infectious diseases unit 5 lesson 2 plan
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Infectious Diseases Unit 5 Lesson 2 plan. Do now. What is Innate Immunity?. Do now. What is innate immunity? N on-specific mechanisms of immune defense that do not change. Review of immune structures. Physical Chemical Cellular. Cancer Cell. Neutrophil. - PowerPoint PPT PresentationTRANSCRIPT
Infectious DiseasesUnit 5 Lesson 2 plan
Do now
• What is Innate Immunity?
Do now
• What is innate immunity?
– Non-specific mechanisms of immune defense that do not change.
Review of immune structures
• Physical
• Chemical
• CellularA neutrophil ingesting a cell
Neutrophil
Cancer Cell
Physical
• Skin
• Mucus
• Tears
Chemical
• Defensins
• Complement
• Stomach Acid
CellularInnate cells:
• Macrophages• Dendritic cells• Neutrophils
Adaptive cells:• B cells• T cells
Innate cells Adaptive cells
All immune cells are made in bone marrow
They all come from a parent cell (stem cell)
Innate cells patrol the body using receptors to identify
invaders
MacrophageNeutrophil
Do you think PAMP patterns will be found in host cells?
• Innate immune receptors ‘see’ foreign molecules called PAMPs
• PAMPs may be:• Bacteria or fungal cell
wall parts, like PS• Flagellin (flagellum
protein)• Bacterial DNA• Viral RNA
PAMPs (Pathogen Associated Molecular
Patterns)
Innate cells respond to invaders in two ways
1. Phagocytosis: Eating the invader
2. Chemotaxis: Recruiting help
• http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter2/animation__phagocytosis.html
Eating the invader:Phagocytosis
Eating the invader:Phagocytosis
Recruiting help:Chemotaxis
Innate cells also activate adaptive cells
1. After digesting the pathogen some innate cells stick its parts (antigens) on their cell membrane:• They are called Antigen Presenting Cells (APCs)
2. By presenting the antigens like this they can activate T cells.
Wrap up1. Physical and chemical barriers are part of the innate immune system
on the outside of the body.
2. Innate cells are in the sterile interior.
3. Innate cells have receptors that see pathogen associated patterns (PAMPs) not found in the host (non-self vs. self).
4. After recognizing a PAMP innate cells phagocytose the invader and present its antigens on their surface.
5. Then they secrete chemokines to call for help from more innate cells.
6. Innate receptors cannot adapt to mutating PAMPs, so they may also call for help from the adaptive immune system.