Cell Growth & Differentiation i

4. Footnotes, on a page separate from the text. Designate footnotesconsecutively with superscript Arabic numerals;

See reverse for names and addresses of Editorial Board membersand AACR Publications Department.

Instructions for AuthorsScopeCELL GROWTH & DIFFERENTIATION publishes significant, orig-inal research on the molecular biology of cancer. The journal’sscope encompasses a broad range of in vitro and in vivo studiespertaining to normal and abnormal cellular processes. Topics in-dude oncogenes and tumor suppressor genes, gene expression andregulation, transcription factors, growth factors and their receptors,molecular mechanisms of tumor progression, signal transduction,cell cycle, differentiation, and development. Papers may be of anylength, provided they are written concisely. All submissionsundergo peer review by experts in the field and are publishedwithin about ten weeks of acceptance.

In addition to original studies, the journal publishes ResearchCapsules, invited papers which summarize and update rapidlychanging concepts in molecular biology. The journal also featuresa Viewpoints section which serves as a forum for signed or anon-ymous write-in discussion of studies published in CELL GROWTH& DIFFERENTIATION or in other journals. All submissions to theViewpoints section will be subject to review prior to publication.

5. Tables, on pages separate from the text, with descriptive titlesand/or legends;

6. Figure legends, on pages separate from the text. Define allsymbols and include staining for halftones, where applicable.

ReferencesInclude only those articles that have been published or are in press.Unpublished data or personal communications must be cited asfootnotes to the text. Personal communications should be substan-tiated by a letter of permission.

Number references in the order of their first mention in the text.Cite only the number assigned to the reference. References must bedouble-spaced.

Sample references:

1 . Maniatis, T., Fritsch, E. F., Lauer, J., and Lawn, R. M. Moleculargenetics of human hemoglobins. Annu. Rev. Genet., 14: 145-178, 1981.

2. Davis, L. C., Dibner, M. B., and Battey, J. F. Basic Methods inMolecular Biology, pp. 44-50. New York: Elsevier SciencePublishing Co., Inc., 1986.

Editorial PolicyWhen a manuscript is received for consideration, the Editors as-sume that no similar paper has been or will be submitted forpublication elsewhere. Further, it is understood that all authorslisted on a manuscript have agreed to its submission. Upon accep-tance, authors must transfer copyright to the American Associationfor Cancer Research, Inc., the publisher and copyright owner of thejournal, prior to publication.

Review ProcessThe review process, expedited by FAX transmission and overnightmail service, is conducted as rapidly as possible. Manuscripts may

be submitted directly to one of the Editors or to the Editor-in-Chief.If a paper is returned for revision prior to publication, the revisedversion must be submitted within one month of the provisionalacceptance.

Journal policy requires that authors, reviewers, and AssociateEditors reveal to the Editor-in-Chief any relationship that they be-lieve could be construed as causing a conflict of interest withregard to the manuscript submitted for review.

Manuscript SubmissionMail manuscripts diredly to an appropriate member of the Edi-tonal Board at that member’s institution. Submit three original sets(not photocopies) of illustrations along with four copies of themanuscript. A set of illustrations will be returned to the author if thepaper is not accepted for publication.

Enclose a covering letter specifying:

1 . that the paper should be considered for publication in CELLGROWTH & DIFFERENTIATION

2. the exact address, telephone and FAX numbers of the corre-sponding author

If a manuscript is closely related to papers that are in press or havebeen submitted elsewhere, please provide copies of those paperswith your submission.

FormatManuscripts must be written succinctly in clear, grammaticalEnglish. Define abbreviations in an inclusive footnote to the text.

Double-space on 8 1/2 X 1 1 -inch paper, except for the abstractwhich should be single-spaced. Dot-matrix printing is not accept-able. The format is as follows:1 . Title page, including: title; authors and affiliations; complete

address, FAX and phone numbers of the corresponding author;and an abstract of no more than 250 words single-spaced to fiton the title page;

2. A running title of fewer than 50 characters;

3. Text, arranged in this order: Introduction, Results, Discussion,Materials and Methods, Acknowledgments, References;

Illustrations

Provide three original sets of illustrations (whether line-cut draw-ings or halftones). Label each figure in pencil on the reverse sidewith the first author’s name, figure number, and an arrow indicatingtop of figure. Letters and numbers on illustrations should not belarger than 1 2-point type. All illustrations will be published at awidth of 3 1/8 inches unless the author requests a greater width. Usetissue overlays to indicate important areas of the photographs thatmust be reproduced with the greatest fidelity.

Indicate magnifications by means of a bar on the photograph.Present karyotypes in the form of cardboard plates onto whichchromosome sections from an original photomicrograph arepasted. Present nucleic acid sequences as glossy prints or originaltypescripts.

The complete expense of reproducing color photographs willbe charged to the author. Submit color illustrations on flexiblebacking.

ProofsPage proofs must be returned to the office of the American Asso-ciation for Cancer Research within 24 hours of receipt. Return

proofs by overnight mail. Proofs not received by the deadline willbe published without the authors’ corrections. Accepted manu-scripts are regarded as final copy and should not be altered sub-stantially in proof. Authors will be charged for all changes in proofnot due to printer’s errors. Each author’s alteration in any line oftext costs approximately $6.1 0. Lengthy insertions of entire sen-tences or paragraphs are billed at different rates depending uponthe complexity of the alterations.

Policy Concerning Availability of Materials

It is understood that by publishing any work in CELL GROWTH &DIFFERENTIATION the authors agree to make freely available toother academic researchers any of the cells, clones of cells or DNAantibodies, etc. that were used in the research reported and that arenot available from commercial suppliers. Also, authors may berequired to make primary data available to the Editor-in-Chief incases of dispute.

Typesetting Manuscripts from Computer Disks

CELL GROWTH & DIFFERENTIATION welcomes disks to expediteproduction of accepted manuscripts. If your article is accepted forpublication, you will receive instructions regarding disk submissionand a form which must be completed and returned with your diskto the AACR Publications Department within 48 hours of notifica-tion ofacceptance. It is the author’s responsibility to ensure that thematerial on the disk matches the final accepted version of themanuscript.

li Instructions for Authors

CG&DCeIGr�,wth&Dff1eieritiaflon

Editorial Board

George F. Vande Woude, Ph.D.Editor-in-ChiefABL-Basic Research ProgramNCI-Frederick Cancer Research

and Development CenterP.O. Box B, Building 469Frederick, MD 21702-1201FAX: 301-696-1549

Mariano Barbacid, Ph.D.Dept. of Molecular BiologyBristol-Myers Squibb Pharmaceutical

Research InstituteP.O. Box 4000Princeton, NJ 08543-4000FAX: 609-252-6051

Alan Bernstein, Ph.D.Div. of Molecular & Developmental

BiologyMt. Sinai Hospital Research Institute600 University AvenueToronto, Ontario M5G 1X5CanadaFAX: 41 6-586-8588

Margaret E. Buckingham, Ph.D.Pasteur InstituteMolecular Biology Dept.28 rue du Dr. Roux75724 Paris Cedex 15FranceFAX: 33-1 -45-68-89-63

Webster K. Cavenee, Ph.D.Ludwig Institute for Cancer Research9500 Gilrnan DriveLa Jolla, CA 92093-0660FAX: 619-534-7750

Jonathan Cooper, Ph.D.Fred Hutchinson Cancer ResearchCenter

1 1 24 Columbia StreetSeattle, WA 98104FAX: 206-667-6522

Suzanne Cory, Ph.D.Walter and Eliza Hall InstituteP.O. Royal Melbourne HospitalVictoria 3050AustraliaFAX: 61 -3-347-0852

Sara A. Courtneidge, Ph.D.SUGEN, Inc.51 5 Galveston DriveRedwood City, CA 94063FAX: 415-306-7613

Tom Curran, Ph.D.Dept. of Molecular OncologyRoche Institute of Molecular Biology340 Kingsland StreetNutley, NJ 07110FAX: 201-235-7617

Fran#{231}oisCuzin, Ph.D.INSERM U 273Universite de NiceFaculte des Sciences06108 Nice Cedex 2FranceFAX: 33-93-52-99-17

Robert Eisenrnan, Ph.D.Div. of Basic SciencesFred Hutchinson Cancer Research

Center1 1 24 Columbia Street, A2-025Seattle, WA 98104FAX: 206-667-6522

Raymond L. Erikson, Ph.D.Dept. of Cell & Developmental

BiologyHarvard University1 6 Divinity AvenueCambridge, MA 02138FAX: 617-495-0681

Michael Gottesman, M.D.Laboratory of Cell BiologyNIH, National Cancer InstituteBuilding 37, Room 1 B22Bethesda, MD 20892-003 7FAX: 301-402-0450

Peter Gruss, Ph.D.Dept. of Molecular Cell BiologyMax-Planck-lnstitute of Biophysical

ChemistryD-3400 GottingenGermanyFAX: 49-551 -201 504

Nancy A. Jenkins, Ph.D.ABL-Basic Research ProgramNCI-Frederick Cancer Research

and Development CenterP.O. Box B, Building 539Frederick, MD 21702-1201FAX: 301-846-6666

Donald W. Kufe, M.D.Div. of Cancer PharmacologyDana-Farber Cancer Institute44 Binney StreetBoston, MA 021 15FAX: 61 7-632-2934

Frank McCormick, Ph.D.Onyx Pharmaceuticals3031 Research Drive, Building ARichmond, CA 94806FAX: 510-222-9069

Harold L. Moses, M.D.Dept. of Cell BiologyVanderbilt University

School of MedicineNashville, TN 37232-21 75

FAX: 615-343-4539

Joseph R. Nevins, Ph.D.Howard Hughes Medical InstituteDept. of Microbiology &

ImmunologyDuke University Medical CenterSection of GeneticsP.O. Box 3054Durham, NC 27710

FAX: 919-681-8973

Yasutorni Nishizuka, M.D., Ph.D.Dept. of BiochemistryKobe University School of MedicineKobe 650JapanFAX: 81-78-351-0082

Eric N. Olson, Ph.D.Dept. of Biochemistry &

Molecular BiologyUniversity of TexasM. D. Anderson Cancer Center

1 51 5 Holcombe BoulevardHouston, TX 77030FAX: 713-791-9478

Luis F. Parada, Ph.D.

Center for Developmental BiologyUT-Southwestern Medical Center

6000 Harry Hines Boulevard

Dallas, TX 75235-91 33

FAX: 214-648-1953

Tony Pawson, Ph.D.

Div. of Molecular &

Developmental BiologySamuel Lunenfeld Research InstituteMt. Sinai Hospital600 University Avenue, Room 875Toronto, Ontario M5G 1 X5CanadaFAX: 41 6-586-8857

Gordon G. Peters, Ph.D.Imperial Cancer Research Fund

Laboratories

P.O. Box 12344 Lincoln’s Inn Fields

London WC2A 3PXUnited KingdomFAX: 44-71 -269-3479

Cell Growth & Differentiation iii

Helen M. Piwnica-Worms, Ph.D.Howard Hughes Medical InstituteDept. of Cell Biology & PhysiologyWashington University Medical

School600 S. Euclid AvenueCampus Box 8228St. Louis, MO 63110-1093FAX: 314-362-3709

Carol Prives, Ph.D.Dept. of Biological SciencesColumbia UniversitySherman Fairchild Center

for the Life SciencesNew York, NY 10027FAX: 21 2-865-8246

Joan V. Ruderman, Ph.D.Dept. of Anatomy and Cell BiologyHarvard Medical School220 Longwood AvenueRoom 243-BiBoston, MA 02115-2732FAX: 617-432-0555

Joseph Schlessinger, Ph.D.Dept. of PharmacologyNew York UniversitySchool of Medicine550 First AvenueNew York, NY 10016

FAX: 212-263-7133

James C. Smith, Ph.D.Laboratory of Developmental

BiologyNational Institute for Medical

ResearchThe Ridgeway, Mill Hill

London NW7 1 AA

United Kingdom

FAX: 44-81-906-4477

Bruce M. Spiegelman, Ph.D.Dana-Farber Cancer InstituteHarvard Medical School

44 Binney Street

Boston, MA 021 15FAX: 61 7-632-4655

Charles D. Stiles, Ph.D.Div. of Cellular & Molecular

BiologyDana-Farber Cancer Institute

Harvard Medical School44 Binney Street

Boston, MA 021 15FAX: 617-632-4663

Tadatsugu Taniguchi, Ph.D.

Institute for Molecular andCellular Biology

Osaka UniversityYamadaoka 1-3, Suita-shiOsaka 565JapanFAX: 81 -6-878-9846

Peter K. Vogt, Ph.D.Div. of Oncovirobogy, SBR-7, Rrn.

SR31 1Dept. of Molecular & Experimental

MedicineThe Scripps Research Institute1 0666 N. Torrey Pines RoadLa Jolla, CA 92037FAX: 619-554-6919

Jean Y. J. Wang, Ph.D.Dept. of Biology, 0347University of California, San Diego9500 Gilman DriveLa Jolla, CA 92093-0347FAX: 619-534-0555

AACR Publications DepartmentPublic Ledger Building, Suite 816150 South Independence Mall WestPhiladelphia, PA 191 06-3483FAX: 215-440-9354

AMERICAN ASSOCIATION FOR CANCER RESEARCH

GUIDELINES FOR APPLICATION FOR ACTWE AND

CORRESPONDING MEMBERSHIP

Notification of Candidate

MarchJuly

November

Margaret FotiExecutive Director

I ��‘%�=J ‘

� ‘C’ 1907

1/VCILR �

BENEFITS OF MEMBERSHIP� The American Association for Cancer Research (AACR), a

� scientific society of over 10,000 laboratory and clinical cancer� researchers, was founded in 1907 to facilitate communication and

: dissemination of knowledge among scientists and others dedicated� to the cancer problem; to foster research in cancer and related� biomedical sciences; to encourage the presentation and discussion

� of new and important observations in the field; to foster public

� education, science education, and training; and to advance the� understanding of cancer etiology, prevention, diagnosis, and� treatment throughout the world.� Members of the AACR enjoy the following benefits:

� 1. the privilege of sponsoring a proffered paper (abstract) for� consideration for presentation at the AACR annual meeting;� 2. an advance copy of the Program and Proceedings of the� American Association for Cancer Research pertaining to each

� annual meeting;� 3. reduced registration rates at annual meetings;� 4. priority notice of small, focussed meetings in the AACR’s� exciting series of Special Conferences in Cancer Research;� 5. reduced registration rates for Special Conferences;� 6. opportunities for participation in AACR meetings in North� America and abroad with other scientific societies around the

� world;

� 7. receipt of AACR Newsletters and other important announce-� ments;� 8. early notification of and reduced rates for participation in the� AACR Employment Register;� 9. an up-to-date Membership Directory of thousands of research-� ers in the cancer field;� 10. the professional benefits ofAACR’s public education activities� concerning funding for cancer research and press coverage of

� the latest research findings;� 11. participation in Summer Workshops that foster networking

� opportunities and science education for young investigators;

� and

� 12. many more ongoing benefits.

� QUALIFICATIONS FOR MEMBERSHIP� Active membership in the AACR is open to investigators who� live in the Americas. Individuals who have conducted two years of� research resulting in peer-reviewed publications relevant to cancer,

. or who have made substantial contributions to cancer research in

an administrative or educational capacity, are eligible. If acandidate has conducted research in an area of biomedical science

related to cancer, he or she will qualify for membership. Evidenceof patents relevant to cancer research may be submitted as

qualifications for membership in lieu ofpeer-reviewed publications.

Corresponding membership is open to persons who are notresidents of the Americas. The qualifications for corresponding

membership are the same as those indicated above for activemembership. Visiting scientists from outside the Americas who

intend to return to their countries oforigin by the anticipated timeof election should apply for corresponding membership. All othervisiting scientists should apply for active membership and transfer

to corresponding status upon leaving the Americas.Graduate and medical students, postdoctoral fellows, and

physicians in training who do not yet meet the above qualifications

for active or corresponding membership should apply for associatemembership. Forms for associate membership are available fromthe AACR Office.

PROCEDURES FOR APPLICATIONThere are three deadlines for the receipt of a membership

application: January 1, May 1, and September 1 ofeach year. TheMembership Committee will review all complete applications for

active membership that have been received by these deadlines andwill submit recommendations on each candidate to the Board of

Directors which formally elects all members. The same procedureis followed by the Special Memberships Committee which receives

applications for corresponding membership. Candidates will be

notified according to the following schedule:

Receipt of Application

in AACR Office ________________

January 1May 1

September 1

A complete application consists of the following material:

1. 6 copies of the form on the opposite side of this page, with allrequested information provided.

2. 5 copies of the candidate’s most current curriculum vitae andbibliography.

3. 5 copies of a letter of recommendation from a nominator whois an active, corresponding, emeritus, or honorary member of

the AACR (at least one copy must be a signed, original letter).This letter should describe the candidate’s achievements in

laboratory research, clinical investigations, or epidemiological

research, and it should affirm that this research adheres toaccepted ethical scientific standards. -OR- The nominator may

supply the responses requested at the bottom of the applica-

tion form in the section entitled “STATEMENT OF SUPPORT”(at least one copy of the form must be the signed original).

4. 5 copies of a letter of recommendation as described in Item 3above from a seconder who is an active, corresponding,

emeritus, or honorary member ofthe AACR (at least one copymust be a signed, original letter). -OR- The seconder may

supply the responses requested at the bottom of the applica-tion form in the section entitled “STATEMENT OF SUPPORT”

(at least one copy of the form must be the signed original).

5. 5 reprints of each of two publications on which the candidateappears as author. As noted above, evidence of patentsdeveloped by the candidate may be submitted in lieu ofone or

both of the publications. If submitting patents, supply patent

number and year awarded.All material should be collated into five complete sets with the

original application form as a covering document and sent to the

address given below. Questions regarding procedures for member-

ship application may also be directed to the following address:

American Association for Cancer Research

Public Ledger Building, Suite 816150 5. Independence Mall West

Philadelphia, PA 19106-3483

Phone: 215/440-9300

FAX: 215-440-9313

RESPONSIBILITIES OF MEMBERSHIPCandidates should be aware ofthe following responsibilities of

membership in the AACR. Active members must pay annual dues.In 1995 annual dues for active members are $160, $95 of which is

designated for AACRjournal subscriptions. Newly elected membersof the AACR who have already purchased subscriptions to Cancer

Research, Clinical Cancer Research, Cell Growth & Differentiation,or Cancer Epidemiology, Biomarkers & Prevention at the higher,nonmember rates will receive reimbursement ofthe unused portion

of those subscriptions once their first year’s membership dues are

paid in full.Corresponding members are required to pay dues ($80 in 1995)

and may, if they wish, subscribe to Cancer Research, ClinicalCancer Research, Cell Growth & Differentiation, or Cancer Epide-

. miology, Biomarkers & Prevention at reduced member rates.Applicants elected in March will be responsible for payment of

that year’s dues; applicants elected in July and November will paydues for the following year. Applicants elected in March and July

will be eligible to sponsor an abstract for the next annual meeting.

Every effort will be made to afford the same opportunity toapplicants elected in November.

NAME OF CANDIDATE:

LAST FIRST M.I.

DATE OF BIRTH:________

(Please print) (Please print)

CANDIDATE IS APPLYING FOR (Check one): 0 ACTWE 0 CORRESPONDING MEMBERSHIP

STATEMENT OF SUPPORT (in place of letters of recommendation)

Instead of submitting letters of recommendation, either the nominator or the seconder or both may complete the following section:

(This form may be reproduced.)

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.

Public Ledger Building . Suite 816 . 150 S. Independence Mall West . Philadelphia, PA 19106-3483

APPLICATION FOR ACTIVE OR CORRESPONDING MEMBERSHIP

PRESENT POSITIONtflTLE:_

INSTITUTIONAL AFFILIATION:

INSTITUTIONAL ADDRESS:_

(City) (State/Province)

TELEPHONE NUMBER:__________________________

(Country) (Postal Code)

FAX NUMBER:________________________

E-MAIL NUMBER

PRIMARY FIELD OF RESEARCH (Please check only one):

Biochemistry and Biophysics ............BiostatisticsCellular Biology and Genetics Clinical Investigations

Epidemiology jmmunologyPreclinical Pharmacology and .....Virology

Experimental Therapeutics

(CARRIER):______________________________________

Carcinogenesis

Endocrinology

......Molecular Biology and Genetics

Other:_________________________________

(Please specify)

ACADEMIC DEGREES (Including where and when granted)

EXPERIENCE SINCE HIGHEST DEGREE WAS GRANTED (Please ii st most recent first)

PUBLICATIONS (Reprints of two peer-reviewed articles on which the candidate appears as an author must accompany this

application. For these two articles list the authors, title, journal, volume, inclusive pages, and year. Do not submit abstracts. If

submitting patents, supply patent number and year awarded.)

CANDIDATE

NOMINATED BY*:

How long has the candidate worked in the field of cancerresearch? ��yearsWill the candidate make a long-term contribution to cancerresearch? Yes NoDoes the candidate’s research adhere to accepted ethical

standards? Yes NoI therefore recommend this candidate for membership in theAmerican Association for Cancer Research.

CANDIDATE

SECONDED BY*:

How long has the candidate worked in the field of cancerresearch? ...............yearsWill the candidate make a long-term contribution to cancerresearch? Yes NoDoes the candidate’s research adhere to accepted ethicalstandards? Yes NoI therefore recommend this candidate for membership in theAmerican Association for Cancer Research.

Signature of nominator* Date Signature of seconder* Date

See Guidelines for Application on the reverse side of this form for further instructions.

*Both nominator and seconder must be active, corresponding, emeritus, or honorary members of the AACR.

AMERICAN ASSOCIATION FOR CANCER RESEARCH

�GUIDELINES FOR APPLICATION FOR ASSOCIATE MEMBERSHIP

Margaret Foti

Executive Director

AS�c� C’

, � �

QUALIFICATIONS FOR MEMBERSHIP

Associate membership is open to graduate students, medicalstudents, postdoctoral fellows, and physicians in training who are

following a course of study or who are working in a research

program relevant to cancer. Scientists in training who already

have a substantial record of publications may wish to apply for

active or corresponding membership which confers full benefits of

membership.

BENEFITS OF MEMBERSHIP

The American Association for Cancer Research (AACR), a

scientific society consisting of laboratory and clinical cancerresearchers, was founded in 1907 to facilitate communication and

dissemination of knowledge among scientists and others dedicated

to the cancer problem: to foster research in cancer and related

biomedical sciences; to encourage presentation and discussion of

new and important observations in the field; to foster public

education, science education, and training; and to advance the

understanding of cancer etiology, prevention, diagnosis, and

treatment throughout the world. Associate members of the AACR

enjoy the following benefits:

1. the privilege ofsponsoring a paper for presentation at the AACRannual meeting provided that (a) the associate member is the

presenter of the paper and (b) an active, corresponding, emeri-

tus, or honorary member in good standing of the AACR also

signs the abstract of the paper in support of the work (In this

instance, the member who cosigns the abstract does not lose hisor her own sponsorship privilege.);

2. an advance copy of the scientific Program and (if one has beenpurchased by the associate member) the Proceedings of the

American Association for Cancer Research which containsabstracts of all papers being presented at each annual meeting;

3. the privilege of registering for the annual meeting at the lowstudent rate (This rate is otherwise available only to predoctoral

students.);

4. preferred access to the AACR Employment Register;5. optional subscriptions to the Association’s high-quality journals

Cancer Research, Cell Growth & Differentiation, Cancer Epide-

miology, Biomarkers & Prevention, and Clinical Cancer Resea rchat reduced member rates;

6. priority notification of events in the AACR’s series of specialconferences on timely subjects in the field;

7. reduced registration rates at special conferences;

8. the receipt of AACR newsletters, meeting announcements, andan up-to-date membership directory; and

9. the facilitation of informal scientific exchange with leadingresearchers in the cancer field.

PROCEDURES FOR APPLICATION

Persons wishing to apply for associate membership must use the

official application form on the reverse side of these instructions.Each candidate for associate membership must be nominated by an

active, corresponding, emeritus, or honorary member in goodstanding of the AACR. Three completed copies of the form should

be submitted; at least one of these copies must carry the original

signatures of both the candidate and the nominator. The applica-tion form may be submitted to the Association Office at any time.

After review of applications for associate membership, the

Executive Director will notify candidates of their election or

deferral within one month of the receipt of the application form.

A check for one year’s dues payment must accompany the applica-

tion. Dues for 1994 are $30 for associate members residing in the

Americas and $40 for residents of other countries. For 1995 these

rates are $35 and $45, respectively. This fee will be refunded toany candidate deemed to be ineligible for associate membership.

Checks should be in U.S. currency, made payable to AACR, Inc.,and drawn on a U.S. bank. Send the three copies ofthe application

form and the appropriate dues payment to:

American Association for Cancer Research

Public Ledger Building, Suite 816

150 5. Independence Mall West

Philadelphia, PA 19106-3483

215/440-9300

RESPONSIBILITIES OF MEMBERSHIP

Associate members must pay annual dues in an amount to be

determined by the AACR Board of Directors. Dues for 1994 have

been set at $30 per year for residents of the Americas and $40 for

residents ofother countries. For 1995 these rates are $35 and $45,

respectively. If an application is submitted by August 31, the

accompanying dues payment will be credited to the current year.

Candidates submitting applications between September 1 and

December 31 may indicate whether they wish their dues payments

credited to the current or forthcoming year. Candidates should be

aware, however, that associate members may sponsor an abstract

for the annual meeting only if their dues for the current year are

paid. For example, an associate member submitting an abstract in

October 1994 for the forthcoming annual meeting must have paid

dues for 1994. Any newly elected associate members of the AACRwho have already purchased subscriptions to Cancer Research , CellGrouth & Differentiation, Cancer Epidemiology, Bioniarkers &Prevention, and Clinical Cancer Research at the higher, nonmem-ber rate will receive a refund for the unused portion of that

subscription upon receipt oftheir payment for a member’s subscrip-

tion.

Each Fall the AACR will send to current associate members aninvoice for dues for the forthcoming year. Payment of this invoice

must be accompanied by a statement signed by the associate

member’s current registrar, dean, or department head, verifying

the member’s current academic status. The Association’s By-Laws

state that dues are payable for each year in advance by January 1

of the year to which they should be applied. An individual may be

an associate member for a maximum of five years. Each year in

which an individual pays dues will count as one full year of

associate membership. Thus, an associate member who pays dues

for 1994 may retain associate membership until December 31,

1998. The Board ofDirectors may terminate the membership of an

associate member whose dues are in arrears for two years.

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.

Public Ledger Building . Suite 816 . 150 S. Independence Mall West . Philadelphia, PA 19106-3483

NAME OF CANDIDATE:__________________________________________ DATE OF BIRTH:_________

LAST FIRST MI.

INSTITUTIONAL AFFILIATION:_____________________________________________________________

INSTITUTIONAL ADDRESS:

(City) (StatefProvince) (Country) (Postal Code)

TELEPHONE NUMBER:___________________________ FAX NUMBER:______________________

PRESENT ACADEMIC STATUS/TITLE (Please check only one): E-MAIL NUMBER (CARRIER):__________________

Graduate Student Medical StudentPhysician in Training ..........Postdoctoral Fellow

PRIMARY FIELD OF RESEARCH (Please check only one):

Biochemistry and Biophysics Biostatistics Carcinogenesis

Cellular Biology and Genetics Clinical Investigations Endocrinology

Epidemiology jmmunology ..Molecular Biology and Genetics

Preclinical Pharmacology and Virology Other:________________________________

Experimental Therapeutics (Please specify)

ACADEMIC DEGREES (Please indicate degree(s) acquired to date along with the name of the academic institution and date ofreceipt. Provide information on degree currently being sought and the anticipated date of completion of this degree program.)

RELEVANT RESEARCH EXPERIENCE NOT RELATED TO COURSE WORK (Please list most recent first.)

PUBLICATIONS (List the authors, title, journal, volume, inclusive pages, and year of any article in a peer-reviewed journal on

which the candidate appears as an author. Do not list abstracts. Continue on a separate sheet, if necessary.)

CANDIDATE NOMINATED BY:_________________________________________________________(Please type or print name ofAACR active member in good standing.)

SIGNATURESI hereby apply for associate membership in the American Association for Cancer Research. I have read the instructions on the

reverse side of this form, and I understand the privileges and responsibilities of this class of membership. I certify that the

statements on this application are true.

Signature of Candidate:________________________________________________________ Date:________________

I recommend this candidate for associate membership in the American Association for Cancer Research. To the best of my

knowledge, the candidate is qualified for this class of membership, and the statements on this application are true.

Signature of Nominator*:______________________________________________________________ Date:__________________

Submit three copies of this form. At least one copy must contain the original signatures of the candidate and the nominator.

Enclose a check in U.S. funds, made payable to AACR, Inc., and drawn on a U.S. bank for one year’s dues. For 1994 dues are $30

for associate members residing in the Americas and $40 for residents of other countries. For 1995, these rates will be $35 and $45,

respectively.

Check one of the following boxes only if this form is being submitted between September 1 and December 31:

The enclosed dues payment should be applied to the 0 current 0 forthcoming calendar year.(NOTE: Ifdues are applied to the forthcoming year, membership will take effect on January 1, but the candidate will not be eligible

to sponsor an abstract for presentation at the annual meeting in March or April of that year.) See Guidelines for Application on

the reverse side of this form for further instructions.

*Nominator must be active, corresponding, emeritus, or honorary member of the AACR.

(This form may be reproduced.)

New releases of word processing software are not always immediately available for conversion. In addition,because of the file structures and internal coding, we cannot accept disks created on desktop publishingsystems or those created on proprietary typesetting systems. We also cannot guarantee that all specialcharacters can be translated. Tabular and mathematical material, such as equations, will not be captured fromthe disk but will be rekeyed.

To expedite work and for your own security, we do require that you submit a hard copy printout of the diskfile. The tables and equations will be keyed from this hard copy. We also need to know the name of the file tobe converted, the type of hardware (e.g. ,IBM PC) on which the files were created, the operating system (e.g.,DOS 3.3), and the version of the software (e.g. ,WordPerfect 5.1) used to create the file.

PLEASE FILL OUT ALL INFORMATION ON REVERSE SIDE AND SUBMIT THIS FORM WITH YOUR DISK.

DISKS WILL NOT BE PROCESSED WITHOUT THIS INFORMATION.

Guidelines for Submitting Disksto

American Association for Cancer Research Publications

The word processing packages that we prefer are as follows:

XyWrite Ill Plus (for the IBM)

WordPerfect 4.2, 5.0, 5.1 (for the IBM)WordPerfect (for the Mac)Wordstar (for the IBM)

Also acceptable:

Apple II DOS 3.3Apple with Appleworks SoftwareApple Ill Plus DOS 3.3Apple MacIntosh 400K Disc/

MacWrite 2.2 (text)Apple MacIntosh Plus 800K Disc!

MacWrite 4.5 (text)CPT 8000DEC WPS-8DEC Decmate IIDEC Decmate IllDisplay Write 3

Microsoft Word (for the IBM)Microsoft Word Macintosh

(Versions 1 -4) 400/800KWang 015 (WPS)

Display Write 4IBM Displaywriter Word Processor 6580Lanier Business One StepLanier No ProblemLanier Super No ProblemMASS-il PCMultimatePC WritePFS Professional WriteVolkswriter 4.0

DISK SUBMISSION FORM

AACR joumals are now using personal computers to copyedit manuscripts accepted for publication. Whensubmitting a revised manuscript, authors are encouraged to submit an electronic disk of the paper along withthe required four hard copy printouts. Disks will ultimately be returned to the authors.

T See reverse for the word processing packages that can be accepted.File preparation

Please be sure that the file you send is the most recent version of the manuscript and that it matches themost recently submitted printed copy. The file should contain all the parts of the manuscript in one file.Mathematical and tabular material, however, will be processed in the traditional manner and may be excludedfrom the disk file.

Note: AACR does not assume responsibility for errors in conversion of customized software, newly releasedsoftware, or special characters.

Please label the outside of the disk with the joumal name, the first author’s name, a partial title of themanuscript, and the name of the computer file used to access the manuscript on disk. To process your diskefficiently, we need the following information. Please be sure to provide ALL the information.

Name used to access paper on disk: ____________________

Name of computer used (e.g., IBM/PS2):

Operating system and version (e.g., DOS 3.3):

Word processing program and version (e.g., WordPerfect 5.0):

[See reverse for acceptable programs.]

Manuscript number: _________________________________First authoc _________________________________________

Corresponding author (if different from first author):

Telephone/FAX numbers: ____________________________

This form (both sides) may be reproduced.

AMERICAN ASSOCIATION FOR CANCER RESEARCH

13. many more ongoing benefits.

BENEFITS OF MEMBERSHIP

The American Association for Cancer Research (AACR) is a scientific society consisting oflaboratory and clinical cancer researchers. it was founded in 1907 and its purposes are “tofacilitate communication and dissemination of knowledge among scientists and others dedicatedto the cancer problem; to foster research in cancer and related biomedical sciences; toencourage presentation and discussion of new and important observations in the field; to fosterpublic education, science education, and training; and to advance the understanding of canceretiology, prevention, diagnosis, and treatment throughout the world.” Members of the AACRenjoy the following benefits:

1 . the opportunity to subscribe to the journals Cancer Research, Cell Growth & Differentiation, CancerEpidemiology, Biomarkers & Prevention, and Clinical Cancer Research at the reduced member rate.

. Cancer Research publishes over 7,000 pages per year of timely, significant research. With over40,000 citations to its articles per year, it rates as the most highly cited journal in the cancer field.

. Cell Growth & Differentiation, a journal of the molecular biology of cancer, has established atradition of rapid publication with an average review time of 2-3 weeks and an average of 10weeks between acceptance and publication.

S Cancer Epidemiology, Biomarkers & Prevention has already established itself as a leading journalwith a wholly unique scope, providing a common forum for three scientific areas that are rapidlyexpanding our knowledge of cancer causation and prevention in humans.

. Clinical Cancer Research, the AACR’s newest journal, began publication in 1 995. Focusing oninnovative translational studies, it publishes original laboratory and clinical research on themolecular characterization, prevention, diagnosis, and therapy of human cancer.

2. the privilege of sponsoring a paper for possible presentation at the AACR Annual Meeting;

3. an advance copy of the Program and, if one has been purchased, Proceedings pertaining to eachAnnual Meeting;

4. reduced registration rates at Annual Meetings;

5. priority notice of and reduced registration rates for small, focused meetings in the AACR’s SpecialConferences in Cancer Research;

6. opportunities for participation in the AACR’s meetings with other scientific societies around the world;

7. subscriptions to future AACR journals at reduced member rates;

8. the receipt of AACR newsletters and meeting announcements;

9. early notification of and reduced rates for participation in the Employment Register;

10. an up-to-date Membership Directory;

1 1 . participation in Summer Workshops that foster networking opportunities and science education foryoung investigators;

12. the benefits of the AACR’s public education activities concerning funding for cancer research andpress coverage of the latest research findings; and

THE SURGERY BRANCH, NATIONAL CANCER INSTITUTE, NIH, IS SEEKING

PATIENTS FOR ONGOING CLINICAL TREATMENT PROGRAMS.

PATIENTS WITH THE FOLLOWING MALIGNANCIES

ARE BEING TREATED UNDER COMBINED MODALITY OR INNOVATIVE

IMMUNOTHERAPY PROGRAMS:

. METASTATIC MELANOMA AND KIDNEY CANCERS

. STAGE II OR LOCALLY ADVANCED BREAST CANCER.

. METASTATIC COLORECTAL CANCER TO THE LIVER

. LOCOREGIONAL GASTRIC OR PANCREATIC CANCERS

S MESOTHELIOMA, PULMONARY METASTASES,

STAGE III A, B LUNG CANCER OR ESOPHAGEAL CANCER.

. LOCALIZED SOFT TISSUE SARCOMAS

. PERITONEAL CARCINOMATOSIS.

CARE FOR ALL PATIENTS IS PROVIDED AT THE CLINICAL CENTER, NIH,

BETHESDA, MARYLAND.

FOR MORE INFORMATION ON CANCER PROGRAMS, PLEASE CALL

(301)496-1533

NJi�cf1oNALI ( ANGERINSTITUTE

A Public Service Announcement Courtesy ofthis Publication

. PEER REVIEWED

. ANNUAL INDICES

. SAMPLE COPIES

AVAILABLE

Institutions: Purchase all four journals and save 15% off the total subscription price. Canada: Add 7% GST to all orders. MD: Add state sales tax.

I Four Essentia� �Journa�s frorT� thE? .�.ACRPriority reading for over 50 years - . State-of-the-artlaboratory andcIted more than any other journal In clinical investigationsits field . Advances in Brief

CANCER RESEARCH #{149}Selected review articles. Proceedings oftheAmerican

Vol. 55, 1995 (24 issues) �s��tionfor �Jancer Research:ISSN 0008-5472 annual issue of research abstracts

Editor-in-Chief Individual nonmembers: $460;

Carlo M. Croce, M.D. Outside U.S.: $520

Institutions: $495*; Outside U.S.: $575** Includes a subscription to Clinical CancerResernvh. Available as a combined subscription only.

A major resource on the molecular . Original in vitro and in vivo studiesbiology of cancer ofthe molecular biology of cancer,

CELL GROWTH including normal and abnormal& DIFFERENTIATION cellUlar processes

. Research CapsulesVol. 6, 1995 (12 issues) . ViewpointsISSN 1044-9523

Individual nonmembers: $95Editor-in-Chief OutsideU.S.: $115

George E Vande Woude, Ph.D. Institutions: $ 195; Outside U.S.: $215

An up-to-the-minute journalspanning three vital fields . Original research on causes and

prevention of cancer in humansCANCER EPIDEMIOLOGY, #{149}Invited editorialsBIOMARKERS & PREVENTION #{149}Selected review articles

Vol. 4, 1995 (8 issues) . Short communications

ISSN 1055-9965 . Meeting reports

Individual nonmembers: $85Editor-in-Chief Outside U.S.: $105

Pelayo Correa, M.D.Institutions: $165; Outside U.S.: $185

An exciting new forum for clinical #{149}Research articlesand translational cancer research #{149}Advances in Brief

CLINICAL CANCER RESEARCH #{149}Minireviews. Controversies in Clinical

Vol. 1 , 1995 ( 12 issues) Cancer ResearchISSN 1078-0432 Individual nonmembers: $95

Editor-in-Chief Outside U.S.: $ I 15John Mendelsohn, M.D. Institutions: $495*; Outside U.S.: $575*

*IIlcltIdes a subscription to Cancer Research.

Available as a combined subscription only.

ORDER TODAY!

American Association for Cancer Research

do FULCO, Inc.

P.O. Box 3000

Denville, NJ 07834

1-800-875-2997

FAX: (201)627-5872

AMERICAN ASSOCIATION FOR CANCER RESEARCHSCIENTIFIC CONFERENCES

OCTOBER 14-18, 1995Cytokines and Cytokine Receptors

Chairperson: Steven Gillis, Seattle, WAThe Sagamore, Bolton Landing (Lake George),

NY

NOVEMBER 5-9, 1995Cancer: The Interface Between

Basic and Applied ResearchChairpersons: Bert Vogelstein, Baltimore, MD;

Stephen H. Friend, Seattle, WA; John D.Minna, Dallas, TX

Stouffer Harborplace Hotel, Baltimore, MD

NOVEMBER 17-21, 1995Novel Strategies Against

Resistant CancersChairpersons: Victor Ling, Toronto, Ontario,

Canada; Daniel D. Von Hoff, San Antonio, TXSanibel Harbour Resort & Spa, Ft. Myers, FL

DECEMBER 2-6, 1995The Molecular Basis of

Gene TranscriptionChairperson: Tom Curran, Nutley, NJHotel Del Coronado, Coronado (San Diego), CA

JANUARY 1 7�20, 1996Cancer and the Cell Cycle

Joint Meeting with the Swiss Institute forExperimental Cancer Research

Chairpersons: Edward E. Harlow, Charlestown,MA; Viesturs Simanis, Lausanne, Switzerland

Location to be Announced in Lausanne,Switzerland

FEBRUARY 19-25, 1996Cancer Susceptibility Genes and

Molecular CarcinogenesisChairpersons: Curtis C. Harris, Bethesda, MD;

Allan Balmain, Glasgow, Scotland; KennethOlden, Research Triangle Park, NC

Keystone Resort, Keystone, CO

MARCH 1-5, 1996Proteases and Their Inhibitors

in CancerChairpersons: Lynn M. Matrisian, Nashville, TN;

Bonnie F. Sloane, Detroit, MIMarriott’s Bay Point Resort, Panama City

Beach, FL

APRIL 20-24, 199687th Annual Meeting

Chairperson: Lorraine J. Gudas, New York, NYWashington D.C. Convention Center, Washington,

D.C.Abstract Deadline: December 1 , 1995

JUNE 1996Inducible Genomic Responses

Chairpersons: William T. Beck, Memphis, TN;John A. Hickman, Birmingham, England;Richard I. Morimoto, Evanston, IL

Location to be Announced

OCTOBER 1996Novel Approaches in Blood and

Marrow TransplantationSecond Annual Meeting of the American Society

for Blood and Marrow TransplantationChairpersons: Joseph R. Bertino, New York, NY;

Bruce R. Blazar, Minneapolis, MNLocation to be Announced

OCTOBER 1996Carcinogenesis from Environmental

Pollution: Assessment of Human Risksand Strategies for Prevention

Joint Meeting with International Agency forResearch on Cancer

Chairpersons: Frederica Perera, New York, NY;Paul Kleihues, Lyon, France

Location to be Announced in Budapest, Hungary

OCTOBER 19-23, 1996Programmed Cell Death

Chairperson: Stanley J. Korsmeyer, St. Louis, MOThe Sagamore, Bolton Landing (Lake George), NY

NOVEMBER 16-20, 1996Disrupted Transcription Factors in Cancer

Chairpersons: Peter K. Vogt, La Jolla, CA; FrankJ. Rauscher Ill, Philadelphia, PA

Hotel Del Coronado, San Diego, CA

AACR members will receive brochures on theabove special conferences as soon as they areavailable. Nonmembers should call or write:

American Association for Cancer ResearchPublic Ledger Building, Suite 816150 South Independence Mall WestPhiladelphia, PA 19106-348321 5-440-9300 #{149}21 5-440-931 3 (FAX)