intracellular accumulations.pdf
TRANSCRIPT
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Cellular Response to Injury: Intracellular Accumula5ons
Charles L. Hitchcock, MD, PhD Department of Pathology Wexner Medical Center at The Ohio State University
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MPPC Objec5ve
Describe the mechanisms of cell injury and dieren5ate among the various mechanisms of cell response to injury.
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Specic Objec5ves
List the types of material that can be accumulated within cells and the four major mechanisms of their accumulation.
Compare and contrast the etiologies, the cellular mechanisms, and the morphologic features of intracellular accumulation of:
Lipids in hepatocytes and macrophages Proteins Glycogen in glycogen storage diseases Exogenous and endogenous pigments
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Mechanisms of Intracellular Accumula5ons
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Accumula5on of Lipids
Triglycerides
Cholesterol
Glycolipids ceramide,
gangliosides, & sphingomyelin
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Any Ques5ons?
Contact me at: [email protected]