DM; POLYCYSTIC OVARY SYNDROME; FATTY LIVER; CANCER; NEURAL DEGENERATION; BRAIN INJURY; ALZHEIMER; PARKINSON; HUNTINGTON CHOREA

Sample

Page 24: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

TCM Formulas Indexation 1.9

All formulae existing in the patent documents are indexed to support a special search.

PN: CN1107067 Abstract: A Chinese medicinal pill, TIANJIAN Pill, is composed of

TIAN Pill and JIAN Pill. TIAN Pill is prepared from Cordyceps, Ganoderma, Gecko, Fructus Fici, Radix Astragali, Fructus Ligustri Lucidi, and Poria, by mixing and making pill. JIAN Pill is prepared from Herba Solani Nigri, Gekko Swinhonis, Pheretima, Xylosmae japonici, Herba Agrimoniae, Bulbus Fritillariae Uninbracteatae, Mylabris, Scorpio, and Rhizoma Pinelliae Preparatum, by crushing, extracting with ethanol, and decocting with water. TIAN Pill and JIAN Pill are used together for treating tumor such as lung cancer, esophageal cancer, nasopharyngeal cancer, liver cancer, gastric cancer, and intestinal cancer; and can also relieve adverse side effects of radiotherapy and chemotherapy

Formula1: GEKKO SWINHONIS 0.5-2%; BULBUS FRITILLARIAE UNINBRACTEATAE 16-46%; PHERETIMA 2-8%; MYLABRIS 0.0005-0.0015%; XYLOSMAE JAPONICI 2-8%; SCORPIO 1-5%; HERBA AGRIMONIAE 5-25%; RHIZOMA PINELLIAE PREPARATUM 16-36%; HERBA SOLANI NIGRI 5-20%

Formula2: CORDYCEPS 0.5-1.5%; GANODERMA 5-15%; GECKO 0.5-1.5%; FRUCTUS FICI 7-20%; RADIX ASTRAGALI 18-38%; FRUCTUS LIGUSTRI LUCIDI 18-38%; PORIA 10-28%

Sample

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2. Auxiliary Files

Page 26: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

FIVE auxiliary files are provided together with the database to support and facilitate information retrieval

Compound Registry FileTraditional Medicine Registry FileChinese Traditional Medicine Formula

File TCM Name Dictionary FileSynonym File

Outline

Page 27: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Compound Registry File2.1

All active chemical compounds existing in patent document are registered in the compound registry file as below (a full record).

Page 28: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

All natural medicines existing in patent document are indexed by an unique code system, which provide users comprehensive information relevant to a natural medicine. The following is the sample of a full record.

Traditional Medicine Registry File2.2

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3. Helping Tools

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3.1 TCM Dictionary 3.2 User Thesaurus

With the Two Tools, users are able to-- check TCM name and thesaurus-- expand the search to thesaurus dictionary-- revise, add, delete words in the list

Outline

Page 31: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

The TCM dictionary contains 10 thousands Traditional Chinese medicine records.

Contents in Each Record:• Chinese Standard names• Chinese Synonyms:• English Drug names• Latin Drug names• Latin Plant/Mineral names• Chinese Pinyin

TCM Dictionary 3.1

Page 32: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

The Search Result:

Based on the selected search result, clicking the button of “Search in Abstract DB”, it will conduct crossing search in the indexed patent database by default.

TCM Dictionary Interface

Page 33: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

User Thesaurus

users can add new word

Users can add new group

In “Basic Search” interface, there is a button “Expanded Search ”, click the button, and the system will automatically expand the keyword to the thesaurus list to conduct the search

3.2

User Thesaurus Interface

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4. Searching & Analyzing Platform

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Quick Search Interface 4.1

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Form Search Interface 4.2

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Advanced Search Interface 4.3

Search for herb-based medicine used as “food additive”

Check field code

Page 38: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Click the button, it will move to the corresponding pages to conduct search with the selected IPC field

IPC Search Interface 4.4

Page 39: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

TCM Formula Search Interface

You can add/delete/change the medicine name in the list

4.5

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Formula Similarity Search Interface4.6

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Natural Medicine Search Interface (1)

The result of the medicine “GINSENG” search

Based on the selected result of the name search, the crossing search in the patent abstract database can be make

4.7

Page 42: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Natural Medicine Search Interface (2)

Click the button “Search in Abstract DB” in last slid, it will conduct crossing search in indexed patent database by default as below

Page 43: Introduction to World Traditional Medicine Patent Database (WTMPD) Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207

Chemical Structure Search (1)

Based on the selected search result, clicking the button of “Search in Abstract DB”, it will conduct the crossing search in the indexed patentabstract database by default.

Search Entries

Click the button, there will appear a window for users to draw the chemical structure for search

4.8

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Chemical Structure Search (2)

Chemical Structure Drawing area

Search Result

Search result in indexed patent database basedon the selected result of Chemical structure search

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Display & Download of Search Results

A Full Record

1) Users can set the display option to decide which fields to display

2) Twenty records can be displayed together at a time

3) Users can print the records directly

4) Analyze selected records

5) Save to My Patent

6) THREE optional download formats, including TXT, HTML, ACCESS

1 2 3 4 5 6

4.9

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Analysis of Search Results

Click the    icon to enable statistical options.

4.10

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Click Trend analysis of patent applications link to pop up the statistic page. The default display mode is Table and you may choose other modes, i.e., Histogram, Pie chart and Line graph according to your preference. If the records are showed in multiple pages, click First, Previous, Next, Last, to navigate, or enter a number in the Go to Page box to go to that page directly.

Trends Analysis of Patent Publications

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Click Trend analysis of patent publications link to pop up the statistic page. The default display mode is Table and you may choose other modes, i.e., Histogram, Pie chart and Line graph according to your preference. If the records are showed in multiple pages, click First, Previous, Next, Last, to navigate, or enter a number in the Go to Page box to go to that page directly.

Trends Analysis of Patent Applications

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Click Trend analysis of IPCs link to pop up the statistic page. The default display mode is Table and you may choose Histogram or Line graph according to your preference.

Trends Analysis of IPCs

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Click Co-occurrence analysis of Assignee to expand three options: Top 10 entries, Top 20 entries, Top 50 entries, for displaying the top assignees in different number. Select and click one of them to display the assignee.

Co-occurrence analysis of Assignee

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Click Co-occurrence analysis of IPC to expand three options: Top 10 entries, Top 20 entries, Top 50 entries, for displaying co-classification relation of records in different number.

Co-occurrence analysis of IPC

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5. Search Queries & Result Management

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This database provide users with convenient operation management system under which users are able to save queries and search result.

5.1 My favorite query 5.2 My portfolio 5.3 Search History

Outline

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My Favorite Query 5.1My Favorite Query is a list-view scheme comprised of groups and items

which save your queries in hierarchically. Each group may contain multiple items and each item in a group may serve as a subgroup and further contain multiple items. If you want to reuse the queries saved, click the corresponding group or item conduct the search.

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My Portfolio5.2My Portfolio is a list-view scheme comprised of groups and items which

save your search results hierarchically in the manner of lists of application numbers. Each group may contain multiple items and each item in a group may serve as a subgroup and further contain multiple items. If you want to view the patent records saved, click the corresponding group or item.

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Search History5.3All of your queries are automatically saved in the Search History. The

Search History has four groups saving your queries submitted today, yesterday, the day before yesterday, and three days ago respectively. All queries can only be saved for a week, so save in My Favorite Query those you may probably use sometime later.

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Contact Information Suite A207, The Greatwall Computer Building A 38 Xueyuan Road, Haidian District, Beijing P.R. China100191Tel:+86 10 5129 6683 Fax:+86 10 8207 4085 Email: [email protected] or [email protected]: www.eastlinden.net