infectious spondylodiscitis
TRANSCRIPT
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Infectious Spondylodiscitis
Sebastián Bravo Grau(University los Andes - Faculty of Medicine 7th year)
Dr. Felipe AliagaDr. Gillian Lieberman
September 2009Beth Israel Deaconess Medical CenterHarvard Medical SchoolAdvanced Radiology Clerkship
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Agenda
• Patient Presentation
• Normal Anatomy
• General information
• Imaging of Spondylodiscitis
• Plain films
• CT
• MRI
• Bone scan
• Take Home PointsBackground image from: http://www.flickr.com/photos/deepblue66/369213890/
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Our Patient: PMH
• In Santiago, Chile.• Women - 67 years.• PMH:• Cirrhosis. Child-Turcotte-Pugh class B.• Secondary portal hypertension.• Gastroesophageal varices.
• Diabetes Mellitus Type 2• Hypertension. Hypertensive cardiopathy.
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Our Patient: PMH
• Admitted on June 2009 for UGB• Gastric ulcer - Forrest IIC - treated.
• During this period the patient referred:• 1 month history of upper back pain.• New onset band-like radiation of pain to
right side.
• Afebrile, normal WBC count.
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Our Patient: Thorax CT. Fracture of T4 vertebral body with abnormal soft tissue surrounding
Cortical breakthrough,
bilaterally.
Abnormal soft tissue
surrounding the vertebral body.
Image From Hospital Militar de Santiago, Chile.
Thorax CT: axial view without contrast
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Our Patient Presentation
• To further assess intrathecal pathology, MRI was indicated by the medical team.
• In spite of this, the patient and her family, request discharge.
• At this point, the patient was afebrile, neurological exam was normal, as WBC count.
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Our Patient Presentation
• … 6 days later
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Our Patient: HPI• HPI:• History of 48 hours with progressive
paraparesia and sphincter relaxation.• Afebrile.• Lab:• WBC: 27.400• ESR: 86• Blood cultures: Gram-positive cocci
clusters.• St. Aureus
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Our Patient: MRI. Collapse of T4
Collapse of T4 vertebral body. (inside the box)
Image From Hospital Militar de Santiago, Chile.
T2-weighted image in sagittal plane
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Our Patient: MRI. Spondylodiscitis
Increased signal intensity in the T3-T4 disk.
Abnormal signal in epidural space.
Collapse of T4 vertebral body.
Image From Hospital Militar de Santiago, Chile.
Abnormal soft tissue, anterior to the vertebral body.
T2-weighted image in sagittal plane
*
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Our Patient: MRI. Spinal canal stenosis
Image From Hospital Militar de Santiago, Chile.
T2-weighted image in sagittal plane
Posterior convex border.Retropulsion causing severe
spinal canal stenosis and cord compression.
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Decreased signal intensity of bone marrow in T4 and
T5.
Our Patient: MRI. Severe Compression of T4.
Image From Hospital Militar de Santiago, Chile.T1-w sagittal plane
Severe compression of T4.
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T1-w sagittal plane contrast-enhanced
Our Patient MRI: Spondylodiscitis
Image From Hospital Militar de Santiago, Chile.
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Severe compression of T4 with abnormal enhancement
T1-w sagittal plane contrast-enhanced
Our Patient MRI: Spondylodiscitis. Abnormal soft tissue enhancement
Image From Hospital Militar de Santiago, Chile.
Abnormal enhancement within the T5 vertebral
body. (*)Soft tissue
enhancement *
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Our Patient: MRI. Spondylodiscitis with large paraspinal collection
Both Images From Hospital Militar de Santiago, Chile.
Coronal
Axial
MRI. T2-weighted. Axial and Coronal
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Agenda
• Patient Presentation
• Normal Anatomy
• General information
• Imaging of Spondylodiscitis
• Plain films
• CT
• MRI
• Bone scan
• Take Home PointsBackground image from: http://www.flickr.com/photos/deepblue66/369213890/
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Thoracic Spine: Normal Anatomy on MRI
Image from PACS, BIDMC, Boston, MA.
Spinal cord
Sagittal T1-weighted MRI.
Ligamentum flavum
Vertebral body
Intervertebral disc Spinous process
Superior and inferior endplateAnterior cortical margin
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Diagrams of Normal Anatomy
Diagram from: http://www.spineuniverse.com/displayarticle.php/article1394.html
Diagram from: http://www.spineuniverse.com/displayarticle.php/article1267.html
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Infectious Spondylodiscitis: General Information
• Infectious spondylitis accounts for 2%-4% of cases of skeletal infection.
• The most common infecting organism is Sthaphylococcus aureus. (55%-90%)
• Other causes of pyogenic infections of the spine:• Streptococcus, Pneumococcus, Enterococcus, E. Coli, Salmonella,
Pseudomonas aeruginosa and Klebsiella.
• Non-pyogenic (granulomatous) infections originate from:• Mycobacterium tuberculosis, Brucella, fungi and parasites.
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Infectious Spondylodiscitis: General Information
• Note:
• This presentation is mainly related to pyogenic infectious spondylodiscitis.
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Infectious Spondylodiscitis Epidemiology
• Incidence has steadily risen in recent years because of:
• Increases in spine surgery• Increases in nosocomial bacteremia• Aging of population• Intravenous drug addiction
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Infectious Spondylodiscitis: Clinical Manifestations
• Patients with a spinal infection most often present with axial back pain.
• Other constitutional symptoms may be present.
• Neurologic compromise not usually part of the early manifestations.
• Laboratory results are often, but not always, abnormal.• Leukocytosis often present, but not always.• ESR and CRP are usually, but nor always, elevated.
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Pathophysiology of Spinal Bacterial Infection
• Direct inoculation• Penetrating trauma
• Spinal procedures (percutaneous or open)
• Contiguous spread from an adjacent infection• Local spread following intra-abdominal or retro-peritoneal infections.
• Hematogenous
• From distant septic foci. Skin and soft tissue infections, infected vascular access sites, UTI.
Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
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Pathophysiology: Hematogenous Dissemination
• Venous Theory• Batson demonstrated retrograde flow from the pelvic venous
plexus to the perivertebral venous plexus via valveless meningorrhachidian veins.
• Arteriolar Theory• Wiley and Trueta: bacteria can become lodged in the end-
arteriolar network near the vertebral plate.
Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
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Pathophysiology: Contiguous Spread
• Infection established adjacent to the end plate of one vertebral body.
• Can rupture through it into the adjoining disk and infect the next vertebral body.
• The disk material is relatively avascular and is rapidly destroyed by the bacterial enzymes.
• Cervical spine: if infection penetrates the prevertebral fascia, it can extend into the mediastinum.
Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
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Pathophysiology: Contiguous Spread
• Lumbar spine: abscess formation may track along the psoas muscle and into piriformis fossa, perianal region and the groin.
• Extension into the spinal canal, may result in: epidural abscess or even bacterial meningitis.
• Destruction of the vertebral body and intervertebral disk can potentially lead to instability and collapse. (as in our patient)
• Infected bone or granulation tissue may be retropulsed into the spinal canal, causing neural compression or vascular occlusion.
Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
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Classification of Spinal Infections: Duration of Symptoms
Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
Acute Subacute Chronic
<3 weeks 3 weeks - 3 months >3 months
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• Spinal infections can be devastating and can result in significant pain, deformity, and neurologic deterioration (as in our patient).
• The accurate diagnosis and appropriate treatment of spinal infections is important.
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Menu of Tests Used to Diagnose Infectious Spondylodiscitis
• Plain Film
• CT
• Radionuclide Bone Scan
• MRI
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Plain Radiographs
• Should be taken on all patients with or suspected of having a spinal infection.
• Changes appear at least 3 to 4 weeks after onset of the disease.
• Sensitivity: poor in early acute osteomyelitis.
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Plain Radiographs
• Findings:
• Soft tissue swelling around the area of infection.
• Loss of disc height.
• Endplate sclerosis, from reactive bone formation.
• Cortical resorption: osteopenia, scalloping of endplates, subperiosteal defects.
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Companion Patient 1: Lateral C-Spine
• Spinal infection.
• Early radiographic abnormalities.
• Lateral radiograph of the cervical spine.
• Destructive lesion within the anterior subchondral region of C5 and C4.
• Initial narrowing of C4-C5 disc.
Image From: Jevtic V. VERTEBRAL INFECTION. Eur Radiol 2004;14:E43-E52.
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Companion Patient 2: Lateral L- Spine
• Vertebral infection.
• Advanced radiographic changes.
• Lateral radiograph of the lumbar spine.
• Destruction of vertebral bodies with narrowing of the L3-L4 disc space.
Image From: Jevtic V. VERTEBRAL INFECTION. Eur Radiol 2004;14:E43-E52.
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Spiral CT with IV contrast
• Excellent detail of bony anatomy, including any sequestra or involucra.
• Identify the presence of adjacent soft tissue masses or abscesses.
• Disk space narrowing or decreased attenuation in the disk.
• With contrast: abnormal disk space, vertebral marrow or paravertebral soft tissues may enhance.
• Destruction of vertebral body and fragmentation of vertebral endplates.
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Spiral CT with IV contrast
• Inferior to MRI in evaluating disc spaces and the neural elements.
• The size of the infected granulation tissues or abscesses can be monitored but the inflammatory reaction in the bone marrow is not well depicted.
• CT myelograms is not the preferred imaging technique in pyogenic infections.• Potential for intradural spread of the infection.
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Companion Patient 3: Infectious Spondylodiscitis on CT
Images From: http://www.statdx.com Case Contributor: Jud W. Gurney, MD, FACR
CT. Coronal reconstruction
Disc space narrowing with erosion of the adjacent
vertebral body endplates.
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Companion Patient 3: Infectious Spondylodiscitis on CT
Images From: http://www.statdx.com Case Contributor: Jud W. Gurney, MD, FACR
CT. Axial view
Paraspinal widening.
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•Lets remember our patient ...
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Our Patient: Thorax CT. Fracture of T4 vertebral body with abnormal soft tissue surrounding
Cortical breakthrough,
bilaterally.
Abnormal soft tissue
surrounding the vertebral body.
Image From Hospital Militar de Santiago, Chile.
Thorax CT: axial view without contrast
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Radionuclide Bone Scan• Can be much more sensitive than radiographs
in detecting early disease.
• Menu of Bone Scan:
• Three-phase technetium-99m bone scan
• Gallium-67 citrate scan
• Combination of technetium and gallium
• Indium 111-labeled leukocyte scintigraphy
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Radionuclide Bone Scan: Technetium 99m Three-phase Bone
Scintigraphy• Technetium 99m Three-phase Bone
Scintigraphy:
• Flow phase.
• Blood pooling phase.
• Delayed phase.
• Osteomyelitis causes focally increased uptake in all three phases.
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Three-phase technetium-99m bone scan
• Sensitive (90%) but nonspecific (78%) for spinal infections.
• Particularly in older patients with some degree of spondylosis and degenerative disc disease.
• Provide little anatomic detail.
• Can be positive in the setting of osteoporotic fractures and neoplasms.
An H, Seldomridge J. SPINAL INFECTIONS DIAGNOSTIC TESTS AND IMAGING STUDIES. Clinical Orthopaedics and Related Research 2006;444:27-3
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Gallium-67 citrate scan
• Gallium-67 citrate scans have similar sensitivity (89%) and specificity (85%) and accuracy (86%) as technetium scans in evaluating pyogenic spinal infections.
• Combination of these studies (gallium and technetium scans) can be more helpful in making diagnosis.
• Accuracy of 94%.
An H, Seldomridge J. SPINAL INFECTIONS DIAGNOSTIC TESTS AND IMAGING STUDIES. Clinical Orthopaedics and Related Research 2006;444:27-3
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Indium 111-labeled leukocyte scintigraphy
• Specificity is improved.
• Sensitivity is very low (17%).
• May be helpful only in selected patients.
• Should not be used routinely. (because high rate of false-negative results)
An H, Seldomridge J. SPINAL INFECTIONS DIAGNOSTIC TESTS AND IMAGING STUDIES. Clinical Orthopaedics and Related Research 2006;444:27-3
Whalen JL, Brown ML, McLeod R, Fitzgerald RH Jr. LIMITATIONS OF INDIUM LEUKOCYTE IMAGING FOR THE DIAGNOSIS OF SPINE INFECTIONS. Spine 1991;16:193- 7
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Companion Patient 4. Bone Scan: Labeled white cells. Osteomyelitis.• Posterior labeled
leukocyte scintigraphy shows photopenia in known spinal osteomyelitis.
• Labeled leukocyte scan is often falsely negative in spinal osteomyelitis.
Image From: http://www.statdx.com
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Companion Patient 5. Bone Scan: three-phase technetium-99m. Discitis.
• Posterior bone scan shows increased activity in endplates of two adjacent vertebral bodies.
• Characteristic of discitis or discogenic sclerosis.
Image From: http://www.statdx.com
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MRI• Magnetic resonance imaging is a powerful
diagnostic tool that can be used to help evaluate spinal infection and to help distinguish between an infection and other clinical conditions.
• Gold standard for imaging of spinal infections.• Especially useful in the early stages when other
imaging modalities are still normal or nonspecific.
• Sensitivity (96%) and specificity (92%).
Hwan Hong S, Choi JY, Woo Lee J, Kim N, Choi JA, Kang H. MR IMAGING ASSESMENT OF THE SPINE: INFECTION OR AN IMITATION? Radiographics 2009;29:599-612
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MRI• Usual findings:
• Vertebral endplate destruction• Bone marrow and disk signal abnormalities• Paravertebral or epidural abscesses.
• Typical signal pattern of acute spinal infection:• Increase in fluid signal because of marrow
edema• Signal decrease in T1-weighted sequences• Signal increase in T2-weighted sequences.
Hwan Hong S, Choi JY, Woo Lee J, Kim N, Choi JA, Kang H. MR IMAGING ASSESMENT OF THE SPINE: INFECTION OR AN IMITATION? Radiographics 2009;29:599-612
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MRI
• Not always easy:• Classic MRI features are absent• Unusual patterns of infectious
spondylitis• Noninfectious inflammatory diseases and
degenerative disease may simulate spinal infection.
Hwan Hong S, Choi JY, Woo Lee J, Kim N, Choi JA, Kang H. MR IMAGING ASSESMENT OF THE SPINE: INFECTION OR AN IMITATION? Radiographics 2009;29:599-612
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Companion Patient 6. MRI: diskitis/osteomyelitis
Image From: E-Medicine: http://emedicine.medscape.com/article/340211-media
• Destruction of L3-4 disk space with the adjacent endplate and vertebral body.
• L3 and L4 vertebral bodies show increased T2 signal.
• Retropulsion of debris, with secondary compression.
MRI. T2-w of lumbar spine. Sagittal view.
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Severe compression of T4 with abnormal enhancement
T1-w sagittal plane contrast-enhanced
Our Patient MRI: Spondylodiscitis
Image From Hospital Militar de Santiago, Chile.
Abnormal enhancement within the T5 vertebral
bodySoft tissue
enhancement *
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BIDMC PACS. 84 yo man. MRI. T1 seq. Sag. Acute moderate T6 compression fracture.
Some Differential Diagnosis
This is NOT an infectious
spondylodiscitis
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Osteomyelitis vs Tumor
Osteomyelitis Tumor
Contiguity Yes No
Paraspinal soft tissue mass Yes (abscess) Less common
Disk space Isocenter Not involved
Primer of Diagnostic Imaging. Weisldder. Third Edition.
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Take Home Points
• Changes on plain radiographs occur at late disease.
• MRI is the gold standard for imaging of spinal infection.• Soft tissue helps to narrow the differential diagnosis.
• This is a patient where the imaging findings superseed the clinical findings.
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References (1 of 2)
• Pintado-García V. ESPONDILITIS INFECCIOSA. Enferm Infecc Microbiol Clin 2008;26(8):510-7.
• Fica A, Bozán F, Aristegui M, Bustos P. ESPONDILODISCITIS. ANÁLISIS DE UNA SERIE DE 25 CASOS. Rev Med Chile 2003;131:473-82.
• Jevtic V. VERTEBRAL INFECTION. Eur Radiol 2004;14:E43-E52.
• An H, Seldomridge J. SPINAL INFECTIONS DIAGNOSTIC TESTS AND IMAGING STUDIES. Clinical Orthopaedics and Related Research 2006;444:27-33.
• Tay B, Deckey J, Hu S. SPINAL INFECTIONS. J Am Acad Orthop Surg 2002;10:188-97.
• Grados F, Lescure F, Senneville E, Flipo R, Schmit JL, Fardellone P. SUGGESTIONS FOR MANAGING PYOGENIC (NON- TUBERCULOUS) DISCITIS IN ADULTS. Joint Bone Spine 2007;74:133-9.
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References (2 of 2)
• Sharif H. ROLE OF MR IMAGING IN THE MANAGEMENT OF SPINAL INFECTIONS. AJR 1992;158:1333-45.
• Hwan Hong S, Choi JY, Woo Lee J, Kim N, Choi JA, Kang H. MR IMAGING ASSESMENT OF THE SPINE: INFECTION OR AN IMITATION? Radiographics 2009;29:599-612.
• Whalen JL, Brown ML, McLeod R, Fitzgerald RH Jr. LIMITATIONS OF INDIUM LEUKOCYTE IMAGING FOR THE DIAGNOSIS OF SPINE INFECTIONS. Spine 1991;16:193-7.
• Primer of Diagnostic Imaging. Weisldder. Third Edition.• StatDx – http://www.statdx.com
• Emedicine – http://emedicine.medscape.com
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Acknowledgements
• Dr. Rivka Colen
• Dr. Dan Anghelescu
• Nicolás Ahumada
Background image from: http://www.flickr.com/photos/m750/50103339/
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Thank You
Thank You