information in biology. outline what is synthetic biology? biological clocks the “repressilator”...
TRANSCRIPT
Information in Biology
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
What is synthetic biology?
The design and construction of new biological parts, devices, and systems
The “Repressilator”
The re-design of existing, natural biological systems for useful purposes.
The “Diverter”
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
Biological - Clocks Three questions
1. How does it work
2. How does it synchronize
3. How does it translate to activity
Biological - Clocks
Biological - Clocks
Biological - Clocks
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
The “Repressilator”
Repressilator
oscillations are favored by Strong promotersEfficient ribosome-binding sitesTight transcriptional repression Comparable protein and mRNA decay rates
Repressilator
Repressilator
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
Signal Transduction
The Yeast system
Scaffold proteins
Mediating recruitment Improve efficiency of signal
transfer. Facilitate interactions among
different signal pathways Control localization of signal
proteins within a cell.
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
The Pre-Diverter
The Diverter
Diverter results
Diverter results
Summary What is synthetic biology? The design and construction of new biological parts,
devices, and systems
The Repressilator
The re-design of existing, natural biological systems for useful purposes.
The Diverter
Signal transduction
movies
signal transduction http://www.youtube.com/watch?v=tMMr
TRnFdI4
signal transduction http://www.rpi.edu/dept/bcbp/
molbiochem/MBWeb/mb1/part2/signals.htm#animat2