Hypoallergenic compounding

You cannot lie to an allergy patient

von Dr. med. Siegfried Schlett Apotheker und Arzt

Rewiev of industrial site

Production on a high technical level„Time is money“Course of development needs much time

and money. New compounds cannot be transformed into reality in short time

Technical production has its own price in „quality“ of products

Industrial production

Generate specific demands on raw materials as size of cristal structure, density, moisture and flowing properties

Requires flowing agents to guarantee continously support of powder ore granules to be filled in capsules ore been pressed to tablets ore dragees.

Requires additives to care for the machinesNext page: example for a typical multivitamine

EU-guidelines for additives in nutrition and nutrient formulars

Colouring agents, preservatives, antioxidants, emulgators, melting salts, thickening and emulsifying agents, stabilisators, foam stabilisating agents, taste enhancing, acids, acid-regulating substances ,easy flow and taste masking, lubricants, binders, fillers, disintegrants, diluents, glaze (a shellac), sweeteners, wax, starch, coatings, foam protection, films, moistoring agents, metal containing soaps.

The patients choice?

He needs purest raw material and has to work out hidden lactose or allergenic fillers, which are not on the label of his product Standartized lactose-rub-in raw materials (digestive

enzymes, Bromelain) „No added preservatives“ means, there is no

preservative added by the manufacturer, but the raw material...?

If the product doesn´t state „Manufactured by“ on its label, it is made by a jobber. The presence of excipients might not even be known by the distributor

Bio-energetic investigation

The result of bio-energetic investigation is the sume of all details of your formular

It is quite logic to test with clean formuars, you can count on

Testing materials must be identic with therapeutic agents not only in its main acting substance, but also in the excipients.

Pharmacies and manufacturers should compound in hypoallergenic manners

Effects on environmental factors

Excipients enriched (Magnesiumstearate) undigestable formulars carry pharmaceutical stuff into environmental surroundings.

BGA 1996: Clofibrinic acid in underground water in Berlin (180ng/l)

PZ 2001: 17-ß-Estradiol imGerman rivers already on a level of 1,6ng/l

Niedersachsen is observing the content of Tetracyclin in liquid manure excreted by animals

Ärztezeitung 1.7.2003: antibiotic residues (Sulfametoxazol) im Bavarian drinking water

Allergy patients

Dramaticly increasing rate of allergic reacting children Asthma increased 33% (1995 - 2000) on to 12,5% Pollinosis increased 29% (1995 - 2000) on to 16,1% 2006 even every forth child is an allergy patient Colouring agents and sulfits are dangerous to lung

function. (J. Allergy Clin. Immun. 96 (1996) 839-41Allergic reactions are the most registered site

effects in all countries with departments for supervision of consumers reaction.

Effects of exipients on pharmaceutical kinetics

Metal-containing soaps (Magnesium-stearat and fatty acid compounds as Ascorbylpalmitate) often are used as excipients, which lubrify the filling material (production of tablets and dragees). The working machines do have a lubricant during their high speed actions. The surface of the tablets becomes shining.

Consequences for digestion:

Compounding pharmacies

New chelating compounds for trace elements or minerals, which are not available in industrial production are available through compounding pharmacies.

New vitamin formulars as methylcobalamin (B12) can be produced quickly and in hypoallergenic manner, so the best investigations can be transported into the best form of therapy.

compounding pharmacies, who know to handle with. Sterile manufacturing, are even qualified in this subjects. Klösterl-pharmacy developed a DMSA formular for interavenous use together with Dr.med max Daunderer, Tocxcenter München.

AK promotes cooperation doctor-pharmacist

Individual formulars are available in hypoallergenic quality

Prescriptions are the comunicating billet. Recepies for substances under prescription

(hormones) and not under prescription (vitamins).

Pharmacist collects the recepies and shows, that his manufacuting activities are due to practitioners demand.

Compounding pharmacies

Compounding pharmacies buy proofed raw material and decide together with practitioners, what is the best joice for patients use.

Guarantee independence of imports Improve dialogue between doctor and

pharmacistRealize quickly new dveleopments in therapyGuarantee high level of quality for AK-

practitioners and patients.