Introduction To Introduction To The Addiction The Addiction PsychiatryPsychiatry

What is Addiction What is Addiction PsychiatryPsychiatry

What patients are What patients are misusingmisusing

Dopamine pathwayDopamine pathway

DA neuron cell bodies lie in the DA neuron cell bodies lie in the VTA (ventral tegmented area ). It is VTA (ventral tegmented area ). It is the group of neuron located close the group of neuron located close to the mid brain. It is the origin of to the mid brain. It is the origin of dopaminergic cell bodies. dopaminergic cell bodies.

Mesolimbic := From mid brain to Mesolimbic := From mid brain to nucleus accumbens. It is also in nucleus accumbens. It is also in the hippocampus. the hippocampus.

Mesocortical := it is situated from Mesocortical := it is situated from mid brain to the prefrontal cortex. mid brain to the prefrontal cortex.

Function of DopamineFunction of Dopamine

It insrease the DA release, inhibit It insrease the DA release, inhibit reputake and act as the DA agonist. In reputake and act as the DA agonist. In acute increase of the DA in the both acute increase of the DA in the both mesolimbic and mesocortical mesolimbic and mesocortical pathway to be essential in the linking pathway to be essential in the linking and increasing of the drug taking. and increasing of the drug taking. Nucleus accumbens is also essential. Nucleus accumbens is also essential.

Corticotropin Releseasing Corticotropin Releseasing Factor And HPA AxisFactor And HPA Axis

In response to use the drug activation In response to use the drug activation of the mesolimbic DA system HPA of the mesolimbic DA system HPA axis is upregulated. In case of acute axis is upregulated. In case of acute case withdrawal psychological. case withdrawal psychological. Increase in the cortisol CRF in Increase in the cortisol CRF in addition to neuropeptide, vesopressin addition to neuropeptide, vesopressin are thought to persist in months are thought to persist in months leadin gto the anxiety, it is called leadin gto the anxiety, it is called protacted withdrawal. protacted withdrawal.

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