integrating outcomes, activities, and assessments
DESCRIPTION
Integrating Outcomes, Activities, and Assessments. Carol A. Hurney, Ph.D. Associate Professor, Biology. Snap Shot of Non-Majors Biology. Tuesday. Thursday. in-class activities. Monday. Wednesday. Friday. Saturday & Sunday. out-of-class activities. include OBJECTIVES - PowerPoint PPT PresentationTRANSCRIPT
Integrating Outcomes, Activities, and Assessments
Carol A. Hurney, Ph.D.Associate Professor, Biology
Snap Shot of Non-Majors Biology
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in-classactivities
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out-of-class activities
• include OBJECTIVES• write ASSESSMENTS• connect STRATEGIES• describe IMPACT
Assessments & Strategies
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in-classactivities
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Warm-UpsInteractive LecturesClicker QuestionsClass Activities
ProjectsExams
1
2
3
4
5
review warm-upscustomize class
openingclicker questions
readingswarm – ups
tutorials
class activitiesinteractive lectureclicker questions
closingcustomize warm-up
readingswarm – ups
projectsexams
So what does this really look like??
Designing Instruction
gbio103 – learning objectives
Cancer Unit Objectives – Students will• describe how exposure to carcinogens can lead to cancer• describe how susceptibility to cancer can be inherited• identify genes involved in cell division• predict whether mutations in genes could lead to cancer• connect ideas related to the causes of cancer with cancer treatments• integrate knowledge of cancer to the process of evaluating scientific
resources on cancer• choose to read articles on cancer in the future• find one aspect of the cancer unit fascinating or compelling
General Education Cluster 3 Objectives – Students will• use theories and models as unifying principles that help us
understand natural phenomena and make predictions• evaluate the credibility, use, and misuse of biological information in
scientific developments and public-policy issues
Cancer Unit Objectives – Students will• describe how exposure to carcinogens can lead to cancer• describe how susceptibility to cancer can be inherited• identify genes involved in cell division• predict whether mutations in genes could lead to cancer• connect ideas related to the causes of cancer with cancer treatments• integrate knowledge of cancer to the process of evaluating scientific
resources on cancer• choose to read articles on cancer in the future• find one aspect of the cancer unit fascinating or compelling
General Education Cluster 3 Objectives – Students will• use theories and models as unifying principles that help us
understand natural phenomena and make predictions• evaluate the credibility, use, and misuse of biological information in
scientific developments and public-policy issues
Gene GeneJunk
Promoter Coding Region
Same ProteinNo Protein
Hyper ProteinNo ProteinSame ProteinBroken Protein
Weeks prior to this class..
WU#22A gene is on whenRNA polymerase binds to the promoterRibosomes start translationCell Division occursThe protein from that gene is made
You have just discovered a new protein called, topoisomerase. This protein functions as an enzyme that unwinds the DNA double helix, so it can be copied during S phase of the cell cycle. The amino acid sequence of this enzyme is shown below. Cells that contain defective versions of topoisomerase cannot divide because the cell never exits S phase.
VAL-PRO-ILE-MET-VAL-ser-GLY-GLY-TRP-PHE-gln-asn-tyr-ser-lys-glu-leu-CYS-tyr-asp-asp-ILE-VAL-PRO-TRP-PHE-VAL-ALA-VAL-PRO (hydrophobic amino acids are in CAPS)
What is the shape of topoisomerase?helix-sheet-helix-sheet-helix-sheet-helix helix-sheet-helix sheet-helix-sheet helix-sheet-sheet-helix
In order to get the topoisomerase gene turned on in dividing cells, the gene for this enzyme most likely has a
promoterpromoter next to a coding regionpromoter with a transcription factor bound to it
After class … before next class..
WU#22
Cell A is producing growth factor and sending it to Cell B. Cell A and B are both skin cells. The growth factor gene is on in
A and BABNeither A or B
The RNA polymerase gene is on in
A and BABNeither A or B
The “Smart” gene (which codes for a protein used by brain cells) is on in
A and BABNeither A or B
The growth factor receptor gene is on in
A and BABNeither A or B
After class … before next class..
WU#22
What is a proto-oncogene? The cancer causing version of a growth stimulating gene.The cancer causing version of a growth inhibiting gene.The normal version of a growth stimulating gene. The normal version of a growth inhibiting gene.
What is a tumor suppressor gene?
The cancer causing version of a growth stimulating gene.The cancer causing version of a growth inhibiting gene.The normal version of a growth stimulating gene.The normal version of a growth inhibiting gene.
outside of class
Inside Receiving Cell
Sending Cell
Mutations in Growth Factor Pathway Genes
Interactive mini-lecture
coding region
Protein that is made hasOne amino acid changeNow the protein could
be HYPER!!
promoterJUNK JUNK
Relay protein in growth pathway gene: ras
A
1. Does not damage promoter.2. Changes TATA box
1. Same Protein made2. No Protein made
Protein that is made hasOne amino acid changeCould be BROKEN!!!
No amino acid change:Same protein Made
Coding Region Mutations
B C D
CANCER!!!
Mutant protein in growth pathway
HYPERACTIVE PROTEINIS IN THE GROWTH FACTOR
PATHWAY...
ras gene
ras protein
Growth Factors
Growth Inhibiting Factors
Checkpoints
Which proteins control the cell cycle?
Growth Inhibiting Factors1 Signaling cell releases growth
inhibiting factor (GIF)2 GIF travels to receiving cell3 GIF binds to a receptor protein4 Receptor protein activates
Relay proteins5 Relay proteins activate
Transcription Factor (TF)6 TF travels to nucleus to turns
on genes that tell cell NOT to divide!
7 In this picture, the oval protein will prevent cell division
Inside Receiving Cell
Signaling Cell
CA#21 – Growth Inhibitory PathwayIn-Class Formative
Assessment
CA#21 – Growth Inhibitory Pathway
In-Class Formative Assessment
promoter coding regionJUNK JUNKA
1. Does not damage promoter.2. Changes TATA box
1. Same Protein Still made2. No protein made
D
Protein that is made hasOne amino acid changeNow the protein could
be HYPER!!
B
No amino acid change:Same protein Made
CANCER!!!
Transcription factor in growth inhibition pathway gene
Protein that is made hasOne amino acid changeNow the protein could
be BROKEN!!!
C
Interactive mini-lecture
Growth Inhibiting Pathway
Broken ProteinOr
No Protein
Can’t turn on genes that inhibit cell
Gene 1 Gene 2 Gene 3 Gene 4
Muscle protein Growth Factor Gene
Growth Inhibiting Factor Receptor
Protein
RNA Polymerase
Gene 1 Gene 2 Gene 3 Gene 4
* * * *
Cell dies.Muscle cell can
no longer contract
No Protein
Hyperactive growth factor
Oncogenes
Proto-oncogene Tumor suppressor gene
CQ Mutations in which genes could lead to cancer?
A. Gene 1 and 2B. Gene 2 and 3C. Gene 2 D. Gene 3E. Gene 3 and 4
Interactive mini-lecture
WU#23
A tale of three cells. Skin cell A is making growth factor and sending it to Skin cell B. Skin cell B is making growth inhibiting factor and sending it to Nerve Cell C. Nerve cell C is making growth factor and sending it to skin cell A. Use this information to answer questions 1-7. Which cell is not dividing?
Skin Cell ASkin Cell BNerve Cell CBoth Cell A and Cell B
Which cell(s) have the growth factor receptor gene on?
A and BB and C C and A A only B only C only
If the growth inhibiting factor gene is mutated in skin cell B, which cells could become cancerous?
ABCA, B and C ; A and B; B and C; none of them
After class … before next class..
WU#23
If the coding region of the growth factor receptor gene is mutated in Cell B, which cell could become cancerous?
AB C B and C A and Cnone of the cells could become cancerous
If the promoter of growth inhibitory factor receptor gene is mutated in cell C, which cells could become cancerous?
A BC B and CAll cells could become cancerous.None of the cells could become cancerous.
What is the function of the checkpoint protein BRCA1 protein? (As always, I want you to do some exploring and then give me your answer in your own words.)
Satu
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Thur
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in-classactivities
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activities
Integrating Assessment
formative assessments * * * *summative assessments * tutorial - sources
* unit exam
Impact of Giving Choices•Topics – cancer, colony collapse disorder, addiction•Value of WUs, CQs, CAs,•Value of exams & projects
Scholarship of Teaching & Learning
Choosing topics helped me learn.
(n=127)
Topics
(n=106)
•It made me feel like I was actually part of a large class•Seemed like we just ended up talking about basic biology stuff•Nice change from my other classes•Difficult to schedule things•The class didn’t choose topics I liked
Having control of course points
was a good idea. (n=127)
Points(n=72)
•Having control initiates a feeling of responsibility and ownership that causes a student to feel like they matter, which results in more effort•It was a little stressful … the fact that it lays on me to decide… what if I chose the wrong thing
Interest (n=127) Confidence
(n=127)
Course GradesSpring 2007n=69
ICT Grades 77.9
Fall 2007n=67
LCT Grades
84.8(p=0.0003)
ICT Grades 81.5(p=0.0052)
Spring 2009n=70
LCT Grades
84.9(p=0.0005)
ICT Grades 84.3(p=0.0016)
Programmatic Assessment
Snap Shot of Non-Majors Biology
Satu
rday
&
Sund
ay
Tues
day
Thur
sday
in-classactivities
Wed
nesd
ay
Frid
ay
Mon
day
out-of-class activities
• include OBJECTIVES• write ASSESSMENTS• connect STRATEGIES• describe IMPACT