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    Higher Human Biology

    Human Cell Types

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    Introduction

    The human body is made

    up of many specialised

    cells that perform

    specificfunctions.

    Specialised cells arise

    from the differentiation

    of unspecialised cells

    during embryologicaldevelopment.

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    Stem cellswhat do you know

    already?Use the questions below to help you complete a KWL chart to show the followinginformation:

    K what you know already

    W what you want to learn about stem cells during this unit

    L complete this at the end of the unit to summarise what you have learned

    Some questions to think about

    What is a cell?

    What varieties of cell exist?

    What is a tissue? Give some examples.

    What is an organ? Give some examples.

    What is a system? Give some examples. What is a stem cell?

    What are some different types of stem cells?

    What is the purpose of stem cell research?

    What are some ways that stem cells have been successfully used in medicine?

    What are some of the issues in stem cell research?

    What are some of the misconceptions that people have about stem cell research?

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    What are stem cells?

    Stem cells are unspecialisedcells that have the ability toreproduce and differentiate into a diverse range of

    specialised cells.

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    Types of stem cells

    Embryonic Adult

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    Embryonic stem cells

    Embryonic stem cellsare derived from anembryo about 45days old (bastocyst).

    These cells have theability to differentiate

    into all of the celltypes that make up anorganism.

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    Adult (tissue) stem cells

    Adult or tissue stem cells are foundin small numbers in the tissues and

    organs of adults and children,

    including the brain, bonemarrow,

    skeletal muscleand skin.

    These cells give rise to a much

    more limited range of cell types

    and will tend to develop into cell

    types that are closely related to the

    tissue in which they are found.

    These cells replenish

    differentiated cells that need

    replacedin the tissues in which

    they are found.

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    Other types of stem cells

    Stem cells can alsobe taken from theumbilical cord of newbabies.

    Like adult stem cells,these cells can

    differentiate into alimited range ofspecialised cells.

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    Induced pluripotent stem cells

    Induced pluripotent stem cells are adult cells that

    have been genetically reprogrammed to anembryonic stem cell-like state.

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    Somatic cells

    Somatic cells are the differentiated cells that formthe different types of body tissue that exist.

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    Somatic cells

    B Lymphocyte

    Hyaline cartilage

    Smooth muscle

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    Somatic cells

    Ciliated epithelial cell

    Red blood cellplatelets

    neutrophil

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    Somatic cells

    Cardiac muscle

    Nerve cells

    Squamous epithelial

    cells

    T lymphocyte

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    Germline cells

    Germline cells include the gametes and the cells that

    produce the gametes.

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    Division of germline cells

    Germline cells can

    divide by mitosisto

    produce more

    germline cells.

    Gamete mother cells

    divide by meiosisto

    produce gametes.

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    Stem cell research

    Stem cell research provides us with awealth of information and can be studied in

    a variety of ways, including:

    how cell processes such as growth,

    differentiation and gene regulation work the study of diseases and their

    development

    drug testing

    therapeutic uses in the treatment of

    diseases such as leukaemia (bonemarrow transplant), Hunters disease and

    heart disease

    therapeutic uses in medicine, including

    skin grafts for burns and stem cell grafts

    for cornea repair.

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    For example, stem cells could be turned into new bonecells and then injected into weak or broken bones.

    Skin cells could replace burnt skin, and braincells could help people who have suffered braindamage.

    Or they could become nerve cells that could healspinal cord injuries.

    Stem cells could be taken from someone with heart diseaseand be turned into heart cells, which can gather in a dish andthrob! They could then be injected back into the patient torebuild their heart tissue and combat heart disease.

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    Parkinson's is a very common disease starting with mild symptoms, amask-like face, stiffness and tremors until sufferers eventually becomeimmobile. It is caused by a slow deterioration of certain brain cells (neurons)and there's no cure.

    Replacing the affected brain cells seems more hopeful than finding better

    drugs. Many people think that stem cells could be grown into new braincells that could help to treat or even cure Parkinson's.

    Parkinson's disease

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    Therapeutic stem cell cloning

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    Presentation task

    Using what you have learned already and adding further research,

    create a presentation that covers the following aspects of stem cells:

    the biology of stem cellswhat is a stem cell, types of stem cells

    the potential of stem cellsdetails of one or two research projects

    involving stem cells that you have found particularly interesting,details of potential therapies

    stem cell dilemmasexplore the moral and ethical issues

    surrounding stem cell research (personal points of view can be

    expressed if desired).

    You will be assessed using all three of the above criteria as well as on

    the overall quality of your presentation.

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    Not in our back yard!

    Should a business license be issued to ESC lifeworks Inc. by the city of

    Glasgow?

    http://www.glasgowonvideo.co.uk/
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    Cancer cells

    Cancer cells have many

    characteristics that make themdifferent from normal cells:

    Cancer cells continue toreproduceto produce a mass of

    abnormal cells (a benigntumour).

    They do not respond to normalregulatory signalsthat wouldinstruct them to stop dividingwhen necessary.

    They lose the molecules on theirsurface that would normally holdthem in place and can thereforebe detached from theirneighbours, causing the cells tospread(malignant tumour).

    Skin cancer cells (melanoma)

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    HPV

    Certain strains of the

    human papilloma virus

    (HPV) have been shown

    to cause cervical cancer.

    The routine immunisation

    programme in Scotland is

    for girls aged 12 and 13

    (S2). There is also a one-off, three-year catch-up

    programme for older girls.

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    Your task

    Produce an information leaflet designed to answerthe questions of a patient recently diagnosed with

    cancer. Points to consider:

    How are cancer cells different from other cells?

    What is a tumour?

    How will I know if my cancer has spread?

    What is the difference between a malignant

    tumour and a benign tumour?

    How will my cancer be treated?