innovative biotech ltd nigeria
DESCRIPTION
Innovative Biotech Ltd Nigeria. Dr Simon Agwale. General overview (1). Nigeria is the tenth largest country in the world and the most populous in Africa. It is situated within sub Saharan Africa which harbors about 67% of the world HIV/AIDS burden - PowerPoint PPT PresentationTRANSCRIPT
Innovative Biotech LtdInnovative Biotech LtdNigeriaNigeria
Dr Simon Agwale
General overview (1)General overview (1)General overview (1)General overview (1)
Nigeria is the tenth largest country in the world and the most populous in Africa. It is situated within sub Saharan Africa which harbors about 67% of the world HIV/AIDS burden
It has an estimated population of 120 million (1999), representing over one fifth of the total population of the African continent
It is a democratic Federal Republic consisting of 36 states and the Federal Capital Territory (FCT)
The literacy level is estimated to be 55%
Ever since HIV was reported in the country in 1996, the infection rate has continued to rise steadily from less than 0.1% in 1987, to 1.8% in 1991, to 5.8% in 2001, with a slight decrease in 2003 sentinel survey to 5.0%
The HIV prevalence rates in the two States chosen for the study are 12% for Benue and 9% for Nasarawa. Most of the female sex workers have low literacy rates
Presently, no study has effectively addressed the incidence of the disease among this group till date
General overview (2)General overview (2)General overview (2)General overview (2)
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PREVALENCE
HIV prevalence in Nigeria (1)HIV prevalence in Nigeria (1)HIV prevalence in Nigeria (1)HIV prevalence in Nigeria (1)
According to the National survey, HIV prevalence rate among female sex workers in Nigeria has remained high, and is on the increase from 17.5% in 1991 through 22.5%(1993), to 35.6% in 1995
Female sex workers constitutes an important core group of HIV transmission to the general population
HIV prevalence in Nigeria (2)HIV prevalence in Nigeria (2)HIV prevalence in Nigeria (2)HIV prevalence in Nigeria (2)
Innovative Biotech Ltd (IBL) is a company registered in Nigeria
Investigators have experience with clinical research
Current research at IBL includes: Development of HIV candidate vaccines Subtyping of HIV 1 and 2 in Nigeria HIV drug resistance Surveillance in Nigeria Prevalence of co-infection of HIV with Hepatitis B & C Subtyping of Hepatitis C virus in Nigeria Cross-sectional HIV incidence study among female
sex workers based at brothels in Nasarawa and Benue states
Site overviewSite overviewSite overviewSite overview
Site locationsSite locationsSite locationsSite locations
Interim study findings ( Feb. 07- April Interim study findings ( Feb. 07- April 11, 2006)11, 2006)Interim study findings ( Feb. 07- April Interim study findings ( Feb. 07- April 11, 2006)11, 2006)
Total number of brothels 28
Total number recruited 266
Total number HIV positive 192
Total number of HIV negative 74
Total number of co-infection (HIV-1 and 2) 12
Number of HIV-1alone 180
Number of HIV-2 Nil
HIV prevalence so far 72%
Prevalence of co-infection 4.5%
Challenges Challenges Challenges Challenges
Subjects being skeptical of our intention- such trials are relatively new in the area Not comfortable with staff leaving with their blood
samples Some think their blood will be used for ritual purpose
Resistance sometimes from their male clients Brothel owners not being cooperative in some
places Outright refusal to grant us entrance in some
brothels Resistance to the ideal of someone witnessing
after signing the informed consent form
Current infrastructureCurrent infrastructureCurrent infrastructureCurrent infrastructure
DNA sequencer-DNA analyses Real time PCR for Viral load quantification Facs count for CD4/8 measurement ELISA washer and reader Chemistry analyzer Vaccine administration and post-vaccination
surveillance Training and capacity building for health workers,
organizations and the general public Treatment services for HIV an other tropical infectious
diseases Internet and Data entry/analyses Pharmacy Counselling unit
Reception Reception Reception Reception
Data entry and processing Data entry and processing Data entry and processing Data entry and processing
Serology lab Serology lab Serology lab Serology lab
Lab equipment Lab equipment Lab equipment Lab equipment
IT EquipmentIT EquipmentIT EquipmentIT Equipment
IBL Boardroom IBL Boardroom IBL Boardroom IBL Boardroom