introduction center for future technologies in cancer care · doi: 10.1200/jco.2015.62.2860, jco...
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IntroductionCenterforFutureTechnologies
inCancerCareCatherineKlapperich,Ph.D.
DirectorBostonUniversity
9June2016
NewTherapies
Linda McCulloch William Burhans Andrew Levy
Immunotherapy,BrainCancerRemission
TargetedTherapy,RemissionfromBRCA-positiveprostatecancer
Immunotherapy,LeukemiaRemission
PrecisionMedicine
• Whowillbenefitmostfromthesenewtherapies?• Howcanweimprovehealthcaredeliverytoimpactthemostpatients?
• Willthesenewtherapiesandtheircostworsenhealthdisparities?
“Precision medicine is not the future of cancer care, it is the present. This study reinforces that the more we personalize treatment to the patient and the tumor, the better the outcomes – even in the earliest phases of research,” said Don S. Dizon, MD, FACP.
PointofCareandtheNewCancerCare• Inordertoreducecosts,itwillbenecessarytohavethefollowinginformationaccessibletocliniciansandtheirpatients• Inexpensivesequencingdataofprimaryandmetastatictumors.
• Tumorsmonitoredmolecularlythroughoutthecourseoftreatment.
• Assessmentoftherapyearlierintreatment.Earlydetectionofnewacquiredmutationsthatmightenableresistance.
• Managementoftheseteststhroughoutthecourseofcare.• Hightouchpatientmanagementwithfewerofficevisits.• Puttingqualityoflifeissuesfrontandcenter.
DisparitiesinCancerCare
Documentedcancerhealthdisparitiesinclude:
• ahigherincidenceofaparticularlyaggressiveformofbreastcancer(thetriple-negativesubtype)amongAfricanAmericanwomenthanwomenofotherracial/ethnicgroups
• substantiallyhigherratesofprostatecancerincidenceanddeathamongAfricanAmericanmenthanmenofotherracial/ethnicgroups
• higherratesofkidneycanceramongAmericanIndianandAlaskaNativesthanotherracial/ethnicgroups
• higherratesoflivercanceramongAsianandPacificIslandersthanotherracial/ethnicgroups
• higherratesofcervicalcancerincidenceanddeathamongHispanicandAfricanAmericanwomenthanwomenofotherracial/ethnicgroups
GlobalDisparitiesinCancerCareAreastoaddressglobalhealthdisparitiesincancercareinclude:
• TobaccoControl• Obesity,DietandExercise• Vaccines• Prevention,EarlyDetection,Treatment• PalliativeCare
Meanstoaddressthesedisparities:• MobileHealthApplications• EMRs• PointofCareDiagnosisandRiskStratification• TreatmentMonitoring• QualityofLifeTechnologies
doi: 10.1200/JCO.2015.62.2860, JCO January 2016 vol. 34 no. 1 6-13
CFTCCisfocusedontheidentification,prototypingandearlyclinicalassessmentofinnovativepointofcaretechnologiesforthetreatment,screening,diagnosisandmonitoringofcancers.
Weaidinvestigatorsintheassessmentofearlystagetechnologiesintermsofclinicalneeds,marketdemandsandsettingappropriateness.
TheCenterhasasstrongemphasisonprototypingactivities.
Cancerdetectionandtreatmentisevolvingrapidly,andtheCFTCCstrivestokeeptestdevelopersontopofthechange.
Year 1 Year 2 Year 3 Year 4
Project #1Project #2
Project #3Project #4Project #5
Project #6Project #7Project #8Project #9
Project #10
Project #11
Project #12
Project #13
Project #14
Project #15
Project #16
Project #17
Year 5
Startup/Lic.
IndustryPartner VCFundingCFTCCFollowon
SummaryofPrototypeProjectstoDate
R21
R01BetaProt.
BetaProt.
BetaProt.
R21
HealthSystemFunds
PendingR01
IndustryPartner
BetaProt. IndustryPartner
Clin.TestACSandDODBetaProt.
R44
K22
Coulter$
R01 Startup/Lic
Fullpatentfiled BetaProt.inprog.
IndustryPartner
AdminCore
AlphaCore Funding BetaCore Transition
Prototyping
ProgressofProjectsThroughtheCenter
RFAProcess
Hackathons
Workshops
Symposia
SocialMedia
IndustryPartners
FederalFunding
Licensing
IPConsulting
RegulatoryConsulting
Startup
Press
LocatingClinicalSampleSets
TrainingCore
ClinicalNeedsCore
ScientificPublications
AlphaPrototypingCore
Equipment
• Microarray • Laser Cutter • Wax printer • Cutter Plotter• Real-Time PCR
System
• 3-D Printer • Desktop mill• Laminator • Stereomicroscope
• Class 1000 cleanroom • Precision Measurement Laboratory• EPIC machine shop• BSL 2 Lab Access
Other facilities
Stratasys uPrint SE Nikon SMZ18
FlexCircuit
ProbeHousing
Tumor(4.5cm)
A New Wearable Optical Probe for Chemotherapy Monitoring.Motivation
DiagnosisStage II/III
Locally Advanced
NeoadjuvantSystemic Therapy
Adapted from Zakhireh et al., 2008
Before
Chem
oA
fter C
hemo
Barrier:Adaptive Therapy Requires Better
Feedback
Our Solution:Wearable Diffuse Optical Imaging
Problem:It can take months to determine
chemosensitivity with current methods
Standard of Care
Pathologic Complete Response
PartialResponse
Non-Response
Months
Improved 5-year
survival
Little or no benefit toxic side-effects
broad chemoresistance
PI: Darren Roblyer, Boston University, Biomedical EngineeringCo-PI: Alexis Sauer-Budge, Fraunhofer CFI
The Wearable probe will be placed on the skin of a breast cancer patient over a known tumor location. Continuous measurements will be taken during chemotherapy infusions.
LEDs (750nm, 850nm)
Optical Sensor
The Wearable probe is designed to conform to breast
tissue.
It measures tumor metabolism during chemotherapy for early
response prediction.