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    Submitted by Group 9

    Group member Roll number

    Bhavna Sharma 2011PGP593

    Debojyoti Burman 2011PGP615Himanshu Agarwal 2011PGP649

    Mudit Kalra 2011PGP732

    Nitin Kumar 2011PGP758

    Saindani Pranit 2011PGP844

    Suchit Singh 2011PGP899

    Indian Biotechnology

    Industry

    Portfolio Analysis

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    TABLE OF CONTENTSBiotechnology Industry in India .................................................................................................................... 3

    Introduction .................................................................................................................................................. 3

    The Indian Advantage ............................................................................................................................... 3

    Firms reviewed: ............................................................................................................................................. 5

    1. Bio-pharma sector................................................................................................................................. 5

    1.2 Serum Institute of India Pvt. Ltd. ....................................................................................................... 5

    2. Bioinformatics Sector: ........................................................................................................................... 5

    2.1 Ocimum Biosolutions .................................................................................................................... 5

    2.2 Strand Life Sciences ...................................................................................................................... 6

    3. Bio-Industry Sector: .............................................................................................................................. 6

    3.1 Novozymes .................................................................................................................................... 63.2 Advanced Enzymes ....................................................................................................................... 7

    4. Bio-Services Sector: ............................................................................................................................... 7

    4.1 TransAsia ....................................................................................................................................... 7

    4.2 Quintiles ........................................................................................................................................ 8

    5. Bio-Agri Sector: ..................................................................................................................................... 8

    5.1 Rasi Seeds ...................................................................................................................................... 8

    5.2 Monsanto India Ltd. ...................................................................................................................... 8

    Plotting the GE/McKinsey Matrix: The Approach ......................................................................................... 8

    Analysis of GE matrix: ................................................................................................................................. 11

    Budget 2012: Implications .......................................................................................................................... 11

    Appendix ..................................................................................................................................................... 12

    List of References ........................................................................................................................................ 15

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    Biotechnology Industry in India

    IntroductionIndia is emerging as a significant player in the global biotech industry. Biotechnology is deemed as a

    revolution throughout the world. Scientists, through Research and Development (R&D) are continuing to

    develop cures for diseases that have affected people since time immemorial. With its large population

    of over a billion people India creates almost a perfect environment for biotech companies to shift bases

    here. In addition, the Indian sub-continent, which occupies only 2.4% of the total surface area on earth,

    has the most diverse species of flora and fauna. Also increasing prosperity raises the demand for

    healthcare services.

    The Indian Advantage

    Promising potential to be a global player in the arena of biotechnology Innovation opportunities: Public funding for product innovation and research in the biotech

    sector and focused R&D activities by private biotech firms.

    The sector has experienced significant growth in government spending since 1985 withconstantly increasing budgetary allocations to the biotech sector

    FDI investment up to 100 per cent is permitted via the automatic route Large pool of skilled and cost competitive manpower Well developed and integrated scientific infrastructure Advanced chemical synthesis technologies Manufacturing practices conforming to US and EU norms Diverse biological resources Globally recognized as a producer of low cost, high quality bulk drugs and formulations.

    In the year 2010-11, this industry

    earned revenues to the tune of US$

    3927.6 million growing 21.5 percent

    over the last years revenue of US$

    3233.2 million. The emphasis

    between exports and domestic sales

    has also witnessed minor shifts

    ranging between two-to-five

    percent. The exports across

    segment made up 51 percent of the

    overall revenue contributing a total

    of US$ 2015.7 million. The ratio

    between exports and domestic sales

    stands at 51:49, which is a sign of a robust industry.

    1

    1.4

    1.82.1

    2.5

    3

    3.6

    0

    0.5

    1

    1.5

    2

    2.5

    3

    3.5

    4

    2005 2006 2007 2008 2009 2010 2011

    CAGR~23.8%

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    The biotechnology sector can be divided into 5 sub-sectors namely:

    Bio-Pharma Sector: It is comprised of 130 companies involved mainly in the production ofvaccines, therapeutic drugs and diagnostics. The Indian bio-pharma sector is export-driven, with

    exports accounting for more than 58% of revenue.

    Bio-Services Sector: A number of global companies are now looking at India to conduct largescale global trials. While low costs and large patient pool still remain the crucial deciding factors

    for attracting these companies, skilled investigators and emphasis on quality are some of the

    rising factors contributing to the segments growth. The bio-services sector contributes a total of

    22% to Indian Biotech sector and it widely consists of clinical research, contract manufacturing,

    contract research and consultancy.

    Bio-Industrial Sector: The modern use and application of biotechnology for the sustainableproduction of industrially useful products like bio chemicals, biomaterials and bio-fuels from

    renewable resources, using living cells and/or their enzymes. This results generally in cleanerprocesses with minimum waste generation and energy use. Enzymes which constitute a major

    segment of this sector, are used in industrial processing of starch, distilleries, alcohol, textile &

    garments, leather processing as well as for supplementing healthcare products.

    Bio-Informatics Sector: Bioinformatics is the field of science in which biology, computer science,and information technology merge to form a single discipline. Bio-informatics deal with the

    creation and maintenance of extensive electronic databases on various biological systems; it is

    the smallest part of the current domestic biotechnology industry.It can play important role in

    critical areas such as data mining, mapping and DNA sequencing. There is also opportunity in

    functional genomics, proteomics and molecule design simulation. Major Products and Services

    include Database Services, Integrated research application software, Biotech software services.

    Bio-Agri Sector: BioAgri is the biotechnology applied to agriculture. It is the use of organisms orparts of organisms to improve the agricultural products and processes. Selection of desired

    characteristics, domestication of plant species, and mechanics of cell biology come under this

    sector. In India, BioAgri is further classified into hybrid seeds, transgenic crops, bio-pesticides

    and bio-fertilizers.

    For further insight into the market breakup of the sub-sectors refer appendix at the end of report.

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    Firms reviewed:

    1. Bio-pharma sector1.1 Panacea Biotech: It is the second

    largest vaccine producer in India.

    Major products offered include

    Vaccines, Diabetes Management

    Products, Anti pyretic, Anti renal

    management drugs. Revenues

    totaling $20 million were recorded in

    FY 2011 with a growth of 32%. The

    firm has been in news for the losses of

    INR72 crores after its vaccine

    pentavalent was delisted by WHO. It

    heavily invests in its R&D facilities and expects to enter branded generics in emerging markets

    like Africa and Eastern Europe. The sales figures for 2008-11 are as shown.

    1.2 Serum Institute of India Pvt. Ltd.

    It is the worlds largest producer of Measles and DTP

    vaccines. Major products offered are various anti-

    viral and anti-bacterial vaccines like NASOVAC,

    Tubervac, Anti-cancer and Hormonal products. It

    amassedrevenues of $216 million in FY11 with agrowth of 16%. Its efforts have been constantly

    lauded by WHO for its efforts in research in this area.

    The adjoining graph displays its sales figures.

    2.

    Bioinformatics Sector:2.1 Ocimum Biosolutions

    It is the leading global genomics firm

    providing information solutions. Important

    products and services include Microarray

    services, Comprehensive genomic reference

    databases, life science lab information

    0

    200

    400

    600

    800

    1000

    1200

    FY08 FY09 FY10 FY11

    Sales (INR)

    Sales (INR)

    0

    10

    20

    30

    40

    50

    FY09 FY08 FY07 FY06

    Sales(INR)

    INR Sales

    65

    41.447.57

    65 60

    0

    20

    40

    60

    80

    2010-11 2009-10 2008-09 2007-08 2006-07

    Revenues of OCIMUM

    BIOSOLN

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    management, other research consumables. In 2011 the company recorded revenues of $13 million.

    It has witnessed low growth. The firm manages worlds largest gene expression databases.

    2.2 Strand Life SciencesThe firm is a pioneer in discovery research

    informatics. Core strengths of the firm includedata mining, predictive modeling, bioinformatics

    and computational chemistry. The revenues of

    $10 million in FY11 and it witnessed a record

    growth of 40% in last five years. Clients include 5

    out of top 10 pharmaceutical companies of the

    world.

    3. Bio-Industry Sector:

    3.1 NovozymesIt is the largest supplier firm of industrial

    enzymes and microorganisms in India

    specializing in enzymes and microbes for

    manufacturing of detergents, food, feed,

    textiles, leathers, oil, alcoholic beverages

    and bio-fuels. Revenues to the tune of

    $230 million were earned in FY2011 due

    to a growth of 16%. The firm recently

    acquired Biocons enzyme business for

    $155 million.

    42

    35 35

    20

    10

    0

    10

    20

    30

    40

    50

    2010-11 2009-10 2008-09 2007-08 2006-07

    Revenues of STRANDLIFE SCIENCES

    0

    100

    200

    300

    2010-112009-102008-092007-082006-07

    NovoZymes SouthAsia

    Revenues

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    3.2 Advanced EnzymesIt is the pioneer in plant, animal and microbial

    based enzymes like human healthcareenzymes, animal healthcare, food processing

    and industrial processing enzymes. The

    company recorded revenues of $154 million in

    FY11 and saw a record growth of 26% in last

    five years. The company caters to worldwide

    markets and has 50% export share just from US

    markets.

    4. Bio-Services Sector:4.1 TransAsia

    The company is recognized as a leading player in the diagnostic world. It provides Diagnostic

    Services and Biochemistry Analyzers for hospitals. Revenues of $20 million were recorded in FY 2011

    with a growth of

    32%. McEvoy

    and Farmerreport on IVD

    industry in India

    (2006) ranks

    Transasia as the

    # 1 Company in

    the Indian

    Diagnostic

    Industry. It has

    the largest Sales

    and Installation

    base with over

    20,000installations all

    over the country.

    0

    50

    100

    150

    200

    2010-112009-102008-092007-082006-07

    Advanced Enzymes

    Revenues

    0

    100

    200

    300

    400

    500

    600

    Transasia Biomed Tulip Quintiles India

    2010-11

    2009-10

    2008-09

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    4.2 QuintilesThe firm is a global pioneer in pharmaceutical services like Biostatistics, Central Laboratory Servies,

    Clinical monitoring, Data management offering a functional service provider. The company revenues

    equaled $99 million in FY11 and it registered a growth of 23%. The only global CRO with its presence

    in India verified by US FDA

    5. Bio-Agri Sector:5.1 Rasi Seeds

    The company is one of the leaders in cotton hybrids and maker of one of the most successful BT

    cotton varieties, cotton hybrids, maize hybrids, pearl millets and vegetables. The company amassed

    revenues of $74 million in FY 2011.

    The firm is known for heavily

    investing in its R&D facilities in the

    recent past. The firm has been innews recently for a Rs.10 crore

    outlay in Attur for R&D in virus

    resistant and transgenic seeds.

    5.2 Monsanto India Ltd.The firm is a pioneer in chemical

    weed control and is a market leader

    in rice herbicides, weed herbicides like Roundup, Maize seed hybrids like Dekalb. The company

    earnedrevenues of $75 million in FY11 and witnessed a record growth of 106% in last FY.Firm has

    made some aggressive acquisitions in past and plans to establish many more breeding stations andlaboratories. Recently in news for opposition to its melon patent which violated patent laws.

    Plotting the GE/McKinsey Matrix: The Approach

    The GE/McKinsey Matrix identifies the optimum business portfolio as one that fits perfectly to the

    company's strengths and helps to exploit the most attractive industry sectors or markets.

    Thus, the objective of the analysis is to position each SBU on the chart depending on the SBU's

    Strength and the Attractiveness of the Industry Sector or Market on which it is focused. Each axis is

    divided into Low, Medium and High, giving the nine-cell matrix. The following methodology has

    been adopted to calculate various parameters.

    0

    200

    400

    600

    800

    2007 2008 2009 2010 2011

    Revenues(in Rs. Crores)

    Revenues(i

    n Rs.

    Crores)

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    Business Strength Methodology followed

    Market Share Ratio of revenue to total market size of the

    sector

    Profit Margins Ratio of Net Profit to Sales

    D/E ratio Ratio of total debt/ Total Shareholder's

    Equity

    Percentage of expenses

    on R&D

    Percentage of expenses that were spent on

    research

    Cost of capital Taken as weighted average cost of capital

    Brand Awareness (1 to

    10)

    Subjectively calculated based on secondary

    research

    Product Quality (1 to 10) Subjectively calculated based on secondary

    research

    Industry Attractiveness Methodology followed

    Market Growth CAGR in last 5 years

    Market Size Total Business done by the sector as a whole

    Profit Margins of top 5 players Average profit margins of the top 5 players

    Competitiveness HHL Index has been used to calculate

    competitiveness of the sector

    Calculated using sum of s^2 for top 3 firms

    where s is share of that firm

    Growth in Exports CAGR of export revenues of the sector in last

    5 years

    Regulatory Regime (1-10) Subjectively calculated based on secondary

    research on support given to the industry

    Ease of entry (1-10) Subjectively calculated based on secondary

    research

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    The following table shows the calculation of the indices used in the plotting of the matrix.

    Sector Company Name Business Strength Industry Attractiveness Size (Revenues)

    Bio Agri Rasi Seeds 1.627204074 78.351 370

    Monsanto India Ltd. 1.8 78.351 369.56

    Bio Pharma Panacea Biotech 1.66938 180.609 967

    Serum 1.9 180.609 1080

    Bio Industry Novozyme 1.68736 19.368 254

    Advanced Enzyme 2.33643 19.368 154

    Bio Services Quintiles 1.1 111.596 476

    Transasia 1.23 111.596 364.5

    Bio Informatics Ocimum Biosoltions 0.877676667 11.505 65

    Strand Life Sciences 1.26969 11.505 42

    The GE matrix was plotted as shown below:

    Rasi Seeds

    Monsanto

    India

    SerumPanacea

    Novozyme AdvancedEnzyme

    Quintiles Transasia

    Ocimum

    Strand Life

    Science

    IndustryAttractiveness

    Business Strength

    Bio Agri

    Bio Pharma

    Bio Industry

    Bio Service

    Bio Informatics

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    Analysis of GE matrix:

    Bio-Pharma:This sector dominates the biotech sector. Industry attractiveness is high andbusiness strength is

    moderate to high. Launch of many similar products is expected in two years. It is expected togrow at 25%.

    Bio-Agri:This segment is one of the fastest growing segments. In last 5 years its market share increased

    from 5% to 14%. It has revolutionized the farming space with the launch of Bt Rice, Bt maize, Bt

    Tomato and Bt Cauliflower. The sector needs more investments in R&D and acceptance of

    products among farmers.

    Bio-Informatics:This is the smallest segment of biotech industry. It barely has 2% of market share in overall

    industry. Most of the companies in this segment are small scale. Many big companies like TCS

    and HCL have forayed in this segment. Indian companies need to establish a good reputation to

    protect client data.

    Bio-Industry:This segment has slowest growth rate of 12%. Most of the Indian companies do not have their

    own R&D division. They are importing the enzyme and selling in India. This sector needs more

    investment in order to strive for high growth

    Bio-services:This segment is growing at a rate of 20% and is expected to continue the same growth rate in

    future. The segment is facing competition from small home grown companies. Mandatory

    registration of all clinical trials in India will lead to a rise in the number of global companies

    outsourcing clinical trials to India.

    Budget 2012: Implications

    Following is an analysis to see the impact of the latest budget on the biotechnology sector. Considering

    the significance of this constantly growing sector on the Indian economy it is only sensible to analyze the

    effect of the policy changes.

    Expectations of the Industry:

    Reduction of Excise duty from the present level of 10% to 4% Reduction of services tax by 5% from existing 10.30% Non inclusion of agrochemicals in the list of Free Trade Agreements (FTAs) Permit tax free import of R&D equipments to the tune of 25% of export earnings

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    States should be prevailed upon not to levy VAT on agrochemicalsBudget Outcome:

    Basic customs duty is being reduced from 10% to 5% on probiotics (cost-effective means ofcombating bacterial infections)

    This year it has been decided to make common infrastructure in agriculture markets, soil testinglaboratories and capital investment in fertilizer sector eligible for Viability Gap Funding under

    the Scheme to support PPP in infrastructure

    Increase in the allocation for the initiative of Bringing Green Revolution to Eastern India (BGREI)scheme from 400 crore in 2011-12 to 1000 crore in 2012-13

    Agriculture Credit: The target for agricultural credit in 2012-13 has been raised to 5,75,000 crorewhich represents an increase of 1,00,000 crore over the target for the current year

    Sum of 200 crore for incentivizing research with rewards, both for institutions and the researchteam responsible for such scientific breakthroughs

    Appendix

    The appendix has been included to offer additional insight into the sector breakup into the 5 subsectors.

    Bio-Pharmaceutical sector

    accounted for the largest

    chunk with 61.7% share. Bio-

    Services and Bio-Agri

    followed with a share of 18.8

    and 14.4% shares

    respectivelyBio-Informatics has the least

    share but its one of the most

    rapidly rising sectors owing

    to Indian IT expertiseFigure 1: Market break-up by revenues 2010-11

    61.70%

    18.80%

    14.40%

    3.60%1.50%

    Bio-Pharma

    Bio-Services

    Bio-Agri

    Bio-IndustrialBio-Informatics

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    Bio-Pharma contributes most

    to exports followed by bio-

    services. Outsourcing has

    opened up further avenues ofgrowth for biotech. India is a

    good base outsourcing because

    of its cost effectiveness.

    Expertise in bioinformatics can

    play a significant role in critical

    areas like data mining and

    mapping

    Figure 2: Export share among sub-sectors 2010-11

    Figure 3: Exports of biotechnology products in $ billion

    Revenues from biotech exports valued at $1.8 billion in FY2011, constituting 52% of biotechindustrys revenue. As shown we can see an annual growth of 18.7% over 2007-2010 in export

    driven revenues.

    0

    0.5

    1

    1.5

    2

    2.5

    3

    3.5

    4

    2008 2009 2010 2011

    CAGR~18.7%

    62.50%

    33.70%

    0.80%1.70% 1.20%

    Bio-PharmaBio-Services

    Bio-Agri

    Bio-Industrial

    Bio-Informatics

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    Figure 4: Domestic business growth of biotech industry, FY11

    In domestic sector, India offers a suitable population for clinical trials because of its diverse gene

    pool, which covers a large number of diseases. Owing to a huge agricultural economy, India has a

    huge opportunity in the agri-seeds and agri-chemicals. Lifestyle diseases are set to account for a

    greater part of health care market. Rising per capita income and middle class population is yet

    another contributor to growth.

    Figure 5: Export business growth of biotech industry, FY11

    25.80%

    96.80%

    28.10%

    8.10%

    -6.80%-20.00%

    0.00%

    20.00%

    40.00%

    60.00%

    80.00%

    100.00%

    120.00%

    Bio-Pharma Bio-Services Bio-Agri Bio-Industrial Bio-Informatics

    21.10%

    16.10%19.10%

    28.10%

    43.40%

    0.00%

    10.00%

    20.00%

    30.00%

    40.00%

    50.00%

    Bio-Pharma Bio-Services Bio-Agri Bio-Industrial Bio-Informatics

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    List of References

    http://biospectrumindia.ciol.com/content/BioServices/11106141.asp

    http://biospectrumindia.ciol.com/content/CoverStory/71106091.asp

    http://biospectrumindia.ciol.com/cgi-bin/printer.asp?id=127792

    http://www.indiainbusiness.nic.in/industry-infrastructure/industrial-sectors/Biotechnology1.htm

    http://www.ableindia.in/pdf/eighth_biospectrum_June_10.pdf

    http://www.ibef.org/

    http://biospectrumindia.ciol.com/

    http://www.rasiseeds.com/profile.html

    http://www.monsantoindia.com/

    http://tutor2u.net/business/strategy/ge_matrix.htm

    http://www.business-tools-

    templates.com/U_GuidesPDF/General%20Electric%20GE%20McKinsey%20Matrix%20User%20Guide.pdf

    http://articles.timesofindia.indiatimes.com/2012-03-17/union-budget/31204496_1_weighted-

    deduction-excise-duty-small-biotech-firms

    http://economictimes.indiatimes.com/news/news-by-industry/healthcare/biotech/biotech/budget-

    2012-pranab-mukherjee-fails-to-address-the-wish-list-of-biotechnology-

    sector/articleshow/12303122.cms

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