iccm 2007 intravenous microdialysis : a tool for diagnosis and drug development mark o’connell phd...
Post on 20-Dec-2015
221 views
TRANSCRIPT
![Page 1: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/1.jpg)
ICCM 2007
Intravenous MicrodialysisIntravenous Microdialysis::
A tool for diagnosis and drug developmentA tool for diagnosis and drug development
Mark O’Connell PhD MIBiol CBiol
Director, Probe Scientific Limited
20 September 2007
Any view or opinions expressed are solely those of the author and do not represent the view of the Board unless specifically stated.
![Page 2: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/2.jpg)
MicroEye® sitting beside and within an 18G venous access device
Intravenous microdialysisIntravenous microdialysis- solutions- solutions
![Page 3: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/3.jpg)
Leicester 22 June 2007
Current practices for monitoring?Current practices for monitoring?
![Page 4: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/4.jpg)
Leicester 22 June 2007
Van Den Berghe et al (2001)
Reported that during a 12 month study on 1,550 ICU patients receiving intensive insulin therapy reduced mortality by 42%.overall in-hospital mortality by 34%
bloodstream infections by 46%acute renal failure requiring dialysis or haemofiltration by 41%the median number of red-cell transfusion by 50%critical illness polyneuropathy by 44%
The total hospitalisation cost - intensive treatment group was €6,067,237 (€7,931 per patient) - conventional treatment group was €8,275,394 (€10,569 per patient).
The excess cost of intensive care unit hospitalisation in the conventional versus the intensive treatment group was €2,638 per patient.
Crit Care Med 2006 Vol. 34, No. 3
N Engl J Med. 2001 Nov 8;345(19):1359-67.
![Page 5: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/5.jpg)
Time / min
Dru
g c
once
ntra
tion
Blood sample
Blood Drug Concentration v TimeConventional blood withdrawal
![Page 6: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/6.jpg)
Time / min
Dru
g c
once
ntra
tion
Microdialysis
Blood sample
Blood Drug Concentration v Time using intravenous microdialysis
![Page 7: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/7.jpg)
![Page 8: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/8.jpg)
Basildon and Thurrock University Hospitals NHSFoundation Trust
Blood sample age monitoring device – Paul Cervi & Tony Everitt
• Pre-analytical delay of more than 4 hrs affect the accuracy of certain critical analytes and can adversely influence clinical outcome.
• Clinicians increasingly depend on reliable blood analysis but 30% of samples are more than 4hrs old.
![Page 9: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/9.jpg)
• red cells• white cells• plasma
– platelets– clotting factors– serum
• proteins• lipids• sugars• salts• water
Blood Composition Remove by
centrifugation
clotting
Precipitation / UF
![Page 10: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/10.jpg)
Metabolite Biosensor
CoverCoverMembraneMembrane
G.O.D. orG.O.D. orB.S.A LayerB.S.A Layer(Pt/Carbon)(Pt/Carbon)
DialectricDialectric(Glass)(Glass)
CeramicCeramicSubstrateSubstrate(96% AI203)(96% AI203)
PlatinumPlatinumConductorConductor
![Page 11: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/11.jpg)
Leicester 22 June 2007
• Tissue biopsy
• Discontinuous
• Composition dynamics
– Clotting
– Degradation
• Uncomfortable
• Infectious (disposal)
• Storage is a problem
• Delays
Problems with blood withdrawal?Problems with blood withdrawal?
![Page 12: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/12.jpg)
Leicester 22 June 2007
Clinical Intravenous Clinical Intravenous MicroMicrodialysisdialysis
Chemical monitoring of intensive care patients using intravenous microdialysisH. Stjernstrom, T. Karlsson, U. Ungerstedt, L. HilleredIntensive Care Medicine; 1993; Vol.19:423-428
Clinical drug monitoring by microdialysis: application to levodopa therapy in Parkinson’s diseaseMark T. O’Connell, Francois Tison, Niall P. Quinn and Philip N. PatsalosBritish Journal of Pharmacology 1996; Vol.42:765-769
Antiepileptic Drug Pharmacokinetics in Patents with Epilepsy Using a New Microdialysis Probe: Preliminary ObservationsPN Patsalos, MT O’Connell, HC Doheny, JWAS Sander and SD ShorvonActa Neurochirurgica. Supplement; 1996; Vol. 67:59-62
![Page 13: ICCM 2007 Intravenous Microdialysis : A tool for diagnosis and drug development Mark O’Connell PhD MIBiol CBiol Director, Probe Scientific Limited 20 September](https://reader036.vdocuments.us/reader036/viewer/2022062313/56649d4c5503460f94a2a468/html5/thumbnails/13.jpg)
MicroEyeMicroEye® ® - the future- the future