Dementia Care and Research in ChinaDementia Care and Research in China

Huali WangPeking University Institute of Mental Health

Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia

National Clinical Research Center for Mental Disorders

2Peng X. Science 2011;333:581-587.

Total population: 1.0 billion Total population: 1.3397 billion

Demographic ChangesDemographic Changes

3

Meta-analysis: 9.19 million persons with dementia in 2010

Chan YT, et al. Lancet 2013; 381:2016-23

4Jia J, et al. Alzheimer’s & Dementia 2014;10(1): 1–9.

5

Informal caregiving time and cost

Wang H, et al. Ageing Int 2010;35:153-165

6

Response to the dementia challengeResponse to the dementia challenge

19992001

National Mental Health Plan

2001-2005

2002-2010

2011-2020

2016-2020

China Aging Development Plan (1994-2000)The 10th 5-Year Plan for China Aging Development (2001-2005)The 11th 5-Year Plan for China Aging Development (2006-2010)

White Paper on China Aging Development (2006, the State Council)

The 12th 5-Year Plan for China Aging Development (2011-2015)

2006 2011 2016

National Science & Technology Development

harmonization of assessment instruments (2001-2005) Epidemiology (2006-2010)

New Drug Discovery (2006-2020)Basic science research (2011-2015)

Precision medicineNational Brain Initiative

NCDs management

Improving timely diagnosis and care

8

Delay in seeking diagnosis

Zhao M, et al. Int Psychogeriat 2016;28(2):211–219

9

Improving access to diagnosis

Clinical diagnosis(dementia, MCI)

Cognitive screening

Public health educationTraining community workers

10Xie H, et al. Chinese Journal of Internal Medicine 2014; 53(12):1002-1006

Alzheimer’s Disease Chinese

Consensus on routine memory

check-up for people at

risk of dementia

11

Effect of training for community doctors

3.44%

0.65%0.0%0.5%1.0%1.5%2.0%2.5%3.0%3.5%

screening rateIntensive training Routine training

p=0.036

Hu L, et al. Chinese General Practice 2015

12

Biomarkers for AD diagnosis

Wang et al. Hum Brain Mapp 2015;36:1828-1846 Meng et al. Scientific Reports 2015

13

Caregiver intervention

-0.6

-0.3

0

0.3

0.6

0.9

1.2

NPS

impr

ovem

ent

mea

sure

d w

ith N

PI-Q

4w vs. baseline 12w vs. baseline

Intervention group control group

Zhou S, et al. Peking University Master thesis (2014)

Future research priorities

Aiming to improve accessibility and

affordability of diagnosis, care and

prevention

15

Biomarkers for early diagnosis Culturally appropriate screening and

diagnosis technology Novel drug discovery Caregiver support and intervention Lifestyle support for cognitive health

Thank you!Thank you!