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HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar, MSU Multimedia, Graphics, Webpage Consultant BRUCE L EVATT MD Director, Hematologic Disease Branch Center for Disease Control (CDC)

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Page 1: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

HOW DOES BLOOD CLOT

ROSHNI KULKARNI MDProfessor, Department of Pediatrics & Human Development, Michigan State University

USHA M REDDY MDVisiting Scholar, MSUMultimedia, Graphics, Webpage Consultant

BRUCE L EVATT MDDirector, Hematologic Disease Branch

Center for Disease Control (CDC)

Page 2: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

HEMOSTASIS

• How does blood clot– Hemostasis overview– Platelet activation– Extrinsic pathway– Intrinsic pathway– Tissue factor pathway

• Platelet– Platelet Production– Platelet Membrane– Platelet Body– Platelet Granules– Platelet role in Hemostasis

Page 3: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

HOW DOES BLOOD CLOT - OVERVIEW

Page 4: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

PLATELET ACTIVATION

Page 5: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

EXTRINSIC PATHWAY

Page 6: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

INTRINSIC PATHWAY

Page 7: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

TISSUE FACTOR PATHWAY

Page 8: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

PLATELET

Page 9: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

PLATELET PRODUCTION

Page 10: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

THE PLATELET MEMBRANE

Page 11: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

THE PLATELET BODY

Page 12: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

THE PLATELET GRANULES

Page 13: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

THE PLATELET ROLE IN HEMOSTASIS

Page 14: HOW DOES BLOOD CLOT ROSHNI KULKARNI MD Professor, Department of Pediatrics & Human Development, Michigan State University USHA M REDDY MD Visiting Scholar,

END