interesting linkage between wound healing and hepatoprotective activities
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Chemico-Biological Interactions 190 (2011) 191
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journa l homepage: www.e lsev ier .com/ locate /chembio int
Letter to the Editor
Interesting linkage between wound healing and hepatoprotec-tive activities
In a recent issue, using murine d-galactosamine/lipopoly-saccharide model of hepatic failure, Dr. Lian et al. demonstratehepatoprotective action of gentiopicroside due to the inhibition ofapoptosis , which has been previously demonstrated to possesswoundhealing activities on cultured chicken embryonic broblasts. Thus, we would like to call attention to an interesting linkagebetween hepatoprotective and wound healing activities. There is asimilar coincidence with asiaticosides, active constituents of Cen-tella asiatica, which have been used in the treatment of wounds: Inour laboratory, we have observed in cultured T15 broblasts cellsthat wound healing is promoted by asiaticoside , whose hep-atoprotective activities have been reported recently in the murined-galactosareported thJohns Worof hepatic din culturedinhibitory acells has be
Althoughprotective aregeneratioand prolifeinvolved in
 L.-H. Lianactivity o
murine fulminant hepatic failure, Chem. Biol. Interact. 188 (2010) 127133.
 N. ztrk, S. Korkmaz, Y. ztrk, K.H.C. Baser, Effects of gentiopicroside,sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp.symphyandra), on cultured chicken embryonic broblasts, PlantaMed. 72 (2006)289294.
 S. Korkmaz,H. Zeytinoglu,M. Zeytinoglu, S. Aydn, Y.ztrk, K.H.C. Baser, Testingthe wound healing activity in T15 broblast culture: a morphometric analysis,Altern. Lab. Anim. 28 (2000) 4151.
 L. Zhang, H.Z. Li, X. Gong, F.L. Luo, B. Wang, N. Hu, C.D. Wang, Z. Zhang,J.Y. Wan, Protective effects of asiaticoside on acute liver injury inducedby lipopolysaccharide/d-galactosamine in mice, Phytomedicine 17 (2010)811819.
 Y. ztrk, S. Aydn, K.H.C. Baser, N. Krmer, N. Kurtar-ztrk, Hepatopro-tective activity of Hypericum perforatum L., Phytother. Res. 6 (1992) 4446.
 T. Herekman-Demir, N. ztrk, Y. ztrk, Hepatoprotective effect of St. JohnsWort, Fund. Clin. Pharmacol. 15 (Suppl. 1) (2001) 104 (Abstract).
 N. ztrk, S. Korkmaz-Cetin, Y. ztrk, Wound healing activity of St. Johns WortericumperforatumL.) chickenembryonicbroblasts, J. Ethnopharmacol. 1117) 3339.ou, Yperfo
0009-2797/$ doi:10.1016/j.see front matter 2010 Elsevier Ireland Ltd. All rights reserved.cbi.2010.10.011mine/lipopolysaccharide model . Moreover, we haveat hydroalcoholic extract of Hypericum perforatum (St.t) exhibits a hepatoprotective activity in CCl4-modelsamage in rodents [5,6] and a wound healing activitychicken embryonic broblast cells . In addition, thection of H. perforatum on apoptosis in cultured PC12en reported recently 
the exact mechanism of the linkage between hepato-ction and wound healing is still unknown, the cellularn and repair mechanisms mainly based on mitosisration, as well as the inhibition apoptosis, seem to bethe interesting linkage.
, Y.-L. Wu, Y. Wan, X. Li, W.-X. Xie, J.-X. Nan, Anti-apoptoticf gentiopicroside in d-galactosamine/lipopolysaccharide-induced
 Y.P. ZicumPhyt.H. Lu, D.Z. Wei, Protective effects of a avonoid-rich extract of Hyper-ratum L. against hydrogen peroxide-induced apoptosis in PC12 cells,Res. 24 (Suppl. 1) (2010) S6S10.
Nilgn ztrkAnadolu University, Faculty of Pharmacy,
Departments of Pharmacology and Pharmacognosy,Tepebasi, 26470 Eskisehir, Turkey
Corresponding author. Tel.: +90 2223350580x3743; fax: +90 222 3350750.
E-mail address: firstname.lastname@example.org (Y. ztrk)
Available online 23 October 2010
Interesting linkage between wound healing and hepatoprotective activitiesReferences