how to grow your hippocampus in three months majid fotuhi, md phd founder and chief medical officer...
TRANSCRIPT
![Page 1: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/1.jpg)
How To Grow Your Hippocampus
in Three Months
Majid Fotuhi, MD PhDFounder and Chief Medical Officer
NeurExpand Brain Center
Nothing to disclose
![Page 2: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/2.jpg)
New Perspectives
2
![Page 3: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/3.jpg)
Objectives Why hippocampus shrinks with
aging? How can we grow the size of
hippocampus in a clinical setting?
Brain Fitness Program
3
![Page 4: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/4.jpg)
Hippocampal Atrophy is the Most Robust Marker for Dementia
Duara et al., Neurology 71:1986–92, 2008
![Page 5: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/5.jpg)
Main Factors Contributing to Atrophy in Hippocampus
• “Plaques” and “Tangles”
• Inflammation
• Concussion/TBI
• Vascular disease (obesity, OSA, hypertension, diabetes, CHF, CAD, A Fib, strokes)
• Depression(anxiety, stress, PTSD)
![Page 6: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/6.jpg)
Plaques and Tangles
![Page 7: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/7.jpg)
Vascular Factors
Zlokovic et al. Neurosurgery 43(4), 877–78, 1998
![Page 8: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/8.jpg)
Sleep Apnea Shrinks Hippocampus
Am J Respir Crit Care Med 2002; 166:1382–7
8
![Page 9: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/9.jpg)
Obesity Shrinks Hippocampus
Associated with reduced brain volume
Ward, et al., 2005
Slows cognitive function
Debette, et al., 2011
Brains of overweight and obese individuals appeared 8 and 16 years older, respectively
Raji, et al., 2010
9
Brain Research Volume 1280, 14 July 2009, Pages 186–194
![Page 10: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/10.jpg)
Stress Shrinks Brain Cells in Hippocampus
StressControl
14
![Page 11: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/11.jpg)
Depression Shrinks the Brain
The number of days of depression is associated with the severity of hippocampal atrophy
Sheline, et al, (1996). PNAS, 93(9);3908-13.
Depression is associated with impaired memory, executive function and processing speed
Egger et al, (2008). Psychiatry Research: Neuroimaging; 164(3): 237-44)
Sheline, (1996). PNAS, 93(9);3908-13.
15
![Page 12: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/12.jpg)
Figure 2 Comparison of studies of hippocampal volume in clinical depression and PTSD
Fotuhi, M. et al. (2012) Modifiable factors that alter the size of the hippocampus with ageingNat. Rev. Neurol. doi:10.1038/nrneurol.2012.27
![Page 13: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/13.jpg)
Figure 2 Factors that could cause brain atrophy and cognitive impairment
Fotuhi, M. et al. (2009) Changing perspectives regarding late-life dementiaNat. Rev. Neurol. doi:10.1038/nrneurol.2009.175
![Page 14: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/14.jpg)
Multiple Risk Factors Shrink the Hippocampus
Multiple
Risk Factors
No
Risk Factors
HippocampusHippocampus
14
![Page 15: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/15.jpg)
15
DiabetesHypertensionObesitySleep ApneaHead TraumaGenesStress
Brain-healthy DietPhysical FitnessCognitive StimulationMeditation
![Page 16: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/16.jpg)
Objectives Why hippocampus shrinks with
aging? How can we grow the size of
hippocampus in a clinical setting?
Brain Fitness Program
16
![Page 17: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/17.jpg)
1. Hippocampus Grows Biggerwith Getting Fit
Erikson, PNAS 2011
17
![Page 18: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/18.jpg)
Arch Gen Psychiatry, 2010
Hippocampus Grows Biggerwith Exercise, Even After 3 Months
After
Before
18
![Page 19: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/19.jpg)
Draganski et al. J Neurosci 2006; 26:6314–7
2. Hippocampus Grows Bigger with Memorization Training
19
![Page 20: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/20.jpg)
3. Hippocampus Grows Bigger with
Eating Well & Taking DHA
20
![Page 21: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/21.jpg)
21
More DHA-EPA: Bigger Hippocampus
Pottala J V et al. Neurology 2014;82:435-442
![Page 22: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/22.jpg)
Fotuhi et al., Nature Clinical Practice Neurol 5(3):140–52, 2009
![Page 23: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/23.jpg)
23
4. Hippocampus Grows Bigger with Treatment of Sleep Apnea
Canesa, American Journal of Respiratory Medicine, 2011
![Page 24: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/24.jpg)
5. Hippocampus Grows Bigger with Relaxing Your Mind
Holzel , Psychiatric Research, 2011
24
![Page 25: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/25.jpg)
Figure 3 Pathways leading to hippocampal growth or atrophy
Fotuhi, M. et al. (2012) Modifiable factors that alter the size of the hippocampus with ageingNat. Rev. Neurol. doi:10.1038/nrneurol.2012.27
![Page 26: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/26.jpg)
Objectives Why hippocampus shrinks with
aging? How can we grow the size of
hippocampus in a clinical setting?
Brain Fitness Program
26
![Page 27: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/27.jpg)
Brain Fitness Program
A multidisciplinary program devoted to: • Improving memory and brain performance
• Enhancing long-term brain health
• Reducing risk for dementia, Alzheimer’s disease and stroke in the future
Each patient receives a comprehensive baseline assessment followed by a personalized treatment plan
This program is based on latest research and has shown remarkable results
27
![Page 28: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/28.jpg)
Comprehensive Diagnostics
Customized “Brain Fitness Program”
NeurExpand’s Unique Integrative Approach
28
![Page 29: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/29.jpg)
![Page 30: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/30.jpg)
Figure 2
![Page 31: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/31.jpg)
71 year-old man with AAMI
6/13/12 1/25/130
102030405060708090
100
30
97List-Learning
6/13/12 1/25/130
102030405060708090
100
6
46
List-Learning
6/13/12 1/25/130
102030405060708090
100 Mental Shifting
![Page 32: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/32.jpg)
MRI Results
Hippocampus
HC
After
Before
32
![Page 33: How To Grow Your Hippocampus in Three Months Majid Fotuhi, MD PhD Founder and Chief Medical Officer NeurExpand Brain Center Nothing to disclose](https://reader030.vdocuments.us/reader030/viewer/2022032414/56649ef45503460f94c074b3/html5/thumbnails/33.jpg)
Before
After
HC
2.86 cm3
HC
3.14 cm3