image gallery of bioaxial codim100 super resolution microscopy instrument
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Applications of Conical Diffraction Super Resolution Microscopy and CODIM100 System
Discover some of the possibilities offered by conical diffraction microscopy and the CODIM100
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Bassoon-Alexa488 (pre-synapse) / Homer1-Alexa568 (post-synapse) labelled neurons.Sample courtesy of Maureen McFadden & Zsolt Lenkei, ESPCI ParisTech, Paris, France.
CoDiM reveals the arrangement of critical pre-synaptic and post-synaptic proteins in neurons.
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Confocal CODIM100 Confocal
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TgRNG2-Myc-Alexa488 / TgGAP45-Alexa647 labelled Toxoplasma gondii parasites.Sample courtesy of Arnault Graindorge, Université de Genève, Geneva, Switzerland.
CODIM reveals the ring-like distribution of the Toxoplasma gondii protein RNG2 in its apical complex.
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Live mitochondria in HeLa cells expressing GFP.Samples courtesy of François Prodon, Université de Genève, Geneva, Switzerland.
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CODIM uncovers highly dynamic fission events in live mitochondrias
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LAMP1-Alexa647.Sample courtesy of Ragna Sannerud, VIB & KU Leuven, Belgium.
CODIM unveils LAMP1 sub-diffraction structures
CODIM FWHM = 100nm
EM/CODIM100 Overlay EM/CODIM100 Overlay
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C1-GFP in HeLa cells embedded in resin for electronmicroscopy. Only faint cells were selected to avoid proteinover-expression explaining the low signal on the confocalimages. Images performed with an air 40x 0.95 objective tomeet EM vacuum requirement. Sample and EM imagescourtesy of Lucy Collinson and Chris Peddie, Cancer ResearchUK, London Research Institute, London, UK.
CODIM100Confocal
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CoDiM opens the way to correlative electron and super-resolved 100nm resolution fluorescence microscopy
CODIM100 Benefits and Capabilities
CODIM100 major benefits
• Down to 90 nm super-resolution imaging
• No required specific sample preparation
• Compatible with all standard immunostaining and fluorescent proteins e.g. GFP
• Low phototoxicity1 and negligible bleaching
• Linear response
• Comes with 4 wavelengths standard (405, 488, 561, 640 nm)
• One-button super-resolution zoom
• Integrates seamlessly in regular confocal microscopy workflows
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1 Conical diffraction illumination opens the way for low phototoxicity super-resolution imagingClick to access publication
The CODIM100 is ideal for:
• Imaging live-cells non-invasively thanks to low phototoxicity
• Running long time lapse experiments because of low photobleaching
• Imaging dim/bright structures thanks to high sensitivity and dynamic range
• Performing co-localization experiments with superior accuracy
• Performing CLEM experiments thanks to 100 nm resolution with vaccum-compatible air objectives and full compliance with EM sample preparation
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Thank you for your interest in the CODIM100
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For more information please contact
William Amoyal, VP Sales & Marketing
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BioAxial
24 rue du Faubourg Saint-Jacques
75014 Paris
France
www.bioaxial.com