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1405
IN APPRECIATION
This month the Editor in Chief and Assistant Editor end their terms with The Journal ofPharmacology & Experimental Therapeutics. We wish to express our sincere appreciation toall the Editors for Specific Fields and members of the Editorial Advisory Board who havecontributed so much of their time and expertise to maintaining the excellence of The Journalas a place in which our colleagues from all over the world can share their findings. Further wewish to acknowledge with gratitude the colleagues who contributed special expertise as GuestEditors for Specific Fields in 1991.
Martin W. AdlerEdson X. AlbuquerqueThomas F. BurksPeter CervoniMarlene L. CohenRichard A. CohenCharles R. CraigHarold FemnbergRay W. FullerGary L. HendersonRobert M. JoyBenedict R. Lucchesi
Michael I. LusterJohn McGiffArthur RainesLewis S. SeidenTheodore A. SlotkinLarry SteinRobert I. TaberA.E. TakemoriR. Clinton WebbThomas C. WestfallGrant R. WilkinsonPaul H. Wooley
Additionally, sincere thanks are due to our colleagues not on the Editorial Advisory Board whoreviewed articles for The Journal in 1 991 . Their contributions are acknowledged individually inthe Annual Report of The Journal to The Board of Publications Trustees and The AmericanSociety for Pharmacology and Experimental Therapeutics.
It has been an honor and a privilege to edit The Journal of Pharmacology & ExperimentalTherapeutics.
Eva King Killam, Ph.D., EditorMannfred A. Hollinger, Ph.D., Assistant Editor
INDEX
Volume 259, October-December, 1991
A23187, release ofplatelet-activating factor,prostaglandin production, kidney
(rats), 590Abad, F., see Lopez, M. G., 279
Abraham, S. T., see Rice, P. J., 1182Abrahams, T. P., Hornby, P. J., Walton, D.
P., DaSilva, A. M. T. and Gillis, R.
A. Excitatory amino acid(s) in theventrolateral medulla is (are) re-
quired for breathing to occur in theanesthetized cat, 1388
Acetate, central nervous system effects(rats, mice), 403
Aceto, E. and Vassalle, M. On the mecha-nism of the positive inotropy of lowconcentrations of strophanthidin,182
Acetylcholinedifferential inhibition of neuropeptide Y,
chronotropic and inotropic re-sponses, atrium (dogs), 38
effects of guanidino compounds, NG�mon�omethyl L-arginine (rats), 490
-induced contraction in trachea, chemicaloxidant, cholinesterase inhibition
(rats), 371
N#{176}-monomethyl-L-arginine-inducedpressor response, developmental and
established stages, spontaneously hy-
pertensive rats, 52striatal release, dopaminergic regulation,
Dl and NMDA receptors (rats), 1064
N-Acetyl-L--y-glutamyl, renal selective pro-
drugs (rats), 766
N-Acetylprocainamide, rate-dependent ef-fects of lidocaine, His-Purkinje con-duction, neonatal heart (dogs), 535
N-Acetyltransferase, isozymes in tumor tar-
get organ cytosols, polymorphic andmonomorphic expression (hamsters),
699a-i Acid glycoprotein, oxidation products of
norepinephrine, binding, plasma pro-thins, 551
Action potential, electrophysiology, sodium
channel blockers, left atrium (guineapigs), 884
Adderholt, J. G., see Farley, J. M., 241Adenosine
A2 agonists, cardiovascular effects, li-gands (rats), 1203
A1- and A2-selective agonists and antago-nists, behavioral effects (mice), 286
adenosine 3 ‘ ,5’ -cyclic monophosphateand, intracerebroventricular mor-phine release, spinal cord (rats), 1013
Adenosine triphosphate
-evoked ATP release system, smoothmuscles (guinea pigs), 513
reduction of infarct size by aprikalim, ab-sence of hemodynamic changes
(dogs), 961
Adenylate cyclase
flerobuterol interactions, beta adrenocep-tors, brain (rats), 414
1406
inhibition, attenuation, adenosine recep-tsr-mediated relaxation in coronary
artery (pigs), 508modulation of responsiveness, meth-
ylxanthine treatment, smooth musclecells, 925
monoaminergic receptors, hypothalamic
nuclei, feeding behavior (rats), 124muscarinic stimulation, olfactory bulb
(rats), 673, 680Adipose tissue, beta adrenoceptors, cat-
echolamine tachyphylaxia (humans),317
Adrenal gland, catecholamine release, mem-brane-mediated effects, steroid 17-a-
estradiol (cats), 279Adrenoceptors
a’phaantagonism of norepinephrine by don-
idine, mesenteric vascular bed (rats),653
imidazoline desensitization, epineph-
rine responses in vas deferens (rats),1182
water diuretic effects, AGN 190851
(rats, dogs, monkeys), 1277alpha.1
activation by dexmedetomidine (rats),1147
cardiac outward current reduction(rats), 783
renal medullary collecting duct cells
(rabbits), 1081a�pha-2
behavioral and neurochemical effects,
medetomidine (rats), 848functional subclassification, SK&F
104856 (dogs, rabbits, humans,guinea pigs), 643
subtype identification, SK&F 104078and SK&F 104856 (guinea pigs), 1124
a4,ha-2C, opossum kidney, OK cell line,323
betadesensitization to bronchodilators,
platelet-activating factor (guineapigs), 1
flerobuterol interactions, brain (rats),414
beta-2, intracoronary procaterol, myocar-
dial ischemia (dogs), 732beta-i and beta-2
catecholamine tachyphylaxia, adipose
tissue (humans), 317smooth muscle relaxation, bovine mes-
enteric lymphatics, 365Adrenocorticotropin hormone, cocaine-in-
duced elevation, corticosterone, se-rotonergic neurons (rats), 495
AF-DX 384, binding to cloned and nativemuscarinic receptors (rats), 601
Aging, changes in vascular sympathetic neu-
rotransmission, kidney (rats), 176AGN 190851, water diuretic effect, alpha
adrenoceptor agonist (rats, dogs,monkeys), 1277
Agrawal, D. K., Bergren, D. R., Byorth, P.J. and Townley, R. G. Platelet-acti-vating factor induces nonspecific de-sensitization to bronchodilators inguinea pigs, 1
Aharony, D., Catanese, C. A. and Wood-house, D. P. Binding of the novelligand [4,5-3H-Leut0]substance P tohigh-affinity NK-i receptors onguinea pig lung membranes: Modu-lation by GTP analogs and sulfhydrylmodifying agents, 146
Ahmed, N. K., see Linnik, M. D., 501Aikawa, T., see Ohrui, T., 371
Albumin, oxidation products of norepineph-rine, binding, plasma proteins, 551
Albuquerque, E. X., see Swanson, K. L., 377
Albuquerque, E. X., see Wonnacott, S., 387Alcohols, modulation of GABA receptor-
channel complex (rats), 235Alpert, N. M., see Fischman, A. J., 1351Amar, C., see Pons, C., 1328Amino acid
excitatory
receptor agonist, contralateral turning(rats), 1366
ventrolateral medulla, requirements forbreathing (cats), 1388
p-Aminobenzoic acid, monomorphic ary-
lamine N-acetyltransferase expres-sion, human leukocytes, 1241
‘y-Aminobutyric acid
-mediated inhibition, potentiation byethanol, inferior colliculus (rats),1288
morphine-tolerant longitudinal muscle,myenteric plexus preparation (guineapigs), 1094
sensitivity of cerebellar Purkinje neurons,neurotransmitters, genetically epi-
leptic rats, 10085-Aminocarbonyl-10,ii-dihydro-5H-&-
benz[a,djcyclohepten-5,10- imine,anticonvulsant activity (mice, rats),30
p-Aminohippurate, reduction in transportand passive membrane permeability,dehydroabietic acid, renal mem-
branes (rats), 156D,L-a-Amino-3-hydroxy-5-methyl-4-isoxa-
zole propionate, receptors on synap-tosomes from striatum, presynaptic
facilitation, dopamine release (rats),
692Aminopeptidase, metabolism and poor
membrane permeation, intestinal ab-sorption, leucine enkephalin (rats),
139
Aminopeptidase P, pulmonary endothelial,
species variation (cattle, humans,rats, rabbits, cats, minipigs), 1301
Amitriptyline, imipramine as a discrimina-
tive stimulus (pigeons), 1088
1991 Index 1407
Amphetamine, sensitization to psychostim-
ulants and stress, pertussis toxin in-
jection, AlO dopamine region (rats),916
Amyl nitrite, vascular nitric oxide-generat-
ing activities, organic nitrites, or-
ganic nitrates, 519
Analgesia
antinociceptive action, opiates and opioidpeptides, area tempestas (rats), 1308
distribution of [3H][D-Pen2,D-Pen5]en-
kephalin (mice), 1109increased potency of mu agonists, contin-
uous naloxone infusion (rats), 582
lack of spinal antianalgesic activity, dy-norphins (mice), 1073
opioid receptor activity, GI 870MB
(guinea pigs, rats, mice), 712Anatoxin analogs, nicotinic pharmacology,
377, 387
Anesthesia, opioid receptor activity, GI870MB (guinea pigs, rats, mice), 712
Anesthetics, electrophysiological actions of
BRB-I-28, myocardial tissues (dogs),558
Angiotensin, chronic insulin treatment,
sympathetic activation (rats), 131
Angiotensin-converting enzyme, inhibitor,
inhibition of thromboxane synthe-
tase, antihypertensive action (rats),
219
Angiotensin IIpharmacology of DuP 532 (rats), 861
receptor antagonists PD123177 and DUP
753, inhibitory potency, proximal
nephron and renal transport (rats),687
release of platelet-activating factor, pros-taglandin production, kidney (rats),
590
Antiandrogen, pharmacokinetics and me-tabolism, nilutamide (rats), 1247
Antiarrhythmic drugs
arrhythmogenic activities, atrioventricu-
lar block (dogs), 871
electrophysiological actions of BRB-I-28,
myocardial tissues (dogs), 558rate-dependent effects of lidocaine, His-
Purkinje conduction, neonatal heart(dogs), 535
Anticoagulants, properties of synthetic po-lyanions (humans), 8
Anticonvulsants, 5-aminocarbonyl-10,11-
dihydro-5H-dibenz[a,d]cyclohepten-
5,10 -imine, comparison with dizocil-
pine and carbamazepine (mice, rats),30
Antidepressants, imipramine as a discrimi-
native stimulus (pigeons), 1088Antihypertensive agents, induction of pos-
tural hypotension, central and pe-
ripheral components (rats), 1221
Anti-inflammatory activity, pergolide
(rats), 169
Anti-ischemic agents, TA3090, block of neu-ronal Ca�� influx (rats), 430
Antinociceptionaction of opiates and opioid peptides, uni-
lateral microinjection, area tempes-tas (rats), 1308
distribution and analgesia, [3H][D-Pen2,
D-Pen5]enkephalin (mice), 1109inhibition of tail-flick response, epsilon
and kappa opioid receptors, brema-
zocine (mice), 330
lack of spinal antianalgesic activity, dy-
norphins (mice), 1073
selective antagonism by naltrindole,
cyclic[D-penicillamine2-D-
penicillamine5j enkephalin (rats),725
Antiplatelet agents, plasminogen activatorsand, rapid dissociation, platelet-rich
fibrin clots (humans), 1371
Antiulcer activity, pharmacological profile
ofUP 5145-52 (rats), 190Anxiolytics, behavioral effects of U-78875
(rats), 248
Aortadesensitized, reduced G protein function
(rats), 255
responses to nitric oxide and superoxide,
ultraviolet irradiation of solutions
(rabbits), 1140
Apamin, potassium channel blockers and
cromakalim, mechanical activity, de-trusor smooth muscle (guinea pigs),
1158
Aposhian, H. V., see Maiorino, R. M., 808Aprikalim
reduction of experimental infarct size, ab-
sence of hemodynamic changes
(dogs), 961
vasorelaxation, nicorandil, potassium
channel opening (rats), 526
Arachidonic acid, bradykinin and, neuro-peptide release, capsaicin-sensitive
sensorynerve fibers of heart (guinea
pigs), 759
Arakawa, 0., see Nakahiro, M., 235
Area tempestas, antinociceptive action, opi-ates and opioid peptides (rats), 1308
Argov, Z., Nioka, S., Eleff, S. and Chance,B. Effects of intra-arterial epineph-rine on energy metabolism in exercis-ing rabbit gastrocnemius muscle,
studied by in vivo phosphorus nuclear
magnetic resonance, 458
Armario, A., see Hidalgo, J., 274Arner, P., Kriegholm, E. and Engfeldt, P.
In vivo interactions between Beta-i
and Beta-2 adrenoceptors regulate
catecholamine tachyphylaxia in hu-
man adipose tissue, 317
Aronstam, R. S., see Swanson, K. L., 377
Arrhythmia
stereoselective disposition and metabo-
lism, disopyramide, pediatric pa-
tients, 953
ventricular, intravenous magnesium,
acute myocardial infarction (dogs),939
Artaud, F., see Desce, J. M., 692Artery
contractile responses, sigma receptor li-
gands (rats), 22
coronaryinhibition of adenylate cyclase, adeno-
sine receptor-mediated relaxation
(pigs), 508
nicorandil, vasorelaxation (rats), 526serotonin-induced endothelium-de-
pendent relaxation (bovine), 1316staurosporine, specific inhibitor of pro-
tein kinase C (pig), 10i9
vascular nitric oxide-generating activi-ties, 519
femoral and coronary, vascular actions,
TA 3090 (dogs), 639
superior mesenteric, glucagon pharmaco-
dynamics (cats), 118Arylamine, carcinogen N-acetyltransferase
isozymes, tumor target organ cytosols(hamsters), 699
Arylamine N-acetyltransferase, mono-
morphic, human leukocytes, 1241
Asayama, J., see Shirayama, T., 884Ascorbate, inhibition of binding to PN200-
110 to membranes, lipid peroxidation
(rats), 337Ashford, M. L. J., see Zini, S., 566Ashton, P., Wang, W. and Lee, V. H. L.
Location of penetration and meta-
bollic barriers to levobunolol in the
corneal epithelium of the pigmentedrabbit, 719
Aspirin
inhibition by salicylic acid, oxidation,long chain fatty acids (mice), 894
presystemic acetylation of platelets (hu-mans), 1043
Asthma, nonspecific desensitization to
bronchodilators, platelet-activating
factor (guinea pigs), 1Atrium
differential inhibition of neuropeptide Y,chronotropic and inotropic responses(dogs), 38
functional subclassification, alpha-2 ache-
noceptors (dogs, rabbits, humans,
guinea pigs), 643left, electrophysiology, sodium channel
blockers (guinea pigs), 884Auchampach, J. A., Maruyama, M., Cavero,
I. and Gross, G. J. The new K� chan-nel opener aprikalim (RP 52891) re-duces experimental infarct size indogs in the absence of hemodynamic
changes, 961Aungst, B. J., Blake, J. A. and Hussain, M.
A. An in vitro evaluation of metabo-lism and poor membrane permeation
impeding intestinal absorption ofleucine enkephalin, and methods toincrease absorption, 139
Autoantibodies, human hepatitis anti-liver
kidney microsomes, liver sections(rats), 1328
Autonomic nervous system, differential in-hibition of neuropeptide Y, chrono-tropic and inotropic responses,atrium (dogs), 38
Autoradiography, pharmacological charac-
terization, serotonin-O-carboxyme-
thyl-glyceryl-tyrosinamide (rats,
guinea pigs), 1360Azidothymidine, nonprimate animal model,
zidovudine pharmacokinetics in hu-mans, 1261
Baclofen, cerebrocortex nerve terminals,
GABAB receptors, inhibition of so-matostatin release (rats), 1153
Baines, A. D., see Cardoso, P. F. G., 1271Baker, J. C., see Blaxall, H. S., 323Bakkum, E. A., see Rittenhouse, P. A., 58Balboa, A., see Mays, D. C., 1261Banks, W. A., Ortiz, L., Plotkin, S. R. and
Kastin, A. J. Human interleukin (IL)la, murine IL-la and murine IL-lfi
are transported from blood to brainin the mouse by a shared saturable
mechanism, 988
Barclay, B. W., see Webb, R. L., 1203Barden, A., see Nies, A. S., 590
1408 Index
Barg, J., see Belcheva, M. M., 302Baron, B. M., see Reynolds, I. J., 626
Barrett, J. E., see Zhang, L., 1088
Bascom, H., Kagey-Sobotka, A. and Proud,D. Effect of intranasal capsaicin onsymptoms and mediator release, 1323
Battaglia, G., see Levy, A. D., 495
Bauer, M. R., see Mays, D. C., 1261
Bauer, R. F., see Perkins, W. E., 1004
Bay K 8644, new site for activation, cardiaccalcium channels, FPL 64176 (rats),
982
B#{233}dard, P. J., see Gomez-Mancilla, B., 409Behavior
A1- and A2-selective adenosine agonistsand antagonists (mice), 286
effects of U-78875 (rats), 248
FCE 23884, substrate-dependent interac-tion, dopaminergic system (mice,
rats, dogs, marmosets, monkeys),
345, 356feeding, monoaminergic receptors, hypo-
thalamic nuclei (rats), 124metabotropic excitatory amino acid re-
ceptor agonist, intrastriatal injection,contralateral turning (rats), 1366
reinforcing and subjective effects of mor-phine, post-addicts, 1165
B#{233}langer,P. M., see Turgeon, J., 789
Belcheva, M. M., Barg, J., McHale, R. J.,Gao, X.-M., Chuang, D.-M. and Cos-cia, C. J. Up-regulation of Deltaopioid receptors in neuroblastoma
hybrid cells: Evidence for differences
in the mechanisms of action of so-
dium butyrate and naltrexone, 302Ben-An, Y., see Zini, S., 566
Bendele, A. M., Spaethe, S. M., Benslay, D.N. and Bryant, H. U. Anti-inflam-
matory activity of pergolide, a dopa-
mine receptor agonist, 169
Benishin, C. G., see Sun, Y.-D., 947
Bennett, L. E., see Leedham, J. A., 295Bennett, L. E., see Taylor, D. A., 1084Benslay, D. N., see Bendele, A. M., 169
Benuck, M., see Reith, M. E. A., 1188Benzamide, -induced gastroprokinesis, se-
rotonergic mechanisms (rats), 501Benzodiazepines
behavioral effects of U-78875 (rats), 248
peripheral-type, inhibitory action on do-
pamine release, PC12 pheochromo-cytoma cells, 484
Benzothiazepines, vascular actions of TA3090 (dogs), 639
Bergren, D. R., see Agrawal, D. K., 1
Berlin, K. D., see Patterson, E., 558
Bernat, A., see Herbert, J. M., 44Berson, A., see Deschamps, D., 894Beta blockers, inhibition of thromboxane
synthetase, antihypertensive action,
angiotensin-converting enzyme
(rats), 219
Bezold-Jarisch reflex, serotonin receptorblocking activities, YMO6O (rats), 815
Bile, renal selective N-acetyl-L-’y-glutamylprodrugs (rats), 766
Bilotta, J. M., see James, M. K., 712Bis-aldonic acid amides, antithrombotic and
anticoagulant properties, syntheticpolyanions (humans), 8
l,10-Bis(guanidino)decane, inhibition of N-methyl-D-aspartate responses (rats),
626
Blackburn, T. P., see Hieble, J. P., 643
Bladderarylamine carcinogen N-acetyltransferase
isozymes, tumor target organ cytosols
(hamsters), 699detrusor smooth muscle, mechanical ac-
tivity, potassium channel blockersand cromakalim (guinea pigs), 1158
Blake, J. A., see Aungst, B. J., 139Blaxall, H. S., Murphy, T. J., Baker, J. C.,
Ray, C. and Bylund, D. B. Character-ization of the Alpha-2C adrenergic
receptor subtype in the opossum kid-ney and in the OK cell line, 323
Bleakman, D., Chard, P. 5., Foucart, S. andMiller, R. J. Block of neuronal Ca�influx by the anti-ischemic agentTA3090, 430
Blood-brain barrierdistribution and analgesia, [3H][D-Pen2,
D-Pen5]enkephalin (mice), 1109facilitated transport ofcefodizime, central
nervous system (rats), 620
selective transport of anti-transferrin re-
ceptor antibody (mice, rats, humans,cattle), 66
transport, human interleukin la, murineinterleukin la and lfl, 988
Blood pressurecardiovascular effects of adenosine A2 ag-
onists, ligands (rats), 1203
chronic insulin treatment, sympatheticactivation (rats), 131
increased renin secretion and, DO!, 5-
HT2 receptors (rats), 58
pharmacology of DuP 532 (rats), 861
renal effects and elimination, sulotroban(dogs), 1231
BMY 14802, sigma ligands, contractile re-
sponses (rats), 22
Bonanno, G., Gemignani, A., Fedele, E.,Fontana, G. and Raiteri, M. r-Ami-nobutyric acidB receptors mediate in-hibition of somatostatin release fromcerebrocortex nerve terminals, 1153
Boomsma, F., Man In’T Veld, A. J. andSchalekamp, M. A. D. H. Not nor-epinephrine but its oxidation prod-
ucts bind specifically to plasma pro-teins, 551
Borg, C., Mondot, S., Mestre, M. and Cay-ero, I. Nicorandil: Differential con-tribution of K� channel opeining andguanylate cyclase stimulation to itsvasorelaxant effects on various en-dothelin-1-contracted arterial prepa-
rations. Comparison to aprikalim(RP 52891) and nitroglycerin, 526
Borgeat, P., see De Brum-Fernandes, A. J.,1035
Borges, R., see Lopez, M. G., 279Boulenguez, P., Chauveau, J., Segu, L., Mo-
rel, A., Delaage, M. and Lanoir, J.
Pharmacological characterization of
serotonin-O-carboxymethyl-glycyl-tyrosinamide, a new selective indolicligand for 5-hydroxytryptamine (5-HT)1B and 5-HT1D binding sites, 1360
Brackeen, M. F., see James, M. K., 712Bradycardia
arrhythmogenic activities, antiar-
rhythmic drugs, atrioventricular
block (dogs), 871
-inducing agent, ionic currents, E4080(rabbits), 1396
Vol. 259
serotonin receptor blocking activities,YMO6O (rats), 815
Bradykinin
analogs and, lower esophageal sphincter(opossums), 265
arachidonic acid and, neuropeptide re-lease, capsaicin-sensitive sensorynerve fibers of heart (guinea pigs),759
hypotensive effects of lys-des-ar�-brady-kinin, metabolically protected ago-nists, B1 receptors for kinins (rab-bits), 997
mediation of pertussis toxin-insensitive
biphasic response, circular muscle,ileum (guinea pigs), 659
release of platelet-activating factor, pros-taglandin production, kidney (rats),590
Brainbinding of AF-DX 384, cloned and native
muscarinic receptors (rats), 601
cerebral cortical synaptosomes, tetra-phenylphosphonium accumulation,nicotine-induced changes in mem-
brane potential (rats), 1118
discrete regions, benzodiazepine recep-tors, cocaine (rats), 574
flerobuterol interactions, beta adrenocep-
tors (rats), 414
heterogeneity of NMDA receptor iono-phore complex (rats), 86
5-HT1�2 agonists, thoracic spinal cord(rats), 1335
inferior colliculus, GABA-mediated inhi-bition, potentiation by ethanol (rats),1288
inhibition of binding of PN200-i10 tomembranes, ascorbate, lipid peroxi-dation (rats), 337
membranes, specific binding sites, leuko-triene B4 (guinea pigs), 1035
pharmacological characterization, mm-
tonin-O-carboxymethyl-glyceryl-ty-rosinamide (rats, guinea pigs), 1360
Brater, D. C., see Rudy, A. C., 1133BRB-I-28, electrophysiological actions,
myocardial tissues (dogs), 558Breathing, requirements, excitatory amino
acids, ventrolateral medulla (cats),1388
Breese, G. R., see Simson, P. E., 1288
Bremazocine, inhibition of tail-flick re-sponse, epsilon and kappa opioid re-ceptors (mice), 330
Brodkin, J., see Nash, J. F., 820
Bronchoconstriction
C5a-induced, inhibition by H1 antagonist(guinea pigs), 1213
pharmacologic actions of Ro 24-5913 (hu-
mans, guinea pigs), 751pharmacology of Ro 24-4736 (guinea pigs,
dogs, humans), 78Bronchodilators, induction of nonspecific
desensitization, platelet-activatingfactor (guinea pigs), 1
Bronchus, capsaicin-sensitive and cholin-ergic nerves, functional interactions(guinea pigs), 104
Brooks, D. P., Edwards, R. M., Depalma, P.D., Fredrickson, T. A., Hieble, J. P.and Gellai, M. The water diureticeffect of the Alpha adrenoceptor ag-onist, AGN 190851, is species-de-pendent, 1277
1991 Index 1409
Broomfield, C. A., Maxwell, D. M., Solana,R. P., Castro, C. A., Finger, A. V. and
Lenz, D. E. Protection by butyryl-cholinesterase against organophos-
phorus poisoning in nonhuman pri-
mates, 633
Brush border membrane, mechanism ofvancomycin transport in kidney (rab-bits), 1283
Bryant, H. U., see Bendele, A. M., 169
Bucher, K. D., see Hem, D. W., 699Buciak, J. L., see Pardridge, W. M., 66
Bu#{241}ag,R. D., Krizsan-Agbas, D. and Itoh,H. Sympathetic activation by chronicinsulin treatment in conscious rats,
131
Buonamici, M., Mantegani, S., Cervini, M.
A., Maj, R., Rossi, A. C., Caccia, C.,Carfagna, N, Carminati, P. and Far-iello, R. G. FCE 23884, Substrate-
dependent interaction with the do-paminergic system. I. Preclinical be-havioral studies, 345
Buonamici, M., see Carfagna, N., 356
Burghardt, C., see Crowley, H. J., 78
Burks, T. F., see Weber, S. J., 1109Burton, E. G., see Perkins, W. E., 1004
Bush, L., see Hanson, G. R., 1197
Butler, B. T., see Linnik, M. D., 501
Butyrylcholinesterase, protection against
organophosphorus poisoning, non-
human primates, 633Bylund, D. B., see Blaxall, H. S., 323
Byorth, P. J., see Agrawal, D. K., 1
Cabrera, T. M., see Levy, A. D., 495
Caccia, C., see Buonamici, M., 345
Caccia, C., see Carfagna, N., 356
Caffeine, mechanism of positive inotropy,low concentrations, strophanthidin
(sheep), 182Calcitonin gene-related peptide, longitudi-
nal muscle and myenteric plexus,
ileum (guinea pigs), 947
Calciumcisapride action on muscarinic receptors,
contraction, gastric myocytes (guineapigs), 1294
currents and peptide release, neurohypo-physial terminals, inhibition byethanol (rats), 705
inhibition of NMDA responses, 1,10-
bis(guanidino)decane (rats), 626mechanism of positive inotropy, low con-
centrations, strophanthidin (sheep),
182
neuronal influx, block by TA3090 (rats),430
pertussis toxin-insensitive biphasic re-
sponse, bradykinin, circular muscleof ileum (guinea pigs), 659
specific inhibitor of protein kinase C,staurosporine, coronary arteries
(pig), 1019
stimulation of sodium transport, dura-mycin, colonic epithelia (humans),1050
Calcium channelactions of TA 3090, femoral and coronary
arteries (dogs), 639activation, nondihydropyridine FPL
64176 (rats), 982
bronchial smooth muscle membrane po-
tential, depolarizing agents (dogs),
110
desmethoxyverapamil binding, guanine
nucleotide-binding proteins, vascular
smooth muscle (rats), 164
hypoxic pulmonary vasoconstriction, van-adate (rats), 666
inhibition of binding to PN200-ll0 to
membranes, ascorbate, lipid peroxi-
dation (rats), 337
inhibition of thromboxane synthetase,
antihypertensive action, angiotensin-
converting enzyme (rats), 219
inhibitory action of peripheral-type ben-zodiazepines, dopamine release,
PC12 cells, 484Calcium channel blockers, intravenous
magnesium, ventricular arrhythmias,acute myocardial infarction (dogs),
939Calcium current, vasodilating actions of
E4080, smooth muscle cells, portal
vein (rabbits), 1396Calcium ionophore, release of platelet-acti-
vating factor, prostaglandin produc-
tion, kidney (rats), 590
Calixto, J. B. and Medeiros, Y. S. Charac-terization of bradykinin mediatingpertussis toxin-insensitive biphasic
response in circular muscle of the
isolated guinea pig ileum, 659
Campbell, S. M., see Marks, M. J., 392
Campisi, P., see Carmichael, F. J., 403Camus, P., Coudert, B., D’Athis, P.,
Foucher, P., Delchambre, J., Du-pront, A. and Jeannin, L. Pharma-cokinetics and metabolism of nilu-
tamide in the isolated rat lung, 1247
Candidiasis, pharmacokinetics of ‘8F-la-
beled fluconazole, positron emission
tomography (rats, rabbits), 1351
Cannon, J. G., see Park, K. H., 1221Capsaicin
intranasal, symptoms and mediator re-
lease (humans), 1323
-sensitive and cholinergic nerves, func-
tional interactions, bronchus (guinea
pigs), 104
-sensitive sensory nerve fibers of heart,
neuropeptide release, arachidonicacid and bradykinin (guinea pigs),
759
Carbamazepine, anticonvulsant activity, 5-aminocarbonyl-10,ll-dihydro-5H-di-
benz[a,d]cyclohepten -5,10-imine
(mice, rats), 30
Carcinogens, N-acetyltransferase isozymes,
tumor target organ cytosols (ham-
sters), 699
Cardiovascular system5-HT1�2 agonists, thoracic spinal cord
(rats), 1335
modification of function, central and pe-ripheral injections, 1-(2,5-dime-
thoxy-4-iodophenyl)-2-aminopro-
pane (rats), 1027
Cardoso, P. F. G., Spino, M., Mayer, E., Shi,S.-Q., Pop, R. D., Puskas, J., Perrier,D., Tong, J., Baines, A. D. and Pat-terson, G. A. Use of an isolated insitu canine lung perfusion model to
evaluate dopamine clearance by the
lung, 1271
Carfagna, N., Caccia, C., Mantegani, S., Ca-vanus, S., Fornaretto, M. G., Buon-
amici, M., Rossi, A. C., Roncucci, R.
and Fariello, R. G. FCE 23884, Sub-
strate-dependent interaction with
the dopaminergic system. II. Preclin-
ical biochemical studies, 356
Carfagna, N., see Buonamici, M., 345Carini, D. J., see Wong, P. C., 861Carmichael, F. J., Israel, Y., Crawford, M.,
Minhas, K., Saldivia, V., Sandrin, S.,Campisi, P. and Orrego, H. Centralnervous system effects of acetate:
Contribution to the central effects of
ethanol, 403Carminati, P., see Buonamici, M., 345
Carneiro, R. C . G., Cipolla-Neto, J. andMarkus, R. P. Diurnal variation ofthe rat vas deferens contraction in-
duced by stimulation of presynapticnicotinic receptors and pineal func-
tion, 614
Carrageenan, edema, anti-inflammatory ac-
tivity, pergolide (rats), 169
Carruba, M. 0., Nisoli, E., Garosi, V., Pizzi,M., Memo, M. and Spano, P. Char-acterization of monoaminergic recep-tors in hypothalamic nuclei mediat-
ing feeding behavior in rats, 124
Carter, D. E., see Maiorino, R. M., 808
Casler, J. J., see Perkins, W. E., 1004
Castro, C. A., see Broomfield, C. A., 633Catanese, C. A., see Aharony, D., 146
Catecholamines
activation of alpha-i adrenoceptors, dex-medetomidine (rats), 1147
adrenal release, membrane-mediated ef-
fects, steroid 17-a-estradiol (cats),
279morphine administration, liver metallo-
thionein, zinc metabolism (rats), 274
oxidation products of norepinephrine,binding, plasma proteins, 551
tachyphylaxia, beta adrenoceptors, adi-
pose tissue (humans), 317
Cathapermal, S., see Rego, A., 905Catravas, J. D., see Chen, X., 1301Caussade, F., see Dedieu-Chaufour, C., 190Cavanus, S., see Carfagna, N., 356
Cavero, I., see Auchampach, J. A., 961Cavero, I., see Borg, C., 526Cefoclizime, facilitated transport, central
nervous system (rats), 620
Cell cycle, inhibition of proliferation,
HA1077, bovine smooth muscle cells,738
Central nervous system
acetate effects, ethanol (rats, mice), 403facilitated transport of cefodizime (rats),
620
Cerebellum
endothelium-derived relaxing factor, ni-
triC oxide synthase, high and low oxy-gen tensions, 310
Pukinje neurons, sensitivity to neuro-
transmitters, genetically epileptic
rats, 1008
Cerebrospinal fluid
behavioral and neurochemical effects,
medetomidine (rats), 848
facilitated transport ofcefodizime, central
nervous system (rats), 620
Cervini, M. A., see Buonamici, M., 345
C-fiber
capsaicin-sensitive and cholinergic
nerves, functional interactions, bron-
chus (guinea pigs), 104
environmental tobacco smoke, intranasal
capsaicin, symptoms and mediatorrelease (humans), 1323
1410 Index
C-fiber reflex, dynorphin-induced depres-sion, dorsal root potential, spinal
cord (rats), 608
Chance, B., see Argov, Z., 458Chang, C. C., see Hong, S. J., 932Chang, F. W., see Hu, S. C., 1379Chapman, H., see Hieble, J. P., 643Chapnick, B. M., see Joshi, S. N., 71
Chard, P. S., see Bleakman, D., 430Charman, S. A., see Fitzgerald, G. A., 1043
Charman, W. N., see Fitzgerald, G. A., 1043
Charybdotoxiniberiotoxin and, spontaneous motility and
tonus, smooth muscle tissues (guinea
pigs), 439potassium channel blockers and cromak-
aiim, mechanical activity, detrusor
smooth muscle (guinea pigs), 1158
Chau, F., see Starec, M., 745Chauveau, J., see Boulenguez, P., 1360
Chelating agent, location ofpenetration andmetabolic barriers, levobunolol, cor-
neal epithelium (rabbits), 719
Chelating agnets, dithiol, determination andmetabolism (humans), 808
Chemiosmotic hypothesis, ionophore-in-
duced stimulation of renin secretion
(rabbits), 211
Chen, X., Orfanos, S. E., Ryan, J. W.,Chung, A. Y. K., Hess, D. C. andCatravas, J. D. Species variation inpulmonary endothelial aminopepti-
dase P activity, 1301
Ch#{233}ramy,A., see Desce, J. M., 692Cheymol, G., see Weissenburger, J., 871Ch#{233}zalviel,F., see Weissenburger, J., 871Chiba, K., see Echizen, H., 953Chiba, S., see Ren, L.-M., 38Chibana, T., see Noguchi, K., 732Children, stereoselective disposition and
metabolism, disopyramide, 953
Chiu, A. T., see Wong, P. C., 861Chloride, stimulation of sodium transport,
duramycin, colonic epithelia (hu-
mans), 1050
2-Chloroadenosine, role of endothelium, he-
patic vessels, vasoactive agents
(dogs), 71
Chloroethylclonidine, reduction of cardiac
outward currents, alpha-i adrenocep-tor stimulation (rats), 783
CHO cells, cloned and native muscarinicreceptors, binding of AF-DX 384(rats), 601
Choi, H. K., see Park, C. S., 211Cholinesterase, inhibition, chemical oxi-
dant, acetylcholine-induced contrac-tion in trachea (rats), 371
Chromaffin cells, adrenal catecholamine re-lease, membrane-mediated effects,steroid 17-a-estradiol (cats), 279
Chuang, D.-M., see Belcheva, M. M., 302Chung, A. Y. K., see Chen, X., 1301Chung, C. L., see Park, C. S., 211Ciechanowski, D., see Johnson, M. D., 255Cimetidine, oxygen-induced lung damage in
newborns (rats), 444
Cipolla-Neto, J., see Carneiro, R. C. G., 614Cisapride
benzamide-induced gastroprokinesis, se-rotonergic mechanisms (rats), 501
muscarinic receptors, contraction of gas-
tric myocytes (guinea pigs), 1294
Clarke, D. and Garg, L. C. Alpha-i adrener-
gic receptors in renal medullary col-
lecting duct cells, 1081
Clarkson, C. W., see Dise, T. L., 535Cline, W. H., see Luthin, D. R., 1174Cloarec, A., see Dedieu-Chaufour, C., 190Clonidine
antagonism of norepinephrine, mesen-
teric vascular bed (rats), 653
central and peripheral components, in-
duction, postural hypotension (rats),
1221
lack of spinal antianalgesic activity, dy-norphins (mice), 1073
Cocainebenzodiazepine receptors, discrete re-
gions, brain (rats), 574developmental shift from local to central
control, norepinephrine release, car-
diac-sympathetic axis (rats), 976
enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-
rotransmission (rats), 1174
imipramine as a discrimintaive stimulus
(pigeons), 1088
-induced elevation of plasma adrenocor-
ticotropin hormone, corticosterone,
serotonergic neurons (rats), 495sensitization to psychostimulants and
stress, pertussis toxin injection, AiOdopamine region (rats), 916
tracheal epithelial function and, neuro-transmitter receptors (swine), 241
treatment, immune status and survival,
Friend virus (mice), 745Cogan, M. G., Liu, F.-Y., Wong, P. C. and
Timmermans, P. B. M. W. M. Com-parison of inhibitory potency by non-peptide angiotensin II receptor an-tagonists PD123177 and DuP 753 On
proximal nephron and renal trans-port, 687
Collins, A. C., see Marks, M. J., 392Collins, K. A., see Tseng, L. F., 330Collins, P. W., see Perkins, W. E., 1004Colon
arylamine carcinogen N-acetyltransferase
isozymes, tumor target organ cytosols
(hamsters), 699epithelia, stimulation of sodium trans-
port, duramycin (humans), 1050Complements, C5a-induced bronchocon-
striction, inhibition by H1 antagonist
(guinea pigs), 1213
Cone, E. J., see Su, T.-P., 543
Cornea, epithelium, location of penetration
and metabolic barriers, levobunolol
(rabbits), 719
Correa-Sales, C., see Schwinn, D. A., 1147
Correia, J. A., see Fischman, A. J., 1351Corticosterone, cocaine-induced elevation,
plasma adrenocorticotropin hor-mone, serotonergic neurons (rats),
495
Coscia, C. J., see Belcheva, M. M., 302C#{243}te,D., see Levens, N. R., 219
Coudert, B., see Camus, P., 1247Coutant-Perronne, V., Mansour, H., Mar-
quetty, C., Rouveix, B. and Pocidalo,J.-J. Activities of lung NADPH-cy-tochrome C-reductase and of cyto-chrome P-450 peroxidase during theprotection of rat from hyperoxic in-jury by polyriboinosinic acid-polyri-bocytidilic acid, 1059
Craig, C. R., see Gould, E. M., 1008
Vol. 259
Crawford, M., see Carmichael, F. J., 403Cribb, A. E., Grant, D. M., Miller, M. A.
and Spielberg, S. P. Expression ofmonomorphic arylamine N-acetyl-transferase (NAT1) in human leu-kocytes, 1241
Criswell, H. E., see Simson, P. E., 1288
Cromakalimaction of potassium channel openers, sul-
fonylurea receptors (guinea pigs), 566
anti-ischemic actions of mechanisticallydiverse agents, potassium channelblockade (rats), 97
potassium channel blockers and, mechan-ical activity, detrusor smooth muscle
(guinea pigs), 1158Crowley, H. J., see O’Donnell, M., 751Crowley, H. J., Yaremko, B., Selig, W. M.,
Janero, D. R., Burghardt, C., Welton,A. F. and O’Donnell, M. Pharmacol-ogy of a potent platelet-activatingfactor antagonist Ro 24-4736, 78
Cushing, D. J., see Sabouni, M. H., 508Cuthbert, A. W., see Roberts, M., 1050Cyclic AMP
cisapride action on muscarinic receptors,contraction, gastric myocytes (guineapigs), 1294
flerobuterol interactions, beta adrenocep-tors, brain (rats), 414
intracerebroventricular morphine release,
spinal cord, serotonergic mechanism(rats), 1013
water diuretic effect, alpha adrenoceptor
agonist AGN 190851 (rats, dogs,monkeys), 1277
Cyclic GMPendothelin, formation, endothelium-de-
rived relaxing factor-like substance(pigs), 1102
endothelium-derived relaxing factor, ni-tric oxide synthase, bovine cerebel-lum, 310
inhibition of NMDA responses, 1,10-bis(guanidino)decane (rats), 626
vascular nitric oxide-generating activities,organic nitrites and nitrates, 519
Cyclooxygenase, enhanced inhibitory mod-
ulation, noradrenergic neurotrans-mission, mesenteric vasculature(rats), 1174
Cyclosporin A, systemic vascular effects,normotensive rats, 905
Cyronak, M. J., see Mann, W. A., 1231Cytochrome P-450
activities oflung NADPH-cytochrome C-reductase, protection from hepaticinjury, polyriboinosinic acid-polyri-
bocytidilic acid (rats), 1059
oxygen-induced lung damage in newborns
(rats), 444
Cytochrome P45OIIC11, human hepatitisanti-liver kidney microsomes auto-antibodies, liver sections (rats), 1328
Cytochrome P450I1D6, influence of debri-soquine phenotype, quinidine, mexi-letine disposition (humans), 789
Cytochrome P45OIIE1, pyridine effects,liver (rabbits), 470
Cytokines, interleukin la and lfi, transportfrom blood to brain (humans, mice),988
Cytosols, tumor target organ, N-acetyl-transferase isozymes (hamsters), 699
Czartolomna, J., see Voelkel, N. F., 666
1991 Index 1411
Dage, R. C., see French, J. F., 260D’Almeida, M. S. and Lautt, W. W. Gluca-
gon, pharmacodynamics and modu-lation of sympathetic nerve and nor-
epinephrine-induced constrictor re-sponses in the superior mesentericartery of the cat, 118
Daly, J. W., see Nikodijevi#{233}, 0., 286d’Amore, A., Lorenzini, P. and Massotti, M.
Antinociceptive action of opiates andopioid peptides after unilateral mi-
croinjection into area tempestas in
rats, 1308
Damsma, G., Robertson, G. S., Tham, C.-S.and Fibiger, H. C. Dopaminergic reg-
ulation of striatal acetylcholine re-
lease: Importance of Dl and N-methyl-D-aspartate receptors, 1064
Daniel, E. E., see Janssen, L. J., 110Dansette, P. M., see Pons, C., 1328Dart, R. C., see Maiorino, R. M., 808DaSilva, A. M. T., see Abrahams, T. P., 1388
D’Athis P., see Camus, P., 1247Davis, F., see Lamb, R. J., 1165Davis, T. F., see Weber, S. J., 1109
Davy, J.-M., see Weissenburger, J., 871
Dayanithi, G., see Wang, X., 705Deblois, D., see Drapeau, G., 997Debrisoquine, phenotype, quinidine, mexi-
letine disposition (humans), 789
De Brum-Fernandes, A. J., Guillemette, G.,Borgeat, P. and Sirois, P. Specificbinding sites for leukotriene B4 inguinea pig brain membranes, 1035
de Costa, B. R., see Drower, E. J., 725Dedeo�lu, A. and Fisher, L. A. Central and
peripheral injections ofthe 5-HT2 ag-onist, 1-(2,5-diemthoxy-4-iodo-
phenyl)-2-aminopropane, modifycardiovascular function through dif-ferent mechanisms, 1027
Dedieu-Chaufour, C., Hertz, F., Caussade,F. and Cloarec, A. Pharmacological
profile of UP 5’45-52, an original an-tiulcer and antisecretory agent, 190
Degott, C., see Deschamps, D., 894Dehydroabietic acid, reduction of active p-
aminohippurate transport, passive
membrane permeability, renal mem-branes (rats), 156
Delaage, M., see Boulenguez, P., 1360Del Bianco, E., see Geppetti, P., 759Delchambre, J., see Camus, P., 1247Demarinis, R. M., see Hieble, J. P., 643Depalma, P. D., see Brooks, D. P., 1277de Pascual, R., see Lopez, M. G., 279Deprenyl, locomotor activity, dopaminergic
neurotransmission, nigral dopamineneurons (rats), 841
Desce, J. M., Godeheu, G., Galli, T., Artaud,F., Ch#{233}ramy, A. and Glowinski, J.Presynaptic facilitation of dopaminerelease through D,L-a-amino-3-hy-droxy-5-methyl-4-isoxazole propio-
nate receptors on synaptosomes fromthe rat striatum, 6, 92
Deschamps, D., Fisch, C., Fromenty, B.,Berson, A., Degott, C. and Pessayre,D. Inhibition by salicylic acid of theactivation and thus oxidation of longchain fatty acids. Possible role in thedevelopment of Reye’s syndrome, 894
Desforges, B., see Starec, M., 745Desipramine, imipramine as a discrimina-
tive stimulus (pigeons), 1088
Desmethoxyverapamil, binding to calcium
channels, guanine nucleotide-bindingproteins, vascular smooth muscle(rats), 164
Dexmedetomidine, activation of alpha-iadrenoceptors (rats), 1147
Diazepam, inhibitory action of peripheral-type benzodiazepines, dopamine re-lease, PC12 cells, 484
Dieter, J. P., see Lam, S. C. T., 1371Dihydrexidine, D, and D2 dopamine recep-
tors, spontaneous blink rate (mon-
keys), 595
Diltiazem, vascular actions ofTA 3090, fem-
oral and coronary arteries (dogs), 639i-(2,5-Dimethoxy-4-iodophenyl)-2-amino-
propane, central and peripheral in-jections, cardiovascular function
modification (rats), 1027
Discriminative stimulus
imipramine (pigeons), 1088
quipazine and l-5-hydroxytryptophan, se-
rotonin binding sites (pigeons), 772
Dise, T. L., Stolfi, A., Clarkson, C. W. and
Pickoff, A. S. Rate-dependent effectsof lidocaine on his-purkinje conduc-
tion in the intact neonatal heart-
characterization and amplification
by N-acetylprocainamide, 535
Disopyramide, stereoselective disposition
and metabolism, pediatric patients,953
Dithiol, chelating agents, determination and
metabolism (humans), 808Diuresis
renal effects and elimination, sulotroban
(dogs), 1231
water diuretic effect, alpha adrenoceptor
agonist AGN 190851 (rats, dogs,
monkeys), 1277
Dixon, K. F., see Mays, D. C., 1261
Dixon, W., see Lopez, M. G., 279Dizocilpine, anticonvulsant activity, 5-ami-
nocarbonyl-iO,i1-dihydro-5H-di-
benz[a,djcyclohepten -5,10-imine
(mice, rats), 30
DNA, complementary, ligand-binding prop-erties, tachykinin receptors (rats),968
Dodge, A. L., see Su, T.-P., 543
DO!, increased renin secretion and bloodpressure, 5-HT2 receptors (rats), 58
L-Dopa, D1 and D2 agonists and antagonists,
dyskinesia, i-methyl-4-phenyl-i,2,3,
6-tetrahydropyridine (monkeys), 409
DopamineAlO region, pertussis toxin, sensitization
to psychostimulants and stress (rats),916
benzodiazepine receptors, cocaine, dis-
crete regions of brain (rats), 574
clearance, lung perfusion model (dogs),1271
D1 and D2 agonists and antagonists, dys-kinesia produced by L-dopa, 1-methyl-4-phenyl-i,2,3,6-tetrahydro-
pyridine (monkeys), 409
deprenyl, locomotor activity, nigral do-pamine neurons (rats), 841
3,4-methylenedioxymethamphetamine-
induced release, microdialysis studies(rats), 820
neurotransmission, effect of metaphit,
striatal slices (rats), 1188
release, inhibitory action of peripheral-
type benzodiazepines, PC12 cells, 484release through D,L-a-amino-3-hydroxy-
5-methyl-4-isoxazole propionate re-ceptors, synaptosomes, striatum
(rats), 692
substrate-dependent interaction, FCE
23884 (mice, rats, dogs, marmosets,
monkeys), 345, 356
Dorn, G. W., II. Mechanism for homologousdownregulation of thromboxane A2
receptors in cultured human chronicmyelogenous leukemia (K562) cells,228
Dorsal root ganglion, modulation of GABAreceptor-channel complex, alcohols(rats), 235
Downing, G., see Thibeault, D. W., 444Drapeau, G., Deblois, D. and Marceau, F.
Hypotensive effects of Lys-des-Arg�-
bradykinin and metabolically pro-tected agonists of B1receptors for
kinins, 997
Drieman, J. C. and Thijssen, H. H. W. Renalselective N-acetyl-L--y-glutamyl pro-
drugs. II!. N-Acetyl-L--y-glutamyl-4’-aminowarfarin is not targeted to thekidney but is selectively excreted into
the bile, 766Drower, E. J., Stapelfeld, A., Rafferty, M.
F., de Costa, B. R., Rice, K. C. andHammond, D. L. Selective antago-nism by naltrindole of the antinoci-
ceptive effects of the Delta opioid ag-onist cyclic[D-penicillamine2-D-penicillaminet]enkephalin in the rat,
725Duckles, S. P., see Massamiri, T., 22
DuP 532, pharmacology (rats), 861DuP 753, PD123177 and, inhibitory po-
tency, proximal nephron and renaltransport (rats), 687
Dupront, A., see Camus, P., 1247
Dwyer, T. M., see Farley, J. M., 241Dynorphin
-induced depression of dorsal root poten-
tial, spinal cord (rats), 608
lack of spinal antianalgesic activity(mice), 1073
responses of extrapyramidal and limbic
neuropeptides, fenfluramine admin-
istration (rats), 1197
Dyskinesia, D1 and D2 agonists and antag-
onists, L-dopa, 1-methyl-4-phenyl-1,
2,3,6-tetrahydropyridine (monkeys),
409
Dzwonczyk, S., see Sargent, C. A., 97
E4080, vasodilating actions, ionic currents,
smooth muscle cells of portal vein(rabbits), 1396
Ebersole, B. J. and Molinoff, P. B. Inhibi-
tion of binding of [3H]PN200-110 tomembranes from rat brain and heart
by ascorbate is mediated by lipid per-
oxdiation, 337
Echizen, H., Takahashi, H., Nakamura, H.,Ochiai, K., Chiba, K., Koike, K.,Ogata, H. and Ishizaki, T. Stereose-lective disposition and metabolism ofdisopyramide in pediatric patients,
953
Edwards, M. L., see Reynolds, I. J., 626
Edwards, R., see Hieble, J. P., 643Edwards, R. M., see Brooks, D. P., 1277Ehrlich ascites tumor cells, nitrobenzyl-
1412 Index Vol. 259
thioguanosine, nucleoside transport
mechanisms, 799
Eichelbaum, M., see Turgeon, J., 789
Eikenburg, D. C. Age-related changes in
vascular sympathetic neurotransmis-sion in the rat kidney, 176
Elebring, T., see Engberg, G., 841Electroencephalography, delta wave activ-
ity, naloxone, dose-dependent in-
crease (rats), 464Electromechanical coupling, ion channels in
bronchi (dogs), 110Electrophysiology
actions of BRB-!-28, myocardial tissues(dogs), 558
dynorphin-induced depression, dorsal
root potential, spinal cord (rats), 608rate-dependent effects of lidocaine, His-
Purkinje conduction, neonatal heart(dogs), 543
sodium channel blockers, left atrium(guinea pigs), 884
Eleff, S., see Argov, Z., 458Elmaleh, D. R., see Fischman, A. J., 1351
Elsworth, J. D., Lawrence, M. S., Roth, R.
H., Taylor, J. R., Mailman, R. B.,
Nichols, D. E., Lewis, M. H. and Red-
mond, D. E., Jr. D1 and D2 Dopaminereceptors independently regulatespontaneous blink rate in the vervet
monkey, 595Endothelin, cyclic GMP levels, formation,
endothelium-derived relaxing factor-
like substance (pigs), 1102
Endothelin-3, effects on renal function(dogs), 1256
Endothelium
-dependent relaxation, serotonin, bovinecoronary artery, 1316
responses to hepatic vessels, vasoactive
agents (dogs), 71
selective transport of anti-transferrin re-
ceptor antibody, blood-brain barrier(mice, rats, humans, cattle), 66
Endothelium-derived relaxing factorinhibitor N#{176}-monomethyl L-arginine, ef-
fects of guanidino compounds (rats),
490NG�monomethyl�L�arginine�induced
pressor response, developmental andestablished stages, spontaneously hy-pertensive rats, 52
nitric oxide synthase, bovine cerebellum,high and low oxygen tensions, 310
ultraviolet irradiation of solutions, re-
sponses of aorta, nitric oxide and su-
peroxide (rabbits), 1140vascular actions of TA 3090 (dogs), 639
Endotoxin, hypotensive effects of lys-des-
arg�-bradykinin, metabolically pro-
tected agonists, B1 receptors for kin-ins (rabbits), 997
Energy metabolism, intra-arterial epineph-rine, exercising gastrocnemius mus-cle (rabbits), 458
Engberg, G., Elebring, T. and Nissbrandt,H. Deprenyl (selegiline), a selectiveMAO-B inhibitor with active metab-olites; effects on locomotor activity,
dopaminergic neurotransmisssion
and firing rate of nigral dopamine
neurons, 841Engel, F., see Weissenburger, J., 871
Engfeldt, P., see Arner, P., 317Enkephalin, leucine, metabolism and poor
membrane permeation, intestinal ab-sorption (rats), 139
[D-pen2,D-pen5]Enkephalin
distribution and analgesia (mice), 1109selective antagonism by naltrindole
(rats), 725Epilepsy
anticonvulsant activity, 5-aminocar-bonyl-10,11-dihydro-5H-dibenz[a,d]
cyclohepten -5,10-imine (mice, rats),30
sensitivity of cerebellar Purkinje neurons,neurotransmitters (rats), 1008
Epinephrine
intra-arterial, energy metabolism, exer-
cising gastrocnemius muscle (rab-
bits), 458
responses, desensitization by imidazoline,vas deferens (rats), 1182
Epitheliumacetylcholine-induced contraction, chem-
ical oxidant, trachea (rats), 371colonic, stimulation of sodium transport,
duramycin (humans), 1050cornea!, location of penetration and met-
abolic barriers, levobunolol (rabbits),719
inhibition of airway smooth muscle tone,
phorbol ester, trachea (guinea pigs),198
Ergoline, FCE 23884, substrate-dependentinteraction, dopaminergic system(mice, rats, dogs, marmosets, mon-keys), 345, 356
Ertzbischoff, 0., see Weissenburger, J., 871Esophagus, lower sphincter, bradykinin and
bradykinin analogs (opossums), 26517-a-Estradiol, adrenal catecholamine re-
lease, membrane-mediated effects
(cats), 279
Ethanolcentral nervous system effects, acetate
(rats, mice), 403-induced alterations of thermoregulation,
serotonergic involvement, long-sleep
and short-sleep mice, 833inhibition ofcalcium currents and peptide
release, neurohypophysial terminals
(rats), 705modulation of GABA receptor-channel
complex (rats), 235potentiation of GABA-mediated inhibi-
tion, inferior colliculus (rats), 1288
Eye
corneal epithelium, location of penetra-tion and metabolic barriers, levobu-
nolol (rabbits), 719spontaneous blink rate, D1 and D2 dopa-
mine receptors (monkeys), 595
Facci, L., see Skaper, S. D., 452Fanciullacci, M., see Geppetti, P., 759Fariello, R. G., see Buonamici, M., 345Fariello, R. G., see Carfagna, N., 356Farley, J. M., Adderholt, J. G. and Dwyer,
T. M. Cocaine and tracheal epithelialfunction: Effects on short circuit cur-rent and neurotransmitter receptors,241
Fatty acids, long chain, oxidation, inhibitionby salicylic acid (mice), 894
FCE 23884, substrate-dependent interac-
tion, dopaminergic system (mice,rats, dogs, marmosets, monkeys),345, 356
Fedele, E., see Bonanno, G., 1153
Feinberg, H., see Lam, S. C. T., 1371Feldman, P. L., see James, M. K., 712Fenfluramine, responses of extrapyramidal
and limbic neuropeptides (rats), 1197Fentanyl, opioid receptor activity, GI
870MB (guinea pigs, rats, mice), 712
Fibiger, H. C., see Damsma, G., 1064
Fibrin, platelet-rich clots, dissociation, plas-minogen activators and antiplateletagents (humans), 1371
Finger, A. V., see Broomfield, C. A., 633
Fisch, C., see Desehamps, D., 894
Fischman, A. J., Alpert, N. M., Livni, E.,Ray, S., Sinclair, I., Elmaleh, D. R.,
Weiss, S., Correia, J. A., Webb, D.,
Lisa, R, Straum, H. W. and Rubin,R. H. Pharmacokinetics of 18F-la-beled fluconazole in rabbits with can-didal infections studied with positronemission tomography, 1351
Fiset, C., see Turgeon, J., 789Fisher, L. A., see Dedec�lu, A., 1027Fitzgerald, G. A., Lupinetti, M., Charman,
S. A. and Charman, W. N. Presys-
temic acetylation of platelets by as-pirin: Reduction in rate ofdrug deliv-ery to improve biochemical selectiv-
ity for thromboxane A2, 1043
Flecainide, arrhythmogenic activities, atri-oventricular block (dogs), 871
Fleming, W. W., see Gould, E. M., 1008
Fleming, W. W., see Kong, J.-Q., 653Fleming, W. W., see Leedham, J. A., 295Fleming, W. W., see Taylor, D. A., 1084
Flerobuterol, interactions with beta ache-noceptors, brain (rats), 414
Fluconazole, pharmacokinetics of ‘8F-label-ing, candidal infections, positron
emission tomography (rats, rabbits),1351
Fluorine- 18 fluconazole, pharmacokinetics,candidal infections (rats, rabbits),
1351Foegh, M. L., see Rego, A., 905Folco, G. C., see Geppetti, P., 759Fontana, G., see Bonanno, G., 1153
Fornaretto, M. G., see Carfagna, N., 356
Forskolin, inhibition of adenylate cyclase,adenosine receptor-mediated relaxa-tion, coronary artery (pigs), 508
Foucart, S., see Bleakman, D., 430
Foucher, P., see Camus, P., 1247FPL 64176, new site for activation, cardiac
calcium channels (rats), 982Franklin, S. R., see Tang, A. H., 248
Fraser, D. G. and Regal, J. F. Recombinanthuman C5a-induced bronchocon-striction in the guinea pig Inhibitionby an H1 antagonist after depletionofcirculating granulocytes and plate-lets, 1213
Fredrickson, T. A., see Brooks, D. P., 1277French, J. F., Lambert, L. E. and Dage, R.
C. Nitric oxide synthase inhibiots in-hibit interleukin lfl-induced depres-sion of vascular smooth muscle , 260
French, T. A. and Weiner, N. Serotoninergicinvolvement in ethanol-induced al-tertions of thermoregulation in long-sleep and shrot-sleep mice, 833
Friden, P. M., see Pardridge, W. M., 66
Fridl, A., see Georg, A., 479Friedman, E., see Johnson, M. D., 255Friend virus, immune status and survival,
1991 Index 1413
opiate and cocaine treatment (mice),745
Fromenty, B., see Deschamps, D., 894Fujimori, K., see Ohara-!maizumi, M., 484Fujimoto, J. M., see Rady, J. J., 1073
Fujita, N., see Yamazaki, J., 52Fung, H.-L., see Kowaluk, E. A., 519Furchgott, R. F., see Matsunaga, K., 1140
Furukawa, T., see Katsuragi, T., 513
Furukawa, Y., see Ren, L.-M., 38
Gaddis, R. R., see Linnik, M. D., 501Gaginella, T. S., see Perkins, W. E., 1004Galli, T., see Desce, J. M., 692
Gao, X.-M., see Belcheva, M. M., 302Garcia, A. G., see Lopez, M. G., 279Garcia, M. L., see Suarez-Kurtz, G., 439Garg, L. C., see Clarke, D., 1081Garosi, V., see Carruba, M. 0., 124
Garvey, J. S., see Hidalgo, J., 274Gasiecki, A. F., see Perkins, W. E., 1004
Gastroprokinesis, benzamide-induced, se-
rotonergic mechanisms (rats), 501Gellai, M., see Brooks, D. P., 1277
Gemignani, A., see Bonanno, G., 1153Gene, -mediated pharmacodynamics, effect
of ketoconazole, methylprednisolone
pharmacokinetics (rats), 826Georg, A. and Friedl, A. Identification and
characteization of two Sigma-like
binding sites in the mouse neuro-
blastoma x rat glioma hybrid cell lineNG1O8-15, 479
Gepirone, imipramine as a discriminativestimulus (pigeons), 1088
Geppetti, P., Del Bianco, E., Tramontana,M., Vigano, T., Folco, G. C., Maggi,C. A., Manzini, S. and Fanciullacci,M. Arachidonic acid and bradykininshare a common pathway to releaseneuropeptide from capsaicin-sensi-tive sensory nerve fibers of the guineapig heart, 759
Gerber, N., see Mays, D. C., 1261
GI 870MB, opioid receptor activity (guineapigs, rats, mice), 712
Gibb, J. W., see Hanson, G. R., 1197
Gibson, V. A., see Miller, J. H., 601
Gigo, V., see Herbert, J. M., 44
Gigu#{232}re,R., see Turgeon, J., 789Gilbert, M., see Turgeon, J., 789Gillis, R. A., see Abrahams, T. P., 1388
Giralt, M., see Hidalgo, J., 274
Gleason, M. M. and Hieble, J. P. Ability ofSK&F 104078 to identify alpha-2adrenoceptor subtypes in NCB2O
cells and guinea pig lung, 1124Glibenclamide
action of potassium channel openers, sul-fonylurea receptors (guinea pigs), 566
reduction of infarct size by aprikalim, ab-sence of hemodynamic changes(dogs), 961
tolbutamide and, hyperpolarization of de-nervated skeletal muscle, lemakalim
(mice), 932vasorelaxation, nicorandil, potassium
channel opening (rats), 526Glioma, rat, mouse neuroblastoma hybrid
cell line, sigma-like bindig sites, 479Glomerular filtration rate, renal effects and
elimination, sulotroban (dogs), 1231
Glowinski, J., see Desce, J. M., 692
Glucagon, pharmacodynamics, sympatheticnerve and norepinephrine-induced
constrictor responses, superior mes-
enteric artery (cats), 118Glucocorticoids
methylprednisolone pharmacokinetics,effect of ketoconazole (rats), 826
morphine administration, liver metallo-
thionein, zinc metabolism (rats), 274
Glutamateheterogeneity of NMDA receptor iono-
phore complex, brain (rats), 86metabotropic excitatory amino acid re-
ceptor agonist, intrastriatal injection,contralateral turning (rats), 1366
sensitivity of cerebellar Purkinje neurons,
genetically epileptic rats, 1008
Glyburide, potassium channel blockers andcromakalim, mechanical activity, de-trusor smooth muscle (guinea pigs),
1158
Glycine, GABA-mediated inhibition, poten-tiation by ethanol, inferior colliculus(rats), 1288
Godeheu, G., see Desce, J. M., 692
Goeders, N. E. Cocaine differentially affectsbenzodiazepine receptors in discreteregions of the rat brain: Persistence
and potential mechanisms mediating
these effects, 574
Goldberg, S. R., see Lamb, R. J., 1165Goldstein, R. S., see Mann, W. A., 1231Gomez-Mancilla, B. and B#{233}dard,P. J. Effect
ofD1 and D2 agonists and antagonistson dyskinesia produced by L-DOPAin 1-methyl-4-phenyl-1,2,3,6-tetra-
hydropyridine-treated monkeys, 409
Gould, E. M., Craig, C. R., Fleming, W. W.
and Taylor, D. A. Sensitivity of cer-
ebellar Purkinje neurons to neuro-
transmitters in genetically epileptic
rats, 1008
Goyal, R. K., see Saha, J. K., 265
G proteinsdesmethoxyverapamil binding to calcium
channels, vascular smooth muscle
(rats), 164
ligand-binding properties, tachykinin re-
ceptors (rats), 968
reduced function in desensitized aorta
(rats), 255
up-regulation of sigma opioid receptors,
neuroblastoma hybrid cells, 302Grant, D. M., see Cribb, A. E., 1241Grant, T. L. and Zuzack, J. S. Effects of K�
channel blockers and cromakalim
(BRL 34915) on the mechanical ac-
tivity of guinea pig detrusor smooth
muscle, 1158
Granulocytes, depletion, C5a-induced bron-
choconstriction, inhibition by H1 an-
tagonist (guinea pigs), 1213Grasing, K. and Szeto, H. Naloxone causes
a dose-dependent increase in total
power and Delta wave activity in the
EEG of opioid-naive rats, 464Graybill, S. C., see Webb, R. L., 1203Grech-B#{233}langer, 0., see Turgeon, J., 789
Greene, D. L., see Weber, S. J., 1109
Gregeois, J., see Pons, C., 1328
Gross, G., see Wang, X.-L., 783Gross, G. J., see Auchampach, J. A., 961Grover, G. J., see Sargent, C. A., 97
GTP analogs, substance P binding, high-affinity NK-1 receptors, lung mem-
branes (guinea pigs), 146
Guanethidine, central and peripheral corn-
ponents, induction, postural hypo-
tension (rats), 1221
Guanidino compounds, endothelium-de-
rived relaxing factor, inhibitor NG�
monomethyl L-arginine (rats), 490Guanylate cyclase, formation of endothe-
hum-derived relaxing factor-like sub-
stance, endothelin, increased cyclic
GMP levels (pigs), 1102
Guillemette, G., see De Brum-Fernandes, A.J., 1035
Gund, T. M., see Su, T.-P., 543
HA1O77, inhibition of proliferation, bovine
vascular smooth muscle cells, 738
Ha, S. K., see Park, C. S., 211Hall, S. D., see Rudy, A. C., 1133
Haloperidol, sigma ligands, contractile re-
sponses (rats), 22
Hamdi, A., see Rice, P. J., 1182
Hammond, D. L., see Drower, E. J., 725
Hammond, J. R. Comparative pharmacol-ogy of the nitrobenzylthioguanosine-sensitive and -resistant nucleoside
transport mechanisms of Ehrlich as-
cites tumor cells, 799Hanano, M., see Matsushita, H., 620Hanson, G. R., Singh, N., Bush, L. and
Gibb, J. W. Response of extrapyra-midal and limbic neuropeptides to
fenfluramine administration: Corn-parison with methamphetamine,1197
Hardin, J. C., see Rice, P. J., 1182
Hart, S. D., see Wong, P. C., 861
Hasler, W. L., Heldsinger, A. and Owyang,
C. Cisapride acts of muscarinic (glan-dular M2) receptors to induce con-traction of isolated gastric myocytes:
Mediation via a calcium-phosphoi-nositide pathway, 1294
Hattori, R., see Shirotani, M., 738
Haughey, D. B. and Jusko, W. J. Effect ofketoconazole on methylprednisolonepharmacokinetics and receptor/gene-
mediated pharmacodynamics, 826
Heartarrhythmogenic activities, antiar-
rhythmic drugs, atrioventricular
block (dogs), 871beta-2 adrenoceptor stimulation, intracor-
onary procaterol, myocardial ische-mia (dogs), 732
calcium channel activation, nondihydro-
pyridine FPL 64176 (rats), 982
capsaicin-sensitive sensory nerve fibers,neuropeptide release, arachidonicacid and bradykinin (guinea pigs),
759cardiac outward current reduction, alpha-
1 adrenoceptor stimulation (rats),783
cardiac-sympathetic axis, developmental
shift, norepinephrine release and co-
caine (rats), 976cardiovascular effects of adenosine A2 ag-
onists, structurally distinct ligands
(rats), 1203
differential inhibition of neuropeptide Y,chronotropic and inotropic re-sponses, atrium (dogs), 38
inhibition of binding to PN200-1i0 to
membranes, ascorbate, lipid peroxi-dation (rats), 337
muscarinic stimulation, adenylate cyclase
activity, olfactory bulb (rats), 680
1414 Index Vol. 259
myocardial tissues, electrophysiological
actions, BRB-I-28 (dogs), 558
neonatal, rate-dependent effects, lido-caine (dogs), 535
vasorelaxation, nicorandil, potassiumchannel opening (rats), 526
Heart rate
development of tolerance to nicotine, gen-otype influences (mice), 392
modification of cardiovascular function,
1-(2,5-dimethoxy-4-iodophenyl)-2-
aminopropane (rats), 1027Hem, D. W., Rustan, T. D., Bucher, K. D.
and Miller, L. S. Polymorphic andmonomorphic expression of arylam-
me carcinogen N-acetyltransferase
isozymes in tumor target organ cyto-sols of Syrian hamsters congenic at
the polymorphic acetyltransteraseloucs, 699
Heldsinger, A., see Hasler, W. L., 1294Helke, C. J., Thor, K. B. and Phillips, E. T.
5-Hydroxytryptamine1c/2 agonists in
the thoracic spinal cord: Cardiovas-cular effects and binding sites in the
intermediolateral cell column, 1335
Henningfield, J. E., see Lamb, R. J., 1165
Hepatitis, anti-liver kidney microsomes
autoantibodies, liver sections (rats),
1328
Herbert, J. M., Bernat, A., Valette, G., Gigo,V., Lale, A., Laplace, M. C., Lespy,L., Savi, P., Maffrand, J. P. and LeFur, G. Biochemical and pharmaco-logical activities of SR 27417, ahighly potent, long-acting platelet-
activating factor receptor antagonist,44
Herblin, W. F., see Wong, P. C., 861Hersh, L. B., see Weber, S. J., 1109
Hertz, F., see Dedieu-Chaufour, C., 190
Hess, D. C., see Chen, X., 1301
Hidalgo, J., Giralt, M., Garvey, J. S. andArmario, A. Effect of morphine ad-ministration of rat liver metallothi-onein and zinc metabolism, 274
Hieble, J. P., see Brooks, D. P., 1277
Hieble, J. P., see Gleason, M. M., 1124Hieble, J. P., Sulpizio, A. C., Edwards, R.,
Chapman, H., Young, P., Roberts, S.P., Blackburn, T. P., Wood, M. D.,Shah, D. H., Demarinis, R. M. andRuffolo, R. R., Jr. Additional evi-dence for functional subclassificationof Alpha-2 adrenoceptors based on a
new selective antagonist, SK&F104856, 643
Hillard, C. J. and Pounds, J. J. [3H]Tetra-phenylphosphonium accumulation in
cerebral cortical sysanptosomes as ameasure of nicotine-induced changes
in membrane potential, 1118
Himes, C. S., see Tang, A. H., 248
Hippocampus, pyramidal neurons, activa-tion of NMDA receptors, death re-duction by monosialogangliosides(rats), 452
Histamine, C5a-induced bronchonconstric-tion, inhibition by H1 antagonist(guinea pigs), 1213
Hladky, S. B., see Roberts, M., 1050
Ho, P. M., see Tang, A. H., 248Hollingsworth, P. J., see Walker, E. A., 772Holtzman, S. G., see Paronis, C. A., 582Homberg, J. C., see Pons, C., 1328
Honda, K., see Miyata, K., 15, 815Honeyman, T. W., see Park, C. S., 211Hong, C. D., see Park, C. S., 211Hong, S. J. and Chang, C. C. Hyperpolari-
zation of denervated skeletal muscleby lemakalim and its antagonism byglybenclamide and tolbutamide, 932
Hornby, P. J., see Abrahams, T. P., 1388
Horwitz, S. B., see Ringel, I., 855Hruby, V. J., see Weber, S. J., 1109Hsu, W. M., see Hu, S. C., 1379Hu, S. C., Chang, F. W., Sung, Y. J., Hsu,
W. M. and Lee, E. H. Y. Neurotoxiceffects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the substantia
nigra and the locus ceruleus inBALB/c mice, 1379
Hussain, M. A., see Aungst, B. J., 139l-5-Hydroxytryptophan, quipazine and, dis-
criminative-stimulus effects, sero-tonin binding sites (pigeons), 772
Hypertension
cardiovascular effects of adenosine A2 ag-onists, ligands (rats), 1203
enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-
rotransmission (rats), 1174
inhibition of thromboxane synthetase,angiotensin-converting enzyme in-
hibitor (rats), 219NG�monomethyl�L�arginine.induced
pressor response, developmental andestablished stages, spontaneously hy-pertensive rats, 52
pharmacology of DuP 532 (rats), 861systemic vascular effects, cyclosporin A
treatment, normotensive rats, 905
Hypokalemia, arrhythmogenic activities,antiarrhythmic drugs, atrioventricu-
lar block (dogs), 871Hypotension
lys-des-ar�-bradykinin, metabolicallyprotected agonists, B1 receptors forkinins (rabbits), 997
postural, central and peripheral compo-nents, frequency selectivity (rats),1221
Hypothalamus, nuclei, monoaminergic re-
ceptors, feeding behavior (rats), 124Hypothermia, development of tolerance to
nicotine, genotype influences (mice),392
Hypoxia, endothelium-derived relaxing fac-
tor, nitric oxide synthase, bovine cer-
ebellum, 310
Iberiotoxin, charybdotoxin and, sponta-neous motility and tonus, smoothmuscle tissues (guinea pigs), 439
Ibuprofen
effects of endothelin-3, renal function(dogs), 1256
stereoselective metabolism (humans),
1133!ga, T., see Matsushita, H., 620!komi, F., Kawai, Y. and Ohhashi, T. Beta-
1 and Beta-2 adrenoceptors mediate
smooth muscle relaxation in bovineisolated mesenteric lymphatics, 365
Ileumaction of potassium channel openers, sul-
fonylurea receptors (guinea pigs), 566ATP-evoked ATP release system (guinea
pigs), 513benzamide-induced gastroprokinesis, se-
rotonergic mechanisms (rats), 501
calcitonin gene-related peptide, longitu-dinal muscle and myenteric plexus
(guinea pigs), 947circular muscle, bradykinin, pertussis
toxin-insensitive biphasic response(guinea pigs), 659
Imidazoline, desensitization of epinephrineresponses, vas deferens (rats), 1182
Imipramine, discriminative stimulus (pi-geons), 1088
Immunofluorescence, human hepatitis anti-
liver kidney microsomes, liver sec-tions (rats), 1328
Indomethacinenhanced inhibitory modulation, cycloox-
ygenase products, noradrenergic neu-rotransmission (rats), 1174
plasminogen activators and antiplatelet
agents, rapid dissociation, platelet-rich fibrin clots (humans), 1371
Ingi, T., Kitajima, Y., Minamitake, Y. andNakanishi, S. Characterization of li-gand-binding properties and selectiv-
ities of three rat tachykinin receptorsby transfection and functionalexpression of their cloned cDNAs inmammalian cells, 968
Inotropy, positive, low concentrations, stro-phanthidin (sheep), 182
Inoue, D., see Shirayama, T., 884Inoue, K., see Ohara-Imaizumi, M., 484Inoue, M., see Shirayama, T., 884Insulin, chronic treatment, sympathetic ac-
tivation (rats), 131Interleukin la, transport from blood to
brain (humans, mice), 988
Interleukin 1�-induced depression of vascular smooth
muscle, nitric oxide synthase inhibi-tors (rats), 260
transport from blood to brain (mice), 988Intestine
absorption, metabolism and poor mem-
brane permeation, leucine enkepha-lin (rats), 139
small, sulfonylurea receptors, action ofpotassium channel openers (guineapigs), 566
Ion currents, vasodilating actions of E4080,smooth muscle cells, portal vein (rab-bits), 1396
!onophore
-induced stimulation of renin secretion,chemiosmotic hypothesis (rabbits),211
NMDA receptor, heterogeneity, brain(rats), 86
Iqbal, A., see Rubanyi, G., 639Isaac, L., see Stewart, P., 608Ischemia
reduction ofdeath of hippocampalpyram-idal neurons, monosialogangliosides(rats), 452
reduction of infarct size by aprikalim, ab-sence of hemodynamic changes(dogs), 961
Ishii, K., Warner, T. D., Sheng, H. andMurad, F. Endothelin increasescyclic GMP levels in LLC-PK1 pro-cine kidney epithelial cells via for-mation of an endothelium-derived re-laxing factor-like substance, 1102
Ishizaki, T., see Echizen, H., 953Isobutyl nitrite, vascular nitric oxide-gen-
1991 Index 1415
erating activities, organic nitrites andnitrates, 519
Isoproterenol, chronic insulin treatment,
sympathetic activation (rats), 131Israel, Y., see Carmichael, F. J., 403Ito, H., see Miyata, K., 15, 815Itoh, H., see Bu#{241}ag,R. D., 131Ivins, K. J. and Molinoff, P. B. Desensiti-
zation and down-regulation of 5-HT2
receptors in P11 cells, 423Iwai, A., see Miyata, K., 15
Jackman, S., see Wonnacott, S., 387Jacobson, A. E., see Reith, M. E. A., 1188
Jacobson, K. A., see Nikokijevi#{233}, 0., 286James, M. K., Feldman, P. L., Schuster, S.
V., Bilotta, J. M., Brackeen, M. F.and Leighton, H. J. Opioid receptoractivity of GI 870MB, a novel ultra-short acting analgesic, in isolated tis-sues, 712
Janero, D. R., see Crowley, H. J., 78
Janssen, L. J. and Daniel, E. E. Depolarizingagents induce oscillations in canine
bronchial smooth muscle membrane
potential: Possible mechanisms, 110
Jaouen, M., see Pons, C., 1328Jeannin, L., see Camus, P., 1247Johns, R. A., see Rengasamy, A., 310Johnson, M. D., Wang, H.-Y., Ciechan-
owski, D. and Friedman, E. ReducedG protein function in desensitized rataorta, 255
Jones, P. H., see Perkins, W. E., 1004Jones, S. M., see Rogawski, M. A., 30Joshi, S. N., Lonigro, A. J., Secrest, R. J.
and Chapnick, B. M. Role of endo-thelium in responses of isolated he-
patic vessels to vasoactive agents, 71Jusko, W. J., see Haughey, D. B., 826
Kaczorowski, G. J., see Suarez-Kurtz, G.,439
Kageyama, M., Mori, T., Yanagisawa, T.and Taira, N. Is staurosporine a spe-cific inhibitor of protein kinase C in
intact porcine coronary arteries, 1019
Kagey-Sobotka, A., see Bascom, R., 1323Kajioka, S., see Kamouchi, M., 1396Kalivas, P. W., see Steketee, J. D., 916Kamato, T., see Miyata, K., 15, 815Kamouchi, M., Xiong, Z., Teramoto, N.,
Kajioka, S., Okabe, K. and Kitamura,K. Ionic currents involved in vasodi-lating actions of E4080, a newly syn-tesized bradycardia-inducing agent,in dispersed smooth muscle cells ofthe rabbit portal vein, 13, 96
Kao, J., see Mann, W. A., 1231Karasawa, Y., see Ren, L.-M., 38
Kastin, A. J., see Banks, W. A., 988Katsume, H., see Shirayama, T., 884Katsuragi, T., Tokunaga, T., Ogawa, S.,
Soejima, 0., Sato, C. and Furukawa,T. Existence ofATP-evoked ATP re-
lease system in smooth muscles, 513
Katsuyama, Y., see Miyata, K., 15, 815Katz, J. L., see Lamb, R. J., 1165Kawaguchi, Y., see Matsushita, H., 620Kawai, C., see Shirotani, M., 738Kawai, Y., see Ikomi, F., 365K562 cells, homologous downregulation,
thromboxane A2 receptors, 228Kerr, J. E., see Levy, A. D., 495Ketoconazole, methylprednisolone phar-
macokinetics, receptor/gene-me-
diated pharmacodynamics (rats), 826Kidney
N-acetyl-L--y-glutamyl prodrugs (rats),
766age-related changes, vascular sympathetic
neurotransmission (rats), 176
alpha-2C adrenoceptors, OK cell line, 323arylamine carcinogen N-acetyltransferase
isozymes, tumor target organ cytosols
(hamsters), 699detection of human hepatitis anti-liver
microsomes autoantibodies, liver sec-tions (rats), 1328
elimination of sulotroban (dogs), 1231
excretion, zidovudine, inhibition of glu-
curonidation (rats, humans), 1261function, effects of endothelin-3 (dogs),
1256
mechanism ofvancomycin transport (rab-
bits), 1283
medullary collecting duct cells, alpha-iadrenergic receptors (rabbits), 1081
proximal nephron and renal transport,inhibitory potency, PD123177 and
DUP 753 (rats), 687pulmonary endothelial aminopeptidase P
activity, species variation (cattle, hu-mans, rats, rabbits, cats, minipigs),
1301
release of platelet-activating factor, no
link to prostaglandin production
(rats), 590renal membranes, dehydroabietic acid, p-
aminohippurate transport (rats), 156
Kim, S. G., Philpot, R. M. and Novak, R. F.Pyridine effects on P450I!E1, IIBand IVB expression in rabbit liver:Characterization of high- and low-affinity pyridine N-oxygenases, 470
KininsB1 receptors, hypotensive effects, lys-des-
arg�-bradykinin (rabbits), 997
pertussis toxin-insensitive biphasic re-sponse, bradykinin, circular muscleof ileum (guinea pigs), 659
Kinter, L. B., see Mann, W. A., 1231Kisara, K., see Sakurada, T., 205
Kitajima, Y., see Ingi, T., 968Kitamura, K., see Kamouchi, M., 1396
Klauser, R. J., Raake, W., Meinetsberger,E. and Zeiller, P. Antithrombotic and
anticoagulant properties of synthetic
polyanions: Sulfated bis-aldonic acidamides, 8
Knight, P. M., see Rudy, A. C., 1133
Koike, K., see Echizen, H., 953Kong, J.-Q., Taylor, D. A. and Fleming, W.
W. Antagonism of norepinephrine byclonidine in the isolated rat mesen-
teric vascular bed, 653Kowaluk, E. A. and Fung, H.-L. Vascualr
nitric oxide-generating activities fororganic nitrites and organic nitrates
are distinct, 519Kramer, T. H., see Weber, S. J., 1109
Kriegholm, E., see Arner, P., 317Krizsan-Agbas, D., see Bu#{241}ag,R. D., 131Kroemer, H. K., see Turgeon, J., 789Ksander, G., see Levens, N. R., 219Kuwahara, M., see Rego, A., 905
Labetalol, morphine administration, liver
metallothionein, zinc metabolism
(rats), 274Lacerda, A. E., see Rampe, D., 982
fl-Lactam, facilitated transport of cefodi-zime, central nervous system (rats),620
Lactobionic acid amides, synthetic poly-
anions, antithrombotic and antico-
agulant properties (humans), 8
Lain#{234}e, P., see Weissenburger, J., 871
Lale, A., see Herbert, J. M., 44
Lam, S. C. T., Dieter, J. P., Strebel, L. C.,Taylor, T. M., Muscolino, G., Fein-
berg, H. and Le Breton, G. C. Rapiddissociation of platelet-rich fibrin
clots in vitro by a combination of
plasminagen activators and anti-platelet agents, 1371
Lamb, R. J., Preston, K. L., Schindler, C.W., Meisch, R. A., Davis, F., Katz, J.L., Henningfield, J. E. and Goldberg,
S. R. The reinforcing and subjectiveeffects of morphine in post-addicts:
A dose-response study, 1165
Lambert, L. E., see French, J. F., 260
Lanoir, J., see Boulenguez, P., 1360
Laplace, M. C., see Herbert, J. M., 44
Lautt, W. W., see D’Almeida, M. S., 118Lawrence, M. S., see Elsworth, J. D., 595Lazzara, R., see Patterson, E., 558Le Breton, G. C., see Lam, S. C. T., 1371Lechat, P., see Starec, M., 745
Lee, E. H. Y., see Hu, S. C., 1379Lee, V. H. L., see Ashton, P., 719Leedham, J. A., Bennett, L. E., Taylor, D.
A. and Fleming W. W. Involvementof Mu, Delta and Kappa receptors in
morphine-induced tolerance in theguinea pig myenteric plexus, 295
Leedham, J. A., see Taylor, D. A., 1084
Le Fur, G., see Herbert, J. M., 44
Leighton, H. J., see James, M. K., 712Lemakalim, hyperpolarization of denerv-
ated skeletal muscle, antagonism, gli-benclamide and tolbutamide (mice),932
Lemos, J. R., see Wang, X., 705Lenz, D. E., see Broomfield, C. A., 633
Leon, A., see Skaper, S. D., 452Lespy, L., see Herbert, J. M., 44
Leukocytes, monomorphic arylamine N-acetyltransferase expression (hu-
mans), 1241
Leukotriene B4, specific binding sites, brainmembranes (guinea pigs), 1035
Levens, N. R., C#{243}te,D. and Ksander, G.Inhibition of thromboxane synthe-
tase potentiates the antihypertensiveaction of an angiotensin-convertingenzyme inhibitor by a prostaglandin-dependent but kinin-independent
mechanism, 219
Levobunolol, location of penetration and
metabolic barriers, corneal epithe-hum (rabbits), 719
Levy, A. D., Li, Q., Kerr, J. E., Rittenhouse,P. A., Milonas, G., Cabrera, T. M.,Battaglia, G., Sanz, M. C. A. and Van
De Kar, L. D. Cocaine-induced ele-
vation of plasma adrenocorticotropinhormone and corticosterone is me-
diated by serotonergic neurons, 495Lewis, M. H., see Elsworth, J. D., 595
Li, Q., see Levy, A. D., 495Lidocaine
arrhythmogenic activities, atrioventricu-
lar block (dogs), 871
1416 Index Vol. 259
rate-dependent effects, His-Purkinje con-
duction, neonatal heart (dogs), 535
Ligands
-binding properties, tachykinin receptors(rats), 968
cardiovascular effects of adenosine A2 ag-
onists (rats), 1203
heterogeneity of NMDA receptor iono-
phore complex, brain (rats), 86
sigma compounds derived from phency-
clidine (guinea pigs), 543
sigma receptor, multiple mechanisms, tailartery contractile responses (rats), 22
Linnik, M. D., Butler, B. T., Gaddis, R. R.
and Ahmed, N. K. Analysis of sero-tonergic mechanisms underlying
benzamide-induced gastroprokinesis,
501Lipid peroxidation, inhibition of binding of
PN200-i 10 to membranes, ascorbate,
brain and heart (rats), 337Liss, R., see Fischman, A. J., 1351
Liu, F.-Y., see Cogan, M. G., 687
Liverarylamine carcinogen N-acetyltransferase
isozymes, tumor target organ cytosols
(hamsters), 699
hepatic vessels, role of endothelium, vas-oactive agents (dogs), 71
human hepatitis anti-liver kidney micro-
somes autoantibodies (rats), 1328
metallothionein, zinc metabolism, mor-
phine administration (rats), 274protection from hepatic injury, lung
NADPH-cytochrome C-reductase,
polyriboinosinic acid-polyribocyti-
dilic acid (rats), 1059
pyridine effects, P45011E1, IIB and IVB
(rabbits), 470
Livni, E., see Fischman, A. J., 1351LLC-PK1 cells, cyclic GMP levels, forma-
tion, endothelium-derived relaxing
factor-like substance (pigs), 1102
Locomotor activity
central nervous system effects, acetate,ethanol (rats, mice), 403
development oftolerance to nicotine, gen-
otype influences (mice), 392Locus ceruleus, substantia nigra and, neu-
rotoxic effects, 1-methyl-4-phenyl-i,2,3,6-tetrahydropyridine (mice), 1379
Long, J. P., see Park, K. H., 1221Lonigro, A. J., see Joshi, S. N., 71Lopez, M. G., Abad, F., Sancho, C., de Pas-
cual, R., Borges, R., Maroto, R.,
Dixon, W. and Garcia, A. G. Mem-brane-mediated effects of the steroid
i7-a-estradiol on adrenal cat-
echolamine release, 279
Lorenzini, P., see d’Amore, A., 1308Lung
endothelial aminopeptidase P activity,
species variation (cattle, humans,
rats, rabbits, cats, minipigs), 1301identification of alpha-2 adrenoceptor
subtypes, alpha-2 adrenoceptor sub-
types, NCB2O cells (guinea pigs),1124
membranes, substance P binding, high-affinity NK-i receptors (guinea pigs),
146
NADPH-cytochrome C-reductase, poly-
riboinosinic acid-polyribocytidilic
acid, protection from hepatic injury(rats), 1059
oxygen-induced damage in newborns
(rats), 444perfusion model, dopamine clearance
(dogs), 1271
pharmacokinetics and metabolism, nilu-
tamide (rats), 1247Lupinetti, M., see Fitzgerald, G. A., 1043Luthin, D. R. and Cline, W. H. Evidence for
enhanced inhibitory modulation bycyclooxygenase products of noradre-
nergic neurotransmission in the mes-enteric vasculature of young sponta-
neously hypertensive rats, 1174Lymphatics, mesenteric, beta adrenocep-
tors, smooth muscle relaxation, 365Lys-des-Ar�-bradykinin, hypotensive ef-
fects, metabolically protected ago-fists, B1 receptors and kinins (rab-
bits), 997
Lysergic acid diethylamide, discriminative-
stimulus effects, serotonin bindingsites, quipazine and l-5-hydroxytryp-tophan (pigeons), 772
Lysosomes, up-regulation of sigma opioidreceptors, neuroblastoma hybridcells, 302
MacDonald, E., Scheinin, M., Scheinin, H.and Virtanen, R. Comparison of thebehavioral and neurochemical effectsof the two optical enantiomers of
medetomidine, a selective Alpha-2-adrenoceptor agonist, 848
Macleod, R., see Nattel, S., 939Maffrand, J. P., see Herbert, J. M., 44
Maggi, C. A., see Geppetti, P., 759
Magnesium, intravenous, ventricular ar-
rhythmias, acute myocardial infarc-
tion (dogs), 939
Mailman, R. B., see Elsworth, J. D., 595
Maiorino, R. M., Dart, R. C., Carter, D. E.
and Aposhian, H. V. Determinationand metabolism of dithiol chelatingagents. XII. Metabolism and phar-macokinetics of sodium 2,3-dimer-captopropane-i-sulfonate in hu-mans, 808
Maj, R., see Buonamici, M., 345Makujina, S. R., see Sabouni, M. H., 508
Mammalian cells, ligand-binding proper-
ties, tachykinin receptors (rats), 968
Man In’T Veld, A. J., see Boomsma, F., 551Mann, W. A., Welzel, G. E., Goldstein, R.
S., Sozio, R. S., Cyronak, M. J., Kao,J. and Kinter, L. B. Characterization
of the renal effects and renal elimi-
nation of sulotroban in the dog, 1231Manome, Y., see Sakurada, T., 205Mansour, H., see Coutant-Perronne, V.,
1059
Mansuy, D., see Pons, C., 1328Mantegani, S., see Buonamici, M., 345Mantegani, S., see Carfagna, N., 356
Manzini, S., see Geppetti, P., 759Marceau, F., see Drapeau, G., 997Marks, M. J., Campbell, S. M., Romm, E.
and Collins, A. C. Genotype influ-ences the development of tolerance
to nicotine in the mouse, 392
Markus, R. P., see Carneiro, R. C. G., 614Maroto, R., see Lopez, M. G., 279Marquetty, C., see Coutant-Perronne, V.,
1059
Martin, P., see Zini, R., 414Maruyama, M., see Auchampach, J. A., 961Massamiri, T. and Duckles, S. P. Sigma
receptor ligands inhibit rat tail artery
contractile responses by multiplemechanisms, 22
Massotti, M., see d’Amore, A., 1308Mast cells, environmental tobacco smoke,
intranasal capsaicin, symptoms and
mediator release (humans), 1323Matsunaga, K. and Furchgott, R. F. Re-
sponses of rabbit aorta to nitric oxideand superoxide generated by ultravi-olet irradiation of solutions contain-ing inorganic nitrite, 1140
Matsushita, H., Suzuki, H., Sugiyama, Y.,Sawada, Y., Iga, T., Kawaguchi, Y.and Hanano, M. Facilitated trans-port ofcefodizime into the rat centralnervous system, 620
Maxwell, D. M., see Broomfield, C. A., 633Mayer, E., see Cardoso, P. F. G., 1271Mays, D. C., Dixon, K. F., Balboa, A., Paw-
luk, L. J., Bauer, M. R., Nawoot, S.and Gerber, N. A nonprimate animalmodel applicable to zidovudine phar.macokinetics in humans: Inhibitionof glucuronidation and renal excre-tion of zidovudine pharmacokineticsin humans: Inhibition of glucuroni-dation and renal excretion of zido-vudine by probenecid in rats, 1261
Maze, M., see Schwinn, D. A., 1147McHale, R. J., see Belcheva, M. M., 302McKinney, M., see Miller, J. H., 601Medeiros, Y. S., see Calixto, J. B., 659Medetomidine, behavioral and neurochem-
ical effects (rats), 848Meinetsberger, E., see Klauser, R. J., 8Meisch, R. A., see Lamb, R. J., 1165
Melatonin, diurnal variation of vas deferens
contraction, presynpatic nicotinic re-ceptors (rats), 614
Membrane potential, nicotine-inducedchanges, tetraphenylphosphoniumaccumulation, cerebral cortical syn-aptosomes (rats), 1118
Memo, M., see Carruba, M. 0., 124Mercury, chelating agents, sodium 2,3-di-
mercaptopropane-1-sulfonate phar-macokinetics (humans), 808
Mesentery, vaseulature, enhanced inhibi-
tory modulation, cycbooxygenaseproducts (rats), 1174
Mestre, M., see Borg, C., 526Metallothionein, liver, zinc metabolism,
morphine administration (rats), 274Metaphit, dopaminergic neurotransmission,
striatal slices (rats), 1188
Methamphetamine, responses of extrapyr-
amidal and limbic neuropeptides,fenfluramine administration (rats),
1197
N-Methyl-D-aspartate, inhibition of re-sponses, 1,10-bis(guanidino)decane(rats), 626
3-Methylcholanthrene, oxygen-inducedlung damage in newborns (rats), 444
3,4-Methylenedioxymethamphetamine, -in-duced dopamine release, microdi-alysis studies (rats), 820
(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro- 1H-benzimidazolhy-
drochloride, see YMO6O
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri-
dine
D1 and D2 agonists and antagonists, dys-
kinesia, L-dopa (monkeys), 409
1991 Index 1417
neurotoxic effects, substantia nigra, locusceruleus (mice), 1379
Methylprednisolone, pharmacokinetics, ef-fect of ketoconazole, receptor/gene-
mediated pharmacodynamics (rats),
8265-Methylurapidil, reduction of cardiac out-
ward currents, alpha- 1 adrenoceptor
stimulation (rats), 783
Methylxanthine, treatment of smooth mus-
cle cells, modulation, adenylate cy-clase responsiveness, 925
Metoclopramide, benzamide-induced gas-troprokinesis, serotonergic mecha-
nisms (rats), 501Metoprolol, beta adrenoceptors, smooth
muscle relaxation, bovine mesentericlymphatics, 365
Mexiletine, disposition, influence of debri-
soquine phenotype, quinidine (hu-
mans), 789
Microtubule, -taxol interactions, effect of
alkaline pH, 855Milburn, M. R., see Purdy, R. E., 1316
Miller, J. H., Gibson, V. A. and McKinney,
M. Binding of [3H]AF-DX 384 tocloned and native muscarinic recep-
tors, 601
Miller, L. S., see Hem, D. W., 699
Miller, M. A., see Cribb, A. E., 1241
Miller, R. J., see Bleakman, D., 430Milonas, G., see Levy, A. D., 495Minamitake, Y., see Ingi, T., 968
Minhas, K., see Carmichael, F. J., 403Miosis, reinforcing and subjective effects of
morphine, post-addicts, 1165
Mironneau, C., see Rakotoarisoa, L., 164Mironneau, J., see Rakotoarisoa, L., 164
Miura, K., see Yamashita, Y., 1256Miyata, K., Kamato, T., Nishida, A., Ito,
H., Katsuyama, Y., Iwai, A., Yuki,
H., Yamano, M., Tsutsumi, R., Ohta,M., Takeda, M. and Honda, K. Phar-macologic profile of (R)-5-[(1-methyl-3indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-ben zimidazol Hydro-
chloride (YMO6O), a potent and se-
lective 5-hydroxytryptamine3 recep-
tor antagonist and its enantiomer inthe isolated tissue, 15
Miyata, K., Kamato, T., Yamano, M., Nish-ida, A., Ito, H., Katsuyama, Y., Yuki,
H., Tsutsumi, R., Ohta, M., Takeda,
M. and Honda, K. Serotonin (5-HT)3
receptor blocking activities ofYMO6O, a novel 4,5,6,7-tetrahydro-benzimidazole derivative, and its en-antiomer in anesthetized rats, 815
MK-801
anticonvulsant activity, 5-aminocar-
bonyl-10,11-dihydro-5H-dibenz[a,d}
cyclohepten -5,10-imine (mice, rats),30
heterogeneity of NMDA receptor iono-phore complex, brain (rats), 86
Moerike, K., see Turgeon, J., 789
Molinoff, P. B., see Collins, K. A., 337
Molinoff, P. B., see Ivins, K. J., 423Mondot, S., see Borg, C., 526Monn, J. A., see Rogawski, M. A., 30Monn, J. A., see Sacaan, A. I., 1366
Monoclonal antibodies, selective transport
of anti-transferrin receptor antibody,blood brain barrier (mice, rats, hu-
mans, cattle), 66
NG�Monomethyl L-arginine
effects of guanidino compounds (rats),
490
-induced pressor response, developmental
and established stages, sponta-
neously hypertensive rats, 52
Mono-N-dealkyldisopyramide, stereoselec-
tive disposition and metabolism, di-sopyramide, pediatric patients, 953
Monosialogangliosides, reduction of deathof hippocampal pyramidal neurons,
activation NMDA receptors (rats),
452Morel, A., see Boulenguez, P., 1360
Mori, T., see Kageyama, M., 1019Morin, D., see Zini, R., 414Moromizato, H., see Noguchi, K., 732
Morphinecontinuous naloxone infusion, increased
analgesic potency, mu agonists (rats),
582immune status and survival, Friend virus
(mice), 745
-induced tolerance in myenteric plexus,
mu/delta/kappa receptors (guineapigs), 295
intracerebroventricular release, adeno-
sine and adenosine 3’,S’-cyclic mon-
ophosphate, spinal cord (rats), 1013
lack of spinal antianalgesic activity, dy-
norphins (mice), 1073
liver metallothionein and zinc metabo-
lism (rats), 274
reinforcing and subjective effects, post-
addicts, 1165
Morrison, K. J. and Vanhoutte, P. M. In-
hibition of airway smooth muscle
tone by a phorbol ester in the guinea
pgi trachea: Role of epithelium and
receptor reserve of the contractile
agent, 198
Mott#{233}, G., see Weissenburger, J., 871
Mucus, production, pharmacological profile,
UP 5145-52 (rats), 190Murad, F., see Ishii, K., 1102
Murakami, M., see Ren, L.-M., 38
Murphy, T. J., see Blaxall, H. S., 323Muscle
gastrocnemius, intra-arterial epinephrine,
energy metabolism (rabbits), 458
longitudinalcalcitonin gene-related peptide, ileum
(guinea pigs), 947
morphine tolerance, GABA and myen-
teric plexus preparation (guinea
pigs), 1094
Muscle, skeletal, denervated, hyperpolari-zation by lemakalim, antagonism by
glibenclamide and tolbutamide(mice), 932
Muscle, smooth
airway, inhibition by phorbol ester, tra-
chea (guinea pigs), 198antagonism of norepinephrine, clonidine,
mesenteric vascular bed (rats), 653
ATP-evoked ATP release system (guinea
pigs), 513bronchial, membrane potential, depolar-
izing agents (dogs), 110
coronary artery, adenosine receptor-me-diated relaxation, inhibition of aden-
ylate cyclase (pigs), 508
detrusor, mechanical activity, potassium
channel blockers and cromakalim(guinea pigs), 1158
gastric myocytes, cisapride action, mus-
carinic receptors (guinea pigs), 1294
methylxanthine treatment, modulation,adenylate cyclase responsiveness, 925
portal vein, ionic currents, vasodilating
actions of E4080 (rabbits), 1396
relaxation, beta adrenoceptors, bovine
mesenteric lymphatics, 365
specific inhibitor of protein kinase C,
staurosporine, coronary arteries
(pig), 1019
spontaneous motility and tonus, charyb-
dotoxin and iberiotoxin, smooth
muscle tissues (guinea pigs), 439
vascular
actions of TA 3090, femoral and coro-
nary arteries (dogs), 639
guanine nucleotide-binding proteins,
desmethoxyverapamil binding (rats),
164inhibition ofproliferation, HA1077, 738
interleukin 1�3-induced depression, ni-
tric oxide synthase inhibitors (rats),
260Muscolino, G., see Lam, S. C. T., 1371
Mustafa, S. J., see Sabouni, M. H., 508
Myenteric plexuscalcitonin gene-related peptide, ileum
(guinea pigs), 947morphine-induced tolerance, mu/delta/
kappa receptors (guinea pigs), 295morphine-tolerant longitudinal muscle,
GABA effects (guinea pigs), 1094
Myers, A. C. and Undem, B. J. Functional
interactions between capsaicin-sen-
sitive and cholinergic nerves in the
guinea pig bronchus, 104
Myocardial infarction
acute, intravenous magnesium, ventricu-lar arrhythmias (dogs), 939
reduction of size, aprikalim, absence of
hemodynamic changes (dogs), 961
Myocardial ischemiaanti-ischemic actions of mechanistically
diverse agents, potassium channel
blockade (rats), 97intracoronary procaterol, beta-2 adreno-
ceptor stimulation (dogs), 732
Myocytes, gastric, contraction, cisapride ac-
tion on muscarinic receptors (guinea
pigs), 1294
NADPH-cytochrome C-reductase, lung, p0-
lyriboinosinic acid-polyribocytidilic
acid, protection from hepatic injury
(rats), 1059
Nagao, T., see Yamazaki, J., 52
Nakagawa, M., see Shirayama, T., 884
Nakahiro, M., Arakawa, 0. and Narahashi,
T. Modulation of -y-aminobutyric
acid receptor-channel complex by al-cohols, 235
Nakamura, H., see Echizen, H., 953
Nakanishi, S., see Ingi, T., 968
Nakazawa, H., see Ohrui, T., 371
Nakazawa, K., see Ohara-Imaizumi, M., 484
Naloxonecontinuous infusion, increased analgesic
potency, mu agonists (rats), 582dose-dependent increase in total power,
delta wave activity in EEG (rats), 464Naltrexone, up-regulation of sigma opioid
receptors, neuroblastoma hybridcells, 302
Naltrindole, selective antagonism, cyclic[D-
1418 Index Vol. 259
penicillamine2-D-penicillamine5] en-
kephalin (rats), 725
Narahashi, T., see Nakahiro, M., 235Narita, M., see Ren, L.-M., 38
Nash, J. F. and Brodkin, J. Microdialysis
studies on 3,4-methylenedioxyme-
thamphetamine-induced dopamine
release: Effect of dopamine uptake
inhibitors, 820
Nattel, S., Turmel, N., Macleod, R. andSolymoss, B. C. Actions of intrave-
nous magnesium on ventricular ar-
rythmias caused by acute myocardial
infarction, 939
Nawoot, S., see Mays, D. C., 1261
Neonate, heart, rate-dependent effects, li-
docaine (dogs), 535Nerve
cholinergic, capsaicin sensitivity, bron-
chus (guinea pigs), 104
sympathetic
activation, chronic insulin treatment
(rats), 131
constrictor responses, glucagon phar-macodynamics (cats), 118
Nerve terminals, cerebrocortex, GABAB re-
ceptors, inhibition of somatostatin
release (rats), 1153Neuroblastoma
identification of alpha-2 adrenoceptors
subtypes, SK&F 104078 and SK&F
104856, NCB2O cells and guinea pig
lung, 1124
mouse, rat glioma hybrid cell line, sigma-like binding sites, 479
Neuroblastoma hybrid cells, up-regulation,
sigma opioid receptors, 302Neurohypophysial terminals, inhibition of
calcium currents and peptide release,
ethanol (rats), 705
Neurokinin, substance P binding, high-af-
finity NK-i receptors, lung mem-
branes (guinea pigs), 146
Neurokinin A, capsaicin-sensitive and cho-
linergic nerves, functional interac-
tions, bronchus (guinea pigs), 104
Neurons
nigral, dopaminergic neurotransmission,
deprenyl (rats), 841
serotonergic, cocaine-induced elevation,
plasma adrenocorticotropin hormone
(rats), 495
Neuropeptides
extrapyramidal and limbic, fenfluramine
administration (rats), 1197
release from capsaicin-sensitive sensory
nerve fibers, arachidonic acid and
bradykinin, heart (guinea pigs), 759
Neuropeptide Y, differential inhibition,
chronotropic and inotropic re-
sponses, sympathetic and parasym-
pathetic stimulation (dogs), 38
Neurotransmission
cholinergic, action of potassium channel
openers, sulfonylurea receptors
(guinea pigs), 566
cocaine and tracheal epithelial function
(swine), 241
noradrenergic, enhanced inhibitory mod-
ulation, cyclooxygenase products(rats), 1174
vascular sympathetic, age-related
changes, norepinephrine (rats), 176
Neurotransmitters, sensitivity of cerebellar
Purkinje neurons, genetically epilep-
tic rats, 1008
NG1O8-15, sigma-like binding sites, 479Nichols, D. E., see Elsworth, J. D., 595
Nicorandil, potassium channel opening,
guanylate cyclase stimulation, vaso-
relaxation (rats), 526Nicotine
development of tolerance, genotype influ-
ences (mice), 392-induced changes in membrane potential,
tetraphenylphosphonium accumula-
tion, cerebral cortical synaptosomes(rats), 1118
Nies, A. S., Tunney, A., Barden, A., Sturm,
M. and Vandongen, R. Release ofplatelet activating factor by the iso-lated kidney is not linked to the pro-duction of prostaglandins, 590
Nifedipine, hypoxic pulmonary vasocon-
striction, vanadate (rats), 666Nikodijevi#{234}, 0., Sarges, R., Daly, J. W. and
Jacobson, K. A. Behavioral effects ofA1- and A2-selective adenosine ago-nists and antagonists: Evidence for
synergism and antagonism, 286
Nilutamide, pharmacokinetics and metabo-
lism in lung (rats), 1247Nioka, S., see Argov, Z., 458Nishida, A., see Miyata, K., 15, 815Nisoli, E., see Carruba, M. 0., 124Nissbrandt, H., see Engberg, G., 841
Nitrates, organic, distinction from organic
nitrites, nitric oxide-generating ac-tivities, 519
Nitric oxide
effects of endothelin-3, renal function
(dogs), 1256effects of guanidino compounds, N’-mon-
omethyl L-arginine (rats), 490
formation of endothelium-derived relax-
ing factor-like substance, endothelin,increased cyclic GMP levels (pigs),
1102
-generating activities, organic nitrites, or-
ganic nitrates, 519NG�monomethyl�L�arginine�induced
pressor response, developmental and
established stages, spontaneously hy-pertensive rats, 52
responses of aorta, ultraviolet irradiationof solutions (rabbits), 1140
Nitric oxide synthase
endothelium-derived relaxing factor, bo-vine cerebellum, high and low oxygen
tensions, 310
inhibitors, interleukin 1�3-induced depres-
sion, vascular smooth muscle (rats),
260
Nitrobenzylthioguanosine, -sensitive and -
resistant nucleoside transport, Ehr-lich ascites tumor cells, 799
Nitroglycerin, vasorelaxation, nicorandil,
potassium channel opening (rats),
526Noguchi, K., Ojiri, Y., Chibana, T., Morom-
izato, H. and Sakanashi, M. Cardiaceffects of Beta-2 adrenoceptor stim-
ulation with intracoronary procaterolin the absence and presence of re-
gional myocardial ischemia in dogs,732
Noradrenaline, differential inhibition ofneuropeptide Y, chronotropic and in-otropic responses, atrium (dogs), 38
Nordmann, J. J., see Wang, X., 705Norepinephrine
age-related changes, vascular sympathetic
neurotransmission, kidney (rats), 176antagonism by clonidine, mesenteric vas-
cular bed (rats), 653enhanced inhibitory modulation, cycboox-
ygenase products, noradrenergic neu-rotransmission (rats), 1174
-induced constrictor responses, glucagonpharmacodynamics (cats), 118
mechanism of positive inotropy, low con-
centrations, strophanthidin (sheep),
182
oxidation products, binding to plasma
proteins, 551
reduced G protein function, desensitizedaorta (rats), 255
release and cocaine effects, developmental
shift from local to central control,cardiac-sympathetic axis (rats), 976
sensitivity of cerebellar Purkinje neurons,genetically epileptic rats, 1008
Novak, R. F., see Kim, S. G., 470Nuclear magnetic resonance, intra-arterial
epinephrine, energy metabolism, ex-ercising gastrocnemius muscle (rab-
bits), 458
Nucleoside, transport, nitrobenzylthiogu-anosine, Ehrlich ascites tumor cells,799
Nucleotides, functional studies in subman-dibular duct cell line, salivary glandreceptor subtype, 1344
Nye, H. E., Seidler, F. J. and Slotkin, T. A.Developmental shift from local to
central control of norepinephrine re-
lease in the cardiac-sympathetic axis:Effects of cocaine and related drugs,
976
Obama, T., see Ohara-Imaizumi, M., 484Ochiai, K., see Echizen, H., 953O’Donnell, M., Crowley, H. J., Yaremko, B.,
O’Neill, N. and Welton, A. F. Phar-macologic actions of Ro 24-5913, anovel antagonist of leukotriene D4,751
O’Donnell, M., see Crowley, H. J., 78Ogata, H., see Echizen, H., 953Ogawa, S., see Katsuragi, T., 513Ogita, K., see Yoneda, Y., 86Ohara-Imaizumi, M., Nakazawa, K., Ob-
ama, T., Fujimori, K., Takanaka, A.and Inoue, K. Inhibitory action ofperipheral-type benzodiazepines on
dopamine release from PC!2 pheo-chromocytoma cells, 484
Ohba, M., see Sakurada, T., 205Ohhashi, T., see Ikomi, F., 365Ohkawara, Y., see Ohrui, T., 371
Ohrui, T., Sekizawa, K., Yamauchi, K.,Ohkawara, Y., Nakazawa, H., Ai-kawa, T., Sasaki, H. and Takishima,T. Chemical oxidant potentiates elec-trically and acetylcholine-inducedcontraction in rat trachea: Possible
involvement of cholinesterase inhi-bition, 371
Ohta, M., see Miyata, K., 15, 815Oikari, A., see Pritchard, J. B., 156Ojiri, Y., see Noguchi, K., 732
Okabe, K., see Kamouchi, M., 1396Okumura, M., see Yamashita, Y., 1256Olfactory bulb, muscarinic stimulation,
1991 Index 1419
adenylate cyclase activity (rats), 673,680
Olianas, M. C. and Onali, P. Muscarinic
stimulation of adenylate cyclase ac-tivity ofrat olfactory bulb. I. Analysisof agonist sensitivity, 673
Olianas, M. C. and Onali, P. Muscarinicstimulation of adenlylate cyclase ac-tivity of rat olfactory bulb. II. Char-acterization of the antagonist sensi-tivity and comparison with musca-
rinic inhibitions of the enzyme instriatum and heart, 680
Onali, P., see Olianas, M. C., 673, 680
O’Neill, N., see O’Donnell, M., 751Opiates
opioid peptides and, antinociceptive ac-tion, area tempestas (rats), 1308
reinforcing and subjective effects of mor-
phine, post-addicts, 1165Opioids, distribution and analgesia, [3H][D-
Pen2,D-Pen5]enkephalin (mice), 1109
Orfanos, S. E., see Chen, X., 1301Organophosphorus, poisoning, protection
by butyrylcholinesterase, nonhuman
primates, 633Orrego, H., see Carmichael, F. J., 403Ortiz, L., see Banks, W. A., 988
Owyang, C., see Hasler, W. L., 1294
Oxygenhigh and low tensions, endothelium-de-
rived relaxing factor/nitric oxide syn-thase, 310
-induced lung damage, newborns (rats),
444
Oxymetazoline, imidazoline desensitization,epinephrine responses, vas deferens
(rats), 1182
Page, S. 0., see Schwinn, D. A., 1147
Pardridge, W. M., Buciak, J. L. and Friden,
P. M. Selective transport of an anti-transferrin receptor antibody
through the blood-brain barrier in
vivo, 66
Parish, D. W., see Su, T.-P., 543
Park, C. S., Honeyman, T. W., Ha, S. K.,Choi, H. K., Chung, C. L. and Hong,
C. D. Mechanisms of ionophore-in-duced stimulation of renin secretion
with special regerence to a chemios-
motic hypothesis, 211Park, K. H., Long, J. P. and Cannon, J. G.
Evaluation ofthe central and periph-
eral components for induction of pos-
tural hypotension by guanethidine,clonidine, dopamine2 receptor ago-
fists and 5-hydroxytryptamine1A re-
ceptor agonists, 1, 221Parkinson, A., see Thibeault, D. W., 444Parkinson’s disease, deprenyl, locomotor ac-
tivity, dopaminergic neurotransmis-
sion (rats), 841
Paronis, C. A. and Holtzman, S. G. In-creased analgesic potency of Mu ag-
onists after continuous naloxone in-
fusion in rats, 582
Patterson, E., Scherlag, B. J., Berlin, K. D.and Lazzara, R. Electrophysiological
actions of BRB-I-28 in canine myo-cardial tissues, 558
Patterson, G. A., see Cardoso, P. F. G., 1271Pawluk, L. J., see Mays, D. C., 1261
PC12 cells, inhibitory action of peripheral-type benzodiazepines, dopamine re-
lease, 484
P11 cells, desensitization and down-regula-tion, 5-HT2 receptors, 423
PD123177, DUP 753 and, inhibitory po-
tency, proximal nephron and renaltransport (rats), 687
Penin, E., see Weissenburger, J., 871Pentazocine, immune status and survival,
opiate and cocaine treatment, Friendvirus (mice), 745
Peptide, release, inhibition by ethanol, neu-
rohypophysial terminals (rats), 705
Pergolide, anti-inflammatory activity (rats),169
Perkins, W. E., Burton, E. G., Tsai, B. S.,
Collins, P. W., Casler, J. J., Gasiecki,
A. F., Bauer, R. F., Jones, P. H. andGaginella, T. S. SC-46275: A potent,
long-acting gastric antisecretory
prostaglandin with low oral bioavail-
ability in the dog, 1004
Perrier, D., see Cardoso, P. F. G., 1271
Pertussis toxin
injection into AlO dopamine region, sen-sitization, psychostimulants andstress (rats), 916
-insensitive biphasic response, bradyki-fin, circular muscle of ileum (guinea
pigs), 659
Pessayre, D., see Deschamps, D., 894
pH, alkaline, taxol-microtubule interac-tions, 855
Phencyclidine, sigma compounds, PRE-084
(guinea pigs), 543Phillips, E. T., see Helke, C. J., 1335
Philpot, R. M., see Kim, S. G., 470Phorbol 12,13-dibutyrate, specific inhibitor
of protein kinase C, staurosporine,
coronary arteries (pig), 1019Phorbol ester, inhibition of airway smooth
muscle tone, trachea (guinea pigs),
198
Phorbol myristate acetate, hypoxic pulmo-
nary vasoconstriction, vanadate
(rats), 666
Phosphoinositide hydrolysisactivation of alpha- 1 adrenoceptors, dex-
medetomidine (rats), 1147
desensitization and down-regulation, 5-HT2 receptors, P11 cells, 423
metabotropic excitatory amino acid re-
ceptor agonist, intrastriatal injection,
contralateral turning (rats), 1366Pickles, R. J., see Roberts, M., 1050Pickoff, A. S., see Dise, T. L., 535Pineal gland, diurnal variation of vas def-
erens contraction, presynpatic nico-
tinic receptors (rats), 614
Pizzi, M., see Carruba, M. 0., 124
Plasma, protein binding, oxidation prod-
ucts, norepinephrine, 551
Plasminogen activators, antiplatelet agents
and, rapid dissociation, platelet-rich
fibrin clots (humans), 1371
Platelet-activating factorinduction of nonspecific desensitization,
bronchodilators (guinea pigs), 1
pharmacology of Ro 24-4736 (guinea pigs,
dogs, humans), 78receptor antagonist SR 27417 (rabbits,
humans), 44
release by kidney, no link to prostaglan-
din production (rats), 590
Plateletsdepletion, C5a-induced bronchoconstric-
tion, inhibition by H1 antagonist
(guinea pigs), 1213
homologous downregulation, thrombox-ane A2 receptors, K562 cells, 228
presystemic acetylation, aspirin (hu-
mans), 1043
-rich fibrin clots, dissociation, plasmino-gen activators and antiplatelet agents
(humans), 1371
Plotkin, S. R., see Banks, W. A., 988
PN200-110, inhibition of binding to mem-
branes, brain and heart, ascorbateand lipid peroxidation (rats), 337
Pocidalo, J.-J., see Coutant-Perronne, V.,1059
Pocidalo, J.-J., see Starec, M., 745Poirier, J. M., see Weissenburger, J., 871
Polyanions, synthetic, antithrombotic andanticoagulant properties (humans), 8
Polymorphism, arylamine carcinogen N-acetyltransferase isozymes, tumor
target organ cytosols (hamsters), 699
Polyriboinosinic acid, -polyribocytidilic
acid, lung NADPH-cytochrome C-re-
ductase, protection from hepatic in-
jury (rats), 1059
Pons, C., Dansette, P. M., Amar, C., Jaouen,M., Wolf, C. R., Gregeois, J., Horn-
berg, J. C. and Mansuy, D. Detectionof human hepatitis anti-liver kideny
microsomes (LKM2) autoantibodieson rat liver sections is predominantly
due to reactivity with rat liver P-450
liCli, 1328
Pop, R. D., see Cardoso, P. F. G., 1271
Portal vein, smooth muscle cells, ionic cur-
rents, vasodilating actions of E4080(rabbits), 1396
Positron emission tomography, pharmaco-
kinetics of ‘8F-labeled fluconazole,
candidal infections (rats, rabbits),
1351
Potassium channelblockade, anti-ischemic actions, mechan-
istically diverse agents (rats), 97
blockers and cromakalim, mechanical ac-tivity, detrusor smooth muscle
(guinea pigs), 1158
bronchial smooth muscle membrane po-tential, depolarizing agents (dogs),110
hyperpolarization of denervated skeletal
muscle, lemakalim, antagonism by
glibenclamide and tolbutamide(mice), 932
openersaprikalim, reduction of infarct size
(dogs), 961
nicorandil, vasorelaxation (rats), 526sulfonylurea receptors, small intestine
(guinea pigs), 566Pounds, J. J., see Hillard, C. J., 1118Prazosin
alpha- 1 adrenergic receptors, renal med-
ullary collecting duct cells (rabbits),
1081behavioral and neurochemical effects,
medetomidine (rats), 848
PRE-084, sigma compounds derived fromphencyclidine (guinea pigs), 543
Preservative, location of penetration and
metabolic barriers, levobunolol, cor-neal epithelium (rabbits), 719
Preston, K. L., see Lamb, R. J., 1165
Pritchard, J. B., Walden, R. and Oikari, A.
1420 Index Vol. 259
Dehydroabietic acid, a major anionic
contaminant of pulp mill effluent, re-
duces both active p-aminohippurate
transport and passive membrane
permeability in isolated renal mem-branes, 156
Probenecid, nonprimate animal model, zi-
dovudine pharmacokinetics in hu-
mans, 1261
Procaterol, intracoronary, beta-2 adreno-
ceptor stimulation, myocardial ische-
mia (dogs), 732
Propranolol, arrhythmogenic activities,atrioventricular block (dogs), 871
Prostaglandinenhanced inhibitory modulation, cycloox-
ygenase products, noradrenergic neu-
rotransmission (rats), 1174
hypotensive effects of lys-des-arg9-brady-
kinin, metabolically protected ago-
nists, B1 receptors for kinins (rab-
bits), 997
inhibition of thromboxane synthetase,
antihypertensive action, angiotensin-
converting enzyme (rats), 219pertussis toxin-insensitive biphasic re-
sponse, bradykinin, circular muscleof ileum (guinea pigs), 659
production, release of platelet-activatingfactor, kidney (rats), 590
SC-46275, low oral bioavailability (dogs),
1004
Prostaglandin E1 , plasminogen activatorsand antiplatelet agents, rapid disso-ciation, platelet-rich fibrin clots (hu-
mans), 1371
Protein kinase Chypoxic pulmonary vasoconstriction, van-
adate (rats), 666inhibition of airway smooth muscle tone,
phorbol ester, trachea (guinea pigs),
198specific inhibitor, staurosporine, coronary
arteries (pig), 1019Proteins, plasma, binding, oxidation prod-
ucts of norepinephrine, 551
Proud, D., see Bascom, R., 1323
Psychostimulants, stress and, sensitization,
pertussis toxin injection in AlO do-pamine region (rats), 916
Puech, A. J., see Zini, R., 414
Purdy, R. E. and Milburn, M. R. Evidenceagainst serotonin-induced endothe-
hum-dependent relaxation in bovinecoronary artery, 1316
Purkinje fibersmechanism of positive inotropy, low con-
centrations, strophanthidin (sheep),
182
neurons, sensitivity to neurotransimtters,
genetically epileptic rats, 1008Puskas, J., see Cardoso, P. F. G., 1271Pyridine, effects on P45011E1, IIB and IVB
expression, liver (rabbits), 470Pyrilamine, C5a-induced bronchoconstric-
tion, inhibition by H1 antagonist
(guinea pigs), 1213
Quinidine
arrhythmogenic activities, atrioventricu-
lar block (dogs), 871influence of debrisoquine phenotype,
mexiletine disposition (humans), 789
Quinpirole, monoaminergic receptors, hy-
pothalamic nuclei, feeding behavior
(rats), 124
Quipazine, l-5-hydroxytryptophan and, dis-criminative-stimulus effects, sero-
tonin binding sites (pigeons), 772
Raake, W., see Klauser, R. J., 8Radiolabeling, pharmacokientics of ‘8F-la-
beled fluconazole, candidal infections(rats, rabbits), 1351
Rady, J. J., Fujimoto, J. M. and Tseng, L.F. Dynorphins other than dynorphin
A(1-17) lack spinal antianalgesic ac-tivity but do act on dynorphin A(1-
17) receptors, 1073
Rafferty, M. F., see Drower, E. J., 725Raiteri, M., see Bonanno, G., 1153Rakotoarisoa, L., Mironneau, C., Sayet, I.
and Mironneau, J. Guanine nucleo-tide-binding proteins modulate des-
methoxyverapamil binding to cal-
cium channels in vascular smooth
muscle, 164Rampe, D. and Lacerda, A. E. A new site
for the activation of cardiac calciumchannels defined by the nondihydro-pyridine FPL 641176, 982
Ramwell, P. W., see Rego, A., 905Ramwell, P. W., see Thomas, G., 490Rapoport, H., see Swanson, K. L., 377Rapoport, H., see Wonnacott, S., 387
Rauwolscinealpha-2C adrenoceptors, opossum kidney,
OK cell line, 323identification of alpha-2 adrenoceptor
subtypes, SK&F 104078 and SK&F104856, NCB2O cells and guinea pig
lung, 1124Ravens, U., see Wang, X.-L., 783Ray, C., see Blaxall, H. S., 323Ray, S., see Fischman, A. J., 1351
Receptorsadenosine
methylxanthine treatment, smooth
muscle cells, 925
relaxation in coronary artery, inhibi-tion of adenylate cyclase (pigs), 508
D,L-a-aminO-3-hydrOxy-5-methyl-4-isOX-
azole propionate, presynaptic facili-tation, dopamine release (rats), 692
angiotensin!!
PD123177 and DuP 753, proximalnephron and renal transport (rats),687
pharmacology of DuP 532 (rats), 861anti-transferrin, selective transport
through blood-brain barrier (mice,
rats, humans, cattle), 66B1, kinins, hypotensive effects of lys-des-
arg�-bradykinin (rabbits), 997
benzodiazepine, cocaine, discrete regionsof brain (rats), 574
dopamine, pergolide, anti-inflammatoryactivity (rats), 169
dopamine Dl, regulation, striatal acetyl-
choline release (rats), 1064dopamine D2, induction, postural hypo-
tension (rats), 1221
dopamine D1 and D2dyskinesia, L-dopa (monkeys), 409spontaneous blink rate (monkeys), 595
GABA, channel complex, modulation byalcohols (rats), 235
GABAB, inhibition of somatostatin re-lease, cerebrocortex nerve terminals
(rats), 11535-HT2
desensitization and down-regulation,P11 cells, 423
i-(2,5-dimethoxy-4-iodophenyl)-2-
aminopropane, modification of car-diovascular function (rats), 1027
increased renin secretion and bloodpressure, DOl (rats), 58
5-HT3, blocking activities of YMO6O(rats), 815
5-HT1A, induction, postural hypotension
(rats), 1221
5-HT1�2, agonists, thoracic spinal cord(rats), 1335
5-HT1B and 5-HTLD, pharmacological
characterization, serotonin-O-car-boxymethyl-glyceryl-tyrosinamide
(rats, guinea pigs), 1360leukotriene B4, specific binding sites,
brain membranes (guinea pigs), 1035leukotriene D4, pharmacologic actions, Ro
24-5913 (humans, guinea pigs), 751metabotropic excitatory amino acid, in-
trastriatal injection, contralateralturning (rats), 1366
N-methyl-D-aspartatedeath of hippocampal pyramidal neu-
rons, reduction by monosialoganglio-sides (rats), 452
excitatory amino acids, breathing re-quirements in ventrolateral medulla
(cats), 1388
inhibition of responses, 1,10-
bis(guanidino)decane (rats), 626ionophore complex, brain (rats), 86regulation, striatal acetylcholine re-
lease (rats), 1064
methylprenisolone, effect of ketocona-zole, gene-mediated pharmacody-namics (rats), 826
monoaminergic, hypothalamic nuclei,feeding behavior (rats), 124
muscarinicadenylate cyclase activity, olfactory
bulb (rats), 673, 680
binding of AF-DX 384 (rats), 601
cisapride, contraction of gastric myo-
cytes (guinea pigs), 1294
neurokinin 1, substance P analogs, spinalcord (mice), 205
neurotransmitter, cocaine, tracheal epi-
thelial function (swine), 241
nicotinic, diurnal variation of vas defer-ens contraction, pineal function
(rats), 614
nicotinic acetylcholine, anatoxin analogs,377, 387
NK-1, substance P binding, lung mem-branes (guinea pigs), 146
opioid
activity in isolated tissues (guinea pigs,rats, mice), 712
antinociceptive action, area tempestas
(rats), 1308opioid delta, selective antagonism by nal-
trindole (rats), 725opioid epsilon and kappa, inhibition of
tail-flick response, bremazocine(mice), 330
opioid mu/delta/kappa, morphine-in-duced tolerance, myenteric plexus(guinea pigs), 295
opioid sigmacompounds derived from phencyclidine
(guinea pigs), 543hybrid cell line NG1O8-15, 479
1991 Index 1421
ligands that inhibit artery contractileresponses (rats), 22
up-regulation, neuroblastoma hybrid
cells, 302
platelet-activating factor
antagonist, SR 27417 (rabbits, hu-
mans), 44
pharmacology, Ro 24-4736 (guinea pigs,
dogs, humans), 78
reserve, inhibition of airway smooth mus-
cle tone, phorbol ester (guinea pigs),
198
salivary gland, subtype, nucleotides, 1344
sulfonylurea, action of potassium channel
openers, small intestine (guinea
pigs), 566
tachykinin, ligand-binding properties,
cloned cDNAs in mammalian cells
(rats), 968
thromboxane A2, homologous downregu-lation, K562 cells, 228
Reddy, N., see Thibeault, D. W., 444
Redmond, D. E., Jr., see Elsworth, J. D., 595
Regal, J. F., see Fraser, D. G., 1213
Rego, A., Vargas, R., Cathapermal, S., Ku-
wahara, M., Foegh, M. L. and Ram-well, P. W. Systemic vascular effectsof cyclosporin A treatment in nor-
motensive rats, 905
Reith, M. E. A., Jacobson, A. E., Rice, K.C., Benuck, M. and Zimanyi, I. Effect
of metaphit on dopaminergic neuro-
transmission in rat striatal slices: In-
volvement of the dopamine trans-
porter and voltage-dependent sodiumchannel, 1188
Ren, L.-M., Furukawa, Y., Karasawa, Y.,
Murakami, M., Takei, M., Narita, M.
and Chiba, S. Differential inhibitionof neuropeptide Y on the chrono-
tropic and inotropic responses tosympathetic and parasympatheticstimulation in the isolated, perfuse
dog atrium, 38
Rengasamy, A. and Johns, R. A. Character-ization of endothelium-derived relax-ing factor/nitric oxide synthase from
bovine cerebellum and mechanism ofmodulation by high and low oxygentensions, 310
Renin
cardiovascular effects of adenosine A2 ag-
onists, ligands (rats), 1203
increased secretion and blood pressure,
DO!, 5-HT2 receptors (rats), 58
inhibition of thromboxane synthetase,
antihypertensive action, angiotensin-converting enzyme (rats), 219
secretion, ionophore-induced stimulation,
chemiosmotic hypothesis (rabbits),
211
Renin-angiotensin system, pharmacology ofDuP 532 (rats), 861
Resin acids, dehydroabietic acid, p-amino-
hippurate transport, renal mem-
branes (rats), 156
Reye’s syndrome, inhibition by salicylicacid, oxidation, long chain fatty acids(mice), 894
Reynolds, I. J., Baron, B. M. and Edwards,M. L. 1,10-bis(Guanidino)decane in-
hibits N-methyl-D-aspartate re-
sponses in vitro and in vivo, 626Rhinitis, environmental tobacco smoke,
intranasal capsaicin, symptoms and
mediator release (humans), 1323
Rice, K. C., see Drower, E. J., 725Rice, K. C., see Reith, M. E. A., 1188
Rice, K. C., see Rogawski, M. A., 30
Rice, P. J., Hardin, J. C., Hamdi, A. andAbraham, S. T. Imidazoline desensi-tization of epinephrine responses inrat vas deferens, 1182
Rimcazole, sigma ligands, contractile re-
sponses (rats), 22
Ringel, I. and Horwitz, S. B. Effect of alka-
line pH on taxol-microtubule inter-
actions, 855
Ritanserin, increased renin secretion andblood pressure, DO!, 5-HT2 receptors(rats), 58
Rittenhouse, P. A., Bakkum, E. A. and Van
De Kar, L. D. Evidence that the se-rotonin agonist, DOI, increases reninsecretion and blood pressure through
both central and peripheral 5-HT2receptors, 58
Rittenhouse, P. A., see Levy, A. D., 495
Ro 09-0198, stimulation of sodium trans-port, duramycin, colonic epithelia
(humans), 1050
Ro 24-4736, pharmacology (guinea pigs,dogs, humans), 78
Ro 24-5913, pharmacologic actions (hu-mans, guinea pigs), 751
Roberts, M., Hladky, S. B., Pickles, R. J.
and Cuthbert, A. W. Stimulation of
sodium transport by duramycin in
cultured human colonic epithelia,
1050
Roberts, S. P., see Hieble, J. P., 643
Robertson, G. S., see Damsma, G., 1064
Rogawski, M. A., Yamaguchi, S-I., Jones,S. M., Rice, K. C., Thurkauf, A. and
Monn, J. A. Anticonvulsant activity
of the low-affinity uncompetitive N-
methyl-D-aspartate antagonist (±)-5-
aminocarbonyl-10,i i-dihydro-5H-di-
benzo[a,d]cyclohepten-5,10-imine(ADCI): Comparison with the struc-
tural analogs dizocilpine (MK-801)
and carbamazepine, 30
Romm, E., see Marks, M. J., 392Roncucci, R., see Carfagna, N., 356Rossi, A. C., see Buonamici, M., 345
Rossi, A. C., see Carfagna, N., 356
Roth, R. H., see Elsworth, J. D., 595
Rouleau, J. R., see Turgeon, J., 789Rouveix, B., see Coutant-Perronne, V., 1059
Rouveix, B., see Starec, M., 745
RP 52891, see Aprikalim
Ru 486, morphine administration, liver me-tallothionein, zinc metabolism (rats),
274
Rubanyi, G., Iqbal, A., Schwartz, A. and
Vanhoutte, P. M. Vascular actions ofTA3090, a novel analog of diltiazem:
Interaction with endothelium-de-
pendent relaxation in canine femoraland coronary arteries, 639
Rubin, R. H., see Fischman, A. J., 1351
Rudy, A. C., Knight, P. M., Brater, D. C.and Hall, S. D. Stereoselective me-
tabolism of ibuprofen in human: Ad-
ministration of R-, S- and racemic
ibuprofen, 1133Ruffolo, R. R., Jr., see Hieble, J. P., 643
Rustan, T. D., see Hem, D. W., 699Ryan, J. W., see Chen, X., 1301
Sabouni, M. H., Cushing, D. J., Makujina,
S. R. and Mustafa, S. J. Inhibition ofadenylate cyclase attenuates adeno-
sine receptor-mediated relaxation in
coronary artery, 508Sacaan, A. I., Monn, J. A. and Schoepp, D.
D. Intrastriatal injection of a selec-
tive metabotropic excitatory amino
acid receptor agonist induces contra-
lateral turning in the rat, 1366Saha, J. K., Sengupta, J. N. and Goyal, R.
K. Effects of bradykinin and brady-
kinin analogs on the opossum lower
esophageal sphincter: Characteriza-
tion of an inhibitory bradykinin re-
ceptor, 265
Sakanashi, M., see Noguchi, K., 732Sakurada, S., see Sakurada, T., 205Sakurada, T., Yamada, T., Tan-No, K.,
Manome, Y., Sakurada, S., Kisara,
K. and Ohba, M. Differential effects
of substance P analogs on neurokinin
1 receptor agonists in the mouse
spinal cord, 205
Saldivia, V., see Carmichael, F. J., 403Salicylic acid, inhibition of activation, oxi-
dation of long chain fatty acids,
Reye’s syndrome (mice), 894
Salivary gland, functional studies in sub-
mandibular duct cell line, subtype,
nucleotides, 1344
Sancho, C., see Lopez, M. G., 279Sandrin, S., see Carmichael, F. J., 403
Sanz, M. C. A., see Levy, A. D., 495
Sarcoplasmic reticulum, bronchial smooth
muscle membrane potential, depolar-
izing agents (dogs), 110
Sargent, C. A., Smith, M. A., Dzwonczyk,
S., Sleph, P. G. and Grover, G. J.
Effect of potassium chnnel blockade
on the anti-ischemic actions of me-
chanistically diverse agents, 97
Sarges, R., see Nikodijevi#{233}, 0., 286
Sasaki, H., see Ohrui, T., 371
Sato, C., see Katsuragi, T., 513
Savi, P., see Herbert, J. M., 44
Sawada, Y., see Matsushita, H., 620
Sawynok, J., see Sweeney, M. I., 1013
Sayet, I., see Rakotoarisoa, L., 164
SC-46275, low oral bioavailability (dogs),
1004
Schalekamp, M. A. D. H., see Boomsma, F.,
551
Scheinin, H., see MacDonald, E., 848Scheinin, M., see MacDonald, E., 848
Scherlag, B. J., see Patterson, E., 558Schindler, C. W., see Lamb, R. J., 1165
Schoepp, D. D., see Sacaan, A. I., 1366
Schuster, S. V., see James, M. K., 712
Schwartz, A., see Rubanyi, G., 639
Schwinn, D. A., Correa-Sales, C., Page, S.0. and Maze, M. Functional effects
of activation of alpha-i adrenocep-
tors by dexmedetomidine: In vivo and
in vitro studies, 1147
Secrest, R. J., see Joshi, S. N., 71
Segu, L., see Boulenguez, P., 1360
Seidler, F. J., see Nye, H. E., 976
Seizures
anticonvulsant activity, 5-aminocar-
bonyl-10,11-dihydro-5H-dibenz[a,d]cyclohepten -5, 10-imine (mice, rats),
30
GABA-mediated inhibition in inferior
1422 Index Vol. 259
colliculus, potentiation by ethanol
(rats), 1288
Sekizawa, K., see Ohrui, T., 371Selegiline, locomotor activity, dopaminergic
neurotransmission, firing rate of ni-
gral dopamine neurons (rats), 841
Selig, W. M., see Crowley, H. J., 78
Sengupta, J. N., see Saha, J. K., 265
Serotoninagonist DO!, increased renin secretion
and blood pressure, 5-HT2 receptors(rats), 58
binding sites, discriminative-stimulus ef-
fects, quipazine and l-5-hydroxytryp-
tophan (pigeons), 772
cocaine-induced elevation, plasma adren-ocorticotropin hormone, corticoster-
one (rats), 495
ethanol-induced alterations, thermoregu-
lation, long-sleep and short-sleep
mice, 833
imipramine as a discrimnative stimulus(pigeons), 1088
-induced endothelium-dependent relaxa-tion, bovine coronary artery, 1316
intracerebroventricular morphine release,adenosine and adenosine 3’,5’-cyclic
monophosphate, spinal cord (rats),
1013
mechanisms underlying benzamide-in-duced gastroprokinesis (rats), 501
modification of cardiovascular function,1-(2,5-dimethoxy-4-iodophenyl)-2-
aminopropane (rats), 1027responses of extrapyramidal and limbic
neuropeptides, fenfluramine admin-
istration (rats), 1197Serotonin-O-carboxymethyl-glycyl-tyrosi-
namide, pharmacological character-ization (rats, guinea pigs), 1360
Shah, D. H., see Hieble, J. P., 643
Sharma, S. D., see Weber, S. J., 1109Sheng, H., see !shii, K., 1102
Shi, S.-Q., see Cardoso, P. F. G., 1271Shirayama, T., !noue, D., !noue, M., Tat-
sumi, T., Yamahara, Y., Asayama, J.,
Katsume, H. and Nakagawa, M.Electrophysiological effects of so-
dium channel blockers on guinea pig
left atrium, 884Shirotani, M., Yui, Y., Hattori, R. and Ka-
wai, C. A new type of vasodilator,HA1077, an isoquinoline derivative,
inhibits proliferation of bovine vas-
cular smooth muscle cells in culture,
738
Shukla, K., see Su, T.-P., 543
Simson, P. E., Criswell, H. E. and Breese,G. R. Ethanol potentiates -y-amino-butyric acid-mediated inhibition in
the inferior colliculus: Evidence for
local ethanol/’y-aminobuytyric acid
interactions, 1288
Sinclair, I., see Fischman, A. J., 1351
Sinet, M., see Starec, M., 745
Singh, N., see Hanson, G. R., 1197
Sirois, P., see De Brum-Fernandes, A. J.,1035
Skaper, S. D., Leon, A. and Facci, L. Deathof cultured hippocampal pyramidal
neurons induced by pathological ac-
tivation of N-methyl-D-aspartate re-ceptors is reduced by monosialogan-
gliosides, 452
SKF 10047, sigma-like binding sites, hybrid
cells line NG1O8-15, 479
SK&F 104078, SK&F 104856 and, alpha-2adrenoceptor subtypes, NCB2O cells
and guinea pig lung, 1124
SK&F 104856, functional subclassification,
alpha-2 adrenoceptors (dogs, rabbits,humans, guinea pigs), 643
Sleep, ethanol-induced alterations of ther-moregulation, serotonergic invovle-
ment (mice), 833Sleph, P. G., see Sargent, C. A., 97Slotkin, T. A., see Nye, H. E., 976
Smith, C. B., see Walker, E. A., 772
Smith, M. A., see Sargent, C. A., 97Smith, R. D., see Wong, P. C., 861Sodium, transport, duramycin, colonic epi-
thelia (humans), 1050Sodium 2,3-dimercaptopropane-1-sulfo-
nate, determination and metabolism(humans), 808
Sodium butyrate, up-regulation of sigmaopioid receptors, neuroblastoma hy-
brid cells, 302Sodium channel
blockers, electrophysiological effects,atrium (guinea pigs), 884
dopaminergic neurotransmission, effectof metaphit, striatal slices (rats),
1188
Soejima, 0., see Katsuragi, T., 513Sokol, P. P. Mechanism of vancomycin
transport in the kidney: Studies inrabbit renal brush border and baso-lateral membrane vesicles, 1283
Solana, R. P., see Broomfield, C. A., 633
Solymoss, B. C., see Nattel, S., 939
Somatostatin, inhibition of release, GABABreceptors, cerebrocortex nerve tar-minals (rats), 1153
Sonderfan, A. J., see Thibeault, D. W., 444Sotalol, arrhythmogenic activities, atrioven-
tricular block (dogs), 871Sozio, R. S., see Mann, W. A., 1231Spaethe, S. M., see Bendele, A. M., 169Spano, P., see Carruba, M. 0., 124
Sphincter, lower esophageal, bradykininand bradykinin analogs (opossums),265
Spielberg, S. P., see Cribb, A. E., 1241Spinal cord
dynorphin-induced depression, dorsalroot potential (rats), 608
intracerebroventricular morphine release,adenosine and adenosine 3’,S’-cyclicmonophosphate (rats), 1013
selective antagonism by naltrindole,
cydlic[D-penicillamine2-D-
penicillamine5j enkephalin (rats),
725substance P analogs, neurokinin 1 recep-
tor agonists (mice), 205
thoracic, 5-HT1c2 agonists (rats), 1335Spino, M., see Cardoso, P. F. G., 1271SR 27417, biochemical and pharmacological
activities (rabbits, humans), 44Stapelfeld, A., see Drower, E. J., 725Starec, M., Rouveix, B., Sinet, M., Chau, F.,
Desforges, B., Pocidalo, J.-J. and Le-chat, P. Immune status and survivalof opiate- and cocaine-treated miceinfected with friend virus, 745
Staurosporine
hypoxic pulmonary vasoconstriction, van-adate (rats), 666
specific inhibitor ofprotein kinase C, cor-onary arteries (pig), 1019
Steatosis, inhibition by salicylic acid, oxi-
dation, long chain fatty acids (mice),894
Steketee, J. D. and Kalivas, P. W. Sensiti-zation to psychostimulants and stressafter injection of pertussi toxin intothe AlO dopamine region, 916
Stewart, P. and Isaac, L. Dynorphin-in-duced depression of the dorsal rootpotential in rat spinal cord: A possi-
ble mechanism forpotentiation of theC-fiber reflex, 608
Stiles, G. L., see Stille, C. J., 925Stille, C. J. and Stiles, G. L. Methylxanthine
treatment of smoothmuscle cells dif-ferentially modulates adenylate cy-clase responsiveness, 925
Stolfi, A., see Dise, T. L., 535Stomach, cisapride action on muscarinic re-
ceptors, contraction, gastric myo-cytes (guinea pigs), 1294
Strauss, H. W., see Fischman, A. J., 1351Strebel, L. C., see Lam, S. C. T., 1371
Streptokinase, plasminogen activators andantiplatelet agents, rapid dissocia-
tion, platelet-rich fibrin clots (hu-mans), 1371
Stress
morphine administration, liver metallo-thionein, zinc metabolism (rats), 274
psychostimulants and, pertussis toxin in-
jection, AlO dopamine region (rats),916
Striatumacetylcholine release, dopaminergic regu-
lation, Dl and NMDA receptors(rats), 1064
dopaminergic neurotransmission, effectof metaphit (rats), 1188
3,4-methylenedioxymethamphetamine,
induced dopamine release, microdi-alysis studies (rats), 820
muscarinic stimulation, adenylate cyclase
activity, olfactory bulb (rats), 680responses of extrapyramidal and limbic
neuropeptides, fenfluramine adinin-istration (rats), 1197
synaptosomes, dopamine release, D,L-a-
amino-3-hydroxy-5-methyl-4-isoxa-zole propionate receptors (rats), 692
Strophanthidin, low concentrations, mech-anism, positive inotropy (sheep), 182
Sturm, M., see Nies, A. S., 590
Su, T.-P., Wu, X.-Z., Cone, E. J., Shukla,K., Gund, T. M., Dodge, A. L. andParish, D. W. Sigma compounds de-rived from phencyclidine: Identifica-tion of PRE-084, a new, selective
Sigma ligand, 543Suarez-Kurtz, G., Garcia, M. L. and Kac-
zorowski, G. J. Effects of charybdo-toxin and iberiotoxin on the sponta-neous motility and tonus of differentguinea pig smooth muscle tissues, 439
Submandibular duct cells, functional stud-
ies, receptor subtype, nucleotides,
1344
Substance Panalogs, neurokinin 1 receptor agonists,
spinal cord (mice), 205binding to high-affinity NK-i receptors,
lung membranes (guinea pigs), 146capsaicin-sensitive and cholinergic
1991 Index 1423
nerves, functional interactions, bron-chus (guinea pigs), 104
responses of extrapyramidal and limbicneuropeptides, fenfluramine admin-
istration (rats), 1197
Substantia nigradeprenyl, locomotor activity, dopami-
nergic neurotransmission (rats), 841locus ceruleus and, neurotoxic effects, 1-
methyl-4-phenyl-i,2,3,6-tetrahydro-
pyridine (mice), 1379
Sudden death, actions of intravenous mag-nesium, ventricular arrhythmias,acute myocardial infarction (dogs),939
Sufentanil, opioid receptor activity, GI
87084B (guinea pigs, rats, mice), 712
Sugiyama, Y., see Matsushita, H., 620Sulfhydryl, modifying agents, substance P
binding, lung membranes (guinea
pigs), 146Sulpizio, A. C., see Hieble, J. P., 643
Sultroban, renal effects and elimination(dogs), 1231
Sun, Y.-D. and Benishin, C. G. Effects ofcalcitonin gene-related peptide on
longitudinal muscle and myentericplexus of guinea pig ileum, 947
Sung, Y. J., see Hu, S. C., 1379Superoxide, responses of aorta, ultraviolet
irradiation of solutions (rabbits),1140
Suzuki, H., see Matsushita, H., 620Swanson, K. L., Aronstam, R. S., Wonna-
cott, S., Rapoport, H. and Albuquer-que, E. X. Nicotinic pharmacology ofanatoxin analogs. I. Side chain struc-ture-activity relationships at periph-
eral agonist and noncompetitive an-tagonist sites, 377
Swanson, K. L., see Wonnacott, S., 387Sweeney, M. I., White, T. D. and Sawynok,
J. Intracerebroventricular morphinereleases adenosine and adenosine 3’,5’-cyclic monophosphate from thespinal cord via a serotonergic mech-anism, 1013
Sympathetic nervous system, age-related
changes, neurotransmission, kidney
(rats), 176Synaptosomes
cerebral cortical, tetraphenylphosphon-ium accumulation, nicotine-induced
changes in membrane potential
(rats), 1118cerebrocortex nerve terminals, GABAB
receptors, inhibition of somatostatinrelease (rats), 1153
striatum, dopamine release, D,L-a-amino-3-hydroxy-5-methyl-4-isoxazole pro-
pionate receptors (rats), 692Szeto, H., see Grasing, K., 464
TA3090block of neuronal Ca� influx (rats), 430vascular actions, femoral and coronary
arteries (dogs), 639
Tachykinin
receptors, ligand-binding properties(rats), 968
substance P binding, high-affinity NK-1
receptors, lung membranes (guineapigs), 146
Tachyphylaxia, catecholarnine, beta adre-noceptors, adipose tissue (humans),317
Taira, N., see Kageyama, M., 1019
Takahashi, H., see Echizen, H., 953
Takanaka, A., see Ohara-!maizumi, M., 484Takeda, M., see Miyata, K., 15, 815Takei, M., see Ren, L.-M., 38Takishima, T., see Ohrui, T., 371Tang, A. H., Franklin, S. R., Himes, C. S.
and Ho, P. M. Behavioral effects ofU-78875, a quinoxalinone anxiolytic
with potent benzodiazepine antago-
nist activity, 248
Tan-No, K., see Sakurada, T., 205
Tatsumi, T., see Shirayama, T., 884Taxol, -microtubule interactions, effect of
alkaline pH, 855Taylor, D. A., Leedham, J. A., Bennett, L.
E. and Fleming, W. W. Effects of
GABA in the morphine-tolerant lon-
gitudinal muscle, myenteric plexuspreparation of the guinea pig, 1084
Taylor, D. A., see Gould, E. M., 1008
Taylor, D. A., see Kong, J.-Q., 653Taylor, D. A., see Leedham, J. A., 295
Taylor, J. R., see Elsworth, J. D., 595
Taylor, T. M., see Lam, S. C. T., 1371
Teramoto, N., see Kamouchi, M., 1396
Tetraphenylphosphonium, accumulation,
cerebral cortical synaptosomes, nic-otine-induced changes in membranepotential (rats), 1118
Tham, C.-S., see Damsma, G., 1064
Theophylline, A1- and A2-selective adeno-
sine agonists and antagonists, behav-
ioral effects (mice), 286
Thermoregulation, ethanol-induced altera-tions, serotonergic involvement,
long-sleep and short-sleep mice, 833Thibeault, D. W., Downing, G., Reddy, N.,
Sonderfan, A. J. and Parkinson, A.
Oxygen-induced lung damage in new-
born rats, potentiated by 3-methyl-
cholanthrene, a P-450 induceer, andlack ofprotection by cemetidine, a P-450 inhibitor, 444
Thijssen, H. H. W., see Drieman, J. C., 766Thomas, G. and Ramwell, P. W. Effects of
guanidino compounds on the endo-
thelium-derived relaxing factor in-
hibitor NG�monomethyl L-arginine,
490
Thor, K. B., see Helke, C. J., 1335
Thromboembolism, properties of syntheticpolyanions (humans), 8
Thromboxane, renal effects and elimina-tion, sulotroban (dogs), 1231
Thromboxane A2, presystemic acetylationof platelets, aspirin (humans), 1043
Thromboxane synthetase, inhibition andpotentiation of antihypertensive ac-tion, angiotensin-converting enzyme
inhibitor (rats), 219Thurkauf, A., see Rogawski, M. A., 30Tillement, J. P., see Zini, R., 414Timmermans, P. B. M. W. M., see Cogan,
M.G., 687
Timmermans, P. B. M. W. M., see Wong,
P. C., 861
Tobacco smoke, environmental, intranasalcapsaicin, symptoms and mediator
release (humans), 1323
Tokunaga, T., see Katsuragi, T., 513Tolbutamide, glibenclamide and, hyperpo-
larization of denervated skeletalmuscle, lemakalim (mice), 932
Tong, J., see Cardoso, P. F. G., 1271
Tonus, spontaneous motility and, charyb-dotoxin and iberiotoxin, smoothmuscle tissues (guinea pigs), 439
Tosyl-L-arginine methyl ester, environmen-
tal tobacco smoke, intranasal capsai-cm, symptoms and mediator release(humans), 1323
Townley, R. G., see Agrawal, D. K., 1
Trachea, acetylcholine-induced contraction,chemical oxidant, cholinesterase in-hibition (rats), 371
Tramontana, M., see Geppetti, P., 759
Transthyretin, oxidation products of nor-
epinephrine, binding, plasma pro-
teins, 551Treistman, S. N., see Wang, X., 705Tryptophan hydroxylase, ethanol-induced
alterations of thermoregulation, se-
rotonergic involvement, long-sleepand short-sleep mice, 833
Tsai, B. S., see Perkins, W. E., 1004
Tseng, L. F., see Rady, J. J., 1073
Tseng, L. F. and Collins, K. A. Involvementof Epsilon and Kappa opioid recep-
tors in inhibition of the tail-flick re-
sponse induced by bremazocine in the
mouse, 330
Tsutsumi, R., see Miyata, K., 15, 815
Tubulin, taxol-microtubule interactions, ef-fect of alkaline pH, 855
Tunney, A., see Nies, A. S., 590Turgeon, J., Fiset, C., Gigu#{232}re,R., Gilbert,
M., Moerike, K., Rouleau, J. R.,Kroemer, H. K., Eichelbaum, M.,
Grech-B#{233}langer, 0. and B�langer, P.M. Influence of debrisoquine pheno-type and of quinidine on mexiletinedisposition in man, 789
Turmel, N., see Nattel, S., 939Turner, J. T., see Yu, H., 1344Tyrosine aminotransferase, receptor/gene-
mediated pharmacodynamics, effectof ketoconazole, methylprednisolone
pharmacokinetics (rats), 826
U-78875, behavioral effects (rats), 248
Ultraviolet irradiation, responses of aorta,
nitric oxide and superoxide (rabbits),1140
Undem, B. J., see Myers, A. C., 104UP 5145-52, pharmacological profile, origi-
nal antiulcer and antisecretory agent
(rats), 190
Uridine, nitrobenzylthioguanosine-sensitive
and -resistant nucleoside transport,Ehrlich ascites tumor cells, 799
Valette, G., see Herbert, J. M., 44Valinomycin, ionophore-induce stimula-
tion, renin secretion, chemiosmotic
hypothesis (rabbits), 211Vanadate, hypoxic pulmonary vasoconstric-
tion (rats), 666Vancomycin, mechanism of transport, kid-
ney (rabbits), 1283Van De Kar, L. D., see Levy, A. D., 495Van De Kar, L. D., see Rittenhouse, P. A.,
58
Vandongen, R., see Nies, A. S., 590
Vanhoutte, P. M., see Morrison, K. J., 198
Vanhoutte, P. M., see Rubanyi, G., 639Vargas, R., see Rego, A., 905
Vas deferens
ATP-evoked ATP release system (guinea
pigs), 513contraction, diurnal variation, presyn-
1424 Index Vol. 259
aptic nicotinic receptors and pineal
function (rats), 614
imidazoline desensitization, epinephrineresponses (rats), 1182
opioid receptor activity, GI 87084B(guinea pigs, rats, mice), 712
Vasoactive agents, role of endothelium, he-
patic vessels (dogs), 71Vasoconstriction, hypoxic pulmonary, van-
adate (rats), 666Vasodilation
E4080, ionic currents, smooth muscle
cells of portal vein (rabbits), 1396
enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-
rotransmission (rats), 1174
Vasopressin
calcium currents and peptide release, in-
hibition by ethanol, neurohypophy-
sial terminals (rats), 705
modification of cardiovascular function,i-(2,5-dimethoxy-4-iodophenyl)-2-
aminopropane (rats), 1027
water diuretic effect, alpha adrenoceptor
agonist AGN 190851 (rats, dogs,
monkeys), 1277
Vasorelaxation, nicorandil, potassium chan-
nel opening, guanylate cyclase stim-
ulation (rats), 526Vassalle, M., see Aceto, E., 182
Vein, functional subclassification, alpha-2adrenoceptors (dogs, rabbits, hu-
mans, guinea pigs), 643
Ventrolateral medulla, excitatory aminoacids, requirements for breathing(cats), 1388
Vigano, T., see Geppetti, P., 759
Virtanen, R., see MacDonald, E., 848Voelkel, N. F. and Czartolomna, J. Vana-
date potentiates hypoxic pulmonary
vasoconstriction, 666
Walden, R., see Pritchard, J. B., 156
Walker, E. A., Yamamoto, T., Holling-
sworth, P. J., Smith, C. B. and
Woods, J. H. Discriminative-stimu-lus effects of quipazine and I-5-hy-droxytryptophan in relation to sero-
tonin binding sites in the pigeon, 772
Walton, D. P., see Abrahams, T. P., 1388
Wang, H.-Y., see Johnson, M. D., 255
Wang, W., see Ashton, P., 719
Wang, X., Dayanithi, G., Lemos, J. R.,
Nordmann, J. J. and Treistman, S.N. Calcium currents and peptide re-lease from neurohypophysial termi-nals are inhibited by ethanol, 705
Wang, X.-L., Wettwer, E., Gross, G. andRavens, U. Reduction of cardiac out-ward currents by Alpha-i adrenocep-
tor stimulation: A subtype-specificeffect?, 783
Warfarin, renal selective N-acetyl-L-y-glu-tamyl prodrugs (rats), 766
Warner, T. D., see Ishii, K., 1102Water, diuretic effect, alpha adrenoceptor
agonist AGN 190851 (rats, dogs,
monkeys), 1277
Webb, D., see Fischman, A. J., 1351
Webb, R. L., Barclay, B. W. and Graybill,S. C. Cardiovascular effects of aden-
osine A2 agonists in the consciousspontaneously hypertensive rat: A
comparative study of three structur-ally distinct ligands, 1203
Weber, S. J., Greene, D. L., Sharma, S. D.,Yamamura, H. I., Kramer, T. H.,Burks, T. F., Hruby, V. J., Hersh, L.
B. and Davis, T. F. Distribution andanalgesia of [3H][D-Pen2,D-Pen5]en-
kephalin and two halogenated ana-
logs after intravenous administra-
tion, 1109Weiner, N., see French, T. A., 833
Weiss, S., see Fischman, A. J., 1351
Weissenburger, J., Davy, J.-M., Ch#{233}zalviel,
F., Ertzbischoff, 0., Poirier, J. M.,
Engel, F., Lain#{233}e, P., Penin, E.,
Mott#{233},G. and Cheymol, G. Arrhyth-mogenic activities of antiarrhythmic
drugs in conscious hypokalemic dogs
with atrioventricular block: Compar-
ison between quinidine, lidocaine,
flecainide, propranolol and sotalol,871
Welton, A. F., see Crowley, H. J., 78
Welton, A. F., see O’Donnell, M., 751Welzel, G. E., see Mann, W. A., 1231Wettwer, E., see Wang, X.-L., 783
Wexler, R. R., see Wong, P. C., 861
White, T. D., see Sweeney, M. I., 1013
Wolf, C. R., see Pons, C., 1328Wong, P. C., Hart, S. D., Chiu, A. T., Her-
blin, W. F., Carini, D. J., Smith, R.
D., Wexler, R. R. and Timmermans,P. B. M. W. M. Pharmacology of DuP532, a selective and noncompetitiveAT1 receptor antagonist, 861
Wong, P. C., see Cogan, M. G., 687Wonnacott, S., Jackman, S., Swanson, K.
L., Rapoport, H. and Albuquerque, E.x. Nicotinic pharmacology of ana-
toxin analogs. II. Side chain struc-ture-activity relationships at neu-ronal nicotinic ligand binding sites,387
Wonnacott, S., see Swanson, K. L., 377
Wood, M. D., see Hieble, J. P., 643
Woodhouse, D. P., see Aharony, D., 146Woods, J. H., see Walker, E. A., 772
Wu, X.-Z., see Su, T.-P., 543
Xanthines, A1- and A2-selective adenosine
agonists and antagonists, behavioral
effects (mice), 286Xiong, Z., see Kamouchi, M., 1396
Yamada, T., see Sakurada, T., 205Yamaguchi, S.-!., see Rogawski, M. A., 30Yamahara, Y., see Shirayama, T., 884
Yamamoto, K., see Yamashita, Y., 1256Yamamoto, T., see Walker, E. A., 772Yamamura, H. I., see Weber, S. J., 1109
Yamano, M., see Miyata, K., 15, 815Yamashita, Y., Yukimura, T., Miura, K.,
Okumura, M. and Yamamoto, K. Ef-fects of endothelin-3 on renal func-
tions, 1256Yamauchi, K., see Ohrui, T., 371Yamazaki, J., Fujita, N. and Nagao, T. No.
Monomethyl-D-arginine-induced
pressor response at developmentaland established stages in sponta-neously hypertensive rats, 52
Yanagisawa, T., see Kageyama, M., 1019Yaremko, B., see Crowley, H. J., 78Yaremko, B., see O’Donnell, M., 751YMO6O
pharmacologic profile (guinea pigs, dogs,rabbits, rats), 15
serotonin receptor blocking activities(rats), 815
Yohimbine, alpha-2C adrenoceptors, opos-
sum kidney, OK cell line, 323Yoneda, Y. and Ogita, K. Heterogeneity of
the N-methyl-D-aspartate receptorionophore complex in rat brain, asrevealed by ligand binding tech-niques, 86
Young, P., see Hieble, J. P., 643Yu, H. and Turner, J. T. Functional studies
in the human submandibular ductcell line, HSG-PA, suggest a secondsalivary gland receptor subtype fornucleotides, 1344
Yui, Y., see Shirotani, M., 738Yuki, H., see Miyata, K., 15, 815Yukimura, T., see Yamashita, Y., 1256
Zeiller, P., see Klauser, R. J., 8Zhang, L. and Barrett, J. E. Imipramine as
a discriminative stimulus, 1088Zidovudine, nonprimate animal model,
pharmacokinetics in humans, 1261Zimanyi, I., see Reith, M. E. A., 1188
Zini, R., Morin, D., Martin, P., Puech, A. J.and Tillement, J. P. Interactions offlerobuterol, and antidepressant drugcandidate, with Beta adrenoceptors
in the rat brain, 414
Zini, S., Ben-An, Y. and Ashford, M. L. J.
Characterization of sulfonylurea re-
ceptors and the action of potassium
channel openers on cholinergic neu-rotransmission in guinea pig isolated
small intestine, 566Zuzack, J. S., see Grant, T. L., 1158
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The Journal of Pharmacology & Experimental Therapeutics
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addressed to Dr. Eva King Killam or to the assigned Specific Field Editor.
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