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TRANSCRIPT
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PathologyThyroidKristine Krafts, M.D.
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases
Neoplastic diseases
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Introduction
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Normal thyroid follicles
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TRH
TSH
thyroid growth
hormone synthesis
3°
2°
1°
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Lab Tests
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Thyroid Lab Tests
TSHT4
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Euthyroidism (Normal)
Normal TSHNormal T4
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Primary Hyperthyroidism
T4↑ TSH↓
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Secondary Hyperthyroidism
T4↑ TSH↑
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Primary Hypothyroidism
TSHT4 ↑↓
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Secondary Hypothyroidism
T4↓ TSH↓
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Hyperthyroidism
A hypermetabolic state caused by increased thyroid hormone.
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General: weight loss, heat intolerance
Cardiac: rapid pulse, arrhythmias
Neuromuscular: tremor, emotional lability
Skin: warm, moist
Gastrointestinal: diarrhea
Eye: lid lag
Thyroid storm: extreme, dangerous symptoms
Hyperthyroidism Signs and Symptoms
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Lid lag
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Introduction
Hyperthyroidism
Hypothyroidism
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Hypothyroidism
A hypometabolic state caused by increased thyroid hormone.
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General: fatigue, weight gain, cold intolerance
Cardiac: slow pulse, impaired contraction
Nervous: delayed reflexes, lethargy
Skin: rough, dry, cool
Gastrointestinal: reduced appetite, constipation
Myxedema: deepened voice, “edema”
Myxedema coma: deteriorating mental status
Hypothyroidism Signs and Symptoms
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Myxedema
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases• Thyroiditis• Graves disease• Goiter
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases• Thyroiditis
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• Most common cause of hypothyroidism in the US!
• Autoimmune destruction of gland
• Diagnostic autoantibodies:• Anti-thyroglobulin antibody• Anti-thyroid peroxidase antibody
Hashimoto Thyroiditis
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Female
“Hash”Myxedema
Hashimoto Thyroiditis
Mrs. Potatohead
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Hashimoto thyroiditis: Hürthle cells
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• Big, sore thyroid
• Recent URI
• Immune cross-reaction with thyroid follicles
• Self-limiting
DeQuervain Thyroiditis
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Looks scary
Really harmlessGoes away by itself
DeQuervain Thyroiditis
Rex
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De Quervain thyroiditis: multinucleated giant cell
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• Post-partum or middle age.
• Painless, slightly enlarged thyroid.
Silent Thyroiditis
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Silent Thyroiditis
Bullseye
SilentDoesn’t cause problems
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Silent thyroiditis: lymphoid infiltrate
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• Rare!
• Rock-hard neck mass
• Hypothyroidism
• Tracheal compression
Reidel Thyroiditis
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Fibrosing Thyroiditis
Woody
Woody
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Reidel thyroiditis
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases• Thyroiditis• Graves disease
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• Most common cause of hyperthyroidism in the US!
• Classic triad: hyperthyroidism, ophthalmopathy, dermopathy
• Autoimmune stimulation of thyroid
• Diagnostic autoantibody: anti-TSH receptor antibody (stimulates growth)
Graves Disease
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Marty Feldman
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Exophthalmos
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Graves disease dermopathy
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Graves disease: papillae and scalloped colloid
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases• Thyroiditis• Graves disease• Goiter
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• “Goiter” = big thyroid gland
• You can see a goiter in Graves disease and in some cases of thyroiditis.
• You can also see a goiter in patients who aren’t making enough T4 .
Goiter
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Goiter
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Goiter
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no iodine
enzyme defects
¯ T4 TSH
unknown reasons
How you get a goiter from ¯ T4 synthesis
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hyperplasia
involution
trauma
simple goiter
multinodular goiter
Over time, goiters enlarge and become nodular.
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Multinodular goiter
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases
Neoplastic diseases• Benign• Malignant
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases
Neoplastic diseases• Benign
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Most neoplasms present as nodules.
• Nodules are common!
• Most are benign.
• Thyroid carcinoma is uncommon.
Thyroid neoplasms
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adenoma
carcinoma
Incidence of thyroid carcinoma vs. adenoma
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Thyroid fine needle aspiration
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• Common! • Most patients are euthyroid• Some are hyperthyroid
Thyroid adenoma
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Adenoma
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Adenoma
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Treatment: take it out!
Q. Why, if it’s benign?
A. Because thyroid adenomas can look exactly like follicular thyroid carcinoma!
Thyroid adenoma
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Introduction
Hyperthyroidism
Hypothyroidism
Non-neoplastic diseases
Neoplastic diseases• Benign• Malignant
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papillary (80%)
follicular (10%)
anaplastic (<5%)
Incidence of Different Types of Thyroid Carcinoma
medullary (5%)
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• Most common thyroid malignancy
• Excellent prognosis (>95% 10y survival)
• “Orphan Annie” tumor
Papillary Thyroid Carcinoma
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Papillary thyroid carcinoma
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Papillary carcinoma: Orphan Annie nuclei
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Papillary carcinoma: psammoma body
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• Often affects younger women
• Tends to stay around for years without getting any bigger
• Is usually well-behaved; seldom kills people
• Has nuclei that resemble Orphan Annie’s eyes
• Has psammoma bodies (from the greek psammos, or sand) -Annie’s dog is named Sandy
Papillary Carcinoma: The Little Orphan Annie Tumor
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• Second most common type
• Young patient with small, minimally invasive tumor: 95% 10y survival
• Prognosis worsens with increasing age, tumor size, and invasiveness
Follicular Thyroid Carcinoma
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Follicular thyroid carcinoma: vascular invasion
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• Rare
• Endocrine tumor (of C cells)
• Confined to thyroid: 90% 10y survival
• Distant mets: 20% 10y survival
Medullary Thyroid Carcinoma
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Medullary thyroid carcinoma
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• Rarest type
• Bulky, fast-growing, invasive neck mass
• Usually metastatic at diagnosis
• Very bad prognosis (<10% 5y survival)
Anaplastic Thyroid Carcinoma
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Anaplastic thyroid carcinoma
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