infographic- mapping the interplay of viral and host genomics with hifi sequencing · 2020. 4....
TRANSCRIPT
Vir
al G
eno
mic
s
Hum
an G
eno
mics &
Tran
scriptom
ics
Immune Resp
onse
Vir
us S
eque
ncin
g
Vaccine
Development
Host Genetics
Highly accurate long reads (HiFi reads) enable
every aspect of your viral research
DeletionSNP
Inversion
Insertion Tandem Duplication
Interspersed Duplication
Translocation
Find all the variants that impact susceptibility, immune response,
and disease progression
Chromosome 6
HLA region6p21.1-21.3
Class IClass II
DP DM DQ DR B C E A G F
Explore how allelic variation in HLA genes correlates with susceptibility
or disease progression
Sequence full-length B cell receptor repertoires
Understand how the germline IGH locus impacts
the immune response
Identify conserved regions and mutational hotspots
Immune escape Drug resistance
Rx
Monitor quasispecies dynamics or the emergence of minor variants
under selective pressure
For Research Use Only. Not for use in diagnostic procedures. PN: INF105-042720pacb.com/COVID-19
Mapping the Interplay of Viral and Host Genomicswith HiFi Sequencing
HiFi reads span viral genomes
Understand the spread of a novel virus or strain through
communities
New Virus Discovered
Understand the efficacy of vaccines
Intact genes
Explore links between metagenomes and all aspects of virus infection and
treatment response
HiFi reads provide reference-quality
assemblies
HiFi Reads