Nepsy C. Ucag, PH IV B8-5-15Physical Incompatibility has been defned as a physical o che!ical in"eac"ion be"#een "#o o !oe ingedien"s #hich lead "o a $isibly ecogni%able change in "he&o! o& a goss pecipi"a"e, ha%e, o colo change. 'so(ce) Co!piled *ec"(e No"es&o Pha!ace("ical Che!is"y +, '-(g .(ali"y Con"ol 1/01a!ples) 1. 2o!e dosage-&o! incompatibilities !ay be "he es(l" o& (n#an"ed co!ple1a"ion eac"ions. 3o e1a!ple, so!e #idely (sed polye"hes '4#eens, Cabo#a1es, o P05s/ can &o! pecipi"a"es#i"h H-bond donos s(ch as phenols and cabo1ylic acids. '6e!ing"on 71s"0di"ion/7. Physical inco!pa"ibili"ies &e8(en"ly can be pedic"ed by 9no#ing "he che!ical chaac"eis"ics o& "he d(gs in$ol$ed. 3o e1a!ple, "he sodi(! sal"s o& #ea9 acids, s(ch as pheny"oin sodi(! o phenobabi"al sodi(!, pecipi"a"e as &ee acids #hen added "o in"a$eno(s :(ids #i"h an acidic pH.'6e!ing"on 71s"0di"ion/+. Calci(! sal"s pecipi"a"e #hen added "o an al9aline !edi(!. In;ec"ions "ha" e8(ie a special dil(en" &o sol(bili%a"ion, s(ch as dia%epa!, pecipi"a"e #hen added "o a8(eo(s sol("ions beca(se o& "hei lo# #a"e sol(bili"y. '6e!ing"on 71s"0di"ion/Chemical incompatibility is classifed as a eac"ion in #hich a $isible changes does no" occ(.2ince "hee is no $isible e$idence o& de"eioa"ion, "his "ype o& inco!pa"ibili"y e8(ies "ained, 9no#ledgeable pesonnel "o ecogni%e i", sho(ld i" occ(. 'so(ce) Co!piled *ec"(e No"es &o Pha!ace("ical Che!is"y +, '-(g .(ali"y Con"ol 1/ 01a!ples)1. Ce"ain che!ical inco!pa"ibili"ies ha$e been epo"ed in #hich "he flle in"e&eed #i"h "he bioa$ailabili"y o& "he d(g as in "he case o& calci(! phospha"e and "e"acycline ? and "he eac"ion o& ce"ain a!ine bases #i"h lac"ose in "he pesence o& !agnesi(! s"eaa"e. '*iebe!ann, *ach!an and 2ch#a"%, Pha!ace("ical -osage 3o!s 4able"s, Vol. 1/7. 4he eady ed(cibili"y o& sil$e ion "o ele!en"al sil$e gi$es ise "o $aio(s ins"abili"y poble!s and inco!pa"ibili"ies. Beca(se sil$e co!po(nds ae ligh" sensi"i$e, "hey !(s" be po"ec"edby "he (se o& ligh"-esis"an" con"aines. 4he sol(ble sil$e sal"s ae "o1ic. Ho#e$e, "he "o1ici"y (s(ally is li!i"ed, o#ing "o local pecipi"a"ion o& adheen" layes o& sil$e po"ein and sil$e chloide. '6e!ing"on 71s"0di"ion/Nepsy C. Ucag, PH IV B8-5-15+. Peo1ide i!p(i"ies in poly!es !ay ca"aly%e o1ida"i$e degada"ion eac"ions #i"h d(gs, incl(ding po"eins, "ha" ae o1ygen sensi"i$e. '6e!ing"on 71s"0di"ion/Therapeutic incompatibility has been defned as an (ndesiable pha!acological in"eac"ion be"#een "#o o !oe ingedien"s #hich lead "o 1. po"en"ia"ion o& "he "heape("ic e@ec"s o& "he ingedien"s, 7. des"(c"ion o& "he e@ec"i$eness o& one o& "he ingedien"s, o +. occ(ence o& a "o1ic !ani&es"a"ion #i"hin "he pa"ien". 'so(ce) Co!piled *ec"(e No"es &o Pha!ace("ical Che!is"y +, '-(g .(ali"y Con"ol 1/01a!ples)1. 4able" pe&o!ance has been sho#n "o $ay &o 9e"oolac "o!e"ha!ine, depending (pon "he 9ind o& s"ach "ha" #as (sed. Cons"ach sho#ed a deceased disin"ega"ion "i!e and dissol("ion a"e as a &(nc"ion o& blending "i!e #heeas pegela"ini%ed s"ach sho#ed no s(ch dependency. 4he di@eence be"#een "hese "#o e1cipien"s #as a""ib("ed "o "he &o!a"ion o& d(gAcons"ach agglo!ea"es #i"h !agnesi(! s"eaa"e.'6e!ing"on 71s"0di"ion/7. Cas"o Bil and o"he f1ed oil sho(ld no" be gi$en #i"h san"onin o aspidi(! oleoesin as "he oil inceases "he sol(bili"y o& "he ac"i$e pinciple and "h(s incease"hei "o1ici"y.2o(ce) h""p)AA1is"so(ce.blogspo".co!A7+1>A>CApha!acy-inco!pa"ibili"y-"heape("ic.h"!lD!E1+. 612odii salicyla"is FFFF..FF ii o%Hydag. Chloid. Gi"is FF.. 1ii gG. &". p(l$. H1ii2ig. Bne e$ey + ho(s.4he sodi(! salicyla"e inceases "he sali$a"ing po#e o& calo!el. and "he dose o& "he la""e, consideing "he &e8(ency o& ad!inis"a"ion, is 8(es"ionable "ho(gh no" necessaily dangeo(s.h""p)AA1is"so(ce.blogspo".co!A7+1>A>CApha!acy-inco!pa"ibili"y-"heape("ic.h"!lD!E1