international science & engineering visualization … · 2010-03-05 · netic analyzers take...
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Visualization in all its
forms has the power to
illuminate and educate. It
explains and makes clear
all aspects of the world
around us. It feeds insight
and provokes curiosity.
The National Science
Foundation (NSF) and the
journal Science, published by the
American Association for the
Advancement of Science, invite
you to participate in this year’s
Challenge. The competition
recognizes scientists, engineers,
visualization specialists, and
artists who produce innovative
work in visual communication.
Winning entries will be
published in Science and Science
Online, and will be displayed on
the NSF web site.
Award Categories
• Photographs/Pic tures
• I l lustrat ions/Drawings
• Informational Posters
and Graphics
• Interac tive Games
• Non- Interac tive Media
I N T E R N A T I O N A L S C I E N C E & E N G I N E E R I N G
V I S U A L I Z A T I O N C H A L L E N G E
CALL FOR ENTRIES
’
ENTRY DEADLINE: SEPTEMBER 15, 2010
C E I:
..//
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“How dowe know
this leadmolecule
is novel?”
Need to assess the novelty of substances?
SciFinder is the answer.
It includes CAS REGISTRY,SM themost comprehensive
substance information available, integrated with relevant
journal articles and patents.
Give your research team the highest quality andmost timely
scienti�c information resource.
Make SciFinder an essential part of your research process.
For more information about SciFinder, visit www.cas.org or
e-mail [email protected].
SciFinder®—Part of the process.TM
CAS is a division of the American Chemical Society
��
SciFinder—
of course.
www.cas.org
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Visit www.emdbiosciences.com/widescreen for technical information on the broad
range of WideScreen™ products available. To order WideScreen™ products: USA and
Canada 800.854.3417. Outside North America contact your local Merck office.
Refer to next page for details.
Without high-quality biomarker data,
am I making the best decisions?
What is your risk tolerance?
WideScreen™ BeadPlex™ Multiplex Assays.
Assay solutions that are extensively
validated for clarity you can count on.
When it comes to biomarker patterns,
insight is everything.
That's what's in it for you. EMD Chemicals
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Cancer:Human Cancer Panel 1 (Tumor Markers)•
Human Cancer Panel 2 (Growth Factors)•
Human Breast Cancer Panels (3)•
Human MMP Panel•
Signaling Cancer Panels:Erk/MAPK Pathway Panels 1&2•
Receptor Tyrosine Kinase (RTK) Panel 1•
Phospho-Receptor Tyrosine•
Kinase (RTK) Panel 1
Phospho-EGFR Profiling 9-plex•
Coming soon:Receptor Tyrosine Kinase (RTK) Panel 2•
Phospho-Receptor Tyrosine•
Kinase (RTK) Panel 2
CardioVascular Disease:Human CVD Panel 1 (Apolipoprotein)•
Human CVD Panel 2 (Inflammation)•
Human CVD Panel 3•
Human CVD Panel 4•
Human CVD Panel 5 (Acute Phase)•
Human CVD Panel 6•
Metabolism:Human Metabolism Panel 1•
Human Metabolism Panel 2•
Human Hormone Panel 1•
Rat Metabolism Panel 1•
WideScreen™ BeadPlex™ Biomarker Assay Kits
Large portfolio of multiplex assays developed both internally atMerck KGaA, and with Rules Based Medicine (RBM)Created using assays from RBM’s HumanMAP® and Rat KidneyMAP® service portfolioFocused on specific therapeutic areas and disease statesOur continually expanding portfolio includes:
WideScreen™ BeadPlex™ Toxicity AssaysPanels of key toxicity biomarkers used to detect kidney impairment due to drug-induced toxicity. In
2008, the Predicitive Safety Testing Consortium (PSTC), a public-private consortium led by the Critical
Path Institute, submitted a list of urinary biomarkers indicative of drug-induced kidney damage to
the FDA and EMEA regulatory authorities. The FDA and EMEA have issued new guidelines on the
submission of the biomarkers as indicators of kidney damage in pre-clinical studies. EMD, in partnership
with RBM, has now released assay kits that include four of the seven newly accepted biomarkers
(KIM-1, ß2M, Cystatin C, and Clusterin) along with six other key protein markers for kidney injury.
Rat Kidney Toxicity Panel 1 (KIM-1, ß2-microglobulin, GST• α, TIMP-1, VEGF)
Rat Kidney Toxicity Panel 2 (Cystatin C, NGAL, Calbindin, Clusterin, Osteopontin)•
WideScreen™ BeadPlex™ Multiplex Assays
for the Luminex® xMAP® Platform
WideScreen™ Biomarker Analysis for:
WideScreen™BeadPlex™Multiplex Assaysfor the xMAP®Technology Platform
Toxicity•
Cancer•
Cardiovascular Disease (CVD)•
Metabolism•
Inflammation•
Hormones•
Signaling Pathways•
©Copyright 2009 EMD Chemicals, an affiliate of Merck KGaA, Darmstadt, Germany. All rights reserved. Each product is intended to be used
for research purposes only. It is not to be used for drug or diagnostic purposes nor is it intended for human use. Novagen® is a registered
trademark of EMD Chemicals Inc. in the United States, Europe, Japan and Australia. WideScreen™ and BeadPlex™ are trademarks of EMD
Chemicals Inc. Luminex®, xMAP®, and the xMAP® medallion are registered trademarks of Luminex Corporation. WideScreen™ Biomarker
Assays are manufactured by Rules Based Medicine. RodentMAP™, HumanMAP™ and KidneyMAP™ are trademarks of Rules Based Medicine.
©Copyright 2009 EMD Chemicals, an affiliate of Merck KGaA, Darmstadt, Germany. All rights reserved. Each product is intended to be used
for research purposes only. It is not to be used for drug or diagnostic purposes nor is it intended for human use. Novagen® is a registered
trademark of EMD Chemicals Inc. in the United States, Europe, Japan and Australia. WideScreen™ and BeadPlex™ are trademarks of EMD
Chemicals Inc. Luminex®, xMAP®, and the xMAP® medallion are registered trademarks of Luminex Corporation. WideScreen™ Biomarker
Assays are manufactured by Rules Based Medicine. RodentMAP™, HumanMAP™ and KidneyMAP™ are trademarks of Rules Based Medicine.
Visit www.emdbiosciences.com/widescreenfor technical information on the broad
range of WideScreen™ products available.
To order WideScreen™ products: USA
and Canada 800.854.3417. Outside North
America contact your local Merck office.
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GE HealthcareLife Sciences
It’s all the convenience you want in a spectrophotometer, packaged in a portable,
ergonomic device. NanoVue Plus features a new hydrophobic, gold-colored sample
plate coating that delivers outstanding results for sub-microliter amounts of proteins
and nucleic acids. It operates without a PC and does not require time-consuming third-
party path length recalibration.
NanoVue Plus enables easy protocol selection using advanced software that includes
intuitive drop-down lists for the full range of CyDye™ fluorescent dyes, as well as lists
for common fluors. Results can exported using a USB cable or Bluetooth™ connections
for print via computer (PVC) or stored using the new SD card option. An integrated
printer is also available.
• Swift, accurate analysis of 0.5 µl samples
of nucleic acids and proteins
• Practical drop and measure mechanism
• Outstanding sample recovery
• Reliable and reproducible measurements
• Automatic self-calibration on start up
• Path length recalibration kit available
as accessory
Experience the NanoVue Plus first hand.
Register for a trial at:
www.gelifesciences.com/tryNanoVuePlus
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Drop. Measure. Done.NanoVue™ Plus: intelligent performanceacross all spectrophotometer applications
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Use QIAGEN® solutions from sample to result,and benefit from sensitive and reliable detection systems:
■ Quantitative, real-time PCR detection
■ Automated analysis of DNA fragments and RNA
■ Pyrosequencing® sequence-based DNA detection and quantification
■ Optimized, ready-to-use assays and reagents
Making improvements in life possible — www.qiagen.com
Detection platforms, assays,
and analysis software
by QIAGEN
Choose QIAGEN for detection
Sample & Assay Technologies
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www.abcam.com
We do proteins too!Over 8,000 proteins and peptides available, with 150 new products added
every month. All supported by industry leading datasheets providing detailed
application and technical data, just one click away!
Stay up-to-date on the latest developments with our human expressed proteins
• Optimal post-translational modifications
• Biological activity
• Fc chimera proteins offering advantages in dimerization
Visit www.abcam.com/proteins for more information
Abcam Inc.1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
Tel: 1-617-225-2272
Toll free: 1-888-77-ABCAM
Toll free Fax: 1-866-739-9884
Bioactivity of human expressed proteins
Assays were conducted to compare the
bioactivity of human expressed proteins
and their non-human expressed
counterparts such as E.coli expressed or
other mammalian expressed proteins.
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CLONING & MAPPINGDNA AMPLIFICATION
& PCRRNA ANALYSIS
PROTEIN EXPRESSION &
ANALYSIS
GENE EXPRESSION
& CELLULAR ANALYSIS
Reagents for Sample Preparation from New England Biolabs
Introducing NEBNext™, a series of highly pure reagents that facilitate sample preparation for downstream applications such
as next generation sequencing and expression library construction. Available in sets, master mixes and modules, these robust
reagents undergo stringent quality controls and functional validation, ensuring maximum yield, convenience and value.
www.neb.com
STUNNING QUALITY
Sequencing coverage map of the E. coli genome after using
NEBNext™ DNA Sample Prep Reagent Set 1 for Sample Preparation
E. coli strain MG1655 gDNA was prepared with NEBNext DNA Sample Prep Reagent Set I and sequenced on an Illumina
Genome Analyzer II.
Now available:NEBNext™ dsDNA Fragmentase™
an enzyme-based solution for the
fragmentation of DNA
For more information about NEBNext, including customized solutions,please contact [email protected].
160
140
120
100
80
0 1x106 2x106 3x106 4x106
Seq
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over
age
Genome Position
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Today millions of people with Alzheimer’s can no longer remember the onesthey love. That number is expected to increase dramatically over the next 20years. And it’s one more reason MetLife Foundation continues to supportresearch to find a cure. This year the Foundation honors the outstanding workof Todd E. Golde, MD, PhD, University of Florida, Gainesville, Edward H. Koo, MD,University of California, San Diego, Eckhard Mandelkow, PhD, and Eva-MariaMandelkow, MD, PhD, Max-Planck-Institute for Structural Molecular Biology,Hamburg, Germany, with the MetLife Foundation Award for Medical Research.
Imagine not being able to recognize your best friend.
©2010 MetLife Foundation, NY, NY. PEANUTS ©UFS, Inc.
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The smarter the mouse
the quicker the drug gets to market.
From disease models that facilitate target identification, to humanized models
that test the safety and efficacy of potential therapeutics, Taconic’s “smart” mice
play a pivotal role in speeding new drugs to market.
Taconic’s rapidly expanding portfolio of fully licensed, off-the-shelf ADME-Tox
transgenic models, as well as transgenic models for short term carcinogenicity
testing provide valuable insights into how your drug will behave in humans.
Taconic introduces another breakthrough in in vivo compound testing with
its new transADMET program. Developed in conjunction with CXR Biosciences,
transADMET is transforming the discovery process by better predicting ADMET
in humans. New humanized models are available now.
To learn how Taconic’s “smart mice” can accelerate your
research and help speed a drug to market, visit our website,
www.taconic.com/SOT
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It becomes you.
Introducing the 3500 Series Genetic Analyzer.
Get ready to make an amazing discovery: the new 8-capillary and 24-capillary 3500 Series Ge-
netic Analyzers take DNA analysis to an entirely new level of performance. A level where your
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and intuitive software interface keep you current and in control.
Take a closer look, and you’ll find the new 3500 and 3500xL Genetic Analyzers are like
second nature. Which is our first priority when it’s your data.
Discover the 3500 System at www.appliedbiosystems.com/3500Series
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
© 2010 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners.
For those who require IVD-marked devices, the 3500 Dx and the 3500xL Dx Genetic Analyzers and system accessories meet the requirements of the In Vitro Diagnostics Medical Devices Directive (98/79/EC). The 3500 Dx and 3500xL Dx systems are for distribution and use in
specific European countries only. For more information about the 3500 Dx Series Systems, contact your Applied Biosystems representative.
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ADVANCES IN SCIENCE AND MEDICINE ARE CHANGING THE FACE OF PULMONARY, CRITICAL
CARE AND SLEEP. STAY AT THE FOREFRONT OF YOUR PROFESSION BY ATTENDING
THE AMERICAN THORACIC SOCIETY’S 2010 INTERNATIONAL CONFERENCE.
ATS 2010•New OrleansLouisiana MAY 14-19
• Epigenomics in Lung Cancer: Linking Development to Disease
• Lipid Mediators in Pathogenesis and Resolution of Acute Lung Injury
• Host Defense Mechanisms in Pulmonary Infection*
• Pushing Stem Cells: Cellular Plasticity
• Quantitative Assessment of Lung Structure: Principles and Practical Applications*
• Scientific Breakthroughs of the Year: Stem Cells and Regenerative Medicine
• Coins for the Boatman: Clearance of Apoptotic Cells in Lung Disease
• Vascular-Matrix Interactions in Lung Development and Disease
• Cells in Lung Injury and Repair of the Lung: Scientific and Translational Importance
• Top-Notch Decisions in Lung Development and Disease
*Postgraduate course
Scientists from nearly 100 countries are expected to participate in the 2010ATS International Conference.With more than 400 sessions, 800 speakers and 5,000 original research abstracts, attendees cansample a broad spectrum of topics or concentrate on the latest findings in respiratory molecular and cellbiology, lung structure and function, inflammatory biology and gene therapy.
Here is a selection of scientific and clinical sessions:
Registration for the 2010ATS
International Conference is now open.
Learn more about these and other sessions in
the 2010Advance Program, which is available
online at
www.thoracic.org/go/international-conference
MEETS
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OCTOBER 2009 | Vol. 1 | Nos. 1–4
Submit your work to Science
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INTEGRATING MEDICINE AND SCIENCE
In 2009, AAAS and Science launched Science TranslationalMedicine, a new journal focused on applications of basicresearch knowledge that will improve human health.
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Papers in the following areas will be reviewed andconsidered for publication:
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1149www.sciencemag.org/products SCIENCE VOL 327 26 FEBRUARY 2010
NEW PRODUCTS
LIFE SCIENCE TECHNOLOGIES
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or
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Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
AAAS/Science Business Office
FLOW CYTOMETERSThe guava easyCyte 8HT flow cytometry system is a compact, af-
fordable, six-color detection system with 96-well automation that al-
lows scientists to move their research out of the core lab and into
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multiplexed experiments in which six targets and eight parameters
can be simultaneously analyzed in a single sample of cells. In addi-
tion to allowing researchers to analyze more targets, the six-color
detection range also provides greater freedom to choose fluores-
cent dyes with well-separated emission spectra, which reduces the
chance of overlap in the resulting signals and improves data quality.
Millipore
For information 978-715-1567 www.millipore.com
COLOR CAMERAThe SC30 is an easy-to-use color camera for high-quality microscopy
imaging that offers superior resolution and quality with accurate
color reproduction. Suitable for use in both material and life science
applications, this camera is designed to capture fast frame rates.
Its cost-to-performance ratio makes it a suitable introductory model.
With a native resolution of 2048 x 1532 pixels and multiple binning
modes, the SC30 camera can achieve high levels of sensitivity and
fast frame rates during live cell imaging. Using the 4x binning mode,
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seconds, enabling the user to be in complete control of the image
acquisition process.
Olympus
For information +49-40-2-37-73-5426 www.microscopy.olympus.eu
CYTOMETER FOR LARGE PARTICLESThe Copast Large Particle Flow Cytometers can analyze, sort, and
dispense objects that are too large (20 microns to 1,000 microns) or
too delicate for traditional flow cytometers. Typical samples that can
be analyzed range from small multicellular organisms (C. elegans, D.
melanogaster, and zebrafish) to delicate large cells and cell clusters
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based assays). Samples are analyzed one by one in a continuously
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population enrichment prior to further experiments, isolation of rare
events, and quantification of fluorescence levels of each object.
Union Biometrica
For information 508-893-3115 www.unionbio.com
PROTEIN A COLUMNSA new range of Protein A columns combines the benefits of BioVyon
technology with the economy and convenience of a cartridge-based
separation methodology. Designed for laboratories that handle small
numbers of discrete samples, the columns offer a simple and rapid
method for antibody purification, giving consistent recoveries of
purified IgG. The minicolumns have a capacity of about 2.5 mg IgG,
and the microcolumns have a capacity of 200 µg IgG. They can be
washed and reused several times.
Porvair Sciences
For information +44-1372-824290 www.porvair-sciences.com
MICROULTRACENTRIFUGESThe Sorvall Micro-ultracentrifuge models offer versatility in rapid,
small-volume processing of samples, including viruses, cellular or-
ganelles, lipoproteins, nucleic acids, and nanoparticles. Both new
models offer an expanded volume range, accommodating tubes
from 0.2 ml to 30 ml. These systems offer a cutting-edge drive sys-
tem, providing maintenance-free performance and rotor imbalance
protection for years of reliable and dependable performance. The
benchtop Sorvall MTX 150 puts almost any separation within reach
with a centrifugal force in excess of 1,048,000 x g. It achieves its
maximum rotational speed of 150,000 rpm in just 80 seconds, and
features a user-friendly LCD touch-screen interface. The Sorvall MX
series offers the same versatility as the Sorvall MTX 150 in a floor
model configuration. It is available in two versions, with maximum
speeds of 150,000 rpm or 120,000 rpm.
Thermo Fisher
For information 508-742-5254 www.thermo.com/centrifuge
LC TECHNOLOGYThe Accela 600 high performance liquid chromatography (HPLC) and Accela 1000 ultra-
HPLC systems are designed to enable rapid method development and reduce solvent
consumption. Both systems feature Force Feedback Control, which enables the delivery
of accurate and precise gradients under all operating conditions and provides the
flexibility of quaternary solvent delivery. The systems deliver excellent compositional
and flow rate accuracy and precision, resulting in high levels of reproducibility,
according to the manufacturer. When coupled with the Thermo Scientific LTQ Velos,
these systems create a fast LC-mass spectrometry (MS) system, with increased ion
trapping efficiency and lower fragmentation times.The fast scan rates of the LTQ Velos
allow more MSn experiments to be carried out in shorter chromatographic runs.
Thermo Fisher For information 800-532-4752 www.thermofisher.com/lc
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AAAS, publisher of Science,
thanks the sponsors and supporters of the
2010 Annual MeetingBridging Science and Society
18—22 February • San Diego
Presenting Sponsor
In addition generous funding for AAAS Awards is provided by the Kavli Foundation and Affymetrix.
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Can you see the mutation earlier?
Can you analyze heterogeneous samples?
Can higher accuracy reduce the coveragerequired to detect SNPs?
Can you reduce the cost and time of validation?
Can true paired-end protocols reduce the noise?
Next-generation sequencing just leaped to the next
level in accuracy. The SOLiD™ 4 System leverages
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and fusion transcripts with less input DNA. Using
the SOLiD™ 4 System, your laboratory will have the
ability to detect more variation and spend less time
and money doing it. Take a look at the new SOLiD™ 4
System. See what’s never been seen before.
For Research Use Only. Not for use in diagnostic procedures.©2010 Life Technologies Corporation. All rights reserved. Trademarks of Life Technologies Corporation and
its affiliated companies. All other trademarks are the sole property of their respective owners. Printed in the USA. 01/2010 Publication A-091395 0110
Can you seehow they’llbe different30 yearsfrom now?
Introducing the new,more accurate, higher throughput SOLiD™ 4 System.
SOLiD™ 4SYSTEM SEQUENCING
Formore information, visit us at www.appliedbiosystems.com/solid4