huntington’s disease ii: genetics and cell pathology neurobiology of disease
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Huntington’s Disease II: Genetics and cell pathology
Neurobiology of Disease
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1983 - Gusella, Wexler and colleagues identify locus1993 - Huntintin cloned, CAG, poly Q repeats identified
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Myers 2004 NeuroRx. 1:255-62.
Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107
Mutant mice:
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Rubinsztein 2002
Harjes, Wanker Trends Biochem. Sci. 28:425
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Landles,Bates 2004EMBO Reports 5:958
Landles,Bates 2004EMBO Reports 5:958
Neurotrophins and Receptors
NGF BDNF NT4/5 NT3
NGFBDNF
NT3NT4/5
TrkA TrkB TrkCp75NTR
(Adapted from Neet & Campenot, 2001)
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Bacquet et al. 2004 J Neurosci. 24:4250-8
Arrasate et al. 2004 Nature 431:805
Fig. 2
Gauthier et al. 2004 Fig. 1
Gauthier et al. 2004 Fig. 1
Schroer 2004