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Imunologia Carlos Sinogas 2019/20 IMUNOLOGIA COMPLEXO MAJOR DE HISTOCOMPATIBILIDADE (MHC) - parte I

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IMUNOLOGIACOMPLEXO MAJOR DE HISTOCOMPATIBILIDADE(MHC)- parte I

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MHC

• MHC – Major Histocompatibility Complex

• HLA – Human Leucocyte Antigen

Complexo major de histocompatibilidade

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MHC – superfamília Ig’s

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Genes MHC

• Cromosoma 6

• Região genómica: 7 x 106 bp

• > 200 genes• Heterozigóticos• Expressão co-dominante

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Locus de genes MHC (Homem)

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MHC tipo I e tipo II

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Poligenia e polimorfismo

• Poligénico• Vários genes com diversas especificidades para os antigénios

• Polimórfico• Múltiplas variantes do mesmo gene na população

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Polimorfismos

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Carlos Sinogas – Imunologia 2018/19

Diversidade

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Poligenia (co-dominância)

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Co-expressão de MHC’s

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Expressão dos genes MHC• Expressão individual:• 3 alelos MHC I

(A, B, C)• > 3 alelos MHC II

(DM, DR, DP, DQ)

• 6 proteínas MHC I• ~8 proteínas MHC II (várias combinações)

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Frequência dos MHC no homem

Classe II Classe IDPB1 DPA1 DMA DMB DQB1 DQA1 DRB1 DRA B C A

66 8 4 4 25 16 13 72 136 38 60

3 x 1014

População humana (hoje) » 7x109

3 x 1014 / 7 x 109 = >4 x 104 (40,000)

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Péptidos nos MHC

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Péptido posicionado no MHC

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MHC <> TCR

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