immunology, immunotherapy & radiation oncology · 2020. 12. 17. · biology of immunotherapy...

2020 Radiosurgery Society® Virtual Scientific Meeting

Agenda Subject to Change the Radiosurgery Society® | www.therss.org | www.rssmeetings.org

Immunology, Immunotherapy & Radiation Oncology This session, Immunology, Immunotherapy & Radiation Oncology, is co-sponsored by the National Institutes of Health (NIH)/National Cancer Institute (NCI)/ Division of Cancer Therapeutics and Diagnosis (DCTD), Developmental Therapeutics Program (DTP) and Radiation Research Program (RRP) with the Radiosurgery Society (RSS).

Immunotherapy Primer and Latest Developments

Biology of Immunotherapy & Immune Checkpoint Inhibitors Elizabeth Repasky, PhD, Roswell Park Cancer Institute, Buffalo, NY Immunotherapy: How tumor cells are recognized and targeted Timothy Chan, MD, PhD, Memorial Sloan Kettering, New York, NY Tumor Microenvironment and Changes Michael Lim, MD, Johns Hopkins University, Baltimore, MD Abscopal Effects of Radiation with Immunotherapy Andrew Brandmaier, MD, PhD, Weill Cornell University, New York, NY

Radiobiology of Stereotactic Radiosurgery and Stereotactic Body Radiotherapy Radiation Effects on Tumor Micro-environment Chandan Guha, MBBS, PhD, Professor and Vice Chair, Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY Combining Immunotherapy & Radiation Therapy Elizabeth Repasky PhD, Roswell Park Cancer Institute, Buffalo, NY Landscape of Combination Immunotherapy and Radiation Therapy Andrew Brandmaier, MD, PhD, Weill Cornell University, New York, NY Is Immune Modulation Possible with Radiation Treatment? - Report of a Randomized Phase III Study Irradiating Canine De-Novo Brain Tumors Vijayananda Kundapur, MD, FRCR, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Combining Immunotherapy and SRS/SBRT for the Treatment of Cancer Combination Immunotherapy and SRS for Treating Brain Metastases Jing Li, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX Combination Immunotherapy and SBRT for Lung Cancer Nitin Ohri, MD, Montefiore Medical Center, Bronx, NY Combination Immunotherapy and SBRT for Metastatic Melanoma Chad Tang, MD, The University of Texas MD Anderson Cancer Center, Houston, TX Overview of Clinical Trials Elad Sharon, MD, MPH, Investigational Drug Branch, National Institute of Health, Bethesda, MD



Showdown Debate: SBRT vs Brachytherapy for Prostate Cancer Moderators: Debra Freeman, MD, Naples Radiation Oncology, Naples, FL and Shankar Siva, PhD, MBBS, FRANZCR, Peter MacCallum Cancer Centre, Australia

Andrew Loblaw, MD, FRCPC, MSc, Sunnybrook Research Institute, Toronto, Ontario, Canada Glenn Bauman, MD, FRCPC, London Regional Cancer Center, London, Ontario, Canada

Showdown Debate: SBRT for Ultra-Central Lung Tumors Moderator: Percy P. Lee, MD, MD Anderson Cancer Center, Houston, TX

Gregory Videtic, MD, CM, FRCPC, FACR, FASTRO, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH Alexander Louie, MD, PhD, MSc, FRCPC, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada

SRS/SBRT Back to Basics: Treatment Planning & Delivery SRS for Brain Metastases Einsley-Marie Janowski, MD, PhD, University of Virginia, Charlottesville, VA

SBRT for Prostate Cancer Debra Freeman, MD, Naples Radiation Oncology, Naples, FL and Jing Feng, MS, Philadelphia CyberKnife, Havertown, PA

Imaging and Targeting for Stereotactic Radiotherapy Introduction to Imaging and Targeting Spine and Liver William Yuh, MD, MD, MSEE, University of Washington, Seattle, WA

Spine Imaging, Anatomy and Function Nina A. Mayr, MD, FASTRO, FAAAS, University of Washington, Seattle, WA

Contouring the Spine Simon S. Lo, MD, FACR, FASTRO, University of Washington, Seattle, WA

Post SBRT Imaging of Spine Pejman Maralani, MD, FRCPC, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Liver Imaging, Anatomy and Function Tae Kyoung Kim, MS, PhD, MD, University of Toronto, Toronto, Ontario, Canada

Contouring the Liver Smith “Jim” Apisarnthanarax, MD, University of Washington, Seattle, WA

Post Liver SBRT Imaging Michael Lock, MD, CCFP, FRCPC, London Regional Cancer Center, London, Ontario, Canada



Emerging Ablative, Precision Radiation Therapies SBRT for Early-Stage Breast Cancer Asal Rahimi, MD, MS, University of Texas Southwestern, Dallas, TX

Partial Prostate SBRT Rodney J. Ellis, MD, Penn State Health Milton S. Hershey Medical Center, Hershey, PA

Clinical Abstract Presentations - CNS

Stereotactic Radiosurgery with Immunotherapy Improves Overall Survival in Patients with Either Melanoma or Non-Small Cell Lung Cancer Metastatic to the Brain: An Analysis of the National Cancer Database Julie Jiang, MD, PhD, Montefiore Medical Center, Bronx, NY

Frameless Radiosurgery with Gamma Knife Icon: Initial Clinical Experience Yasemin Bolukbasi, MD, Koc University, Istanbul, Turkey

Dosimetric Comparison of Protons Versus Photons for Treatment of Vestibular Schwannoma Shivani Sud, MD, UNC Hospitals, Chapel Hill, NC

Frameless Image-guided Robotic Radiosurgery for Trigeminal Neuralgia Pantaleo Romanelli, MD, CDI Centro Diagnostico Italiano S.p.A., Milan, Italy

Preliminary Results of a Phase I/II Clinical Trial for Coneless, Frameless MLC-based Radiosurgical Thalamotomies for Essential and Parkinsonian Tremor Evan M. Thomas, MD, PhD, University of Alabama at Birmingham, Birmingham, AL

Brainstem Radiosurgery: Analysis of Dose and Radiographic Adverse Events Eric J. Lehrer, MD, Icahn School of Medicine at Mount Sinai, New York, NY

Post-Radiosurgery Hemorrhage in Pediatric Arteriovenous Malformations: A 30-Year Perspective Michael M. McDowell, MD, University of Pittsburgh, Pittsburgh, PA

Automated Segmentation of Multimodal MRI/MRA Images for Cerebral AVM SRS Treatment Planning - A Deep Learning Approach Aaron Benjamin Simon, MD, PhD, University of California, San Diego, La Jolla, CA

Single-fraction Stereotactic Body Radiation Therapy (SBRT) using a Simultaneous-Integrated Boost (SIB) Approach for the Treatment of de Novo Spinal Metastases Samantha Brocklehurst, BS, UT Southwestern Medical Center, Dallas, TX

Single Fraction and Fractionated Radiosurgery compared to Conventional Radiotherapy for Management of Spinal Metastases: A Systematic Review and Meta-Analysis of Clinical Outcomes Raj Singh, MD, Virginia Commonwealth University Health System, Richmond, VA

MiT Award Winner

MiT Award Winner

MiT Award Winner



The Effect of Physiologic Spinal Cord Motion on Cord Dose in Spine SBRT Murat Alp Oztek, MD, University of Washington Medical Center, Seattle, WA

Radiosurgery to the Spinal Dorsal Root Ganglion Induces Fibrosis and Inhibits Satellite Glial Cell Activation While Preserving Axonal Neurotransmission Ezequiel Goldschmidt, MD, PhD, University of Pittsburgh, Pittsburgh, PA

Normal Tissue Complication Probability of Vertebral Compression Fracture after Stereotactic Body Radiotherapy for Spine Metastasis Xuguang Chen, MD, PhD, Johns Hopkins School of Medicine, Baltimore, MD

Clinical Abstract Presentations –Thoracic & Gastrointestinal Lesions

Single Fraction Stereotactic Body Radiotherapy (SBRT) for Primary and Metastatic Lung Tumors Luis Larrea, MD, PhD, Hospital Vithas Virgen del Consuelo, Valencia, Spain

Stereotactic Ablative Body Radiotherapy versus Conventionally Fractionated Radiotherapy for Early Stage Large Cell Neuroendocrine Carcinoma of the Lung Stephen Abel, DO, Alleghany Health Network, Pittsburgh, PA

Stereotactic Body Radiotherapy for Pulmonary Oligometastases in Colorectal Cancer Patients: Clinical Outcomes and Prognostic Factors Zhiyong Yuan, MD, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

Confirmation of Independent Functional Liver Imaging Predictors of Survival in Cirrhotic Hepatocellular Carcinoma Patients Stephanie K. Schaub, MD, University of Washington, Seattle, WA

Stereotactic Body Radiotherapy (SBRT) for Colorectal Liver Metastasis - Updated Clinical Outcomes from the International Multi-Institutional RSSearch® Patient Registry Andy Gaya, MD, Leaders in Oncology, London, United Kingdom

Radiotherapy May Improve Progression Free Survival in Patients with Hepatocellular Carcinoma Treated with Nivolumab Aviva Berkowitz, MD, Montefiore Medical Center, Bronx, NY

Determining Changes in Organ Sparing with Increasing Target Dose Heterogeneity for Pancreatic SBRT VMAT Evan Meekins, BS, MS, Geisinger Health System, Danville, PA

Clinical Abstract Presentations – Genitourinary & Gynecological Tumors

MRI-Linac Guided Stereotactic Body Radiotherapy with Simultaneous Integrated Boost for Prostate Cancer: Initial Results of a Feasibility Study Josephine Kang, MD, PhD, Weill Cornell Medical College, New York, NY

MiT Award Winner

MiT Award Winner



Spatially Fractionated Radiation Therapy with Lattice Radiation in Far-advanced Bulky Cervical Cancer: A Clinical and Molecular Imaging Outcome Study Beatriz E. Amendola, MD, FACR, FASTRO, FACRO, Innovative Cancer Institute, South Miami, FL

Clinical Outcomes of Stereotactic Body Radiation Therapy (SBRT) for Metastases from Gynecologic Primary Malignancies: Results from a Multi-Institutional Patient Registry Hayden Anthony Ansinelli, MD, MS, University of Arizona, Tucson, AZ

New and Innovative Technology Platforms RefleXion/PET-Linac Delivery Cal Huntzinger, RefleXion Medical, Hayward, CA

CybeRay Rotation Co-60 Stereotactic System: RT Pro from OUR United Group, Xian, China Chang-Ming Charlie Ma, PhD, FASTRO, Fox Chase Cancer Center, Philadelphia, PA

MagnetTx Oncology Solutions B. Gino Fallone, OMRI, PhD, PPhys, FCCPM, DABMP, DABR, FAAPM, FCOMP, University of Alberta, Edmonton, Alberta, Canada

MASEP Infini System Pradeep Patra, MS, DABR, West Cancer Center & Research Institute, Memphis, TN

ZAP Self-Shielded SRS System Stephen Sorensen, PhD, DABR, College of Medicine-Phoenix, Dignity Health, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

MRIdian System for Clinical Treatments: Technical Considerations Anthony Doemer, MS, Henry Ford Health System, Detroit, MI

Stereotactic Radiation Therapy of Early Stage Breast Cancer With Gammapod™ Cedric Yu, DSc, University of Maryland School of Medicine, College Park, MD

Medical Physics - Auto Planning Session

Widespread Clinical Adoption of Knowledge-Based Planning Across Multiple Disease Sites: A NonInferiority Study and Impact on Workforce Efficiency Kevin L. Moore, PhD, University of California, San Diego, La Jolla, CA Machine Learning Optimization (MLO) for Auto Planning in Lung and Liver SBRT Yi Wang, PhD, DABR, Massachusetts General Hospital, Boston, MA Auto-Planning on Spine SBRT Ping Xia, PhD, Cleveland Clinic, Cleveland, OH Auto-Planning for Whole Breast Radiation Therapy using Electronic Compensation Yang Sheng, PhD, Duke University Medical Center, Durham, NC



SRS/SBRT Quality Assurance

An Update on AAPM TG 135U: Quality Assurance for Robotic Radiosurgery Lei Wang, PhD, Stanford University, Stanford, CA

AAPM TG-218 and SBRT Delivery QA Robert A. Price, PhD, DABR, FASTRO, Fox Chase Cancer Center, Philadelphia, PA

Physics Abstract Presentations

An Artificial Intelligence Agent for Rapid IMRT Planning of Prostate SBRT: A Feasibility Study Xinyi Li, MS, Duke University Medical Center, Durham, NC

Development of a Dose-driven Radiomic Feature Extraction Technique for Early-stage Non-Small-Cell Lung Cancer SBRT Yin Gao, BS, CMD, Duke University, Durham, NC

Cherenkov Imaging for Adaptive Replanning Guidance in Head and Neck Radiotherapy Daniel A. Alexander, BS, MS, Dartmouth College, Thayer School of Engineering, Hanover, NH

Robust Treatment Planning with Conformal Arc Informed Volumetric Modulated Arc Therapy (CAVMAT) Justus Adamson, PhD, and Will Giles, Duke University Medical Center, Durham, NC

Fluence Map Prediction via Deep Learning for Pancreas SBRT Wentao Wang, MS, Duke University, Durham, NC

Dosimetric Evaluation of Spine Radiosurgery with a Novel Carbon Fiber Spinal Instrumentation System Ron Lalonde, PhD, UPMC Shadyside, Pittsburgh, PA

CyberKnife MLC Planning for Multiple Brain Metastases Stereotactic Radiosurgery: A New Treatment Planning Approach Tatsiana A. Reynolds, PhD, Minnesota Oncology, St. Paul, MN

3-D Optical Tomography Using CMOS Camera Provides Accurate Central Axis Data for Small SRS Cones Muhammad Ramish Ashraf, BS, Dartmouth College, Hanover, NH

Patient Specific Quality Assurance for Stereotactic Radiosurgery (SRS) Treatment Plans Generated for Novel Self-Shielded Radiosurgery System Shiv Srivastava, PhD, DABR, Barrow Neurological Institute (BNI), St. Joseph’s Hospital & Medical Center, Phoenix, AZ

Validation of Robotic Radiosurgery Target Tracking for APBI Treatments Using a Bioabsorbable Fiducial Array and Plastic Scintillating Detector Jonathan Hill, MS, Erlanger Health System, Chattanooga, TN

MiT Award Winner

MiT Award Winner

MiT Award Winner



Evaluation of Radiation Isocenter Uncertainty for Various SRS Collimation Systems using NIPAM kVCBCT Dosimetry Justus Adamson, PhD, Duke University Medical Center, Durham, NC

Analysis of Potential Interactions in the Concurrent Use of Electromagnetic Anti-Mitotic Therapy with Radiation Therapy Jimm Grimm, PhD, Geisinger Health System, Danville, PA

Abdominal Tumor Tracking of CBCT Projections Using Template Matching and Sequential Triangulation Algorithm Oluwaseyi Oderinde, PhD, University of California, San Diego, La Jolla, CA

GRID Therapy

Activation of Anti-Tumor Immune Response By Spatially Fractionated GRID Radiotherapy Adriana Haimovich-Friedman, PhD, Memorial Sloan Kettering, New York, NY

Spatially Fractionated (GRID) Radiotherapy for High-risk Soft Tissue Sarcoma: An illustrative, Initial Clinical Experience JW Snider, MD, University of Alabama, Birmingham, AL

A Novel 3D-VMAT Based GRID Therapy Xin Zhang, PhD, Boston University, Boston, MA

Minibeam Radiation Therapy: From Photons to Charged Particles Yolanda Prezado, PhD, CNRS-Institute Curie, France

Emerging Clinical Trial Concepts for GRID Majid Mohiuddin, MD, University of Chicago, Chicago, IL

Lattice Therapy

GRID and Lattice Radiotherapy: Where do we stand biologically? Mansoor Ahmed, PhD, Radiation Research Program, NIH/NCI, Bethesda, MD Clinical Applications of Lattice: The Innovative Cancer Institute Experience Beatrice Amendola, MD, Innovative Cancer Institute, Miami, FL Modeling Biological Effects for SFRT Xiadong Wu, PhD, Biophysics Institute, University of Miami, Miami, FL

Lattice Radiation Therapy Practical Clinical Protocol Concepts Anand Mahadevan, MD, Geisinger Health, Danville, PA



Microbeam Therapy

Combined Preclinical Studies Using Microbeam Radiation Therapy Valentin Djonov, MD, University of Bern, Switzerland

Immune Modulation with Radiation-Is it a Hoax? Results of Phase III Study with Mini (Micro)beam Treatment of Canine Brain Tumor Vijayananda Kundapur, MD, Saskatoon Cancer Centre, University of Saskatchewan, Canada

Should Peak Dose be Used to Prescribe Spatially-fractionated Radiation Therapy Treatment? Sha Chang, PhD, University of North Carolina, Durham, NC

FLASH Therapy

The Evolving Saga of FLASH Radiotherapy: An Effective Treatment Against Glioblastoma that Minimizes Neurocognitive Side Effects Charles Limoli, PhD, University of California, Irvine, CA and Marie-Catherine Vozenin, PhD, HDR, University of Lausanne, Switzerland

FLASH RT – Clinical Translation – The Physics Perspective Claude Bailat, PhD, University of Lausanne, Switzerland

Emerging Clinical Trial Concepts in FLASH Therapy Charles Simone, MD, New York Proton Center, New York, NY

Electronic Posters

Linac-Based Hypofractionated Stereotactic Radiosurgery for Brainstem Lesions Amelia Wexler, N. Scott Litofsky, Leslie L. Phillips, Gregory Biedermann, University of Missouri, Columbia, MO

Multiple Brain Metastases (BMs) Radiosurgery (SRS) with Single Isocenter: Automatic Lower Dose Objective or Intratumor Lower Dose Approach? Fabiana Gregucci, Ilaria Bonaparte, Alessia Surgo, Roberta Carbonara, Alba Fiorentino, General Regional Hospital, F. Miulli, Acquaviva delle Fonti-Bari, Italy

Quantitative Effects of Surgical Resection in Stereotactic Radiosurgery for Brain Metastases Joshua Salazar, Evan Meekins, Alejandro Bugarini, Anand Mahadevan, Geisinger Medical Center, Danville, PA

Patient Preferences Between Frame-based and Masked Stereotactic Radiosurgery Matthew Pavlica, Michael Schulder, Anuj Goenka, Troy Dawley, NYITCOM, Glenhead, NY

Linear Accelerator Stereotactic Radiosurgery for Treatment of Glomus Jugulare Tumors: Long-Term Follow-Up of 39 Patients Ankur Patel, Joshua Rodriguez-Lopez, Steven A. Burton, John Flickinger, David Clump, UPMC Hillman Cancer Center, Pittsburgh, PA



Early Results with Gamma Knife ICON Frameless Hypofractionated Radiosurgery for the Treatment of Intracranial Meningiomas Yasemin Bolukbasi, Ömer Batu Hergünsel, Ali Ihsan Atasoy, Selcuk Peker, Koc University, Istanbul, Turkey

Meningiomas Treated with Radiosurgery and Stereotactic Radiotherapy: A Single Institution Experience with 127 Cases –Oncology Hospital, Mexico City, IMSS Jessica Chavez, Centro Medico Nacional Siglo XXI, Mexico City, Mexico

Clinical Experience with Cranial Frameless Stereotactic Radiosurgery System Using Optical Surface Imaging for Motion Monitoring Zhengfeng Liu, Edward Lawrence, Congwu Cui, Farah Naz, Horizon Health Network, Saint John Regional Hospital, Saint John, Canada

Clinical Outcomes of Automated VMAT Radiosurgery and SBRT Matthew Brown, Richard Popple, Markus Bredel, Evan Thomas, John Fiveash, University of Alabama, School of Medicine, Birmingham, AL

Long Term Outcomes Following Three or More Courses of Repeat Lung Radiation Using Stereotactic Body Radiotherapy Anthony Ricco, Sara A. Barlow, Janson Jacob, Raj Singh, Jing Feng, Alexandra Hanlon, Alicia Lozano, Stephen Arrigo, Olusola Obayomi-Davies, John Lamond, Jun Yang, Rachelle M. Lanciano, Virginia Commonwealth University Health, Richmond, VA

Evaluating the Dosimetric Benefit of “Raised Arms” Patient Positioning for Thoracic VMAT SBRT Evan Meekins, Geisinger Cancer Institute, Danville, PA

Linac Based Stereotactic Arrhythmia Radioablation (STAR) of Ventricular Tachycardia: A Case Report Alessia Surgo, Roberta Carbonara, Fabiana Gregucci, Ilaria Bonaparte, Alba Fiorentino, General Regional Hospital F. Miulli, Acquaviva delle fonti, Italy

Liver SABR in “The Real World”: Experience within an NHS Public Cancer Centre Pollyanna Leite, Kasia Owczarczyk, Claire Hartill, Vicky Goh, Andrew Gaya, GSTT, London, United Kingdom

CyberKnife MLC Patient Specific Quality Assurance Using Mapcheck Diode Array Tatsiana A. Reynolds, Mustafa A. Ozer, MN Oncology, St. Paul, MN

The Use of Correction Factor Free Detectors to Validate Ultra-Small Field Dose Distributions Lauren Weinstein, Matthew Skinner, Kaiser Permanente, South San Francisco, CA

Relating Dose Agreement to Chamber Orientation in Patient Specific Quality Assurance for Robotic Stereotactic Radiotherapy Jose Garcia-Cobian, Christopher Anderson, Bing Fang, Northwest Medical Physics Center, Lynnwood, USA

immunology, immunotherapy & radiation oncology · 2020. 12. 17. · biology of immunotherapy...

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