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Restful Nights and Cheerful Days from Food Sourced Tryptophan

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Page 1: Hudson Zen Bev

Restful Nights and Cheerful Days from Food Sourced

Tryptophan

Page 2: Hudson Zen Bev

Tryptophan Isolated in 1901Sir Frederick Hopkins

Page 3: Hudson Zen Bev

Tryptophan & Serotonin

Tryptophan

Step 1

+ OH

Step 2-COOH

Serotonin

Page 4: Hudson Zen Bev

Tryptophan Metabolism Is Light Dependent

Tryptophan

Serotonin

Melatonin

Page 5: Hudson Zen Bev

Control Mechanisms in Melatonin Synthesis

Pineal Gland

Pineal Cells•Similar in structure to retinal cells•Secrete melatonin at night•Secrete serotonin in the day

Page 6: Hudson Zen Bev

Julius Axelrod

Page 7: Hudson Zen Bev

Melatonin-Serotonin & Light

Serotonin

Superiour Cervical Ganglion

Melatonin

Supra Chiasmatic Nucleus

Page 9: Hudson Zen Bev

5-HydroxyTryptophan 5-HTP

Tryptophan

Step 1

+ OH

Step 2-COOH

Serotonin

Page 10: Hudson Zen Bev

Tryptophan Usage/ 100,000 population

(NEJM 1990)

• Prior to FDA ban 2% of American Households used tryptophan in a regular basis

• The sales growth curve was exponential

0200400600800

1000120014001600

18002000

1980 1984 1988

Males

Females

Page 11: Hudson Zen Bev

Tryptophan Ban

• FDA based on cases of EMS• Before and after Showa Denka product• Genetics play a role?• Contamination plays a role?• Most likely some combination of genetics &

contamination

Page 12: Hudson Zen Bev

Tryptophan Available From Natural Sources But...

• Protein Sources Rich in Tryptophan decrease brain tryptophan levels.

Page 13: Hudson Zen Bev

BBB (Blood Brain

Barrier)

Page 14: Hudson Zen Bev

Transport Sites

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Transport Sites

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Transport Sites(Sites occupied)

Page 17: Hudson Zen Bev

• In fact a high protein meal increases blood levels of tryptophan but lowers brain levels

Tryptophan level

Serotonin level

Page 18: Hudson Zen Bev

• Carbohydrates prompt the pancreas to create insulin

• Insulin reduces the blood level of all amino acids except for tryptophan

• Tryptophan levels rise relative to other amino acids

Carbohydrate

Page 19: Hudson Zen Bev

=

Insulin

Page 20: Hudson Zen Bev

• Carbohydrates reduce blood levels of all amino acids except for tryptophan

Page 21: Hudson Zen Bev

Finding the right protein

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+

=

Page 23: Hudson Zen Bev

• Zenbev increases the serotonin level in the brain

• With Zenbev, brain levels of tryptophan go up as blood levels go up

Zenbev Tryptophan=

Anxiety level

Serotonin level

Page 24: Hudson Zen Bev

At night, serotonin turns into melatonin

Increase in serotonin

Melatonin =

Page 25: Hudson Zen Bev

Sleep StudyNutritional Neuroscience

Chronic Insomnia

RestBites Tryptophan + Carbohydrate Carbohydrate

Page 26: Hudson Zen Bev

Protein Source Tryptophan versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia

Page 27: Hudson Zen Bev

Anxiety StudyCanadian Journal Of Physiology & Pharmacology

Social Phobia

RestBites Carbohydrate

Page 28: Hudson Zen Bev

Protein-source tryptophan as an efficacious treatment for social anxiety disorder: a pilot study

Page 29: Hudson Zen Bev

Eat 1 chocolate ½ hour before bedtime. Try this for three nights and if required, increase by 1 chocolate until the desired effect is achieved.

•90 calories per square•Low Fat (2.5 g)•0 Trans Fats•Caffeine Free•Low Sodium

Page 30: Hudson Zen Bev

Ingredients: Partially Defatted Deoiled Organic Pumpkinseed Flour, Organic Agave

Nectar, Sugar, Chocolate Coating, Caramel, Sunflower Oil, Water, Agar, Soybean Oil, Soy Lecithin – Caffeine Free

Page 31: Hudson Zen Bev

FAQ’s

• What if I take Zenbev during the day, will I get sleepy?

• Can’t I just eat some pumpkin seeds?

• Why does this have Dextrose in it? • I took some Zenbev last night and I

did not sleep any differently. Why?• What is the difference between this

and l-tryptophan?• Is this different than the tryptophan

that was banned a couple of years ago?

Page 32: Hudson Zen Bev

Amide Form

Amine Form

Page 33: Hudson Zen Bev

Benefits• Promotes Deep, Restful Sleep and Daytime Calm

• No Hangover effect in the morning

• Return to sleep easily after waking up in the night

• No risk of dependence or tolerance

• Replace Daytime Stress with a sense of calm control

• Organic Ingredients

• Clinically Proven effective

• Patented product