ich 2010 guidelines
TRANSCRIPT
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ICH 2010 Guidelines
Muhammad Asim RanaBSc, MBBS, MRCP, SF-CCM, EDIC, FCCP
Intensive Care Department King Saud Medical City
Riyadh, Saudi Arabia
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Introduction
• Spontaneous ICH is a significant cause of morbidity and mortality.
• Most patients present with small ICHs that are readily survivable with good medical care but sometimes needs aggressive surgical intervention.
• The last ICH Guidelines were published in 2007 and this serves to update those guidelines.
http://www.strokecenter.org/trials/
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ICH & Deterioration
• ICH is a medical emergency-high morbidity and mortality• Hematoma expansion and early deterioration are common
within the first few hours after onset• 20% or more of patients will experience a decrease in the
Glasgow Coma Scale (GCS) score of 2 points between the pre-hospital emergency medical services assessment and the initial evaluation in the emergency department (ED). Average change of GCS is 6 points.
• Mortality rate is 75%. • On presentation to a hospital, 15% of patients demonstrate
a decrease in the GCS score of 2 points in the 1st hour.
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• The risk for early neurological deterioration and the high rate of poor long-term outcomes underscores the need for aggressive early management.
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Pre-hospital Management
• Provide respiratory and cardiovascular support and to transport the patient to the closest facility prepared to care for patients with acute stroke.
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• EMS should notify the ED about the arrival of a potential stroke patient so that critical pathways can be initiated and consulting services can be alerted.
• Advanced notice by EMS can significantly shorten time to CT Scan in the A&E.
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• Obtaining a focused history regarding the timing of symptom onset (or the time the patient was last normal) and information about medical history, medication, and drug use.
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Management in A&E
• Tertiary care center & well equipped A&E • Resources necessary –neurology–neuroradiology–neurosurgery – critical care facilities
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Management in A&E
• Emergency neurosurgical management – hematoma evacuation– external ventricular drainage – invasive monitoring and treatment of ICP
• ICU may come in for– BP management– intubation– reversal of coagulopathy
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Protocol driven ICH management
• Although many centers have critical pathways developed for the treatment of acute ischemic stroke, few have protocols for the management of ICH.
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Neuroimaging
• Rapid neuroimaging with CT or MRI is recommended to distinguish ischemic stroke from ICH – (Class I; Level of Evidence: A). – (Unchanged from the previous guideline)
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Neuroimaging
• CT angiography and contrast-enhanced CT may be considered to help identify patients at risk for hematoma expansion – (Class IIb; Level of Evidence: B)
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Neuroimaging
(Class IIa; Level of Evidence: B). (New recommendation)
• CT angiography, • CT venography, • Contrast-enhanced CT• Contrast-enhanced MRI• Magnetic resonance
angiography• Magnetic resonance
venography
• can be useful to evaluate for underlying structural lesions, including vascular malformations and tumors when there is clinical or radiological suspicion
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Medical Treatment for ICH
• Patients with a severe coagulation factor deficiency or severe thrombocytopenia should receive appropriate factor replacement therapy or platelets– (Class I; Level of Evidence: C) – (New recommendation)
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Medical Treatment for ICH
• Patients with ICH whose INR is elevated due to OACs should have their warfarin withheld, receive therapy to replace vitamin K–dependent factors and correct the INR, and receive intravenous vitamin K
• (Class I; Level of Evidence: C)
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Medical Treatment for ICH
• PCCs have not shown to improve outcome compared with FFP but may have fewer complications compared with FFP and are reasonable to consider as an alternative to FFP
• (Class IIa; Level of Evidence: B)
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Medical Treatment for ICH
• rFVIIa does not replace all clotting factors, and although the INR may be lowered, clotting may not be restored in vivo; therefore, rFVIIa is not routinely recommended as a sole agent for OAC reversal in ICH – (Class III; Level of Evidence: C) – (Revised from the previous guideline)
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Medical Treatment for ICH
• Although rFVIIa can limit the extent of hematoma expansion in noncoagulopathic ICH patients,
• There is an increase in thrombo-embolic risk with rFVIIa and no clear clinical benefit in unselected patients.
• Thus rFVIIa is not recommended in unselected patients. – (Class III; Level of Evidence: A)– (New recommendation)
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Medical Treatment for ICH
• Further research to determine whether any selected group of patients may benefit from this therapy is needed before any recommendation for its use can be made.
• The usefulness of platelet transfusions in ICH patients with a history of antiplatelet use is unclear and is considered investigational – (Class IIb; Level of Evidence: B). – (New recommendation)
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Medical Treatment for ICH
• Patients with ICH should have intermittent pneumatic compression for prevention of venous thrombo-embolism in addition to elastic stockings – (Class I; Level of Evidence: B) – (Unchanged from the previous guideline)
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Medical Treatment for ICH
• After documentation of cessation of bleeding, lowdose subcutaneous low-molecular-weight heparin or unfractionated heparin may be considered for prevention of venous thromboembolism in patients with lack of mobility after 1 to 4 days from onset – (Class IIb; Level of Evidence: B)– (Revised from the previous guideline)
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Blood Pressure and Outcome in ICH
• Until ongoing clinical trials of BP intervention for ICH are completed, physicians must manage BP on the basis of the present incomplete efficacy evidence.
• Current suggested recommendations for target BP in various situations are listed in Table 6 and may be considered – (Class IIb; Level of Evidence: C) – (Unchanged from the previous guideline)
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Blood Pressure and Outcome in ICH
• In patients presenting with a systolic BP of 150 to 220 mm Hg, acute lowering of systolic BP to 140 mm Hg is probably safe – (Class IIa; Level of Evidence: B)– (New recommendation)
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General Monitoring
• Initial monitoring and management should take place in an intensive care unit with physician and nursing neuroscience intensive care expertise – (Class I; Level of Evidence: B) – (Unchanged from the previous guideline)
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Management of Glucose
• Glucose should be monitored and normoglycemia is recommended – (Class I: Level of Evidence: C) – (New recommendation)
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Seizures and Antiepileptic Drugs
• Clinical seizures should be treated with antiepileptic drugs – (Class I; Level of Evidence: A)– (Revised from the previous guideline)
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Seizures and Antiepileptic Drugs
• Continuous EEG monitoring is probably indicated in ICH patients with depressed mental status out of proportion to the degree of brain injury – (Class IIa; Level of Evidence: B)
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Seizures and Antiepileptic Drugs
• Patients with a change in mental status who are found to have electrographic seizures on EEG should be treated with antiepileptic drugs – (Class I; Level of Evidence: C)
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Seizures and Antiepileptic Drugs
• Prophylactic anticonvulsant medication should not be used
• (Class III; Level of Evidence: B)• (New recommendation)
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ICP Monitoring and Treatment
• Patients with a GCS score of <8, those with clinical evidence of transtentorial herniation, or those with significant IVH or hydrocephalus might be considered for ICP monitoring and treatment.
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ICP Monitoring and Treatment
• A cerebral perfusion pressure of 50 to 70 mm Hg may be reasonable to maintain depending on the status of cerebral autoregulation
• (Class IIb; Level of Evidence: C)• (New recommendation)
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ICP Monitoring and Treatment
• Ventricular drainage as treatment for hydrocephalus is reasonable in patients with decreased level of consciousness
• (Class IIa; Level of Evidence: B)• (New recommendation)
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Intraventricular Hemorrhage
• Although intraventricular administration of recombinant tissue-type plasminogen activator in IVH appears to have a fairly low complication rate– efficacy and safety of this treatment is uncertain
and is considered investigational – (Class IIb; Level of Evidence: B)– (New recommendation)
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Minimally Invasive Surgical Removal of ICH
• For most patients with ICH, the usefulness of surgery is uncertain• (Class IIb; Level of Evidence: C) • (New recommendation)
Specific exceptions to this recommendation are following
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Minimally Invasive Surgical Removal of ICH
• Patients with cerebellar hemorrhage who are deteriorating neurologically or who have brainstem compression and/or hydrocephalus from ventricular obstruction should undergo surgical removal of the hemorrhage as soon as possible – (Class I; Level of Evidence: B). (Revised from the previous
guideline) • Initial treatment of these patients with ventricular
drainage alone rather than surgical evacuation is not recommended – (Class III; Level of Evidence: C). (New recommendation)
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Minimally Invasive Surgical Removal of ICH
• For patients presenting with lobar clots >30 mL and within 1 cm of the surface, evacuation of supratentorial ICH by standard craniotomy might be considered – (Class IIb; Level of Evidence: B). – (Revised from the previous guideline)
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Minimally Invasive Surgical Removal of ICH
• The effectiveness of minimally invasive clot evacuation utilizing either stereotactic or endoscopic aspiration with or without thrombolytic usage is uncertain and is considered investigational – (Class IIb; Level of Evidence: B). – (New recommendation)
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Timing of Surgery
• Although theoretically attractive, no clear evidence at present indicates that ultra-early removal of supratentorial ICH improves functional outcome or mortality rate.
• Very early craniotomy may be harmful due to increased risk of recurrent bleeding – (Class III; Level of Evidence: B). – (Revised from the previous guideline)
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Prevention of Recurrent ICH• In situations where stratifying a patient’s risk of
recurrent ICH may affect other management decisions, it is reasonable to consider the following risk factors for recurrence: – lobar location of the initial ICH– older age– ongoing anticoagulation– presence of the apolipoprotein E 2 or 4 alleles– greater number of microbleeds on MRI
• (Class IIa; Level of Evidence:B)• (New recommendation)
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Prevention of Recurrent ICH
• After the acute period, no medical contraindications, BP should be well controlled, particularly for ICH location typical of hypertensive vasculopathy – (Class I; Level of Evidence: A)– (New recommendation)
• After the acute ICH period, a goal target of a normal BP of <140/90 (<130/80 if diabetes or chronic kidney disease) is reasonable – (Class IIa; Level of Evidence: B). – (New recommendation)
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Prevention of Recurrent ICH
• Avoidance of long-term anticoagulation as treatment for nonvalvular atrial fibrillation is probably recommended after spontaneous lobar ICH because of the relatively high risk of recurrence – (Class IIa; Level of Evidence: B).
• Anticoagulation after nonlobar ICH and antiplatelet therapy after all ICH might be considered, particularly when there are definite indications for these agents – (Class IIb; Level of Evidence: B) – (Unchanged from the previous guideline)
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Prevention of Recurrent ICH
• Avoidance of heavy alcohol use can be beneficial – (Class IIa; Level of Evidence: B).
• There is insufficient data to recommend restrictions on use of statin agents or physical or sexual activity – (Class IIb; Level of Evidence: C)– (New recommendation)
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Outcome Prediction and Withdrawal of Support
• Aggressive full care early after ICH onset and postponement of new DNR orders until at least the second full day of hospitalization is probably recommended
• (Class IIa; Level of Evidence: B). • Patients with preexisting DNR orders are not
included in this recommendation.
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Outcome Prediction and Withdrawal of Support
• Current methods of prognostication in individual patients early after ICH are likely biased by failure to account for the influence of withdrawal of support and early DNR orders.
• Patients who are given DNR status at any point should receive all other appropriate medical and surgical interventions unless otherwise explicitly indicated. – (Revised from the previous guideline)
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Rehabilitation and Recovery• Given the potentially serious nature and complex pattern
of evolving disability, it is reasonable that all patients with ICH have access to multidisciplinary rehabilitation – (Class IIa; Level of Evidence: B)
• Where possible, rehabilitation can be beneficial when begun as early as possible and continued in the community as part of a well-coordinated (seamless) program of accelerated hospital discharge and home-based resettlement to promote ongoing recover – (Class IIa; Level of Evidence: B) – (New recommendation)
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Thank you