inflammation & repair
DESCRIPTION
Inflammation & Repair. Chronic Inflammation. Chronic Inflammation. Cell Types in Chronic Inflammation. Macrophages Types of Macrophages (fixed) Kupffer cells - liver Pulmonary alveolar macrophages Histiocytes - connective tissue Microglia - brain Osteoclasts - bone Spleen/lymph nodes - PowerPoint PPT PresentationTRANSCRIPT
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Inflammation & Repair
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Chronic Inflammation
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Chronic Inflammation
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Cell Types in Chronic Inflammation
• Macrophages• Types of Macrophages (fixed)
– Kupffer cells - liver– Pulmonary alveolar macrophages– Histiocytes - connective tissue– Microglia - brain– Osteoclasts - bone– Spleen/lymph nodes– Langerhans cells - epidermis
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Other Cell Types• Lymphocytes• Plasma cells• Eosinophils
– IgE mediated, parasitic infections• Mast Cells
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Granulomatous Inflammation
• Granulomatous inflammation– focal accumulations of activated macrophages
with an epithelial-like (epithelioid) appearance. • Granuloma
– microscopic aggregation of epitheliod macrophages surrounded by a collar of lymphocytes and occasionally plasma cells.
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Granulomatous Inflammation - TB
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Granulomatous Inflammation - TB
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Granulomatous Inflammation - TB
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Granulomatous Inflammation - TB
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Granulomatous Inflammation - TB
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Healing and Repair
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Cell Types with Different Regenerative Capacities
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Resolution vs Repair
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Granulation Tissue
• Proliferation of new blood vessels and fibroblasts
• Fibroblasts myofibroblasts
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Granulation Tissue
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Granulation Tissue
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Wound Healing
• Primary union (healing by 1st intention) – healing of a clean surgical incision– very little tissue damage is present
• Secondary union (healing by 2nd intention)– healing of a large tissue defect
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Healing by First Intention Healing by Second Intention
24 Hours
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Healing by First Intention Healing by Second Intention
3 to 7 Days
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Healing by First Intention Healing by Second Intention
Weeks
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Aberrations of Wound Healing
• Inadequate granulation tissue/healing• Excessive repair
– Hypertrophic scar– Keloid
• Contractures
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Hypertrophic Scar
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Keloid
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Conditions Inhibiting/Delaying Wound Healing
• Poor local vascular supply– Poor oxygenation, decreased bacterial
resistance, low temperature, and an acid pH• Deficiencies of vitamin C, protein, zinc• Infection• Tissue necrosis
– Foreign material delay healing and acts as a nidus for bacterial infection
• Excessive movement
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Extracellular Matrix- Collagen -
• Tropocollagen is the basic unit• Intracellular
– procollagen• Extracellular
– procollagen cleavage & lysine oxidation cross-linking
– tensile strength
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Wound Healing
• Replacement of Type III collagen by Type I in wound healing will have a maximal tensile strength of 70-80% of normal (takes about 3 months)
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Outcomes of Acute Inflammation
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The End
Chronic Inflammation&
Repair