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Impact of Bioinformatics in our life and BME engineer

responsibility

Dr Fadhl Alakwaafadhl-alakwa.weebly.com

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The Central Dogma1

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TargetBookBook shelvesLibrary

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Protein Synthesis: DNA, RNA, and the Flow of Information

TranslationTranscription

Replication

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Protein synthesis mechanism

protein 1Gene 1

Gene 2 protein 2

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Protein synthesis mechanism

protein 1Gene 1

Gene 2 protein 2

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Protein synthesis mechanism

protein 1Gene 1

Gene 2 protein 2

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Protein synthesis mechanism

protein 1Gene 1

Gene 2 protein 2

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We know a little about this gene regulation mechanism

Gene Regulatory Network Slide 8/330

Protein synthesis mechanism

Gene 1

Gene 2

Balance Feedback Loop system

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Gene Regulatory Network Slide 9/330

Gene Regulatory Network “GRN”

Gene x

Gene x2

Gene x7

Gene x3

Gene x5

Gene x4

Gene x6

Gene x8

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Gene Regulatory Network Slide 10/330

Drug discovery

Gene x

Gene x2

Gene x7

Gene x3

Gene x6

Gene x8Gene x5

Gene x4

DRUG

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Gene regulation network5

If we have 40,000 genes how the mechanism looks like.

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Gene regulation network5

50k nodes and 250k esges

Gene Regulatory Network Slide 13/330

http://cytoscape.org/screenshots/26_ss1.png

Gene Regulatory Network Slide 14/330

500K nodes and 500k edges; 5GB of memory is used

OUTCOMESWhy our body is very complicated?

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Bioinformatics

Statistics

BiologyComputer Science

Chemistry

Data structuresSoftware engineering

(C, C++,PERL)

Cell structureGenome, genes

DNA, RNA

Protein structureMolecular bounds

Markof ModelNeural Network

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1 Summary

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• The subareas within bioinformatics include Genomics and Proteomics.

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Genome comparisonevolutionary tree

Microarray AnalysisGene predicationGene classificationGene regulation

Protein 3D predicationProtein protein interactionProtein alignment

2 Summary: Bioinformatics Subareas

Gene Regulatory Network Slide 18/337

خلق • مما االنسن فلينظرشي • كل أحسن خلقهء الذيتبصرون • افال انفسكم وفييتبين • حتى انفسهم وفي االفاق في آياتنا سنريهم

الحق انة لهمدونة • من الذين خلق ماذا فاروني اللة خلق هذا

3 Summary

Gene Regulatory Network 25/10/2008Slide 19/337

Gene Regulatory Network25/10/2008 Slide 20/337

خلقكم من اكبر والرض السموات لخلقانفسكم

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References

• http://biology.ucok.edu/bidlack/biology/notes.htm

• http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=genomes

• http://www.estrellamountain.edu/faculty/farabee/biobk/biobooktoc.html

• http://www.werathah.com/• http://lectures.molgen.mpg.de/online_lecture

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References

• http://www.biology.lsu.edu/webfac/jmoroney/BIOL3090/

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THANKYOU FOR YOUR

ATTENATIONFadhl-alakwaa.weebly.com