1

Human Genome Project• Long completed; began 60 years ago

• Goal is to understand & control

• Supercomputers are key

• Bioinforamtics Information science Biology Medicine Genome mapping Drug – DNA matching Predictive-preventive

2

Genotyping• Still controversial – your DNA tells all

• Genotyped people get best care Single nucleotide polymorphisms (SNP) 0.1% of total DNA Only 20 main SNP classes determines you and health characteristics.

• SNP uses Easier diagnosis – predicable problems Better preventative medicine “Customized” medicine; by SNP class

3

Genotyping cont.

The haplotypes in the human genome have been produced by the mechanisms of reproduction and record the history of our species.

They are closely linked genetic markers in a chromosome inherited as a group

4

Bioinforamtics

• DNA decoded; Blue Gene unlocked code

• 2005; 180 days to decode the 3.2 billion DNA letters

• 2055; decode/profile in 8 minutes and affordable

• Today, diagnose, predict, fix/modify as required

BioMEMS analyzer

5

• Monitors - Implanted; data via wireless.

• Pharmacy-on-Chip provides medication

• Gene modification

• Nano-robotics for body maintenance and repair

Important Bio-med Areas

6

Simple Bio Implants

WirelessPersonal monitoring

wireless

7

Cosmetic Surgery

• Popular

• Standard library

• Computerized

• Mostly robotic (CAD-like)

8

Early BioDetector

Pathogen/Bad Gene DetectorIBM

500 µm long, 100 µm wide

and about 1 µm thick

9

Lab-on-Chip

DNA can be amplified, separated and identified on a chip

10

Lab on Chip Diagram

11

NanoChip® Electronic Microarray

Portable DNA ExamplesCaliper Tech.

“pumping occurs by applying electric voltage to fluid.

Sandia

12

Sight Restoration 2015

iHUD

Or link directly to

13

FluidFocus Lens

Phillips

14

Sight Restoration 2055

• Retina regeneration

• Optic nerve repair

• Replacement optics

• Grown and transplanted bio-parts

• Moving toward eye grown in place

15

Fantastic Journey?

• Turbines• Tweezers• Cutters• Detectors• Sensors• Pumps• Legs• Wireless• Jets• More

16

Death• Intervention up to age 80

• Euthanasia acceptable, but not suicide

• You may be reactivated in suicide for obligations

• Immortality research was banned in 2025

• Near-mortality is feasible; neg. consequences

17

Birth in the Brave New World

• Parents/Donors DNA QC’d

• Gene “adjustment” OK No super babies allowed Minor modification; gene defect repair Gene libraries; limited use

• Will birth parents matter?