•“INTRODUCTION TO BIOINFORMATICS”

•by•(Aqsad)

What is Bioinformatics?

Bioinformatics = Biology + Information

Biology is becoming an information science.

Computational methods are necessary to analyze the Massive amount of information that are coming out of the genome projects.

Easy Answer - Using computers to solve

molecular biology problems

Hard Answer -

Computational techniques for management and

analysis of biological data and knowledge.

What is Bioinformatics?

BioinformaticsBioinformatics: is the

development and use of computer applications for the Analysis, Interpretation, and Prediction of biological Systems and corresponding experimental methods in nature sciences.

BB I O L O G Y

P H Y S II O M I C S

C E L L OO M I C S

B II O T E C H

E V O L U T I O NN

I N FF O T E C H

O N T OO L O G Y

P RR O T E O M I C S

M O L E C U L A R MM O D E L I N G

M AA T H E M A T I C S

M E TT A B O L O M I C S

T R A N S C R II P T O M I C S

G E N O M I CC S

SS T A T I S T I C S

Bioinformatics combines the tools of

Biology, Chemistry, Mathematics,

Statistics and Computer Science to

understand Life & its processes.

Bioinformatics bridges many disciplines

6

BioinformaticsHISTORY

Biology Molecular BiologyBiochemistry

Biophysics

Physics & Chemistry, 1950s

Bioinformatics

Computer Sc. & Statistics, 1970s

Margaret Dayhoff

Biological Data and Bioinformatics.

NAILS

=

DATA

Hammer

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BIOINFORMATICS

What is bioinformatics?•   Main goal is to convert complex data

into information and knowledge •   Data includes gene and protein

sequences, nucleotide sequences .•   Information used to build synthetic and

predictive models.•   Future applications in biology, chemistry,

pharmaceuticals, medicine, and agriculture

Bioinformatics:Studying Biology on Computer

data management; data mining; modeling; prediction; theory formulation.

Computer system

scientific aspect

bioinformatics

genes, proteins, protein complexes, pathways, cells, organisms, ecosystem

Discovery from Data Mining (I)

DNA - Sequence

.....acctc ctgtgcaaga acatgaaaca cctgtggttc ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcacct gcaggagtcg ggcccaggac tggggaagcc tccagagctc aaaaccccac ttggtgacac aactcacaca tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccgtgccc acggtgccca gagcccaaat cttgtgacac acctccccca tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccgtgccc ccggtgccca gcacctgaac tcttgggagg accgtcagtc ttcctcttcc ccccaaaacc caaggatacc cttatgattt cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaagtg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ctgcgggagg agcagtacaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagc aaccaagtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaacacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg aacatcttct catgctccgt gatgcatgag gctctgcaca accgctacac gcagaagagc ctctc.....