The Pfister Hotel, Milwaukee, WI

10th INTERNATIONAL SYMPOSIUM ON

JOINTLY SPONSORED BY

University of Wisconsin School of Medicine and Public Health, Office of Continuing Professional Development in Medicine and Public HealthMadison, WI

International Foundation for Functional Gastrointestinal DisordersMilwaukee, WI

APRIL 12–14, 2013The Pfister HotelMilwaukee, Wisconsin

FUNCTIONAL GASTROINTESTINAL DISORDERS

STATEMENT OF NEED

Functional gastrointestinal disorders are among the most common conditions seen by primary care and specialty practices. Research is rapidly changing the understanding of the multiple underlying mechanisms in these disorders. Patient management and treatment remains challenging, and there is a lack of effective pharmacologic treatments available.

OBJECTIVES

The sessions will provide participants with opportunities to:

�� Apply advances in the pathophysiology of functional gastrointestinal (GI) and motility disorders

�� Apply newer technologies involved with diagnostic assessment of functional GI and motility disorders

�� Develop improved clinical skills in the diagnosis and care of patients with functional GI and motility disorders

�� Develop strategies and skills relating to interview technique, communication skills, and patient-centered care in order to improve patient satisfaction, adherence, and clinical outcome

�� Network and share information experiences with other conference participants

�� Recognize the influence of genetics, early life, and socio-cultural factors on the clinical expression of functional GI and motility disorders

�� Identify the role of neurotransmitters and receptors in the development of clinical symptoms

TARGET AUDIENCE

The 10th International Symposium on Functional Gastrointestinal Disorders has been developed to enhance the knowledge and skills of physicians, psychologists, fellows, physician assistants, nurses, and allied health professionals in their care of patients with functional gastrointestinal disorders.

ELEMENTS OF COMPETENCE

This CME activity has been designed to change learner competence and performance and focuses on the American Board of Medical Specialties areas of medical knowledge, patient care and procedural skills, and interpersonal and communications skills.

FOR FURTHER INFORMATION

For registration information please contact: Terese Bailey of the Office of Continuing Professional Development in Medicine and Public Health, 2701 International Lane, #208, Madison, Wisconsin 53704; telephone: 608/240-2141; e-mail: tmbailey@ocpd.wisc.edu.

For other inquiries please contact: Elisabeth Vink of the International Foundation for Functional Gastrointestinal Disorders (IFFGD), PO Box 170864, Milwaukee, Wisconsin 53217; telephone: 414/964-1799; e-mail: symposium@iffgd.org.

10th INTERNATIONAL SYMPOSIUM ON FUNCTIONAL GASTROINTESTINAL DISORDERS

April 12–14, 2013The Pfister Hotel Milwaukee, Wisconsin

PLANNING COMMITTEE

Douglas A. Drossman, MD (Chair), Adjunct Professor of Medicine and Psychiatry, UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Lin Chang, MD, Center for Neurovisceral Sciences and Women’s Health Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA

William D. Chey, MD, AGAF, FACG, Professor of Medicine; Director, GI Physiology Laboratory; Director, Michigan Bowel Control Program, A. Alfred Taubman Health Care Center, University of Michigan Medical Center, Ann Arbor, MI

Carlo Di Lorenzo, MD, Chief, Division of Pediatric Gastroenterology, Nationwide Children’s Hospital; Professor of Clinical Pediatrics, The Ohio State University, Columbus, OH

Ronnie Fass, MD, Professor of Medicine, University of Arizona; Chief of Gastroenterology and Head, Neuroenteric Clinical Research Group, Tucson, AZ

John E. Kellow, MD, Head, Discipline of Medicine, Sydney Medical School-Northern, University of Sydney; Director, Gastrointestinal Investigation Unit, Royal North Shore Hospital, Sydney, Australia

Gary Mawe, PhD, Professor, Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT

Nancy J. Norton, President & Founder, International Foundation for Functional Gastrointestinal Disorders, Milwaukee, WI

Henry Parkman, MD, Professor of Medicine, Gastroenterology Section, Temple University Hospital, Philadelphia, PA

Max J. Schmulson W., MD, Professor of Medicine; Faculty of Medicine, National Autonomous University of Mexico-UNAM, Laboratory of Liver, Pancreas, and Motility (HIPAM), Department of Experimental Medicine, General Hospital of Mexico, Mexico City, Mexico

Keith A. Sharkey, PhD, Professor and AI-HS Medical Scientist, Department of Physiology & Pharmacology; Deputy Director, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Magnus Simrén, MD, PhD, Professor, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Ami Sperber, MD, MSPH, Tel-Aviv Medical Center; Emeritus Professor of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Brennan Spiegel, MD, MSHS, FACG, AGAF, Associate Professor of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, UCLA School of Public Health; Director, UCLA GI Fellowship Training Program; Director, UCLA/VA Center for Outcomes Research and Education (CORE), Los Angeles, CA

Jan Tack, MD, PhD, Professor and Head of Clinic, Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, Lueven, Belgium

William E. Whitehead, PhD, Professor of Medicine and Adjunct Professor of OBGYN, Center for Functional GI & Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

John Bryant Wyman, MD, Professor of Medicine, Section of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI

FACULTY

Fernando Azpiroz, MD, PhD, Department of Digestive Diseases, University General Vall d’Hebron, Barcelona, Spain

Giovanni Barbara, MD, Department of Clinical Medicine, University of Bologna; St. Orsola-Malpighi Hospital, Bologna, Italy

Elizabeth Beckett, PhD, Lecturer, Discipline of Physiology, School of Medical Sciences, The University of Adelaide, Adelaide, Australia

Adil E. Bharucha, MD, Professor of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN

L. Ashley Blackshaw, PhD, Neurogastroenterology Group, Bluzard Institute, Queen Mary University of London, London, England, United Kingdom

Lin Chang, MD, Center for Neurovisceral Sciences and Women’s Health Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA

William D. Chey, MD, AGAF, FACG, Professor of Medicine; Director, GI Physiology Laboratory; Director, Michigan Bowel Control Program, A. Alfred Taubman Health Care Center, University of Michigan Medical Center, Ann Arbor, MI

Giuseppe Chiarioni, MD, Senior Staff, Division of Gastroenterology, University of Verona, Verona, Italy; Associate Professor of Medicine, Division of Gastroenterology and Hepatology, Center for Functional & GI Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Sheila E. Crowe, MD, FRCPC, FACP, FACG, AGAF, Professor of Medicine; Director of Research, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA

Willem M. de Vos, PhD, Professor of Microbiology, Academy Professor of the Finnish Academy of Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

Inge Depoortere, PhD, Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Leuven, Belgium

Carlo Di Lorenzo, MD, Chief, Division of Pediatric Gastroenterology, Nationwide Children’s Hospital; Professor of Clinical Pediatrics, The Ohio State University, Columbus, OH

Luda B. Diatchenko, MD, PhD, Associate Professor, Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC

Alexander M. Djuricich, MD, Associate Dean for CME; Program Director, Medicine-Pediatrics Residency; Associate Professor of Clinical Pediatrics and Clinical Medicine, Indiana University School of Medicine, Indianapolis, IN

Douglas A. Drossman, MD, Adjunct Professor of Medicine and Psychiatry, UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Gianrico Farrugia, MD, Director, Center for Individualized Medicine, Division of Gastroenterology, Hepatology, Internal Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN

Ronnie Fass, MD, Professor of Medicine, University of Arizona; Chief of Gastroenterology and Head, Neuroenteric Clinical Research Group, Tucson, AZ

Christophe Faure, MD, Professor of Pediatrics, Division of Gastroenterology and Nutrition, CHU Sainte-Justine, Montreal, QC, Canada

Dee E. Fenner, MD, Furlong Professor of Women’s Health; Director of Gynecology, Department of Obstetrics and Gynecology, University of Michigan Hospital and Health Systems, Ann Arbor, MI

Carlos Francisconi, MD, PhD, Associate Professor of Medicine, The Federal University of Rio Grande do Sul, Clinic Hospital of Porto Alegre, Porto Alegre, RS, Brazil

Shin Fukudo, MD, PhD, Professor, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Aoba, Sendai, Japan

Michael D. Gershon, MD, Professor, Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, NY

Albena Halpert, MD, Assistant Professor of Medicine, Department of Gastroenterology, Boston University School of Medicine, Boston, MA

Frank A. Hamilton, MD, MPH, Chief of the Digestive Disease Branch, Division of Digestive Diseases & Nutrition, NIH/NIDDK, Bethesda, MD

William Hasler, MD, Professor of Internal Medicine, Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI

Ruyi He, MD, Medical Team Leader, Division of Gastroenterology and Inborn Error Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD

Steve Heymen, PhD, Associate Professor of Medicine; Director of Biofeedback Services, Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Ikuo Hirano, MD, Professor of Medicine; Fellowship Program Director, Northwestern University Feinberg School of Medicine, Chicago, IL

Lesley A. Houghton, PhD, CBiol, FSB, FACG, AGAF, Professor of Medicine, College of Medicine, Mayo Clinic; Director of Research, Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL; Honorary Professor of Neurogastroenterology, Translational Medicine, University of Manchester, Manchester, England, United Kingdom; Honorary Consultant, University Hospital of South Manchester NHS Foundation Trust, South Manchester, England, United Kingdom

Tracy L. Hull, MD, Professor of Surgery, Holder of the Shafran Family Charitable Trust Endowed Chair, Department of Colon and Rectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH

A. Pali Hungin, MD, Head of School; Dean of Medicine in Medicine and Health, School of Medicine and Health, Durham University, Stockton-on-Tees, England, United Kingdom

Paul Hyman, MD, Chief, Pediatric Gastroenterology, Children’s Hospital at New Orleans, New Orleans, LA

Mutsuhiro Ikuma, MD, PhD, Senior Medical Reviewer, Pharmaceutical and Medical Devices Agency, Tokyo, Japan

Stephen James, MD, Director, Division of Digestive Diseases & Nutrition, NIDDK-NIH, Bethesda, MD

Michael P. Jones, PhD, Associate Professor, Department of Psychology, Macquarie University, Sydney, Australia

Peter J. Kahrilas, MD, Professor of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL

Laurie Keefer, PhD, Associate Professor of Medicine; Director, Center for Psychosocial Research in GI, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL

John E. Kellow, MD, Head, Discipline of Medicine, Sydney Medical School-Northern, University of Sydney; Director, Gastrointestinal Investigation Unit, Royal North Shore Hospital, Sydney, Australia

J. S. Labus, PhD, Adjunct Assistant Professor, Semel Institute (NPI), Oppenheimer Family Center for Neurobiology of Stress, UCLA Division of Digestive Diseases, Los Angeles, CA

Jeffrey M. Lackner, PsyD, Associate Professor, Department of Medicine, University at Buffalo School of Medicine, SUNY, Buffalo, NY

Brian E. Lacy, MD, PhD, Director, Gastrointestinal Motility Lab, Division of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH

Anthony J. Lembo, MD, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA

Rona L. Levy, MSW, PhD, MPH, Professor and Director, Behavioral Medicine Research Group; Professor, School of Social Work; Adjunct Professor of Medicine and Psychology, University of Washington, Seattle, WA

Ann C. Lowry, MD, Clinical Professor of Surgery, Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN

Gary Mawe, PhD, Professor, Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT

Emeran A. Mayer, MD, Director, Oppenheimer Family Center for Neurobiology of Stress; Co-Director, CURE Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA

Hayat Mousa, MD, AGAF, Medical Director, Center for Advanced Research in Neuromuscular Gastrointestinal Disorders (C.A.R.I.N.G); Director, Fellowship in the Advanced Training in Gastrointestinal Motility and Functional Disorders; Professor in Clinical Pediatrics, Ohio State University College of Medicine, Nationwide Children’s Hospital, Division of Gastroenterology, Columbus, OH

Michel Neunlist, PhD, Head of Inserm Unit 913, Neuropathies of the Enteric Nervous System and Digestive Diseases, Institute of Digestive Diseases, Nantes University Hospital, Nantes, France

Beate Niesler, PhD, Group Leader, Neurogastroenterology and Psychiatric Disorders; Head of nCounter Core Facility, University of Heidelberg, Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg, Germany

Nancy J. Norton, President & Founder, International Foundation for Functional Gastrointestinal Disorders, Milwaukee, WI

Samuel Nurko, MD, MPH, Associate Professor of Pediatrics; Director, Center for Motility and Functional Gastrointestinal Disorders, Children’s Hospital Boston, Harvard Medical School, Boston, MA

Kevin W. Olden, MD, Vice Chairman of Medicine, St. Joseph’s Hospital and Medical Center; Professor of Medicine and Psychiatry, Creighton University School of Medicine, Phoenix, AZ

Tamas Ordog, MD, SAC and Director, Gastroenterology Research Unit, Division of Gastroenterology and Hepatology; Director, Epigenomics Translational Program, Center for Individualized Medicine; Associate Professor, Physiology and Biomedical Engineering and Enteric Neuroscience Program, College of Medicine, Mayo Clinic, Rochester, MN

John E. Pandolfino, MD, Associate Professor, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL

Henry Parkman, MD, Professor of Medicine, Gastroenterology Section, Temple University Hospital, Philadelphia, PA

P. Jay Pasricha, MD, Director, Johns Hopkins Center for Neurogastroenterology, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD

Mark Pimentel, MD, FRCPC, Director, GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA

Charlene M. Prather, MD, MPH, Professor of Internal Medicine, Division of Gastroenterology and Hepatology, St. Louis University School of Medicine, St. Louis, MO

Eamonn Quigley, MD, Professor of Medicine and Human Physiology; Principal Investigator, Alimentary Pharmabiotic Center, Department of Medicine, University College Cork, Cork, Ireland

Satish S. C. Rao, MD, PhD, FRCP, FACG, AGAF, Professor of Medicine; Chief, Section of Gastroenterology/Hepatology; Director, Digestive Health Center, Georgia Health Sciences University, Medical College of Georgia, Augusta, GA

Helen Raybould, PhD, Professor and Department Chair, Department of Anatomy, Physiology, and Cell Biology, UC Davis, School of Veterinary Medicine, Davis, CA

Richard J. Saad, MD, MS, Assistant Professor of Medicine, Division of Gastroenterology, Department of Internal Medicine, University of Michigan Hospital and Health Systems, Ann Arbor, MI

Yuri Saito, MD, MPH, Assistant Professor of Medicine, Division of Gastroenterology & Hepatology, Division of Epidemiology, Mayo Clinic, Rochester, MN

Kenton M. Sanders, PhD, Professor and Chair, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV

Miguel Saps, MD, Director of Gastrointestinal Motility and Functional Bowel Disorders Program and Attending Physician, Gastroenterology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL

Elmer Schabel, MD, Clinical Assessor, European Medicines Agency; Scientific Advice Working Party, Federal Institute for Drugs and Medical Devices, Bonn, Germany

Max J. Schmulson W., MD, Professor of Medicine; Faculty of Medicine, National Autonomous University of Mexico-UNAM, Laboratory of Liver, Pancreas, and Motility (HIPAM), Department of Experimental Medicine, General Hospital of Mexico, Mexico City, Mexico

Reza Shaker, MD, Joseph E. Geenen Professor & Chief, Division of Gastroenterology and Hepatology; Senior Associate Dean and Director, Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI

Keith A. Sharkey, PhD, Professor and AI-HS Medical Scientist, Department of Physiology & Pharmacology; Deputy Director, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Robert J. Shulman, MD, Professor of Pediatrics, Baylor College of Medicine, Children’s Nutrition Research Center, Texas Children’s Hospital, Houston, TX

Magnus Simrén, MD, PhD, Professor, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Manu Sood, MD, Department of Pediatric Gastroenterology, Medical College of Wisconsin, Milwaukee, WI

Ami Sperber, MD, MSPH, Tel-Aviv Medical Center; Emeritus Professor of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Brennan Spiegel, MD, MSHS, FACG, AGAF, Associate Professor of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, UCLA School of Public Health; Director, UCLA GI Fellowship Training Program; Director, UCLA/VA Center for Outcomes Research and Education (CORE), Los Angeles, CA

Robin Spiller, MD, FRCP, Professor of Gastroenterology; Head of Division of Gastroenterology; Lead Director of NIHR Biomedical Research Unit, Nottingham Digestive Diseases Center, University Hospital, Nottingham, England, United Kingdom

Jan Tack, MD, PhD, Professor and Head of Clinic, Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, Lueven, Belgium

Yvette Taché, PhD, Professor of Medicine, David Geffen School of Medicine at UCLA; Director, CURE: Digestive Diseases Research Center - Animal Core; Co-Director, Center for Neurobiology of Stress & Women’s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA

Nikhil Thapar, BM, MRCP, MRCPCH, PhD, Senior Lecturer in Pediatric Gastroenterology, Gastroenterology and Neural Development Units, University College London Institute of Child Health, Honorary Consultant in Pediatric Gastroenterology, Division of Neurogastroenterology and Motility, Department of Gastroenterology, Great Ormond Street Hospital; Co-director, Academy of Pediatric Gastroenterology, London, England, United Kingdom

Kirsten Tillisch, MD, Assistant Professor of Medicine, Division of Digestive Diseases, The Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, UCLA, Los Angeles, CA

Irene Tracey, BA, MA (Oxon), PhD, FRCA, Nuffield Professor of Anesthetic Science; Director, Oxford Center for FMRI of Brain; Head, Nuffield Division Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, United Kingdom

Nimish Vakil, MD, FACP, FACG, AGAF, FASGE, Clinical Professor of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI

René M. van den Wijngaard, PhD, Scientific Staff Member, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands

Lukas Van Oudenhove, MD, PhD, Consultant Psychiatrist; FWO Postdoctoral Research Fellow, Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, University Hospital Gasthuisberg, Leuven, Belgium

Miranda van Tilburg, PhD, Assistant Professor of Medicine, Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Stephen J. Vanner, MD, MSc, FRCPC, Director, Gastrointestinal Diseases Research Unit, Queen’s University, Kingston, ON, Canada

Elena Verdú, MD, PhD, Associate Professor, Department of Medicine; Director, Axenic Gnotobiotic Unit, McMaster University, Hamilton, ON, Canada

Arnold Wald, MD, Professor of Medicine, Section of Gastroenterology & Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI

William E. Whitehead, PhD, Professor of Medicine and Adjunct Professor of OBGYN, Center for Functional GI & Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC

Jackie D. Wood, MSc, PhD, AGAF, Professor, Department of Physiology & Cell Biology, The Ohio State University College of Medicine, Columbus, OH

Katie Zarzar, Director of Strategic Accounts - Linguistic Validation, TransPerfect, RTP, NC

SCHEDULE • 2013

FRIDAY, APRIL 12AM7:00 Registration and Breakfast

8:00 Greetings - Nancy J. Norton & Stephen James, MD

AM PlenaryClinical Approach8:20 Moderator: Douglas A. Drossman, MD

8:25 Global Epidemiology - Eamonn Quigley, MD

8:45 What’s New in Pathophysiology of FGIDs - John E. Kellow, MD

9:05 Integrated Approach to FGIDs - Douglas A. Drossman, MD

9:50 Discussion

10:15 Refreshment Break

Hot Topics10:45 Moderator: William D. Chey, MD, AGAF, FACG

10:50 What is the Link Between the Gut Microbiome and FGIDs - Willem M. de Vos, PhD

11:20 Food and GI Symptoms: Effects on Permeability, Immunology, Motility, and Sensation - Elena Verdú, MD, PhD

11:45 Manipulating the Gut Microbiome as a Treatment Strategy for FGIDs - Magnus Simrén, MD, PhD

12:10 Discussion

12:30 Lunch

PM PlenaryNeurogenesis, Neuroplasticity, and FGIDs 1:30 Co-Moderators: Gary Mawe, PhD & Keith A. Sharkey, PhD

1:35 Emerging Topics in Neurogastroenterology and Motility - Keith A. Sharkey, PhD

1:55 Neurogenesis in the Adult Enteric Nervous System - Michael D. Gershon, MD

2:15 Visceral Hypersensitivity - Stephen J. Vanner, MD, MSc, FRCPC

2:35 Pain, Emotion, and Interoception - Irene Tracey, BA, MA (Oxon), PhD, FRCA

2:55 Discussion

3:15 Refreshment Break

PM Mini Symposia3:30 - 5:00 (1.5 hours)S1: Neural Regulation of Human Gut

Function and Sensation Chair: Gary Mawe, PhD

•Enteric Nervous System Stem Cells Derived From Human Gut Mucosa - Nikhil Thapar, BM, MRCP, MRCPCH, PhD

•Neuronal and Glial Signaling in the Human Gut - Michel Neunlist, PhD

•Functional Brain-Gut Imaging in Health and Functional Bowel Disorders - Emeran A. Mayer, MD

S2: Treatment of Pain Predominant Pediatric FGIDs Chair: Carlo Di Lorenzo, MD

•Pharmacological Treatments - Miguel Saps, MD•Behavioral Treatments - Rona L. Levy, MSW, PhD, MPH•Early Life Events: What Are The Implications For

Children With FGIDs? - Miranda van Tilburg, PhD•Time for Gastric and Colonic Pacing?

- Hayat Mousa, MD, AGAF

S3: Genetics Chair: Yuri Saito, MD, MPH

•State-of-the-Art: How to Set Up a Genetic FGID Study - Beate Niesler, PhD

•Basic Foundations - Yuri Saito, MD, MPH•Future in Research - Luda B. Diatchenko, MD, PhD

S4: Gastric Motility Disorders Chair: Henry Parkman, MD

•Gastroparesis - P. Jay Pasricha, MD•Functional Dyspepsia - Jan Tack, MD, PhD•Dumping Syndrome - William Hasler, MD•Rumination Syndrome: How to Distinguish it

From Functional Vomiting - Ronnie Fass, MD

S5: Opioid and Narcotic Bowel Chair: Douglas A. Drossman, MD

•Mechanisms of Opioid Bowel - Elizabeth Beckett, PhD•Treatments of Opioid Bowel - Lin Chang, MD•Narcotic Bowel - Douglas A. Drossman, MD

5:00 Adjourn

5:30 Reception, Awards Program, and Dinner

SATURDAY, APRIL 13AM7:00 Breakfast

AM PlenaryState-of-the-Art on What’s New in Pediatric FGIDs 8:00 Moderator: Paul Hyman, MD

8:05 What’s New in Pathophysiology of Pain Predominant FGIDs - Christophe Faure, MD

8:25 What’s New in Pathophysiology of Defecation Disorders - Samuel Nurko, MD, MPH

8:45 What’s New in Diagnosis of Upper GI Tract FGIDs - Manu Sood, MD

9:05 What’s New in Diagnosis of Defecation Disorders - Carlo Di Lorenzo, MD

9:25 Discussion

9:40 Refreshment Break

SCHEDULE • 2013

AM Mini Symposia10:00 - 12:30 (2.5 hours)S6: Novel Biomarkers

Chair: Satish S. C. Rao, MD, PhD, FRCP, FACG, AGAF

•Gastric Emptying and Colonic Transit - Satish S. C. Rao, MD, PhD, FRCP, FACG, AGAF

•Blood, Urine, and Stool - Michael P. Jones, PhD•Psychosocial - Lukas Van Oudenhove, MD, PhD

S7: Intestinal Permeability and Visceral Hypersensitivity Chair: Yvette Taché, PhD

•Differences/Interaction Between Nutrient Sensing and Pain Processing Afferents - L. Ashley Blackshaw, PhD

•Primary Sensory Neurons - Stephen J. Vanner, MD, MSc, FRCPC

•Central Processing of Pain - Irene Tracey, BA, MA (Oxon), PhD, FRCA

• Immune Cells, Permeability, and Visceral Hypersensitivity - René M. van den Wijngaard, PhD

•New Insights Into Intestinal Permeability - Clinical Implications in IBS - Giovanni Barbara, MD

S8: Bloating, Distension, and Gas Chair: Max J. Schmulson W., MD

•Mechanisms - Lesley Houghton, PhD, CBiol, FSB, FACG, AGAF•Bacterial Flora - Mark Pimentel, MD, FRCPC•Bloating Treatments - Max J. Schmulson W., MD• Impact of the Symptoms and Clinical Value of

Treatments - Eamonn Quigley, MD•Psychological Aspects - Laurie Keefer, PhD

S9: Challenging Cases Chair: Arnold Wald, MD

•Dyspepsia and SMA - Brian E. Lacy, MD, PhD•Polysymptomatic FGIDs - Albena Halpert, MD•Refractory Heartburn - Ronnie Fass, MD•Refractory Lower Bowel - Arnold Wald, MD

S10: The Rome Working Group, Food & FGIDs Chair: Jan Tack, MD, PhD

•Nutrient Sensing Mechanisms - Helen Raybould, PhD•Food and GI Function: How Does Food Change

GI Function in Man? - Fernando Azpiroz, MD, PhD•Dietary Factors and Upper GI Symptoms: What is

Known, What is Proven? - Jan Tack, MD, PhD•Dietary Factors and Lower GI Symptoms

- William D. Chey, MD, AGAF, FACG•Gluten Sensitivity and its Role in

Functional GI Symptoms - Sheila E. Crowe, MD, FRCPC, FACP, FACG, AGAF

S11: Sorting Out Treatments for Constipation Chair: Magnus Simrén, MD, PhD

• IBS-C v. Chronic Constipation v. Dyssynergia: Is There Really a Difference? - William E. Whitehead, PhD

•Biofeedback - Giuseppe Chiarioni, MD•Emerging Therapies - Magnus Simrén, MD, PhD•Surgery - Ann C. Lowry, MD•Constipation in an Aged Population

- Charlene M. Prather, MD, MPH

12:30 Lunch

PM Workshops2:00 - 5:00 WORKSHOP (3 hours)A1: Interview Techniques and

Communication Skills Coordinator: Douglas A. Drossman, MD; Albena Halpert, MD

2:00 - 3:30 WORKSHOPS (1.5 Hours) B1: Clinical Pearls for the Clinician

Coordinator: Lin Chang, MD

•Psychological Pearls - Jeffrey M. Lackner, PsyD•Diagnostic Pearls - William D. Chey, MD, AGAF, FACG•Physiology Pearls - Henry Parkman, MD•Treatment Pearls - Lin Chang, MD

B2: Anorectal Dysfunction Coordinator: Adil E. Bharucha, MD

•Pelvic Floor Dyssynergia - Richard J. Saad, MD, MS•Levator Ani Pain and Proctalgia Fugax

- Adil E. Bharucha, MD•Hemorrhoids and Fissures - Tracy L. Hull, MD

B3: Brain/Gut Modulation of GI Symptoms Coordinator: Kirsten Tillisch, MD

•Objective Measure in Volume Changes - J. S. Labus, PhD

•Clinical Implications of Brain Imaging - Lukas Van Oudenhove, MD, PhD

•Drug Studies: Brain Activation Patterns With Relation to Drugs - Kirsten Tillisch, MD

B4: Neuromuscular Function and Dysfunction Coordinator: Kenton M. Sanders, PhD

• Interstitial Cells of Cajal in Health and Disease - Gianrico Farrugia, MD

•Epigenetic Regulation of Smooth Muscle Growth and Function in the Gut - Tamas Ordog, MD

•Fibroblast-like Cells and Purinergic Neuromuscular Signaling - Kenton M. Sanders, PhD

B5: International Drug Development Coordinator: Robin Spiller, MD, FRCP

• Japan - Shin Fukudo, MD, PhD•Europe - Robin Spiller, MD, FRCP•Latin America - Carlos Francisconi, MD, PhD•United States - Anthony J. Lembo, MD

3:30 Refreshment Break

4:00 - 5:30 WORKSHOPS (1.5 Hours)C1: FGIDs in the Technological Era

Coordinator: Ami Sperber, MD, MSPH

•Social Media and Medicine - Alexander M. Djuricich, MD

•Tools for Global Research: Linguistic Validation and ePRO - Katie Zarzar

•Assessing and Diagnosing IBS as a Global Phenomenon - How Can the Technological Era Help? - Ami Sperber, MD, MSPH

C2: Esophageal Disorders Coordinator: Ronnie Fass, MD

•Globus - Peter J. Kahrilas, MD•Esophageal Dysmotility - Reza Shaker, MD•Refractory GERD - Ronnie Fass, MD•Eosinophilic Esophagitis - Ikuo Hirano, MD

C3: Serotonin - New Insights in Signaling and Therapeutic Implications Co-Coordinators: Keith A. Sharkey, PhD and Jackie D. Wood, MSc, PhD, AGAF

• Serotonin Signaling in the Gut - Michael D. Gershon, MD•New Insights Into The Prokinetic and

Antinociceptive Actions of 5-HT4 Receptor Activation - Gary Mawe, PhD

•Translational Studies of The Role of 5-HT in Visceral Pain and GI Motility - Jan Tack, MD, PhD

C4: Update on the Diagnosis and Treatment of Less Common FGIDs Coordinator: John E. Kellow, MD

•Noncardiac Chest Pain - John E. Pandolfino, MD•Chronic Idiopathic Nausea and Functional

Vomiting - Kevin W. Olden, MD•Functional Sphincter of Oddi Disorder

- Nimish Vakil, MD, FACP, FACG, AGAF, FASGE

C5: Fecal Incontinence Coordinator: William E. Whitehead, PhD

•Definitions, Epidemiology, and Quality of Life Impact - William E. Whitehead, PhD

•NIDDK Public Awareness Campaign - Frank A. Hamilton, MD, MPH

•Pathophysiology and Diagnostic Evaluation - Adil E. Bharucha, MD

•Overlap of Fecal Incontinence with Urinary Incontinence and Other Pelvic Floor Disorders - Dee E. Fenner, MD

•Conservative Management and Biofeedback - Steve Heymen, PhD

•Surgical Treatments, Including: SNS, TOPAS Sling, and Bulking Agents - Ann C. Lowry, MD

5:30 Adjourn - Dinner on your own

SUNDAY, APRIL 147:00 Breakfast

AM Mini Symposia8:00 - 10:30 (2.5 hours)S12: Clinical Trial Design and

Outcome Measurement Chair: William D. Chey, MD, AGAF, FACG

•Clinical Trial Design Issues for FGIDs - Ruyi He, MD•GERD - Brennan Spiegel, MD, MSHS, FACG, AGAF•Functional Dyspepsia - Jan Tack, MD, PhD•Gastroparesis - Henry Parkman, MD• IBS - Lin Chang, MD•The Regulatory Issues Around FGIDs in Europe

- Elmer Shabel, MD•The Regulatory Issues Around FGIDs in Japan

- Mutsuhiro Ikuma, MD, PhD

S13: Rome Chair: Douglas A. Drossman, MD

•What’s New in Rome IV - Douglas A. Drossman, MD•Multi-Dimensional - Douglas A. Drossman, MD•Primary Care - A. Pali Hungin, MD•Question Validation - William E. Whitehead, PhD•Multi-National - Ami Sperber, MD, MSPH

S14: Pediatric Research Chair: Carlo Di Lorenzo, MD

•Gut Microbe Signatures in Children with IBS - Robert J. Shulman, MD

•Role of Serotonin Signaling in Children with Functional Abdominal Pain - Christophe Faure, MD

•Working Together For a Better Understanding of Childhood FGIDs: Lessons from the Digestive Health Alliance Children’s Research Network - Carlo Di Lorenzo, MD

•Time to Treat the Parents to Make the Children Better - Rona L. Levy, MSW, PhD, MPH

S15: Nutrients, Emotion, and Food Intake Chair: Emeran A. Mayer, MD

•Fat Signaling and Emotion - Lukas Van Oudenhove, MD, PhD

•Bitter Taste Receptors, Food Intake, and GI Motor Function - Inge Depoortere, PhD

•Nutrient Signaling and Vagal Control of Gut Function - Helen Raybould, PhD

•Nutrient Signaling and Pain Sensation - L. Ashley Blackshaw, PhD

10:30 Refreshment Break

AM PlenaryClinical Application10:45 Moderator: Lin Chang, MD

10:50 Maximizing the Physician/Patient Relationship - Albena Halpert, MD

11:10 Central Pharmacological Treatments for FGIDs - Douglas A. Drossman, MD

11:30 New and Emerging Treatments of the Gut - William D. Chey, MD, AGAF, FACG

11:50 Behavioral Treatments for FGIDs - Laurie Keefer, PhD

12:10 Discussion

12:25 Closing Remarks - Nancy J. Norton & Douglas A. Drossman, MD

12:40 Adjourn - Box lunch to go

SCHEDULE • 2013

REGISTRATION FORM #4006; AME-GAST

10TH INTERNATIONAL SYMPOSIUM ON FUNCTIONAL GASTROINTESTINAL DISORDERS

April 12 - 14, 2013

Please Print in BLOCK Letters

STEP 1. Participant Information:

Name First MI Last

Professional Degree (for credit and name badge) MD; DO; PhD; RN; PA; Other, please specify

Company Name

Dept. Name or Mail Code

Work Address

City, State, Zip, Country

Day Phone

FAX E-mail

STEP 2. Confirmation:

Work Address (as provided in Step 1) or Home Address

Home Address

City, State, Zip, Country

STEP 3. Registration Fees:

$600 MD/DO/PhD Fee $400 Fellow/RN/Resident/PA/Other(s) Fee

TOTAL FEE REMITTED: _____________

____PO or check enclosed (payable to University of Wisconsin)

____Please bill my company

____Credit Card: MasterCard VISA American Express

Cardholder’s Name

Card Number

Expiration Date

The University of Wisconsin provides equal opportunities in employment and programming, including Title IX requirement.

The University of Wisconsin School of Medicine and Public Health fully complies with the legal requirements of the ADA and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please notify Terese Bailey in order to receive service. Please call: 608/240-2141.

WORKSHOP & MINI SYMPOSIA REGISTRATION: Please check the sessions you would like to attend. Requests will be honored on a first-come, first-served basis.

FRIDAY, APRIL 12 – PM MINI SYMPOSIA

Please choose one 1.5 hour session.

Mini Symposia: 3:30 pm – 5:00 pm (1.5 hours) S1. Neural Regulation of Human Gut Function

and Sensation S2. Treatment of Pain Predominant Pediatric FGIDs S3. Genetics S4. Gastric Motility Disorders S5. Opioid and Narcotic Bowel

SATURDAY, APRIL 13 – AM MINI SYMPOSIA

Please choose one 2.5 hour session.

Mini Symposia: 10:00 am - 12:30 pm (2.5 hours) S6. Novel Biomarkers S7. Intestinal Permeability and

Visceral Hypersensitivity S8. Bloating, Distension, and Gas S9. Challenging Cases S10. The Rome Working Group, Food & FGIDs S11. Sorting Out Treatments for Constipation

SATURDAY, APRIL 13 – PM WORKSHOPS

Please choose one 3 hour workshop – OR – two 1.5 hour workshops.

3 hour workshop: 2:00 pm - 5:00 pm A1. Interview Techniques and Communication Skills

1.5 hour workshops: 2:00 pm - 3:30 pm B1. Clinical Pearls for the Clinician B2. Anorectal Dysfunction B3. Brain/Gut Modulation of GI Symptoms B4. Neuromuscular Function and Dysfunction B5. International Drug Development

1.5 hour workshops: 4:00 pm - 5:30 pm C1. FGIDs in the Technological Era C2. Esophageal Disorders C3. Serotonin - New Insights in Signaling and

Therapeutic Implications C4. Update on the Diagnosis and Treatment of Less

Common FGIDs C5. Fecal Incontinence

SUNDAY, APRIL 14 – AM MINI SYMPOSIA

Please choose one 2.5 hour session.

Mini Symposia: 8:00 am - 10:30 am (2.5 hours) S12. Clinical Trial Design and Outcome Measurement S13. Rome S14. Pediatric Research S15. Nutrients, Emotion, and Food Intake

STEP 4. Workshop & Mini Symposium Registration:

STEP 5. Please return your payment with this form to:

CME Specialist, The Pyle Center, Department 101, 702 Langdon Street, Madison, WI 53706 or Fax 1-800/741-7416 (in Madison Fax 265-3163).

GENERAL INFORMATION

Dates: April 12 - 14, 2013Place: The Pfister Hotel 424 E. Wisconsin Avenue Milwaukee, WI 53202Phone: 414/273-8222Toll-free (USA): 800/558-8222Fax: 414/273-5025Website: www.thepfisterhotel.com

SYMPOSIUM FEEThe symposium fee of $600 for physicians and psychologists; $400 for fellows, nurses, residents, physicians’ assistants, and others, includes the cost of tuition, materials, breakfasts, refreshment breaks, lunches, one dinner, and a nonrefundable registration fee of $50. Should you cancel your registration up to 72 hours prior to the symposium; you will be refunded the entire symposium fee except the $50 nonrefundable portion. No refunds will be made after that time.

EXHIBITSThe symposium will feature both nonprofit and commercial exhibits. Ample time has been included in the program to allow you to view the exhibits and meet representatives on:

Friday, April 127:00 - 8:00 am; 9:50 - 10:50 am; 12:10 - 1:35 pm; 2:55 - 3:30 pm

Saturday, April 137:00 - 8:05 am; 9:25 - 10:00 am; 12:15 - 2:00 pm; 3:15 - 4:00 pm

For an Exhibitor Prospectus, please contact Elisabeth Vink at symposium@iffgd.org or 414/964-1799.

HOUSING A block of rooms has been reserved at The Pfister Hotel, 424 E. Wisconsin Avenue, Milwaukee, WI 53202; telephone: 414/273-8222. The special symposium rates are:

Single: $184/night plus tax

Double: $204/night plus tax

The Pfister will release the block of rooms to the general public on March 20, 2013. Please call or write the Hotel directly for your reservation and mention “10th International Symposium on Functional Gastrointestinal Disorders” to the hotel staff when making your reservation. You can also make your reservation online at: http://booking.ihotelier.com/istay/istay.jsp?groupID=773088&hotelID=73000.

FOUR EASY WAYS TO REGISTEROn-line: www.ocpd.wisc.edu/ course_catalog

By Mail: Return your completed registration form & payment.

By Phone: 608/262-1397. Please call with your billing

information or pay by MasterCard, VISA, or American Express.

By Fax: 1-800/741-7416 (in Madison fax 265-3163).

Download a one page pdf of the registration for faxing or mailing at: www.ocpd.wisc.edu/course_catalog www.iffgd.org/symposium

CONFIRMATIONSAll registrations are confirmed in writing. If you do not receive a confirmation, please call 608/262-1397.

CONFERENCE ATTIRETo ensure your comfort in the conference rooms, please bring a sweater or jacket to accommodate temperature variations.

CREDIT Accreditation StatementThis activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the University of Wisconsin School of Medicine and Public Health and the International Foundation for Functional Gastrointestinal Disorders. The University of Wisconsin School of Medicine and Public Health is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation StatementThe University of Wisconsin School of Medicine and Public Health designates this educational activity for a maximum of 18.75 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Continuing Education UnitsThe University of Wisconsin-Madison, as a member of the University Continuing Education Association (UCEA), authorizes this program for 1.875 continuing education units (CEUs) or 18.75 hours.

Policy on Faculty and Sponsor Disclosure It is the policy of the University of Wisconsin School of Medicine and Public Health that the faculty, authors, planners, and other persons who may influence content of this CME activity disclose all relevant financial relationships with commercial interests in order to allow CME staff to identify and resolve any potential conflicts of interest. Faculty must also disclose any planned discussion of unlabeled/unapproved uses of drugs or devices during their presentation(s). Detailed disclosures will be made in the activity handout materials.

Non-Profit OrganizationUS Postage

PAIDMadison, Wisconsin

Permit No. 658

University of Wisconsin School of Medicine and Public HealthOffice of Continuing Professional Development in Medicine and Public Health2701 International Lane, Suite 208Madison, WI 53704-3126

UNIVERSITY OF WISCONSIN–MADISON

School of Medicineand Public Health

APRIL 12–14, 2013 | Milwaukee, Wisconsin

10th INTERNATIONAL SYMPOSIUM ON

FUNCTIONAL GASTROINTESTINAL DISORDERS