idealp pharma corporate overview jan 2010 str
TRANSCRIPT
Corporate overview
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As a contract research company which supports its customers'
drug discovery activities,
Idealp-Pharma provides a range of flexible services :
contract research in medicinal chemistry
contract research chemistry
custom synthesis
Idealp-Pharma mission statement
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Key figures
Founded in 2000 by Serge Petit
1500 square meters of labs
30 staff
10 years of collaboration with pharma & biotechs
Idealp-Pharma at a glance
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Contract research in medicinal Chemistry
FTE based flexible contract research
Experienced medicinal chemistry team
Focused library synthesis
Develop SAR
Biological screening analysis cycles
ADME/Tox properties analyses
Speed up the hit optimisation process
Identify lead compounds with desired activity and physical properties
Medicinal Chemistry
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Contract Research in chemistry
FTE based flexible contract chemistry research
Novel molecule synthesis contract projects
Particular expertise in multi-step synthesis
Design and synthesis of high quality small to medium sized libraries.
Patent exemplification
Expend and develop your SAR in an efficient and reliable manner
Flexible management of molecule optimisation projects
Clients may refocus their project at any time
Chemistry
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Custom synthesis
Fee for service based
Customer's need for a particular compound
Up to the 500 gram scale
Customer may wish to supply a known route
Knowledge to devise or improve synthetic routes
IP assumes full responsibility for delivering your molecules
Custom synthesis
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Chemistry Capabilities
For synthetic chemistry:Radleys Carousel reaction stationsQuest 205 ArgonautMicrowave apparatus Variomag reaction blocksGenevac HT4 evaporating system
For purification :Flash chromatographyAutomated systems :- Biotage- Combiflash Isco SystemGilson-Thermo Quest AQA semi-preparative LC-MS
For analytical chemistry :LC-MS: Agilent and Gilson-Thermo Quest AQABruker NMR spectrometers: AC 200, ALS 300, DRX 300 and DRX 500. Mass spectrometers: Nermag R10-10H and Thermo Quest MAT 95XLIR: Nicolet FTIR
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In vitro early ADMET
Physicochemical properties
Permeability assays (PAMPA)
Metabolic and plasmatic stability on human and murine microsomes
CYP450 inhibition
Cytotoxicity tests (MTT, ATP and LDH release tests)
Cardiotoxicity (hERG Chanel assay on 384 well plates)
Exploratory PK and Toxicity
Management of in vivo PK and toxicity studies
ADMET Capabilities
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Key project management steps
Signature of a confidentiality agreement
First meeting with focused discussion between the partners
Rapid project proposal and pricing from our team
Terms agreed, followed by contract drafting
Selection of a dedicated PhD-level project manager
and the project team
Scheduled project meetings/reports and/or on request: face-to-face and/or phone meetings, encrypted e-mail…
Final report and product delivery
Work practices
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Idealp-Pharma’s values
High-quality work which meets your needs
Meeting your deadlines
Responsiveness and flexibility
Transparency
Rigorous procedures for data management, backup and security
Work practices
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www.idealp-pharma.com
Thanks for your attention
Contact
Mehdi ChelbiBusiness Development Manager
Idealp-PharmaBâtiment CEI66, Bd Niels Bohr - BP 5213269603 Villeurbanne - France
Tel : +33 437 488 795Mob : +33 663 878 861E-mail : [email protected]