introduction to biomedical engineering i · 2019-02-25 · lecture 6 ety494 – introduction to...
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Lecture 6
ETY494 – Introduction to Biomedical Engineering (2019 Spring Semester)
MATERIALS SCIENCE AND TECHNOLOGY DEPARTMENT UNIVERSITY OF CRETE
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Cloning What is tissue engineering Building blocks Biomaterials Bioreactors Cells
Type of human cells Cell differentiation
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3 https://www.youtube.com/watch?v=k1a2larfMIA
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4 https://www.youtube.com/watch?v=kkvslrfaCLY
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Genetic Engineering
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Cell Engineering
Tissue Engineering
Organ Engineering
Human Engineering ???
https://geneticliteracyproject.org/2018/01/16/crispr-answer-genetic-engineerings-prayers/
https://www.nature.com/scitable/topicpage/what-is-a-cell-14023083
https://www.proprofs.com/quiz-school/story.php?title=tissue-quiz
https://www.icems.kyoto-u.ac.jp/en/originality/tissue/
https://back-shop.com/the-spine-perfect-human-engineering/
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A large mass of similar cells that make up a part of an organism and perform a specific function
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https://rontherapist.wordpress.com/2012/10/24/connective-tissue-the-very-basics/
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7 https://slideplayer.com/slide/10510567/
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8 https://slideplayer.com/slide/8690848/
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10 https://www.youtube.com/watch?v=TLVwELDMDWs
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Are engineered cells enough to give solutions?
11 https://geneticliteracyproject.org/2017/12/05/genetic-engineering-synthetic-biology-poised-boost-photosynthesis-carbon-capture/
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12 https://jisakos.bmj.com/content/2/2/60
Growth factors Signals
Biocompatibility Porosity Degradability Mechanical matrix
Stem Cells
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13 https://www.oshasafetymanagement.com/blog/establishing-scaffold-safety-guidelines-training/
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Allow cell attachment and migration Deliver and retain cells and biochemical
factors Enable diffusion of vital cell nutrients and
expressed products Exert certain mechanical and biological
influences to modify the behavior of the cell phase
Need a certain porosity, biodegradability,
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15 https://www.popsci.com/consent.php?redirect=https%3a%2f%2fwww.popsci.com%2fscience%2farticle%2f2013-07%2fartificial-human-ear-good-shape
Why you think this "might" be important?
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16 “Additive manufacturing of tissues and organs” https://www.sciencedirect.com/science/article/pii/S0079670011001328
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CONDITIONS STRATEGIES
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Birla, Ravi - Introduction to tissue engineering applications and challenges, Wiley-IEEE Press (2013)
https://www.worldkidneyday.org/faqs/topics/cardiovascular-disease/
Acute myocardial failure Atherosklerosis Valve stenosis Hypoplastic left heart
syndrome
Pharmacological agents Mechanical devices Pumps
Surgical interventions Heart transplantation
https://en.wikipedia.org/wiki/Hypoplastic_left_heart_syndrome
https://www.labroots.com/trending/cardiology/2335/preventing-heart-failure-after-acute-myocardial-infarction
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18 https://www.organdonor.gov/statistics-stories/statistics.html
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19 https://www.prosancons.com/education/pros-and-cons-of-statistics/
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20 https://unos.org/data/
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CURRENT
Uses mechanical components
Biomaterials (as defined in Lecture 4)
OBJECTIVE OF T.E.
Fabricate biological artificial organs that are similar in form and function to mammalian organs
Uses a combination of cells, biomaterials, and engineering technologies
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Cardiovascular Heart muscle Blood vessels Valves Cell based cardiac pump Ventricles Bioartificial heart
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https://www.freepik.com/free-photos-vectors/cell https://www.britannica.com/science/blood-vesse
https://www.cardiosmart.org/heartvalvedisease
https://www.science20.com/news/engineering_the_heart_piece_by_piece
https://www.thoughtco.com/ventricles-of-the-heart-373254
http://www.medicalautomation.org/2014/07/3-d-printing-a-bioartificial-heart/
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23 https://www.youtube.com/watch?v=HU_pgHlWsdc
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Musculoskeletal Bone
Cartilage
Skeletal muscle
Tendons
24 https://clinicalposters.com/products/musculoskeletal-system-22x28?variant=5160524873761
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Urinary system Kindney
Urinary bladder
Ureters
Urethras
25 https://www.pharmamad.com/271-2/
https://nurseslabs.com/urinary-system/
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Airway system Artificial trachea
Artificial lung tissue
26 https://myhealth.alberta.ca/Health/Pages/conditions.aspx?hwid=hw144088
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Digestive system Artificial liver tissue
Pancreas
Intestine tissue
Esophageal tissue
27 https://www.scientificpublishing.com/product/the-digestive-system/
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Artificial skin
Central nervous system
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http://www.orissapost.com/scientists-develop-artificial-skin-with-superpowers/
http://www.richardsonthebrain.com/central-nervous-system
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29 https://www.youtube.com/watch?v=7Q3S6q97FiU
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30 (IEEE Press series in biomedical engineering) Birla, Ravi - Introduction to tissue engineering _ applications and challenges-Wiley-IEEE Press (2013)
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https://www.researchgate.net/publication/315589595_Stem_cell_homing-based_tissue_engineering_using_bioactive_materials
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http://3d2go.com.ph/blog/breakthrough-applications-of-3d-printing-for-healthcare-and-medical-science/
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33 https://www.youtube.com/watch?v=u468xY1T8fw