how heat can affect the development of amyloid plaques in alzheimer’s disease
DESCRIPTION
How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease. research proposal by Alexander J. Colón. Alzheimer’s Disease?. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/1.jpg)
How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease
RESEARCH PROPOSAL BY ALEXANDER J. COLÓN
![Page 2: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/2.jpg)
Alzheimer’s Disease?
Alzheimer's disease leads to nerve cell death and tissue loss throughout the brain. Over time, the brain shrinks dramatically, affecting nearly all its functions.
![Page 3: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/3.jpg)
![Page 4: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/4.jpg)
![Page 5: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/5.jpg)
Hypothesis:
Regular and consistent use of a hair dryer can cause Amyloid Plaques to form and indirectly lead to the development of Alzheimer’s Disease.
![Page 6: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/6.jpg)
Reasons:
![Page 7: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/7.jpg)
A conventional hair dryer can reach temperatures between 95 degrees Fahrenheit and 131 degrees Fahrenheit.
The Human Body runs at an average temperature of 98.6 degrees Fahrenheit.
It’s a temperature difference of more than 30 degrees.
![Page 8: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/8.jpg)
How does heat affect the brain?
A fever raises body temp. and can affect the brain.
“Brain damage from a fever generally will not occur unless the fever is over 107.6 °F (42 °C).”
www.nlm.nih.gov
![Page 9: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/9.jpg)
Amyloid Plaques
Alzheimer's tissue has many fewer nerve cells and synapses than a healthy brain.
Plaques, abnormal clusters of protein fragments, build up between nerve cells.
Dead and dying nerve cells contain tangles, which are made up of twisted strands of another protein.
Scientists are not absolutely sure what causes cell death and tissue loss in the Alzheimer's brain, but plaques and tangles are prime suspects.
![Page 10: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/10.jpg)
![Page 11: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/11.jpg)
![Page 12: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/12.jpg)
![Page 13: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/13.jpg)
Method of Investigation:
InterviewsPatient HistoryPolls
![Page 14: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/14.jpg)
Method of Investigation:
MRI Patient BrainsCompare Results
![Page 15: How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease](https://reader035.vdocuments.us/reader035/viewer/2022081515/56815a37550346895dc77615/html5/thumbnails/15.jpg)
References:
R. Brookmeyer, E. Johnson, H.M. Arrighi et al.
Forecasting the global burden of Alzheimer's disease
Alzheimers Dement., 3 (2007), pp. 186–191
D.J. Selkoe
Alzheimer's disease: genes, proteins, and therapy
Physiol. Rev., 81 (2001), pp. 741–766
L. Cruz, S.V. Buldyrev, R. Christie, T. Gomez-Isla, S. Havlin et al.
Aggregation and disaggregation of senile plaques in Alzheimer disease
Proc Natl Acad Sci USA, 94 (1997), pp. 7612–7616