interesting linkage between wound healing and hepatoprotective activities

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  • Chemico-Biological Interactions 190 (2011) 191

    Contents lists available at ScienceDirect

    Chemico-Biological Interactions

    journa l homepage: www.e lsev ier .com/ locate /chembio int

    Letter to the Editor

    Interesting linkage between wound healing and hepatoprotec-tive activities

    In a recent issue, using murine d-galactosamine/lipopoly-saccharide model of hepatic failure, Dr. Lian et al. demonstratehepatoprotective action of gentiopicroside due to the inhibition ofapoptosis [1], which has been previously demonstrated to possesswoundhealing activities on cultured chicken embryonic broblasts[2]. Thus, we would like to call attention to an interesting linkagebetween hepatoprotective and wound healing activities. There is asimilar coincidence with asiaticosides, active constituents of Cen-tella asiatica, which have been used in the treatment of wounds: Inour laboratory, we have observed in cultured T15 broblasts cellsthat wound healing is promoted by asiaticoside [3], whose hep-atoprotective activities have been reported recently in the murined-galactosareported thJohns Worof hepatic din culturedinhibitory acells has be

    Althoughprotective aregeneratioand prolifeinvolved in


    [1] L.-H. Lianactivity o

    murine fulminant hepatic failure, Chem. Biol. Interact. 188 (2010) 127133.

    [2] N. ztrk, S. Korkmaz, Y. ztrk, K.H.C. Baser, Effects of gentiopicroside,sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp.symphyandra), on cultured chicken embryonic broblasts, PlantaMed. 72 (2006)289294.

    [3] S. Korkmaz,H. Zeytinoglu,M. Zeytinoglu, S. Aydn, Y.ztrk, K.H.C. Baser, Testingthe wound healing activity in T15 broblast culture: a morphometric analysis,Altern. Lab. Anim. 28 (2000) 4151.

    [4] L. Zhang, H.Z. Li, X. Gong, F.L. Luo, B. Wang, N. Hu, C.D. Wang, Z. Zhang,J.Y. Wan, Protective effects of asiaticoside on acute liver injury inducedby lipopolysaccharide/d-galactosamine in mice, Phytomedicine 17 (2010)811819.

    [5] Y. ztrk, S. Aydn, K.H.C. Baser, N. Krmer, N. Kurtar-ztrk, Hepatopro-tective activity of Hypericum perforatum L., Phytother. Res. 6 (1992) 4446.

    [6] T. Herekman-Demir, N. ztrk, Y. ztrk, Hepatoprotective effect of St. JohnsWort, Fund. Clin. Pharmacol. 15 (Suppl. 1) (2001) 104 (Abstract).

    [7] N. ztrk, S. Korkmaz-Cetin, Y. ztrk, Wound healing activity of St. Johns WortericumperforatumL.) chickenembryonicbroblasts, J. Ethnopharmacol. 1117) 3339.ou, Yperfo


    0009-2797/$ doi:10.1016/j.see front matter 2010 Elsevier Ireland Ltd. All rights reserved.cbi.2010.10.011mine/lipopolysaccharide model [4]. Moreover, we haveat hydroalcoholic extract of Hypericum perforatum (St.t) exhibits a hepatoprotective activity in CCl4-modelsamage in rodents [5,6] and a wound healing activitychicken embryonic broblast cells [7]. In addition, thection of H. perforatum on apoptosis in cultured PC12en reported recently [8]

    the exact mechanism of the linkage between hepato-ction and wound healing is still unknown, the cellularn and repair mechanisms mainly based on mitosisration, as well as the inhibition apoptosis, seem to bethe interesting linkage.

    , Y.-L. Wu, Y. Wan, X. Li, W.-X. Xie, J.-X. Nan, Anti-apoptoticf gentiopicroside in d-galactosamine/lipopolysaccharide-induced


    [8] Y.P. ZicumPhyt.H. Lu, D.Z. Wei, Protective effects of a avonoid-rich extract of Hyper-ratum L. against hydrogen peroxide-induced apoptosis in PC12 cells,Res. 24 (Suppl. 1) (2010) S6S10.

    Yusuf ztrk

    Nilgn ztrkAnadolu University, Faculty of Pharmacy,

    Departments of Pharmacology and Pharmacognosy,Tepebasi, 26470 Eskisehir, Turkey

    Corresponding author. Tel.: +90 2223350580x3743; fax: +90 222 3350750.

    E-mail address: (Y. ztrk)

    Available online 23 October 2010

    Interesting linkage between wound healing and hepatoprotective activitiesReferences