NERVE STIMULATION WORKS

Introducing Quell™, a 100% drug free technology proven to fight pain1

PN 2204150 REV A

A new option for relief from chronic pain

Published evidence in support of intensive nerve stimulation:

• Lower Back and Leg Pain: Significant reduction in pain, as assessed by the visual analog scale2

• Diabetic Neuropathy: Significant reductions in pain and analgesic use3

• Fibromyalgia: Combined with exercise, decreased pain, fatigue, and stiffness4

Site of Pain Block- Activation of δ-opioid Receptors

Elevated GABA Concentration

Pain Signal

Dorsal Root Ganglion (DRG)

Nociceptive Neuron

SPINAL CORD

ROSTRAL VENTRALMEDULLA (RVM)

CAUDAL MIDBRAIN

Raphe Nuclei

Descending Pain Regulatory Pathway

Ascending PainPathway

Periacqueductal Gray Matter (PAG)

SpinothalamicTract

Dorsal Horn

Transcutaneous Electrical NerveStimulation Activates PAG

Pain A�erent Fiber

Quell stimulates dense clusters of sensory nerve fibers in the upper calf. This, in turn, activates descending pain inhibition systems in the brainstem.

Precise, high-frequency nerve stimulation triggers a neurotransmitter cascade, starting in the periaqueductal gray matter and progressing to the rostroventral medulla and ultimately the dorsal horn of the spinal cord.

Enkephalins, powerful endogenous opioids released during this process, inhibit pain signal transmission for a widespread analgesic response.

Enkephalins target different pain receptors than prescription opioids, activating δ-opioid receptors, while prescription opioids act on the μ-opioid system.

Unique new wearable design blocks pain in the body

References: 1. Gozani SN, Science Behind Quell™ Wearable Pain Relief Technology for Treatment of Chronic Pain, NeuroMetrix Inc, 2015. 2. Buchmuller A, Navez M, Milletre-Bernardin M, et al. Value of TENS for relief of chronic low back pain with or without radicular pain. Eur J Pain. May 2012; 16(5):656-665. 3. Szopinski S, Lochner G, Szopinska H. The effectiveness of analgesic electrotherapy in the control of pain associated with diabetic neuropathy. Souther African Journal of Anesthesia & Analgesia. 2002:12-18; 4. Carbonario F, Matsutani LA, Yuan SL, Marques AP. Effectiveness of high-frequency transcutaneous electrical nerve stimulation at tender points as adjuvant therapy for patients with fibromyalgia. Eur J Phys Rehabil Med. Apr 2013; 49(2):197-204.