IMAGE GALLERY LIST OF SERVICES

APPLICATIONS

CONTACT INFORMATION

Our Mission is to Provide State of the Art Technology to Non-

Invasively Image Disease Models and Biological Processes in Living

Systems

The In Vivo Imaging Facility provides a non-invasive approach to observe various disease and biological models in living systems. We currently have equipment to detect all luminescent genetic reporters (luciferase, GFP, RFP, β-gal, etc.) and fluorescent probes ranging from green to near infrared. Our multispectral capabilities permit unmixing of spectrally overlapping fluorophores in the same sample. We also offer planar X-ray for digital radiographic imaging of various types of specimens. Our technology is also applicable to a wide range of In Vitro samples including gels, blots, 96-well plates, and numerous others. Our goal is to train and empower users to independently utilize the facility and its resources. Contact the Managing Director, Dr. Matt Leevy, for training, consultation, and/or experimental service.

OVERVIEW: In Vivo Imaging Facility

W. Matthew Leevy, Ph.D.Managing DirectorMultimodal In Vivo Imaging FacilityUniversity of Notre DameOffice Location: 003 Galvin HallOffice Phone: 574-631-1683Cell Phone: 314-494-6747E-mail: wleevy@nd.edu

Bioluminescent prostate cell detection

X-ray image of a mouse injected IV with a contrast agent

X-ray image of an ~4 cm trout In vivo detection of S. aureus

bacterial infection with a fluorescent probe

Multispectral fluorescence imaging of quantum dots

1 cm

X-ray and fluorescence imaging of murine GI tract

Tumor imaging with a fluorescent probe

Multispectral Fluorescence ImagingBioluminescenceSpecimen RadiographyBone Density MeasurementPlanar Radioisotopic ImagingX-ray computed tomography (Spring ’09)

Tumor ImagingInfection ImagingGene ExpressionBone Growth/DensityMultimodal ImagingKinetic measurements of various biological phenomena (In Vitro and In Vivo)

X-ray image of a fly

In Vivo Imaging FacilityNotre Dame Integrated Imaging Facility