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HRB Centre for Primary Care ResearchDepartment of General PracticeRCSI Medical School
Developing an International Register of CPRs for Primary Care: Identifying an Optimal Strategy to Search the Literature Claire Keogh
Quality Assessment of CPR studiesEmma Wallace
1) Developing an international register of CPRs for primary care
2) Search strategies to identify CPRs relevant to primary care
3) Quality assessment of CPR studies
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The International Register of CPRs for Primary Care
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The International Register of CPRs for Primary Care
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• Develop a register of CPRs for use in primary care
• Developed as part of the Cochrane Primary Health Care Field (http://www.cochraneprimarycare.org/en/index.html)
• Currently 239 relevant articles on the register
The International Register of CPRs for Primary Care
• Problems associated with developing and maintaining the register– No internationally agreed term for CPRs– No internationally agreed term for primary care– No Medical Subject Heading (MeSH) term for CPRs – Over two million articles are published every year
• Haynes and the Hedges Team have developed search tools to identify CPRs. These are not specific to primary care
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Developing an electronic search strategy for MEDLINE
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Electronic Search Filters: Method
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Database Filter type Filter search string
PubMed Haynes Broad Filter (predict*[tiab] OR predictive value of tests[mh] OR scor*[tiab] OR observ*[tiab] OR observer variation[mh])
PubMed Haynes Narrow Filter (validation[tiab] OR validate[tiab])
EBSCO host McGrath/Murphy Broad Filter ((predict* N3 rule* OR predict* N3 model OR predict* N3 models) OR (decision* N3 rule*) OR (TX validat*))
EBSCO host McGrath/Murphy Narrow Filter
((predict* N3 rule* OR predict* N3 model OR predict* N3 models) OR (decision* N3 rule*))
Electronic Search Filters: Results
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Total number of articles CPRs for primary care
Manual ‘Gold Standard’ 6344 44
N articles retrieved by each filter
Haynes Broad Filter 1241 34
Haynes Narrow Filter 88 13
McGrath/Murphy Broad Filter
258 24
McGrath/Murphy Broad Filter
62 16
Combination of filters
HBF and MMBF 1391 35
Electronic Search Filters: Results
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Register
The International Register of CPRs for Primary Care
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Quality assessment of CPR studies
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• CPRs are utilised in decisions regarding patient care
• Quality of CPR studies of key importance• Clinicians need to be able to evaluate
research • Need for clarity and accuracy in research
reporting
Clinical prediction rules (CPRs)
Health research reporting
Health research reporting
• International initiative ‘Equator’ set up in 2008
• Aim to provide resources and education enabling improvement of reporting and monitor progress and improvements
• Develop network of reporting guidelines e.g. CONSORT, STARD, STROBE, PRISMA
Quality assessment of CPRs
• Wasson et al, 1985, Laupacis et al, 1997, McGinn et al, 2000
• Specifically review methodological standards for CPR studies
• Different quality markers for derivation and validation CPR studies
Quality assessment of CPRs
• Currently piloting quality checklists for CPR studies on register
• Combination of quality markers from available resources to develop CPR quality checklist e.g. QUADAS, McGinn
Discussion
• Addition of new search terms?
• Acceptable level missing articles?
• Other available resources for literature?
• Decide on quality guidelines
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HRB Centre for Primary Care ResearchDepartment of General PracticeRCSI Medical School
Developing an International Register of CPRs for Primary Care: Identifying an Optimal Strategy to Search the Literature Claire Keogh
Quality Assessment of CPR studiesEmma Wallace