INFECTIOUS HEPATITIS

RDH KARUNADASA2011 BATCH

INFECTIOUS HEPATITIS

Hepatitis A Was Called Infectious Hepatitis . Infectious hepatitis is an acute infectious

disease of the liver caused by the hepatitis A virus.

HEPATITIS A Hepatitis A is a disease caused by the hepatitis

A virus which results in inflammation of the liver

DEFINITION HEPATITIS

Hepatitis means inflammation of the liver

Hepat (liver) + itis (inflammation)= Hepatitis

Viral hepatitis means there is a specific virus that is causing your liver to inflame (swell or become larger than normal)

ETIOLOGY

Hepatitis A virus (HAV) HAV can not cause cytopathy, replicate within

cytoplasma of hepatocytes and via bill are discharged with feces

Only one antigen-antibody system. Anti-HAV IgM is diagnostic evidence of recent infection, IgG is protective antibody.

Resistance of HAV: 56°C, 30 min, usually temperature 1 week, dry feces at 25°C 30 days, fresh water, sea water ,shellfish or soil for several months. 70% alcohol at 25°C , 3 min, 100°C, 5 min and ultraviolet, 1 min

PATHOLOGY

DegenerationNecrosisRegenerationInfiltration of inflammatory cellsHyperplasia of interstitial cells

WHO GETS HEPATITIS A?

Anyone can get hepatitis A, but it occurs more often in children.

But most adults who develop

HAV

HEPATITIS A CLINICAL FEATURESIncubation period 28 days (range 15-50

days)

Illness not specific for hepatitis A

Likelihood of symptomatic illness directly related to age

Children generally asymptomatic, adults symptomatic

HEPATITIS A EPIDEMIOLOGYReservoir Human. Endemic

Transmission Fecal-oral

Temporal pattern None

Communicability 2 weeks before to1week after onset

incubating period 02-06 weeks

EPIDEMIOLOGIC FACTORS

Fecal oral transmission Poor hygiene High population density Day care centers and minor epidemics

SIGNS AND SYMPTOMSThe first symptoms are usually

Fever, Loss of appetite, Nausea, Vomiting, and Malaise

Dark colored urine Abdominal pain Diarrhea Jaundice (yellowing of the skin and the whites of the eyes).

DIAGNOSIS

History of illness Physical examination AST (SGOT) ALT (SGPT) Igm IgG

TREATMENT

Acute hepatitis Isolation

HA: 3 weeks after onset

Rest DietAnti-virus therapyhepatinice

PREVENTION

Control of source of infection Cut off the route of transmission Protection of susceptible population

Active immunity Passive immunity

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