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© 2013 LanzaTech Inc. All rights reserved.
Innovative Use of Waste Gasesto Make SustainableFuels and Chemicals
Dr. Robert [email protected]
May 13th 2014
Business Confidential
Company Profile Founded in January 2005 in Auckland by Dr. Sean Simpson and Dr. Richard Foster Global HQ in Chicago, IL; R&D in Auckland; Operations in US, China and India Funding
– Series A: Khosla Ventures ‐ $US 12M in 2007
– Series B: Qiming Ventures ‐ $US 18M in 2010
– Series C: Burrill MLSCF ‐ $US 60M in 2012, Petronas as Strategic Investor
– Series D: Mitsui & Co.‐ $US 60M in 2014, Mitsui and Siemens as Strategic Investor
TeamCEO: Dr. Jennifer HolmgrenCSO/Founder: Dr. Sean Simpson
– Over 100 staff Synthetic Biology, Fermentation, Analytical Engineering, Separation, Operations IP, Business Development
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Business Confidential
Natural Gas, CH4Associated Gas
BiogasMethane Hydrates
BiomassSolid WasteIndustrial, MSW,
DSW
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Inorganic CO2
COCO CO + H2CO + H2 CO + H2 + CO2CO + H2 + CO2 CO2 + H2CO2 + H2 CO2 + H2O + e-CO2 + H2O + e-
Fuels Chemicals
Gas Fermentation
Reforming Gasification RenewableElectricity
Renewable H2
Industrial Waste Gas
Steel, PVC, Ferroalloys
Business Confidential
Waste Carbon as a Resource
Business Confidential
Gas feed stream
Gas reception Compression Fermentation Recovery Producttank
• Gases are sole source of energy• Production of fuels and chemicals• Potential to make material impact on the future energy pool • Completely outside of the food value chain• Biofuel, carbon capture and energy efficiency technology solution
Novel gas fermentation technology captures CO-rich
gases and converts the carbon to fuels and chemicals
The LanzaTech Process
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Business Confidential
100-130 billion gal/yr1.3 billion MTApotential in US
Petcoke
Ethanol Potential Through theLanzaTech Process
Biomass
Significant Impact on Fuel Pool,no Impact on Food Production
Available High Volume Point Sourced Low Value Non Food
130 million MTAGlobally
Business Confidential
Steel Industry
1.4 billion MTA Globally
Petcoke
Waste as a Fuels and Chemicals Resource
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Business Confidential
Pre-commercial plants(2 units)
16,000 L Vessel
Demo
Scalable design(Lab)
Up to 100L capacity
LabPilot
Bench top(Lab)
0.5-10L vessels
CSTR
NZ Steel mill pilot(operated since 2008)
2 x 500L Vessels
Pilot
Business Confidential
Clear Path to Scale
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Business Confidential
Pyruvate
CO/H2
Acetyl-CoA
Ethanol
2,3-Butanediol
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LanzaTech proprietary bacterial strain
The natural LanzaTech gas fermenting microbe can make both ethanol and 2,3-butanediol
Fuels and Chemicals from Gas
Business Confidential
Industrial WasteBiomass
NGCoal
MSW/DSW
Syngas
2,3-BDO
AdvancedBiofuel
Butadiene
Ethanol
Styrene Butadiene Rubber (SBR)~4.9M tons, ~$13B
Polybutadiene Rubber (BR)~3M tons, ~$8B
ABS Resins~8M tons, ~$16B
Nylon 6,6~1.8M tons, ~$6.9B
Global Market Size: ~11 million tons, ~$22 billion
Butadiene: Key Chemical Intermediate
Business Confidential
C4 Chemicals from Gases
OHH3C
OHCH3
2,3-Butanediol
Reductive EliminationCatalytic Dehydration Catalytic Dehydration
1,3-Butadiene Methyl Ethyl Ketone(MEK/Butanone)
Butenes
1-Butylene(But-1-ene)
2-Butylene(But-2-ene)
Isobutylene(2-Methylpropene)
H H
HH H
HC CC C
H
H HC C
CH2 CH31 2
3 4H3C
H HC C
CH32 3
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H CH3
C CCH3
1 2H
3
H3C-CH2-C
CH3
O
New Route to C4s Without Current Supply Challenges 10
CO + H2
Business Confidential
Business Confidential11
Acetogenic bacterium with ability to utilize gases as sole energy and carbon source
LanzaTech has developed a proprietary strain of Clostridium autoethanogenum
Obtained by extensive natural selection program, having improved characteristics
Sequencing revealed several variations
RearrangementDeletion Variation Insertion
Business Confidential
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Proprietary Acetogenic Biocatalyst
Business Confidential 12
Genetic Tool Development
Developed a genetic toolbox from scratch that allows to effectively modify the organism
1. Efficient transformation technology
2. Plasmid-based gene expression
3. Gene knock-in / knock-out
4. Closed genome sequence
Business Confidential
Pyruvate
CO/H2
Acetyl-CoA
Fatty Acids,Terpenoids
Discovery LabCont.
Culture
Pilot/Demo
Ethanol
i-PropanolAcetone
3-HB
D-(-)-2,3-Butanediol
MEK
FAEE/FABE
Farnesene
Succinate
sec-Butanol
n-Butanol
Lactate
meso-2,3-butanediolAcetoin
3-HP
Isoprene
1,2-PDO
Acetonei-Propanol
Propanaln-Propanol
Business Confidential
Butyrate
1,3-BDO
1 organism, >20 products so far…
(Mevalonate Pathway)
Partnerships
Physiology• Shift Ethanol:BDO
ratio (BDO KO)• Ethanol tolerance• Vitamin biosynthesis
Partnershipsi-butylene 2-HIB
1,3-BD