innate immunity: signaling via toll-like receptors in reactome
DESCRIPTION
Innate Immunity: Signaling via Toll-Like Receptors in Reactome. Peter D’Eustachio June 11, 2012. Data model in a nutshell. Regulation. Input 1. Output 1. protein ( UniProt ) or m molecule ( ChEBI ) or complex ( GO/PRO ). Reaction. Input 2. Output 2. CatalystActivity - PowerPoint PPT PresentationTRANSCRIPT
Innate Immunity: Signaling via Toll-LikeReceptors in Reactome
Peter D’EustachioJune 11, 2012
Data model in a nutshell
Pathway (GO biol process)
Pathway Reaction Reaction
CatalystActivity(GO mol function)
Output 1
Reaction
Input 1
Input 2 Output 2
Regulation
location(GO cell component)
protein (UniProt) ormmolecule (ChEBI)
orcomplex (GO/PRO)
Data model details: working form of a protein, complex
Web site home page (www.reactome.org)
Divide reaction space into ~160 “canonical pathways”, each represented by
an SBGN-like diagram
Event hierarchy for Toll-like receptor signaling
Early events in TLR4 signaling – details of a complex
TLR4 signaling – functional interactors of CD14
Functional interactors link TLR signaling pathways
OICR / CSHLLincoln SteinMichael CaudyMarc GillespieRobin HawBruce MayMarija Orlic-MilacicKaren RothfelsJoel WeiserGuanming Wu
Credits
NHGRI Grant # U41 HG003751
EBIHenning HermjakobEwan BirneyDavid CroftAntonio Fabregat-MundoPhani GarapatiBijay JassalSteve Jupe
NYUPeter D'EustachioLisa MatthewsVeronica Shamovsky
EU 6th Framework Programme grant LSHG-CT-2005-518254 "ENFIN"
