iliac vein recanalization: when and how? · svs/avf guidelines: esvs recommendations: in a patient...
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Iliac vein recanalization: When and how?
Oliver Schlager
Division of Angiology,
Department of Medicine II
Medical University of Vienna
Austria
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Disclosure
Speaker name:
Oliver Schlager
I have the following potential conflicts of interest to report:
Consulting (Optimed, BARD/BD)
Employment in industry
Stockholder of a healthcare company
Owner of a healthcare company
Other(s)
I do not have any potential conflict of interest
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35 year-old male patients with severe pain and swelling oft left leg,
sudden onset 6-8 hours ago.
Uneventful medical history.
Case 1
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Boston Scientific
Case 1
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May R, Thurner J. Angiology 1957;8(5):419-27
www.veinguide.com
May-Thurner-Syndrom
VIDIO trial (multiplane venography vs. IVUS): 26% of obstructions NOT detected by venography
Gagne PJ et al. J Vasc Surg Venous Lymphat Disord 2017;5:678-87
Gagne PJ et al. J Vasc Surg Venous Lymphat Disord 2018;6:48-56
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Case 1
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Kahn SR et al. J Vasc Surg Venous Lymphat Disord 2020
ATTRACT study
Randomization (1:1)
PMT-arm
5 days of parenteral AC,
immediate bridge to warfarin
(INR 2.0-3.0)
5 days of parenteral AC,
concurrent PMT, then bridge to
warfarin (INR 2.0-3.0)
Conservative-arm
Vedantham S et al. N Engl J Med 2017
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Postthrombotic syndrome
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Vedantham S et al. N Engl J Med 2017
Notten P et al. Lancet Haematol 2020
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- Mixed study population (including IF-DVT and FP-DVT)
- No systematic use of IVUS
- Low stentrate (28%)
- No systematic use of dedicated venous stents
- Binary endpoint analysis
Limitations ATTRACT
- Underpowered (withdrawal of informed consent, loss of follow-up)
Limitations CAVA
Limitations both studies
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37 year-old male patients with chronic leg swelling, feeling of heaviness,
Venous claudication (pain-free walking distance 70 m)
History of DVT of right leg including IVC 5 years ago.
Case 2
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Case 2
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SVS/AVF guidelines:
ESVS recommendations:
In a patient with inferior vena cava or iliac vein chronic total occlusion or severe stenosis,
with or without lower extremity deep venous reflux disease, that is associated with skin
changes at risk for venous leg ulcer (C4b), healed venous leg ulcer (C5), or active venous
leg ulcer (C6), we recommend venous angioplasty and stent recanalization in addition to
standard compression therapy to aid in venous ulcer healing and to prevent recurrence.
[Grade – 1; Level of evidence - C]
In patients with clinically relevant chronic ilio-caval or ilio-femoral obstruction or in patients
with symptomatic non-thrombotic iliac vein lesions, percutaneous transluminal angioplasty
and stent placement using large self expanding stents should be considered. [Grade – IIa;
Level of evidence B]
O‘Donnel TF et al. J Vasc Surg 2014
Wittens C et al. Eur J Vasc Endovasc Surg 2015
CIRSE recommendations:
Patients with CEAP clinical class 3-6 and chronic venous outflow obstruction should be
considered for interventional therapyMahnken AH et al. Cardiovasc Intervent Radiol 2014
Recommendations
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Razavi MK et al. Circ Cardiovasc Interv 2015
Nonthrombotic (N=1122)
Acute thrombotic (N=629)
Chronic post-thrombotic (N=1118)
Outcomes after venous stenting
VIRTUS trial
Decrease in VCSS score (4.4 point decrease)
VERNACULAR trial
Improvement in VCSS score and CIVIQ-20 score (p<0.0001)
Dake M presented @ LINC 2019 & CIRSE 2019
Razavi M presented @ LINC 2019
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Conclusions
- Individual decision making (weighing risks against benefits)
- Equipment-Expertise-Environment
- Reducing the burden of the postthrombotic syndrome
- Close post-interventional follow-up and anticoagulation management
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Iliac vein recanalization: When and how?
Oliver Schlager
Division of Angiology,
Department of Medicine II
Medical University of Vienna
Austria