Proteus ®PLUS*, TAILOR-MADE IMAGE-GUIDED IMPT SOLUTIONProteus®PLUS is inspired by clinical excellence with an extensive attention to patient experience. It is a unique proton therapy solution for leading cancer centers striving to meet the treatment needs of a large and growing patient base, while further advancing your clinical reputation in cancer care, regionally and nationally. Its cutting-edge features can be configured into a tailored solution to meet your research, clinical and business objectives.

IBA

Gro

up

| IBA

L01/5045 | P

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n th

erapy 2016

REALIZING THE PROMISE OF PROTON THERAPYWe brought proton therapy to clinical cancer care. Ever since we started more than 30 years ago,

our collaborations, our visionary roadmap and progressively unrivalled experience have led us to innovate.

Care givers now benefit from leading, side-effect-minimizing, cost-effective proton therapy technologies.

Today, our complete range of Image-Guided IMPT* solutions can easily be integrated in most healthcare settings to make

it available to all patients who need it. Backed by IBA’s unique service offer (financing, workflow optimization, education),

our solutions range from the single-room Proteus®ONE to the tailor-made Proteus®PLUS. These are supported by robust

processes (installation, operations and upgrades) and are developed in collaboration with our endusers.

Tomorrow, our unique and open culture of sharing will further strengthen clinical and patient communities that we have

always cared for. As we work collectively we make proton therapy available to anyone who needs it.

We’re simply offering more cancer patients better quality of life.

AMERICAS

Toll-free: 1 877 IBA 4 PBT

T +1 904 491 6080

EUROPE, MIDDLE EAST AND AFRICA

T +32 10 203 342

F +32 10 475 923

E-mail: pplus@iba-group.com

RUSSIA & CIS

T/F +7 495 648 69 00

E-mail: info@iba-russia.ru

ASIA PACIFIC

T +86 10 8080 9186

MORE INFORMATION: www.iba-protontherapy.com

THE INFORMATION CONTAINED IN THIS DOCUMENT IS PROPRIETARY AND CONFIDENTIAL. ANY USE AND/OR DISTRIBUTION OF THE MATERIAL CONTAINED HEREIN IS STRICTLY PROHIBITED WITHOUT THE WRITTEN PRIOR APPROVAL OF IBA. // THE MODEL PRESENTED IS A SIMPLIFIED MODEL FOR ILLUSTRATION PURPOSES ONLY. IBA SHALL NOT BE LIABLE FOR ANY DIRECT OR INDIRECT DAMAGE CAUSED BY THE UTILIZATION OF THE MODEL.// PROTEUSPLUS IS THE BRAND NAME OF THE PROTEUS 235 FDA CLEARED AND CE MARKED PRODUCT.

www.iba-protontherapy.com

EXCELLENCE IN PROTON THERAPYProton therapy is widely accepted as a safe, effective and compassionate cancer treatment modality. It represents true progress in the battle against cancer. The right partner can help you break down a complicated process into a series of manageable steps. This partner can lead you along the way to bring this extraordinary treatment modality to your community.

Over the years, IBA helped its renowned clinical customers treat over 30,000 patients with proton

therapy. Those patients benefited from a more compassionate cancer treatment that ensured a better

quality of life during and after treatment.

IBA has installed over 50% of clinically operating proton therapy centers worldwide with over 30

projects that are already operational or at various stages of development. Leading institutions have

already chosen IBA. Join them to develop the future of cancer care together

With thirty years of experience in medical accelerators, IBA, the market leader, has designed

and equipped the majority of clinically operating proton therapy centers around the world.

You benefit from a learning curve that allows us to significantly reduce the time required to reach

first patient treatments.

30

30+

30,000+

YEARS OF EXPERIENCE

PROTON CENTERS PROJECTS DEVELOPED

PATIENTS TREATED

TECHNICAL HIGHLIGHTS OF Proteus ®PLUS

*Some features are under development and will be subject to review by competent authorities (FDA, Notified bodies, et al...)

Turning health care into human care

HOW TO BUILD A PROTON THERAPY CENTER A GENERIC BUSINESS MODEL

www.iba-protontherapy.com

PLUS®Proteus

TYPICAL MEDICAL STAFF

1 PHYSICIAN1 DOSIMETRIST

1 PHYSICIST3 RADIATION THERAPISTS

1 NURSE

ABOUT 7 FULL TIME EQUIVALENT PER ROOM PER 8-HOUR SHIFT

STANDARD INSTALLATION PLANNING

1 2

BUILDING CONSTRUCTIONAPPROX. 18-24 MONTHS

3

4

APPROX. 10-12 MONTHS FROM EQUIPMENT INSTALLATION TO 1ST TREATMENT ROOM ACCEPTANCE

APPROX. 3 MONTHSPER ADDITIONAL ROOM CLINICAL COMMISSIONING

* From building occupancy date at Seattle Cancer Care Alliance (SCCA) Proton Therapy Center, a ProCure Proton Therapy Center, Seattle, WA, USA

RECORD TIME OF 12 MONTHS TO FIRST PATIENT *

HOW TO BUILD A PROTON THERAPY CENTER ?

CYCLOTRON AND BEAM TRANSPORT

SYSTEM

APPROX 55M/180FT

APPROX 30M/100FT

FIXED BEAM TREATMENT ROOM

DIAGNOSTIC &ADMINISTRATION

360° ISOCENTRIC GANTRY TREATMENT ROOM

YEARLY OPERATIONAL EXPENDITURES (OPEX)

Clinical staff

Training of staff

Equipment operation & maintenance

Building maintenance & cleaning

Property insurance

General & administrative

Patients supplies

Power - equipment

FIXED OPEXCAPEX Proton Therapy equipment

OIS/TPS + dosi

Building

SOFT COSTS Development

Capitalized financial costs

Pre-operation & start-up expenses

VARIABLE OPEX

INITIAL INVESTMENT

THESE CHARTS ARE ILLUSTRATIVE ONLY AND VARY MARKET BY MARKET. WITH THE WORLD’S LARGEST INSTALLED BASE, WE HAVE EXPERTISE IN ALL MARKETS. WOULD YOU LIKE A PERSONALIZED BUSINESS CASE WITH DETAILED ESTIMATES FOR YOUR MARKET? CONTACT: PPLUS@IBA-GROUP.COM

TYPICAL CANCER INDICATION MIX % PATIENTS

HEAD & NECK 15%

BRAIN 10%

LUNG 15%

GENITOURINARY/ PROSTATE 15%

GASTROINTESTINAL 20%

OTHERS 5%

PEDIATRIC 15%

RETREATMENT 5%

TYPICAL SCHEDULE OF OPERATIONS

TOTAL NUMBER OF PATIENTS TREATED

PATIENTS TREATED* AT CAPACITY BETWEEN 1000 - 1500 PER YEAR

NUMBER OF FRACTIONS* DELIVERED BETWEEN 125 - 180 PER DAY * This information is highly dependent on the patient mix and

the schedule of operations.

275 DAYSper year

14 HOURSper day

HOURS OF OPERATION

DAYS OF OPERATION

0

20

40

60

80

100

120

0

20

40

60

80

100

120

RESEARCH ROOM