8/10/2019 HLA and NK Cell in Pregnancy

1/17

By:Hartini Sri Utami (011314653010)Ririn Ratnasari (011314653003)

HLA and NK Cell In Pregnancy

8/10/2019 HLA and NK Cell in Pregnancy

2/17

1. Agi Harliani S. 2010. Human Leucocyte-G (HLA-G)Dan Peranannya Dalam Reproduksi. MajalahKesehatan Pharma Medika Vol. 2 No. 1

2. Ashley Moffett-King. 2002. Natural Killer Cells AndPregnancy. Nature Rieviews Immunology Vol 2.Nature Publishing group

3. E. Albert Reece, John C. Hobbins, John Wiley &

Sons. 2008. Clinical Obstetrics: The Fetus AndMother. Oxford UK: Blackwell Publishing4. Joan S. Hunt, Margaret g. Petroff, Remsey H.

McIntire, and Carole Ober. 2005. HLA-G AndImmune Tolerance In Pregnancy. The FASEBJournal Vol. 19

8/10/2019 HLA and NK Cell in Pregnancy

3/17

Not Rejected

1. Multiple mechanismsprovide protection

2. Both the fetus and themother contribute todevelopment andmaintenence of the

pregnant uterus as animmune privilage site

3. Fetal factors drivechanges in maternalimmune respons

(Hunt, et al., 2005)

Normalpregnancy

8/10/2019 HLA and NK Cell in Pregnancy

4/17

Hunt, et al. ,2005

8/10/2019 HLA and NK Cell in Pregnancy

5/17

HLA

(Human

Leucocyte Antigen)

MHC(Major

Histocompatibility Complex)

System is the locus of

genes that encode forproteins on the surface

of cells that areresponsible for

regulation of the immune

system in humans Wikipedia, 2014Harliani, 2010

Function: Activatingimmune respons

(innante andadaptive immune)

8/10/2019 HLA and NK Cell in Pregnancy

6/17

HLAE,F,G(class 1bmolecules)

HLADM,DO

HLAClass I

HLA A,B,C

(class 1a molecules)

Classical HLAclass genes

NonclassicalHLA class

genes

HLADP, DQ, DR

HLAClass

II

HLAClass

III

Selsomati

k

Activatedsubgrup immunecells

Makrofag Sel dendritik

Sel epitelkelenjar timus Harliani, 2010

8/10/2019 HLA and NK Cell in Pregnancy

7/17Harliani, 2010

8/10/2019 HLA and NK Cell in Pregnancy

8/17

Reece,et al,

2008

8/10/2019 HLA and NK Cell in Pregnancy

9/17

HLA G(sHLA G in amnion fluids )

HLA C

HLA E

Moffett-King, 2002

8/10/2019 HLA and NK Cell in Pregnancy

10/17

Type of cytotoxic lymphocyte cell Large lymphocytes that have abundant

granule-containing cytoplasmWhat?

In pregnancy decidua (maternal)Where?

Trofoblast invasion in decidua 1sttrimester called uNK (Uterine NaturalKiller) cellWhen?

Moffett-King, 2002

8/10/2019 HLA and NK Cell in Pregnancy

11/17

CSF (Colony stimulating factor), LIF (Leukaemiainhibitory factor) for trofoblast growth and differentiation

TNF- , IFN- ,IFN- , TGF- for inhibits trofoblast growth

Function:Secreatecytokine

NK cell express receptors : NKC (Nk complex of lectin-related genes on chromosome 12), LRC (leukocytereceptor immunoglobulin-lectin-related genes onchromosome 19)

HOW

Activating Inhibitory

Some of theligands for NK cellreceptors are HLA

class I

Interaction

Moffett-King, 2002

8/10/2019 HLA and NK Cell in Pregnancy

12/17

Hunt, et al , 2005

8/10/2019 HLA and NK Cell in Pregnancy

13/17

45 50%

20%

10%

0%

1,7%

Hunt et al , 2005 and Reece et al ,2008

1 st Trimester

8/10/2019 HLA and NK Cell in Pregnancy

14/17

Moffett-King, 2002

8/10/2019 HLA and NK Cell in Pregnancy

15/17

Immune respons inpregnancy that could lead to

rejection of the fetusReece et al , 200

8/10/2019 HLA and NK Cell in Pregnancy

16/17

Immunoregulatory mechanismsin pregnancy that prevent the

rejection of the fetus In normal

pregnancy Reece et al , 200

8/10/2019 HLA and NK Cell in Pregnancy

17/17

SUMMARY

Fetus assemiallograft

Pregnancy Fetusinvasion in decidua

Fetus(EVT)HLA

Endometrium uNK

Immunoadaptive

Fetus not rejectionNORMAL

PREGNANCY