hypertension: blood pressure measurement and the new nice guideline prof richard mcmanus bhs annual...
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Hypertension:
Blood Pressure Measurement and the
new NICE guidelineProf Richard McManus
BHS Annual Meeting Cambridge 2011
NICE clinical guideline 127
Overview
•Blood Pressure Measurement – where are we now?
•Implications of measurement modalities on diagnosis
•Systematic Review of methods for diagnosing hypertension
•Cost effectiveness modelling
•Guideline recommendations
•Issues and conclusions
Routine measurement is often flawed
Last_practice_systolic20019018017016015014013012011010090
Dotplot of Last_practice_systolic
Each symbol represents up to 4 observations.
Same population with routine and research measurement
occasion
systolic
654321
146
144
142
140
138
136
134
132
130
Interval Plot of systolic vs occasion95% CI for the Mean
occasions
diastolic
654321
83
82
81
80
79
78
77
Interval Plot of diastolic vs occasions95% CI for the Mean
Even on a single occasion BP drops
•Approx 1500 patients
•24 practices
•6 readings at 1min intervals
•12 mmHg systolic drop
•Stable after 5th reading
Family Practice 1997; 14:130-135
BP takes some time to settle with repeated measurement over weeks/months
BP measurement and diagnosis
•Out of office measures:
•better estimation of “usual blood pressure”
•better correlated with prognosis
Ambulatory vs clinic for Prognosis
•2 pooled plus 11 individual studies
•ABPM superior to clinic BP in predicting CVD events
•Greater risk per mmHg increase in ABPM vs clinic
Hansen J Hyp 2007
Journal of Hypertension 2004, 22:1099–1104
Home vs clinic for prognosis
•4 studies•2 biggest did not show convincing additional prognostic benefit from home above office• Some evidence from smaller studies of improvement from home (esp DBP) but underpowered•Greater risk per mmHg from home
•Out of office measures allow better estimation of “usual blood pressure”
•Better correlated with prognosis
•Detection of White Coat (and masked) HT
BP measurement and diagnosis
•Out of office measures allow better estimation of “usual blood pressure”
•Better correlated with prognosis
•Detection of White Coat (and masked) HT
•ABPM de facto gold standard for most clinicians
•What you do when there is uncertainty
BP measurement and diagnosis
How do clinic and out of office measurements compare?
•Reviewed literature: 2914 studies of which 20 were relevant
•7 compared ABPM with clinic monitoring for diagnosis
•3 compared HBPM with clinic monitoring for diagnosis
•Full details: BMJ 2011;342:d3621 doi: 10.1136/bmj.d3621
Many people currently potentially misdiagnosed...
Worse if only studies around diagnostic threshold used:sensitivity of 86% andspecificity of 46%
What about Home Monitoring?
Relative sensitivity and specificity of clinic and home measurement vs ABPM
What threshold ABPM ?
Based on Head et al BMJ 2010
•adjust by 5/5 mmHg at lower threshold (stage 1 hypertension, 140/90 mmHg clinic)
•ie < 135/85 mm Hg
•10/5 mmHg at higher threshold (stage 2 hypertension, 160/100 mmHg clinic)
•Ie < 150/95 mmHg
Is Out of Office Diagnosis cost effective?
•Modelling to evaluate the most cost-effective
method of confirming a diagnosis of hypertension
in a population suspected of having hypertension
•ABPM vs Home vs clinic
•Further details Lovibond et al, Lancet 2011
Markov Model
•Health and personal social services perspective•Lifetime horizon•Assume all have raised clinic screening•People aged 40 and over
Markov Model
•Costs from published sources and NHS•Test performance from systematic review•Risk calculated using Framingham equation
Results
•ABPM most cost effective for every age group
•Robust to wide range of sensitivity analyses
•Sensitive to
•Assumption of equal test performance•Assumption of no effect of Rx below
140/90 mmHg
If the clinic blood pressure
is 140/90 mmHg or higher,
offer ambulatory blood
pressure monitoring
(ABPM) to confirm the
diagnosis of hypertension
Diagnosing hypertension (1)
When using the following to confirm diagnosis ensure:
ABPM:–two measurements per hour during the person’s usual waking hours (Day time mean)
HBPM:–two consecutive seated measurements, at least 1 minute apart–blood pressure is recorded twice a day and for at least 4 days –measurements on the first day are discarded – average value of all remaining is used
Diagnosing hypertension (2)
Care Pathway
CBPM ≥160/100 mmHg & ABPM/HBPM
≥ 150/95 mmHg
Stage 2 hypertension
Consider specialist referral
Offer antihypertensive drug treatment
Offer lifestyle interventions
If younger than 40 years
If target organ damage present or 10-year cardiovascular risk > 20%
Offer annual review of care to monitor blood pressure, provide support and discuss lifestyle, symptoms and medication
Offer patient education and interventions to support adherence to treatment
CBPM ≥140/90 mmHg & ABPM/HBPM ≥ 135/85 mmHg
Stage 1 hypertension
ABPM issues
•Won’t upfront costs be very expensive?
•Will my (specialist) service be over run?
•ABPM vs home choice
Conclusions
•Diagnosis of Hypertension is changing
•Implementation challenging but benefits can be realised in terms of better targeting of treatment and reduced costs