iii international scientific congress of maritime, tropical, hyperbaric and travel medicine...
TRANSCRIPT
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III International Scientific Congress of Maritime, Tropical, Hyperbaric and Travel Medicine
Copenhagen / Oslo, 20-24 May 2015 on-board the DFDS SEAWAYS ferry. Organisers: Polish Society of Maritime, Tropical and Travel Medicine
Institute of Maritime and Tropical Medicine – Medical University of Gdansk National Centres for Maritime, Tropical and Hyperbaric Medicine in Gdynia
International Maritime Health Association
Events’ motto: Healthcare upon the sea and in the travel
The IDEAL Intervention study model of the Non-Communicable Diseases –A challenge
Olaf Jensen, Centre for Maritime Health and Society,
Esbjerg, Denmark
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Background
The World Health Organization reports the Non-Communicable Diseases to be by far the leading cause of death in the world, representing over 60% of all deaths. Risk factors such as a person's physical activities and the type and amount of food are known to be the major preventable risk factors.
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Natural History of Obesity Leading to Type 2 Diabetes
Genetic susceptibilityEnvironmental factors
NutritionPhysical inactivity
AtherosclerosisHyperglycemiaHypertension
RetinopathyNephropathyNeuropathy
BlindnessRenal failureCHDAmputation
Onset ofdiabetes
Complications
Disability
DeathOngoing hyperglycemiaIGTObesity Insulin resistance
Risk forDisease Metabolic
Syndrome
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Tendencias Obesidad Entre Adultos EEUU (BMI ≥ 30)
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Intervention research – success?
•Intervention studies to prevent the Non-Communicable Diseases have been increasingly used in many countries. The methods are most often counselling or education to modify the specific risk factors for overweight, cardiovascular diseases, diabetes and hypertension,
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Intervention research – success?
The objective here is to present the methodological gold standard for the intervention studies and to discuss how to improve the intervention studies and the prevention of this global epidemy
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Goal of intervention research
The primary goal of intervention research is to try out in a sample whether some particular learning could or should be implemented in a larger scale to improve health.
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1.Incidence/prevalence(of health and exposures)Cross sectional or cohort
2. 2. Causal analysisCohort or case-referent
3. 3. Intervention - prognosticCohort (before and after randomized)
• Full-scale implementation
Triad of Epidemiology
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Objective _ example
To reduce the number of seafarers unable to pass the health examination caused by high BMI from 10% to 5% in 3 years.
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Study design, example
• Randomized cohort of seafarers aged 20-40 years from long distance cargo ships
• Development of program • Implementation of program• Epidemiological Impact evaluation • Qualitative evaluation of learning and change objectives• Evaluation of sustainability and full scale implementation
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1. Define the cohort to be used for the intervention
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2. Randomize the cohort in 2 groups
Randomized
Inter-vention
Persons=104
ReferenceGroupPersons=
98
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3. Define time shedule
Randomized
Inter-vention
Persons=104
ReferenceGroupPersons=
98
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3. Define time shedule
Randomized
T0 T1
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year
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3. Define time shedule
Randomized
T0 T1
T2
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year 1 year
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3. Define time shedule
Randomized
T0 T1
T2 T3
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year 1 year 1 year
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4. Define intervention period
Randomized
T0 T1
T2 T3
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year 1 year 1 year
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5. Define type of intervention
Randomized
T0 T1
T2 T3
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year 1 year 1 year
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6. Measure incidence rates T0-T1 before intervention
Randomized
T0 T1
T2 T3
Inter-vention
Persons=104
ReferenceGroupPersons=
98
1 year 1 year 1 year
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6. Measure incidence rates T0-T1 before intervention
Randomized
T0 T1
T2 T3
Inter-vention
Persons=104
* * * * * * *
*•* *
**
ReferenceGroupPersons=
98
1 year 1 year 1 year
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6. Measure incidence rates T0-T1 before intervention
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
Inter-vention
Persons=104
* * * * * * *
*•* *
**
121255
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
1 year 1 year 1 year
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6. Measure incidence rates T0-T1 before intervention
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
Inter-vention
Persons=104
* * * * * * *
*•* *
**
121255
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
121222
1 year 1 year 1 year
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7. Perform the intervention T1-T2
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
Inter-vention
Persons=104
* * * * * * *
*•* *
**
121255
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
121222
1 year 1 year 1 year
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7. Perform the intervention T1-T2
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
Inter-vention
Persons=104
* * * * * * *
*•* *
**
121255
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
121222
1 year 1 year 1 year
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8. Measure incidence rates T1-T2 during intervention
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
Inter-vention
Persons=104
* * * * * * *
*•* *
**
121255
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
121222
1 year 1 year 1 year
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8. Measure incidence rates T1-T2 during intervention
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
B T1-T2
Inter-vention
Persons=104
* * * * * * *
*•* *
**
* ** *
* *
*
121255
6767
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
* * * *
*•* *
* *
121222
102102
1 year 1 year 1 year
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9. Measure incidence rates T2-T3 after intervention
Rates per 1000 persons per year
Randomized
T0 T1
T2 T3 A T0-T1
B T1-T2
C T2-T3
Inter-vention
Persons=104
* * * * * * *
*•* *
**
* ** *
* *
*
* ** *
* *
* *
*
121255
6767 7777
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
* * * *
*•* *
* *
* * *
**
** *
*
121222
102102 9292
1 year 1 year 1 year
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10. Calculate Relative Risks T1/T3 after/before intervention
Rates per 1000 persons per year RR
Randomized
T0 T1
T2 T3 A T0-T1
B T1-T2
C T2-T3 C/A
Inter-vention
Persons=104
* * * * * * *
*•* *
**
* ** *
* *
*
* ** *
* *
* *
*
121255
6767 7777 0.60.622
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
* * * *
*•* *
* *
* * *
**
** *
*
121222
102102 9292 0.70.755
1 year 1 year 1 year
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11. Relative Risks of Intervention and reference groups
Rates per 1000 persons per year RR
Randomized
T0 T1
T2 T3 A T0-T1
B T1-T2
C T2-T3 C/A
Inter-vention
Persons=104
* * * * * * *
*•* *
**
* ** *
* *
*
* ** *
* *
* *
*
121255
6767 7777 0.60.622
ReferenceGroupPersons=
98
* * * * *
*•* *
** *
* * * *
*•* *
* *
* * *
**
** *
*
121222
102102 9292 0.70.755
1 year 1 year 1 year RR 1.0 0.650.65 0.830.83
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Conclusion of the theoretical example
• Let´s say there was no significant effect of the intervention
• Should a large scale program be implemented ?
• Why ?
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Worksite Nutrition and Physical Activity Interventions - review
… found that worksite nutrition and physical activity programs achieve modest improvements in employee weight status at the 6–12-month follow-up.
Anderson LM, Quinn TA, Glanz K, Ramirez G, Kahwati LC, Johnson DB, et al. The effectiveness of worksite nutrition and physical activity interventions for controlling employee overweight and obesity: a systematic review. Am J Prev Med. 2009 Oct;37(4):340–57.
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The ’Healthy Heart Programmes’ Cochrane review
Multiple risk factor interventions in 57 studies had little or no impact on the risk of coronary heart disease mortality or morbidityThe effects of attempting behaviour change in the general population are limited and do not appear to be effective.
Ebrahim S, Taylor F, Ward K, Beswick A, Burke M, Davey Smith G. Multiple risk factor interventions for primary prevention of coronary heart disease. Cochrane Database of Systematic Reviews. Issue 1, 2011, Issue 2, 2013
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Lancet Series 1 ”The global obesity pandemic: shaped by global drivers and local environments”
• The increases in obesity in almost all countries seem to be driven mainly by changes in the global food system.
• Unlike other major causes of preventable death and disability, such as tobacco use, there are no exemplar populations in which the obesity epidemic has been reversed by public health measures.
• Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011 Aug 27;378(9793):804–14.
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1950 - multifactural causal model multifatural prevention
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1980 -> limited causal model limited or no prevention
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1980 -> limited – individual causal model limited effect documented
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2014 -> a comprehensive model
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ILO: Integrating health promotion into workplace
•Integrating health promotion into workplace OSH policies•Stress •Violence, •Smoke-free workplaces•Alcohol and drugs, •Nutrition, •Physical activity, •Healthy sleep •HIV/AIDS.
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WHO: Definition of health
Good health is a state of complete physical, social and mental well-being, and not merely the absence of disease or infirmity. Good health is a fundamental human right - Universal Declaration of Human Rights (1948).
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ConclusionsHealth promotion intervention studies are so far likely to have only small impact on mortality and morbidity
Despite these facts: health promotion intervention research is still needed to persue the other part of the WHO goals: physical, mental and social well-being.
This may on the long run, reduce the mortality and morbidity – time will show
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To reduce mortality and morbidity, concerted actions with comprehensive structural programs by the national governments, civil communities, educators, employers, unions etc are needed
In the maritime area, interventions should be wider than on board the ships
– the maritime industry may go together with the national and international (ILO-WHO) public and occupational health programs
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Issues for discussion
1) How can effective maritime health intervention studies be designed? 2) How can the seafarer´s health examinations be used for systematic health intervention programs? 3) A challenge for the global maritime industry with the IMHA-Research joining the public health programs
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Thank you very much